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| 1 | An analysis of the effect of government- enterprise game in the Government leading Industrial Energy Saving Model 显示文摘 | Mu Shutao Niu Jiangao | 2011 | Energy Procedia2011，，05： | 1 |
| 2 | PDLLA length on anti-breast cancer efficacy of acid-responsive self-assembling mPEG-PDLLA–docetaxel conjugates显示文摘Engineering small-molecule drugs into nanoparticulate formulations provides an unprecedented opportunity to improve the performance of traditional chemo drugs,but suffers from poor compatibility between drugs and nanocarriers.Stimuli-responsive mPEG-PDLLA–drug conjugate-based nanomedicines can facilitate the exploitation of beneficial properties of the carrier and enable the practical fabrication of highly efficacious self-assembled nanomedicines.However,the influence of hydrophobic length on the performance of this type of nanomedicine is little known.Here we synthesized two acid-sensitive ketal-linked mPEG-PDLLA–docetaxel prodrugs with different lengths of PDLLA,and engineered them into self-assembled sub-20 nm micellar nanomedicines for breast cancer chemotherapy.We found that the nanomedicine consisting of a mPEG-PDLLA–docetaxel prodrug with the shorter length of PDLLA stood out due to its potent cytotoxicity,deep penetration into multicellular spheroids,and improved in vivo anticancer performance.Additionally,our prodrug-based nanomedicines outperformed the generic formulation of commercial Nanoxel in terms of safety profile,tolerated doses,and tumor suppression.Our findings indicate that the hydrophobic content of a polymeric prodrug nanomedicine plays an important role in the performance of the nanomedicine,and should be instructive for developing polymeric prodrug-based nanomedicines with clinical translational potential. | Tao Liu Hui Zou Jingqing Mu Xi Zhang Guohua Liu Na Yu Bo Yuan Xiaoyong Yuan Xingjie Liang Shutao Guo | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 3 | Acid-sensitive PEGylated cabazitaxel prodrugs for antitumor therapy显示文摘Although the antitumor drug cabazitaxel shows great therapeutic potential,its high toxicity and poor water solubility limit its utility.However,the use of stimuli-responsive prodrugs is a promising strategy for overcoming these limitations.Herein,we report the synthesis of two highly water soluble,acidsensitive PEGylated acyclic-ketal-linked cabazitaxel prodrugs(PKCs)with improved antitumor efficacy.In an acidic tumor microenvironment,the PKCs hydrolyzed rapidly to release the native drug,whereas they were stable in the normal physiological environment.Compared with cabazitaxel injection,the PKCs had much higher maximum tolerated doses:and in an MDA-MB-231 subcutaneous xenograft nude mouse model,the PKCs showed better antitumor efficacy and safety than cabazitaxel injection.The prodrug strategy reported herein could be useful for the development of other water soluble,acidsensitive prodrugs with improved efficacy. | Tao Liu Hui Zou Jingqing Mu Na Yu Yang Xu Guohua Liu Xingjie Liang Shutao Guo | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
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