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| 1 | Hypothesis review:The direct interaction of food nanoparticles with the lymphatic system显示文摘Besides digestion and assimilation,there are other modes of direct interaction between food and human body.As it is known,the mucosal layer of the digestive tract interfaces with food after the digestion process.It has been demonstrated to uptake the micro-and nanoparticles via mucosa-associated lymphatic tissues(MALT).On the other hand,food is a typical polydisperse system and contains micro-and nanoparticles with different sizes and properties.Accordingly,it is hypothesized that food nanoparticles can directly interact with MALT and more specifically with the support of the preliminary experimental data from our research,that antioxidant nanoparticles can interact with the lymphatic vessels.This kind of interaction would be of great physiological importance.The confirmation of the hypothesis will establish a significant and novel approach to understand food system and provide answers to currently incomprehensible phenomena such as the biological functions of phytochemicals with low bioavailability.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Wei Lu Jingke Guo Jianwu Zhou Lijing Ke Shutao Liu Guanzhen Gao Huiqin Wang Wei Ding Pingfan Rao | 2012 | Food Science and Human Wellness2012，1，1： | 5 |
| 2 | Nonswellable hydrogels with robust micro/nano-structures and durable superoleophobic surfaces under seawater显示文摘Hydrogels, composed mainly of water trapped in three dimensional cross-linked polymer networks, have been widely utilized to construct underwater superoleophobic surfaces. However, the swelling nature and instability of hydrogels under complex marine environment will weaken their underwater superoleophobicity. Herein, we synthesize structured poly(2-hydroxyethylmethacrylate)(PHEMA) hydrogels by using sandpaper as templates. The robust non-swelling of PHEMA hydrogel ensures that micro/nano-structures on the surface of PHEMA hydrogels can be well maintained. Moreover, when roughness Ra of about 3~4 μm, the surface has superior oil-repellency. Additionally, even after immersing in seawater for one-month, their breaking strength and toughness can be well kept. The non-swellable hydrogels with long-term stable under seawater superoleophobicity will promote the development of robust superoleophobic materials in marine antifouling coatings,biomedical devices and oil/water separation. | Ling Lin Hui Yi Xinglin Guo Pengchao Zhang Lie Chen Dezhao Hao Shutao Wang Mingjie Liu Lei Jiang | 2018 | Science China Chemistry2018，61，1： | 3 |
| 3 | Control system for cryogenic permanent magnet undulator(CPMU)of high energy photon source(HEPS)显示文摘Background High energy photon source(HEPS)is the fourth-generation light source,which uses a large number of highperformance insertion devices to generate synchrotron radiation.The control system is an important part of the insertion device(ID).Purpose Cryogenic permanent magnet undulator(CPMU)is one kind of IDs that works in liquid nitrogen temperature and ultra-high vacuum environment,and its control system is more difficult and complex than in-air ID.The design of the control system for CPMU will be introduced in detail.Method The sub-systems include high-precision magnetic gap control,safety protection,measurement and compensation of magnetic gap at cryogenic temperature and cryogenic temperature monitoring.Mature,reliable,stable technical schemes are designed to meet the technical specifications of sub-systems.Results The experiment results show that the magnetic gap motion accuracy can be controlled within 0.2–0.3μm under the step size of 1μm.The safety protection system has been tested in turn,and the predetermined protection can be achieved.The average value of magnetic gap cold contraction is 1.512 mm measured by optical micrometer,and the compensation is realized by software.The average temperature of the main magnet structure measured by the temperature sensors is 81.0 K,and the temperature gradient is 0.7 K/m.The temperature monitoring is reliable and stable.Conclusion The CPMU control system which is based on EPICS has been successfully applied to the CPMU prototype,and the test results have met the design specifications. | Shutao Zhao Jianshe Cao Huihua Lu Xiaoyu Li Shuchen Sun Yajun Sun Xiangzhen Zhang Lei Zhang Yuhui Li Zhiqiang Li Wan Chen Lingling Gong Qing Guo Keyun Gong Yongsheng Huang Yanwei Yang Yufeng Yang | 2021 | Radiation Detection Technology and Methods2021，5，1： | 2 |
| 4 | The template-assisted zinc ion incorporation in SAPO-34 and the enhanced ethylene selectivity in MTO reaction显示文摘The SAPO-34 catalyst was fine-tuned with zinc cations through a straightforward template-assisted ion incorporation (TH) process, without the necessary template pre-removal and the preparation of NH4- SAPO-34 intermediate, which is more facile, efficient and cost-effective than the conventional ion exchange process. The template-assisted zinc cations incorporated SAPO-34 catalysts were characterized by XRD, XRF, N2 adsorption-desorption, XPS, SEM, EDX,NMR, respectively. Enhanced selectivity to ethylene and ratio of ethylene to propylene in MTO reaction are observed over the zinc cations modified SAPO-34 catalysts, due to the facilitated formation of lower methylbenzenes that favour the ethylene gen eration, as well as the increased diffusion hindrance originated from the zinc cations incorporation and the facil让ated generation of aromatics compound. | Jiawei Zhong Jingfeng Han Yingxu Wei Shutao Xu Tantan Sun Xinwen Guo Chunshan Song Zhongmin Liu | 2019 | Journal of Energy Chemistry2019，28，5： | 2 |
| 5 | Mechanical design of a cryogenic Delta-Knot undulator for high energy photon source显示文摘Introduction A novel type of pure permanent cryogenic Delta–Knot Undulator was developed at IHEP to supply a high flux of full adjustable polarization synchrotron radiation with low on-axis power density.This prototype was an active attempt and early exploration for future APPLE–Knot undulator,which will be used at high energy photon source(HEPS).Materials and methods There are several challenges to develop a cryogenic delta undulator,such as the complicated structure,the influence of large magnetic force,and the magnetic measurement difficulty due to the very small gap.In this paper,the mechanical design for overcoming these difficulties will be presented in detail.Conclusion A special hall measuring system is developed,and the preliminary results agree with the theoretical results.This undulator prototype will provide valuable experience for angle magnetization technology,intricate magnetic attraction structure design,and magnetic field measurement under closed small space. | Shuchen Sun Huihua Lu Xiaoyu Li Xiangzhen Zhang Yanwei Yang Yajun Sun Lei Zhang Yuhui Li Zhiqiang Li Wan Chen Lingling Gong Shutao Zhao Qing Guo Keyun Gong Yongsheng Huang Yufeng Yang | 2021 | Radiation Detection Technology and Methods2021，5，1： | 1 |
| 6 | Propagation properties of foreshock cavitons: Cluster observations显示文摘Foreshock cavitons are transient phenomena observed in the terrestrial foreshock region.They are characterized by a simultaneous depression of magnetic field magnitude and plasma density,which are bounded with enhancements of these two parameters and surrounded by ultralow frequency(ULF)waves.Previous studies focused on the interplanetary magnetic field(IMF)conditions,solar wind(SW)conditions,and the growth of the foreshock waves related to the generation of foreshock cavitons.Previously,a multipoint spacecraft analysis method using Cluster data was applied to analyze only two foreshock cavitons,and this method did not consider uncertainties.In this study,multipoint spacecraft analysis methods,including the timing method,the minimum directional derivative(MDD)method,and the spatiotemporal difference(STD)method are applied to determine the velocity in both spacecraft and solar wind frames.The propagation properties show good agreement with previous results from simulations and observations that most cavitons move sunward in the solar wind frame,with the velocities larger than the Alfvén speed.The propagation properties of foreshock cavitons support the formation mechanism of cavitons in previous simulations,which suggested that cavitons are formed due to the nonlinear evolution of compressive ULF waves.We find that there is clear decreasing trend between the size of cavitons and their velocity in the solar wind frame.In addition,the timing method considering errors has been applied to study the evolution properties by comparing the velocities with errors of the leading and trailing edges,and we identify three stable cavitons and one contracting caviton,which has not been studied before.Most cavitons should remain stable when they travel toward the Earth’s bow shock.The relationship between the size of foreshock cavitons and their distance from the bow shock is also discussed. | WANG MengMeng YAO ShuTao SHI QuanQi ZHANG Hui TIAN AnMin DEGELING Alexander William ZHANG Shuai GUO RuiLong SUN WeiJie LIU Ji BAI ShiChen SHEN XiaoChen ZHU XiaoQiong FU SuiYan PU ZuYin | 2020 | Science China(Technological Sciences)2020，63，1： | 1 |
| 7 | Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid显示文摘 | Wendi Zhang Qiang Cheng Shutao Guo | 2013 | Biomaterials2013，34，5： | 1 |
| 8 | Investigation on properties of P((MAA-co- DMAEMA)-g-EG) polyampholyte nanogels显示文摘 | Deng Liandong Zhai Yinglei Guo Shutao | 2009 | J Nanopart Res2009，11，2： | 1 |
| 9 | Synthesis andProperties of Polycaprolactone-graft-Poly(2-(dimethylamino)ethyl Methacrylate-co-methoxy Polyethylene Glycolmonomethacrylate)as Non-viral Gene Vector显示文摘 | Shutao Guo Yong Qiao Weiwei Wang | 2011 | Poly AdvTechnol2011，22，12： | 1 |
| 10 | Poly (3-caprolactone) graft-poly (2-(N,N dimethylamino) ethyl methacrylate) nanoparticles= pH dependent thermo- sensitive multifunetional carriers for gene and drug delivery 显示文摘 | SHUTAO GUO YONG QIAO WEIWEI WANG | 2010 | Journal of MaterialsChemistry2010，20，： | 1 |
| 11 | Effects of Intracellular Superoxide Removal at Acupoints with TAT-SOD on Obesity显示文摘 | Jingke Guo Yue Chen Bin Yuan Shutao Liu Pingfan Rao | 2011 | Free Radical Biology and Medicine2011，，12： | 1 |
| 12 | Statistical properties of kinetic-scale magnetic holes in terrestrial space显示文摘Kinetic-scale magnetic holes(KSMHs)are structures characterized by a significant magnetic depression with a length scale on the order of the proton gyroradius.These structures have been investigated in recent studies in near-Earth space,and found to be closely related to energy conversion and particle acceleration,wave-particle interactions,magnetic reconnection,and turbulence at the kineticscale.However,there are still several major issues of the KSMHs that need further study—including(a)the source of these structures(locally generated in near-Earth space,or carried by the solar wind),(b)the environmental conditions leading to their generation,and(c)their spatio-temporal characteristics.In this study,KSMHs in near-Earth space are investigated statistically using data from the Magnetospheric Multiscale mission.Approximately 200,000 events were observed from September 2015 to March 2020.Occurrence rates of such structures in the solar wind,magnetosheath,and magnetotail were obtained.We find that KSMHs occur in the magnetosheath at rates far above their occurrence in the solar wind.This indicates that most of the structures are generated locally in the magnetosheath,rather than advected with the solar wind.Moreover,KSMHs occur in the downstream region of the quasi-parallel shock at rates significantly higher than in the downstream region of the quasi-perpendicular shock,indicating a relationship with the turbulent plasma environment.Close to the magnetopause,we find that the depths of KSMHs decrease as their temporal-scale increases.We also find that the spatial-scales of the KSMHs near the subsolar magnetosheath are smaller than those in the flanks.Furthermore,their global distribution shows a significant dawn-dusk asymmetry(duskside dominating)in the magnetotail. | ShuTao Yao ZongShun Yue QuanQi Shi Alexander William Degeling HuiShan Fu AnMin Tian Hui Zhang Andrew Vu RuiLong Guo ZhongHua Yao Ji Liu Qiu-Gang Zong XuZhi Zhou JingHuan Li WenYa Li HongQiao Hu YangYang Liu WeiJie Sun | 2021 | Earth and Planetary Physics2021，5，1： | 1 |
| 13 | Research on Camera Self-Calibration of High-Precision in Binocular Vision显示文摘 | Zetao Jiang Lianggang Jia Shutao Guo | 2012 | Procedia Engineering2012，，： | 1 |
| 14 | PDLLA length on anti-breast cancer efficacy of acid-responsive self-assembling mPEG-PDLLA–docetaxel conjugates显示文摘Engineering small-molecule drugs into nanoparticulate formulations provides an unprecedented opportunity to improve the performance of traditional chemo drugs,but suffers from poor compatibility between drugs and nanocarriers.Stimuli-responsive mPEG-PDLLA–drug conjugate-based nanomedicines can facilitate the exploitation of beneficial properties of the carrier and enable the practical fabrication of highly efficacious self-assembled nanomedicines.However,the influence of hydrophobic length on the performance of this type of nanomedicine is little known.Here we synthesized two acid-sensitive ketal-linked mPEG-PDLLA–docetaxel prodrugs with different lengths of PDLLA,and engineered them into self-assembled sub-20 nm micellar nanomedicines for breast cancer chemotherapy.We found that the nanomedicine consisting of a mPEG-PDLLA–docetaxel prodrug with the shorter length of PDLLA stood out due to its potent cytotoxicity,deep penetration into multicellular spheroids,and improved in vivo anticancer performance.Additionally,our prodrug-based nanomedicines outperformed the generic formulation of commercial Nanoxel in terms of safety profile,tolerated doses,and tumor suppression.Our findings indicate that the hydrophobic content of a polymeric prodrug nanomedicine plays an important role in the performance of the nanomedicine,and should be instructive for developing polymeric prodrug-based nanomedicines with clinical translational potential. | Tao Liu Hui Zou Jingqing Mu Xi Zhang Guohua Liu Na Yu Bo Yuan Xiaoyong Yuan Xingjie Liang Shutao Guo | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 15 | Development of a Completely New PFOS Alternative with Lower Surface Tension for Minimizing the Environmental Burden显示文摘Improving the technical performance of related industrial products is an efficient strategy to reducing the application quantities and environmental burden for toxic chemicals.A novel polyfluoroalkyl surfactant potassium 1,1,2,2,3,3,4,4-octafluoro-4-(perfluorobutoxy)butane-1-sulfonate(F404)was synthesized by a commercializable route.It had a surface tension(γ)of 18.2 mN/m at the critical micelle concentration(CMC,1.04 g/L),significantly lower than that of perfluorooctane sulfonate(PFOS,ca.33.0 mN/m,0.72 g/L),and exhibited remarkable suppression of chromium-fog at a dose half that of PFOS.The half maximal inhibitory concentration(IC_(50))values in HepG2 cells and the lethal concentration of 50%(LC_(50))in zebrafish embryos after 72 hpf indicated a lower toxicity for F404 in comparison to PFOS.In a UV/sulphite system,89.3%of F404 were decomposed after 3 h,representing a defluorination efficiency of 43%.The cleavage of the ether C—O bond during the decomposition would be expected to form a short chain·C_(4)F_(9) as the position of the ether C—O in the F404 fluorocarbon chains is C4—O5.The ether unit is introduced in the perfluoroalkyl chain to improve water solubility,biocompatibility and degradation,thereby minimizing the environmental burden. | ZHOU Zhen GUO Rui CHEN Bolei WANG Ling CAO Huiming WEI Cuiyun HU Ming ZHAN Yuhang LI Shutao WANG Yawei LIANG Yong | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
| 16 | Acid-sensitive PEGylated cabazitaxel prodrugs for antitumor therapy显示文摘Although the antitumor drug cabazitaxel shows great therapeutic potential,its high toxicity and poor water solubility limit its utility.However,the use of stimuli-responsive prodrugs is a promising strategy for overcoming these limitations.Herein,we report the synthesis of two highly water soluble,acidsensitive PEGylated acyclic-ketal-linked cabazitaxel prodrugs(PKCs)with improved antitumor efficacy.In an acidic tumor microenvironment,the PKCs hydrolyzed rapidly to release the native drug,whereas they were stable in the normal physiological environment.Compared with cabazitaxel injection,the PKCs had much higher maximum tolerated doses:and in an MDA-MB-231 subcutaneous xenograft nude mouse model,the PKCs showed better antitumor efficacy and safety than cabazitaxel injection.The prodrug strategy reported herein could be useful for the development of other water soluble,acidsensitive prodrugs with improved efficacy. | Tao Liu Hui Zou Jingqing Mu Na Yu Yang Xu Guohua Liu Xingjie Liang Shutao Guo | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
| 17 | Intra-Articular injection of acid-sensitive stearoxyl-ketal-dexamethasone microcrystals for long-acting arthritis therapy显示文摘Despite advances in treatment of chronic arthritis,there is still a strong need for the development of long-acting formulations that can enable local and sustained drug release at the inflamed tissues.In this work,we fabricated microcrystals of an acid-sensitive stearoxyl-ketal-dexamethasone prodrug for treatment of arthritis.Microcrystals of the prodrug with two sizes were successfully engineered and showed pH-dependent hydrolysis kinetics in vitro.In a collagen-induced arthritis rat model,we evaluated the influence of particle size and injection dose on anti-inflammatory effect after intra-articular injection.Such prodrug demonstrated long-acting anti-arthritis effects with good safety.Our results indicate ketal-based prodrugs are promising for the development of long-acting injectables and may stimulate the development of new treatments for chronic diseases. | Yang Xu Ziqi Chen Zunkai Xu Yanyan Du Jianghao Han Xiaoyong Yuan Shubiao Zhang Shutao Guo | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，2： | 0 |
| 18 | The Yin and Yang of the protein corona on the delivery journey of nanoparticles显示文摘Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled manner.However,tremendous challenges must still be overcome to reach the expected targeting and therapeutic efficacy in vivo.These challenges mainly arise because the interaction between nanoparticles and biological systems is complex and dynamic and is influenced by the physicochemical properties of the nanoparticles and the heterogeneity of biological systems.Importantly,once the nanoparticles are injected into the blood,a protein corona will inevitably form on the surface.The protein corona creates a new biological identity which plays a vital role in mediating the bio–nano interaction and determining the ultimate results.Thus,it is essential to understand how the protein corona affects the delivery journey of nanoparticles in vivo and what we can do to exploit the protein corona for better delivery efficiency.In this review,we first summarize the fundamental impact of the protein corona on the delivery journey of nanoparticles.Next,we emphasize the strategies that have been developed for tailoring and exploiting the protein corona to improve the transportation behavior of nanoparticles in vivo.Finally,we highlight what we need to do as a next step towards better understanding and exploitation of the protein corona.We hope these insights into the“Yin and Yang”effect of the protein corona will have profound implications for understanding the role of the protein corona in a wide range of nanoparticles. | Yi-Feng Wang Yaxin Zhou JiaBei Sun Xiaotong Wang Yaru Jia Kun Ge Yan Yan Kenneth A.Dawson Shutao Guo Jinchao Zhang Xing-Jie Liang | 2023 | Nano Research2023，16，1： | 0 |
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