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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Radiotherapy-induced heart disease:a review of the literature显示文摘Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the multimodal treatment of thoracic cancers.Due to significant improvements in overall cancer survival,radiotherapy-induced heart disease(RIHD)has become an increasingly recognized adverse reaction which contributes to major radiationassociated toxicities including non-malignant death.This is especially relevant for patients suffering from diseases with excellent prognosis such as breast cancer or Hodgkin’s lymphoma,since RIHD may occur decades after radiotherapy.Preclinical studies have enriched our knowledge of many potential mechanisms by which thoracic radiotherapy induces heart injury.Epidemiological findings in humans reveal that irradiation might increase the risk of cardiac disease at even lower doses than previously assumed.Recent preclinical studies have identified non-invasive methods for evaluation of RIHD.Furthermore,potential options preventing or at least attenuating RIHD have been developed.Ongoing research may enrich our limited knowledge about biological mechanisms of RIHD,identify non-invasive early detection biomarkers and investigate potential treatment options that might attenuate or prevent these unwanted side effects.Here,we present a comprehensive review about the published literature regarding clinical manifestation and pathological alterations in RIHD.Biological mechanisms and treatment options are outlined,and challenges in RIHD treatment are summarized. | Bingwen Zou Julius Philipp Schuster Kerun Niu Qianyi Huang Alexander Rühle Peter Ernst Huber | 2019 | Precision Clinical Medicine2019，2，4： | 2 |
| 4 | Talanta显示文摘 | Li Y H Niu W F Lu J R | 2007 | 71:11242007，71，： | 1 |
| 5 | Hypoxia activates NADPH oxidase to increase(i) and(i) through the mitochondrial ROS-PKCvarepsilon signaling axis in pulmonary artery smooth muscle cells显示文摘 | Rathore R Zheng YM Niu CF | 2008 | Free Radic Biol Med2008，21，： | 1 |
| 6 | Role of Rel/NF-kappa B tran- scription factors in apoptosis of human hepatocellular carcinoma cells 显示文摘 | CHIAO P J NA R NIU J | 2002 | Cancer2002，95，8： | 1 |
| 7 | Anal Chim Acta显示文摘 | Jing T Xia H Guan Q Lu W H Dai Q Niu J W Lim J M Hao Q L Lee Y Zhou Y K Mei S R | 2011 | 692:732011，692，： | 1 |
| 8 | Temporal and spatial distri- butions of phosphine in Taihu lake, China 显示文摘 | Niu X J Geng J J Wang X R | 2004 | Science of the To- tal Environment2004，323，13： | 1 |
| 9 | High-Performance Supereapaci- tots Materials Prepared Via in Situ Growth of NiAl-Layered Double Hydroxide Nanoflakes on Well-Activated Graphene Nanosheets 显示文摘 | Niu Y L Li R Li Z J | 2013 | Electrochimica Acta2013，94，： | 1 |
| 10 | Indoor air pollution and risk of lung cancer among Chinese female non-srnoker显示文摘 | Mu L Liu L Niu R | 2013 | Cancer Causes Control2013，24，3： | 1 |
| 11 | A novel thermo-responsive membrane for chiral resolution显示文摘 | Yang M Chu L Y Wang H D Xie R Song H Niu C H | 2008 | Advanced Functional Materials2008，18，4： | 1 |
| 12 | Influence of deposition strate- gies on CdSe quantum dot-sensitized solar cells: A comparison be- tween successive ionic layer adsorption and reaction and chemical bath deposition显示文摘 | Zhou R Niu H H Zhang Q F | 2015 | J Mater Chem A2015，3，12： | 1 |
| 13 | Factors controlling seagrassgrowth in a gulf coastal system:water and sediment quality andlight显示文摘 | Livingston R J McGlynn S E Niu X | 1998 | Aquatic Botany1998，60，： | 1 |
| 14 | A coumarin derivative covalent-ly immobilized on sensing membrane as a fluorescent carrier fornitrofurazone显示文摘 | Jiao C X Niu C G Yu R Q | 2003 | Anal Bioanal Chem2003，376，： | 1 |
| 15 | Development and application of integrated optical sensors for intense E-field measurement显示文摘 | Zeng R Wang B Niu B etaZ | 2012 | Sensors2012，12，11： | 1 |
| 16 | T helper 1 cells and interferon gamma regulate allergic airway inflammation and mucus production 显示文摘 | Cohn L Homer R J Niu N | 1999 | J Exp Med1999，190，9： | 1 |
| 17 | Color match of machinable lithium disillcate ceramics:Effects of cement color and thickness显示文摘 | Niu E Agustin M Douglas R D | 2014 | The Journal of prosthetic dentistry2014，111，1： | 1 |
| 18 | Ion homeostasis in NaCl stress environments显示文摘 | Niu X Bressan R A Hasegawa P M | 1995 | Plant Physiology1995，109，： | 1 |
| 19 | Paracrine modulation of androgen synthesis in rat leydig cells by nitric oxide显示文摘 | Weissman BA Niu E Ge R | 2005 | J Andro12005，526，3： | 1 |
| 20 | Chemical-regulated , sitespecific DNA excision in transgenic Plants 显示文摘 | Zuo J R Niu Q W Moiler S G | 2001 | Nat Biotechnol2001，19，： | 1 |
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