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		题名	作者	年代	出处	被引量
	1	Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD.	Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto	2019	World Journal of Gastroenterology2019，25，14：	5
	2	Postischemic Gene Transfer of Interleukin-10 Protects Against Both Focal and Global Brain Ischemia显示文摘	Hiroaki Ooboshi Setsuro Ibayashi Takashi Shichita Yasuhiro Kumai Junichi Takada Tetsuro Ago Shuji Arakawa Hiroshi Sugimori Masahiro Kamouchi Takanari Kitazono Mitsuo Iida	2005	Circulation2005，，7：	1
	3	Serum micro RNA levels in patients with C rohn’s disease during induction therapy by infliximab显示文摘	Shin Fujioka Ikuo Nakamichi Motohiro Esaki Kouichi Asano Takayuki Matsumoto Takanari Kitazono	2014	J Gastroenterol Hepatol2014，，：	1
	4	Effect of Selective Brain Hypothermia on Regional Cerebral Blood Flow and Tissue Metabolism Using Brain Thermo-Regulator in Spontaneously Hypertensive Rats显示文摘	Setsuro Ibayashi Kentaro Takano Hiroaki Ooboshi Takanari Kitazono Seizo Sadoshima Masatoshi Fujishima	2000	Neurochemical Research2000，，3：	1
	5	Neurotrophin production in brain pericytes during hypoxia: A role of pericytes for neuroprotection显示文摘	Koji Ishitsuka Tetsuro Ago Koichi Arimura Kuniyuki Nakamura Himiko Tokami Noriko Makihara Junya Kuroda Masahiro Kamouchi Takanari Kitazono	2012	Microvascular Research2012，，3：	1
	6	Amiloride inhibits hydrogen peroxide-induced Ca 2+ responses in human CNS pericytes显示文摘	Kuniyuki Nakamura Masahiro Kamouchi Takanari Kitazono Junya Kuroda Yuji Shono Noriko Hagiwara Tetsuro Ago Hiroaki Ooboshi Setsuro Ibayashi Mitsuo Iida	2008	Microvascular Research2008，，3：	1
	7	Duodenal adenomatosis in J apanese patients with familial adenomatous polyposis显示文摘	Yuji Maehata Motohiro Esaki Minako Hirahashi Takanari Kitazono Takayuki Matsumoto	2014	Digestive Endoscopy2014，，：	1
	8	PDGF Receptor β Signaling in Pericytes Following Ischemic Brain Injury显示文摘	Koichi Arimura Tetsuro Ago Masahiro Kamouchi Kuniyuki Nakamura Koji Ishitsuka Junya Kuroda Hiroshi Sugimori Hiroaki Ooboshi Tomio Sasaki Takanari Kitazono	2012	Current Neurovascular Research2012，，1：	1

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