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| 1 | Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B显示文摘AIM:To investigate the predictors of proximal kidney tubular dysfunction(PKTD)induced by adefovir dipivoxil(ADV)treatment for chronic hepatitis B.METHODS:Seventy-nine patients(age at the evaluation of PKTD:56.9±10.7 years)with chronic hepatitis B undergoing long-term oral antiviral nucleos(t)ide analogue treatment were consecutively recruited.PKTD was defined by the presence of at least two of the following five abnormalities:phosphate diabetes,nondiabetic glucosuria,metabolic acidosis,β2-microglobulinuria,or renal hypouricemia.The single-nucleotide polymorphisms(SNPs)in the SLC22A6 gene encoding human organic anion transporter 1(h OAT1)and ABCC2 encoding multidrug resistance protein 2(MRP2)were analyzed using the Taq Man Allelic Discrimination Demonstration Kit.RESULTS:Nine(30.0%)of the 30 ADV-treated patients were diagnosed with PKTD,while no patients without ADV developed PKTD(P<0.001).Three patients with ADV were diagnosed with symptomatic osteomalacia.Among the patients who took ADV,those with PKTD were of higher age at initiation,had significantly longer treatment duration,and had a significantly lower body mass index than those without PKTD.The incidence of PKTD dramatically increased after 96 mo from the start of ADV administration.In contrast,the SNPs were not correlated with PKTD.Logistic regression analysis extracted older age at initiation(OR=5.0,95%CI:1.1-23.4;P=0.040)and longer treatment duration(OR=3.2,95%CI:1.2-8.6;P=0.020)as significant factors associated with PKTD.CONCLUSION:Our results suggest that the tubular function of the kidney of older patients undergoing longterm ADV treatment should be carefully evaluated. | Motohiro Shimizu Norihiro Furusyo Hiroaki Ikezaki Eiichi Ogawa Takeo Hayashi Takeshi Ihara Yuji Harada Kazuhiro Toyoda Masayuki Murata Jun Hayashi | 2015 | World Journal of Gastroenterology2015，21，7： | 18 |
| 2 | Long-term effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer显示文摘 | Yuji Maehata Shotaro Nakamura Kiyoshi Fujisawa Motohiro Esaki Tomohiko Moriyama Kouichi Asano Yuta Fuyuno Kan Yamaguchi Issei Egashira Hyonji Kim Motonobu Kanda Minako Hirahashi Takayuki Matsumoto | 2012 | Gastrointestinal Endoscopy2012，，1： | 10 |
| 3 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 4 | 尼可地尔经皮冠状动脉介入治疗(PCI)降低心肌损伤显示文摘背景尼可地尔作为辅助治疗药物,在缺血性心脏病患者的治疗中具有良好效果。本研究旨在评估尼可地尔选择性经皮冠状动脉治疗(PCI)后对心肌的保护作用。方法我们随机地将49个接受选择性PCI治疗的病人分为尼可地尔及对照这两组。PCI治疗前,尼可地尔组先静脉推注4mg尼可地尔,介入治疗后再以6mg每小时的量静脉滴注24小时。口服尼可地尔给药组持续给药直至接下来的冠状动脉造影(CAG)。PCI治疗前及PCI治疗后0、4、24及48小时分别采集各组静脉血样,检测肌酸激酶(CK)、肌酸激酶MB亚型(CK-MB)、肌钙蛋白Ⅰ(TnI)和肌红蛋白的量。通过对比治疗前后的脑室造影来评价左心室功能及左心室壁运动。结果 PCI治疗后24小时,尼可地尔组的心肌酶水平显著低于对照组;实验组及对照组的CK分别为78.1±34.9,117.4±137.9U/l,显著性P=0.0141,CK-MB为1.57±1.90,2.67±4.50U/l,显著性P=0.0485,TnI为0.37±0.55,0.86±1.65ng/ml,显著性P=0.0101。尼可地尔组的局部左心室壁运动在后期较对照组显著增强。结论尼可地尔能抑制选择性PCI治疗后心肌酶的水平,并在后期显著增强左心室壁的运动,表明尼可地尔可提高PCI治疗时对心肌的保护,降低因血管成形术造成的心肌损伤。 | Tsuyoshi Isono Hiroshi Kamihata Yasuo Sutani Masayuki Motohiro Satoshi Yamamoto Shiori Kyoui Yoshiji Iharada Kouji Kurimoto Katsuko Hara Hakuo Takahashi Toshiji Iwasaka 陈浩 | 2016 | 首都食品与医药2016，23，20： | 3 |
| 5 | The relationship between tyrosine kinase inhibitor therapy and overall survival in patients with non-small cell lung cancer carrying EGFR mutations显示文摘For patients with epidermal growth factor receptor (EGFR) mutation-positive lung cancer, the relationship between the dose or duration of treatment with tyrosine kinase inhibitor (TKI) and overall survival remains unclear. Here, we analyzed clinical data of 39 patients who were diagnosed with EGFR mutation-positive non-small cell lung cancer and treated with TKI, but subsequently died. Several parameters were measured in this study: overall survival; first, second, and overall TKI therapy durations; first TKI intensity (actual dose/normal dose); and TKI rate (overall TKI therapy duration/overall survival). The response rate to TKI therapy was 50% , and the median survival was 553 days. After TKI therapy failed, 38.5% patients were re-challenged with TKI. We observed a moderate relationship [r = 0.534, 95% confidential interval (CI) = 0.263 to 0.727, P < 0.001] between overall TKI therapy duration and overall survival. However, we found no relationship between overall survival and first TKI intensity (r = 0.073, 95% CI = -0.380 to 0.247, P = 0.657) or TKI rate (r = 0.0345, 95% CI = -0.284 to 0.346, P = 0.835). Nonsmall cell lung cancer patients with mutation-positive tumors remained on TKI therapy for, on average, 33% of the overall survival time. These findings suggest that patients with EGFR mutation-positive tumors should not stick to using TKIs. | Hidekazu Suzuki Tomonori Hirashima Norio Okamoto Tadahiro Yamadori Motohiro Tamiya Naoko Morishita Takayuki Shiroyama Tomoyuki Otsuka Kanako Kitai Ichiro Kawase | 2013 | Chinese Journal of Cancer2013，32，3： | 3 |
| 6 | Polymer-Coated Fibrous Packing Materials inMetal Capillary Gas Chromatography显示文摘 | SAITO Yoshihiro OGAWA Mitsuhiro IMAIZUMI Motohiro WADA Hiroo JINNO Kiyokatsu | 2004 | 色谱2004，22，4： | 3 |
| 7 | Advanced technology for the improvement of adenoma and polyp detection during colonoscopy显示文摘 | Tomohiko Moriyama Toshio Uraoka Motohiro Esaki Takayuki Matsumoto | 2015 | Digestive Endoscopy2015，，： | 2 |
| 8 | Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart显示文摘 | Hideyuki Kinoshita Koichiro Kuwahara Motohiro Nishida Zhong Jian Xianglu Rong Shigeki Kiyonaka Yoshihiro Kuwabara Hitoshi Kurose Ryuji Inoue Yasuo Mori Yuhao Li Yasuaki Nakagawa Satoru Usami Masataka Fujiwara Yuko Yamada Takeya Minami Kenji Ueshima Kazuwa | 2010 | Circulation Research2010，，12： | 2 |
| 9 | Primary rhegmatogenous retinal detachment:evaluation of a minimally restricted face-down positioning after pars plana vitrectomy and gas tamponade显示文摘AIM:To evaluate the safety and efficacy of a minimally restricted face-down postoperative positioning following pars plana vitrectomy(PPV)with gas tamponade for primary rhegmatogenous retinal detachment(RRD).METHODS:Patients with primary RRD treated with PPV and gas tamponade and followed up for at least 6 mo were selected for the study.All phakic eyes underwent simultaneous cataract surgery.The patients were required to be in a postoperative position that prevented downward flow of retinal tears.Patients with macular detachment were positioned face-down for only a couple of hours.The patients were assessed for preoperative and postoperative best-corrected visual acuity(BCVA),anatomical retinal reattachment rate,and postoperative complications.RESULTS:In total,40 eyes of 39 patients with primary RRD were included in the study.A single tear was present in 30 eyes(75.0%),multiple retinal tears were present in nine eyes(22.5%),and oral dialysis was present in one eye(2.5%).The anatomical success rate was 90.0%(36 cases)after the primary surgery,and the final anatomical success rate was 100%.The BCVA improved significantly(P<0.001)from 0.75 logarithm angle of resolution(log MAR)preoperatively to 0.12 log MAR at the final visit.Postoperative complications included intraocular pressure elevation(≥25 mm Hg)in 11 patients(27.5%),fibrin formation in two patients(5.0%),pupillary capture of the intraocular lens in two patients(5.0%),and posterior synechia in one patient(2.5%).CONCLUSION:A minimally restricted face-down and flexible postoperative positioning after PPV and gas tamponade for primary RRD is effective and safe. | Kiichiro Kusaba Kotaro Tsuboi Tsuneaki Handa Yukihiko Shiraki Takuya Kataoka Motohiro Kmaei | 2021 | International Journal of Ophthalmology(English edition)2021，14，6： | 2 |
| 10 | 玻璃熔片制样-XRF测定流纹岩中的24种主、次量元素显示文摘采集了雁荡山中折瀑白垩纪古火山口的流纹岩样品,通过二次玻璃熔片法制样,选择多种日本岩石标准物质作为标准样品制作校准曲线,优化建立了X射线荧光光谱法测定流纹岩中SiO_2、TiO_2、Al_2O_3、Fe_2O_3、MnO、MgO、CaO、Na_2O、K_2O、P_2O_5、Th、Pb、Ba、Nb、Zr、Y、Sr、Rb、Zn、Cu、Ni、Co、Cr和V等24种主、次量元素含量的方法。该方法具有环境友好、操作简便、成本低廉等突出优点,并且测定结果的准确度亦令人十分满意。 | 王小平 TSUBOI Motohiro | 2013 | 光谱实验室2013，30，1： | 2 |
| 11 | Comparison of Perioperative and Long-term Outcomes of Total and Proximal Gastrectomy for Early Gastric Cancer: A Multi-institutional Retrospective Study显示文摘 | Toru Masuzawa Shuji Takiguchi Motohiro Hirao Hiroshi Imamura Yutaka Kimura Junya Fujita Isao Miyashiro Shigeyuki Tamura Masahiro Hiratsuka Kenji Kobayashi Yoshiyuki Fujiwara Masaki Mori Yuichiro Doki | 2014 | World Journal of Surgery2014，，5： | 2 |
| 12 | A comparison of postoperative quality of life and dysfunction after Billroth I and Roux-en-Y reconstruction following distal gastrectomy for gastric cancer: results from a multi-institutional RCT显示文摘 | Shuji Takiguchi Kazuyoshi Yamamoto Motohiro Hirao Hiroshi Imamura Junya Fujita Masahiko Yano Kenji Kobayashi Yutaka Kimura Yukinori Kurokawa Masaki Mori Yuichiro Doki | 2012 | Gastric Cancer2012，，2： | 2 |
| 13 | Multi-dimple phenomena in TEHL point contacts显示文摘Theoretical analysis and experimental measurement of the multiple dimples in thermal elastohydrodynamic lubrication (TEHL) point contacts have been carried out. Good agreement is found between the theoretical and experimental results. A thermal multi-spike theory is proposed to explain the multi-dimple phenomena. | 杨沛然 KANETA Motohiro | 2002 | Science China Chemistry2002，45，2： | 2 |
| 14 | Factors Associated with the Clinical Impact of Capsule Endoscopy in Patients with Overt Obscure Gastrointestinal Bleeding显示文摘 | Motohiro Esaki Takayuki Matsumoto Shinichiro Yada Ritsuko Yanaru-Fujisawa Tetsuji Kudo Shunichi Yanai Shotaro Nakamura Mitsuo Iida | 2010 | Digestive Diseases and Sciences2010，，8： | 2 |
| 15 | Mucosal vascular pattern in ulcerative colitis: observations using narrow band imaging colonoscopy with special reference to histologic inflammation显示文摘 | Tetsuji Kudo Takayuki Matsumoto Motohiro Esaki Takashi Yao Mitsuo Iida | 2009 | International Journal of Colorectal Disease2009，，5： | 2 |
| 16 | Genetic analysis is helpful for the diagnosis of small bowel ulceration显示文摘The widespread use of capsule endoscopy and balloonassisted endoscopy has provided easy access for detailed mucosal assessment of the small intestine. However, the diagnosis of rare small bowel diseases, such as cryptogenic multifocal ulcerous stenosing enteritis(CMUSE), remains difficult because clinical and morphological features of these diseases are obscure even for gastroenterologists. In an issue of this journal in 2017, Hwang et al reviewed and summarized clinical and radiographic features of 20 patients with an established diagnosis of CMUSE. Recently, recessive mutations in the PLA2G4A and SLCO2A1 genes have been shown to cause small intestinal diseases. The small bowel ulcers in each disease mimic those in the other and furthermore those found in nonsteroidal anti-inflammatory drug-induced enteropathy. These recent and novel findings suggest that a clinical diagnosis exclusively based on the characteristics of small bowel lesions is possibly imprecise. Genetic analyses seem to be inevitable for the diagnosis of rare small bowel disorders such as CMUSE. | Junji Umeno Takayuki Matsumoto Atsushi Hirano Yuta Fuyuno Motohiro Esaki | 2018 | World Journal of Gastroenterology2018，24，28： | 2 |
| 17 | Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray显示文摘 | MASAKI K MOTOHIRO M Sayaka O | 2005 | Journal of Nutritional Science and Vitaminology2005，51，3： | 1 |
| 18 | European Journal of Lipid Science and Technology 显示文摘 | Xu Fang Sho Kikuchi Motohiro Shima | 2006 | 108(2): 97-1022006，108，2： | 1 |
| 19 | Pulsed electric current sintering of silicon nitride 显示文摘 | MOTOHIRO Suganuma YASUNORI Kitagawa SHIGETAKA Wada | 2003 | J Am Ceram Soc2003，86，38： | 1 |
| 20 | Car-following behavior with instantaneous driver-vehicle reaction delay: a neural- network-based methodology显示文摘 | ZHENG Jian SUZUKI Koji FUJIITA Motohiro | 2013 | Transportation Research Part C Emerging Technologies2013，36，： | 1 |
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