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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Analysis of the impact of conservation measures on streamflow regime in catchments of the Loess Plateau, China 显示文摘 | Mu X M Zhang L McVicar T R | 2007 | Hydrological Processes2007，，21： | 1 |
| 3 | Indoor air pollution and risk of lung cancer among Chinese female non-srnoker显示文摘 | Mu L Liu L Niu R | 2013 | Cancer Causes Control2013，24，3： | 1 |
| 4 | Prognostic value of HIV-1 RNA,CD4 cell count,and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1infection显示文摘 | Mellors J W Margolick J B Phair J P Rinaldo C R Detels R Jacobson L P Mu noz A | 2007 | JAMA2007，297，21： | 1 |
| 5 | Inhibition of Newcastle disease virus replication by RNA interference targeting the matrix protein gene in chicken embryo fibroblasts显示文摘 | Yin R Ding Z Liu X Mu L Cong Y Stoeger T | 2010 | J Virol Methods2010，167，1： | 1 |
| 6 | Chromosome number reports LXXXIX 显示文摘 | Mu S M Shue L R | 1985 | Taxon1985，34，4： | 1 |
| 7 | Online dual updating with recursive PLS model and its application in predicting crystal size of purified terephthalie acid (PTA) process 显示文摘 | Mu S J Zeng Y Z Liu R L | 2006 | Journal of Process Control2006，16，6： | 1 |
| 8 | An intramolecular charge transfer fluorescent probe:Synthesis and selective fluorescent sensing of Ag +显示文摘 | Mu H Gong R Ren L | | 0，，4： | 1 |
| 9 | Experimental analysis of colloid capture by a cylindrical collector in Laminar overland flow显示文摘 | Wu L Gao B Mu?Oz-Carpena R | 2011 | Environmental Science & Technology2011，45，18： | 1 |
| 10 | Property of Concrete Subjected to Freezing and Thawing Under Sulphate Attack显示文摘 | MU R MIAO C L LIU J P | 2001 | Indian Concrete Journal2001，75，7： | 1 |
| 11 | At NAC2,a tran- scription factor downstream of ethylene and auxinsignaling pathways, is involved in salt stress response and lateral root development显示文摘 | He X J Mu R L Cao W H etal | 2005 | Plant J2005，44，： | 1 |
| 12 | Mismatch repair gene mutations in Chinese HNPCC patients显示文摘 | Sheng J Q Fu L Sun Z Q Huang J S Han M Mu H Zhang H Zhang Y Z Zhang M Z Li A Q Wu Z T Han Y Li S R | 2008 | Cytogenetic and Genome Research2008，，1： | 1 |
| 13 | Genome sequence and analysis of the tuber crop potato显示文摘 | Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Tones M Lnzano R Ponce O Martinez D De la Cruz G Chakrabarti S K Patil V U Skryabin K G Kuznetsov B B Ravin N V Kolganova T V Beletsky A V Mardanov A V Di Genova A Bolser D M Martin D M Li G Yang Y Kuang H Hu Q Xiong X Bishop G J Sagredo B Mejia N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M Herrera Mdel R Giuliano G Pietrella M Perrotta G Faeella P O 'Brien K Feingold S E Barreiro L E Massa G A Diambra L Whitty B R Vaillancourt B Lin H Massa A N Geoffroy M Lundback S DellaPenna D Buell C R Sharma S K Marshall D F Waugh R Bryan G J Destefanis M Nagy I Milbourne D Thomson S J Fiefs M Jacobs J M Nielsen K L Sonderkaer M Iovene M Tortes G A Jiang J Veilleux R E Bachem C W de Boer J Bonn T Kloosterman B van Eck H Datema E Hekkert B Goverse A van Ham R C Visser R G | 2011 | Nature2011，475，7355： | 1 |
| 14 | Double-ceramic -layer thermal barrier coatings of La2Zr2OT/YSZ deposited by e- lectron beam-physical vapor deposition 显示文摘 | Xu Z H He L M Mu R D | 2009 | Journal of Al- loys and Compounds2009，473，： | 1 |
| 15 | Two new antiepilepsy compounds-otophyllosides A and B显示文摘 | MU Q Z LU J R ZHOU Q L | 1986 | Sci Sin Ser B (Engl Ed)1986，29，3： | 1 |
| 16 | The inflammasome:a caspase-1 activation platform that regulates immune responses and disease pathogenesis显示文摘 | Franchi L Eigenbrod T Mu(n)oz-Planillo R | | 0，，03： | 1 |
| 17 | Hydrogen storage in carbon nanotubes modified by microwave plasma etching and Pd decoration显示文摘 | Mu Sh Ch Tang H L Qian Sh H Pan M Yuan R Zh | | 0，，： | 1 |
| 18 | Modification of collagen with a natural cross-linker, procyanidin 显示文摘 | He L R Mu C D Shi J B | 2011 | International Journal of Biological Macromolecules2011，48，： | 1 |
| 19 | A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome显示文摘 | Mu?oz-Planil o R Franchi L Mil er LS | | 0，，06： | 1 |
| 20 | AtNAC2, a trauscriptiou factor downstream of ethylene and auxin signaling pathways,is involved in salt stress response and lateral root development显示文摘 | He X J Mu R L Cao W H | 2005 | The Plant Journal2005，44，6： | 1 |
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