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| 1 | EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer显示文摘Tyrosine kinase inhibitors for epidermal growth factor receptor(EGFR TKIs)greatly improved clinical outcomes of patients with non-small cell lung cancer(NSCLC).Unfortunately,primary and acquired resistance limits their clinical benefits.To overcome such resistance,new generations of EGFR TKIs have been developed by targeting newly identified mutations in EGFR.However,much less effort has been put into alternative strategies,such as targeting the intrinsic protective responses to EGFR TKIs.In this study,we found that EGFR TKIs,including gefitinib and AZD9291,impaired lysosome-dependent degradation of SQSTM1,thus compromising their anti-cancer efficiency.By accumulating in the lysosome lumen,gefitinib and AZD9291 attenuated lysosomal acidification and impaired autolysosomal degradation of SQSTM1 owing to their intrinsic alkalinity.As a result,SQSTM1 protein was stabilized in response to gefitinib and AZD9291 treatment and conferred EGFR TKI resistance.Depleting SQSTM1 significantly increased the sensitivity of NSCLC cells to gefitinib and AZD9291 both in vitro and in vivo.Furthermore,a chemically modified gefitinib analog lacking alkalinity displayed stronger inhibitory effects on NSCLC cells.Therefore,targeting accumulated SQSTM1 or chemically modified EGFR TKIs may represent new strategies to increase the effectiveness of EGFR targeted therapy. | Lixian Yang Shilong Ying Shiman Hu Xiangtong Zhao Muchun Li Miaoqin Chen Yiran Zhu Ping Song Liyuan Zhu Tingting Jiang Huimin An Neelum Aziz Yousafzai Wenxia Xu Zhiguo Zhang Xian Wang Lifeng Feng Hongchuan Jin | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 2 | Achieving High Thermoelectric Performance in Rare-Earth Element-Free CaMg_(2)Bi_(2) with High Carrier Mobility and Ultralow Lattice Thermal Conductivity显示文摘CaMg_(2)Bi_(2)-based compounds,a kind of the representative compounds of Zintl phases,have uniquely inherent layered structure and hence are considered to be potential thermoelectric materials.Generally,alloying is a traditional and effective way to reduce the lattice thermal conductivity through the mass and strain field fluctuation between host and guest atoms.The cation sites have very few contributions to the band structure around the fermi level;thus,cation substitution may have negligible influence on the electric transport properties.What is more,widespread application of thermoelectric materials not only desires high ZT value but also calls for low-cost and environmentally benign constituent elements.Here,Ba substitution on cation site achieves a sharp reduction in lattice thermal conductivity through enhanced point defects scattering without the obvious sacrifice of high carrier mobility,and thus improves thermoelectric properties.Then,by combining further enhanced phonon scattering caused by isoelectronic substitution of Zn on the Mg site,an extraordinarily low lattice thermal conductivity of 0.51Wm^(-1) K^(-1) at 873 K is achieved in(Ca_(0.75)Ba_(0.25))_(0.995)Na_(0.005)Mg_(1.95)Zn_(0.05)Bi_(1.98) alloy,approaching the amorphous limit.Such maintenance of high mobility and realization of ultralow lattice thermal conductivity synergistically result in broadly improvement of the quality factorβ.Finally,a maximum ZT of 1.25 at 873K and the corresponding ZTave up to 0.85 from 300 K to 873K have been obtained for the same composition,meanwhile possessing temperature independent compatibility factor.To our knowledge,the current ZTave exceeds all the reported values in AMg_(2)Bi_(2)-based compounds so far.Furthermore,the low-cost and environmentfriendly characteristic plus excellent thermoelectric performance also make the present Zintl phase CaMg_(2)Bi_(2) more competitive in practical application. | Muchun Guo Fengkai Guo Jianbo Zhu Li Yin Qian Zhang Wei Cai Jiehe Sui | 2020 | Research2020，，1： | 2 |
| 3 | On the star chromatic number of Mycielski's graphs of complete graphs and complete-partite graphs显示文摘 | Li Muchun Qiang Huiying Zhang Zhongfu | 2009 | Journal of Fuzhou University(Natural Science Edition)2009，37，2： | 1 |
| 4 | Tracking the Forces behind Volume Patterns显示文摘 | Guo Xiaoli and Li Muchun | 2003 | Futures2003，，11： | 1 |
| 5 | Restructured single parabolic band model for quick analysis in thermoelectricity显示文摘The single parabolic band(SPB)model has been widely used to preliminarily elucidate inherent transport behaviors of thermoelectric(TE)materials,such as their band structure and electronic thermal conductivity,etc.However,in the SPB calculation,it is necessary to determine some intermediate variables,such as Fermi level or the complex Fermi-Dirac integrals.In this work,we establish a direct carrier-concentration-dependent restructured SPB model,which eliminates Fermi-Dirac integrals and Fermi level calculation and emerges stronger visibility and usability in experiments.We have verified the reliability of such restructured model with 490 groups of experimental data from state-of-the-art TE materials and the relative error is less than 2%.Moreover,carrier effective mass,intrinsic carrier mobility and optimal carrier concentration of these materials are systematically investigated.We believe that our work can provide more convenience and accuracy for thermoelectric data analysis as well as instructive understanding on future optimization design. | Jianbo Zhu Xuemei Zhang Muchun Guo Jingyu Li Jinsuo Hu Songting Cai Wei Cai Yongsheng Zhang Jiehe Sui | 2021 | npj Computational Materials2021，，1： | 1 |
| 6 | On the vertex distinguishing equitable edge colouring of graphs显示文摘 | Zhang Zhongfu Li Muchun Yao Bing | 2008 | Ars Combinatoria2008，86，： | 1 |
| 7 | On the vertex distinguishing equitable edge-coloringof graphs 显示文摘 | Zhang Zhongfu Li Muchun Yao Bing | 2008 | ARS Combinatoria2008，86，： | 1 |
| 8 | On the vertex distinguishing equitable edge-coloring of graphs 显示文摘 | ZHANG Zhongfu LI Muchun YAO Bing | 2008 | Ars Com- binatoria2008，86，： | 1 |
| 9 | The Normalized Laplacian Spectrum of Subdivision Vertex-Edge Corona for Graphs显示文摘A subdivision vertex-edge corona G_1~S?(∪ G_3~E) is a graph that consists of S(G_1),|V(G_1)| copies of G_2 and |I(G_1)| copies of G_3 by joining the i-th vertex in V(G_1) to each vertex in the i-th copy of G_2 and i-th vertex of I(G_1) to each vertex in the i-th copy of G_3.In this paper, we determine the normalized Laplacian spectrum of G_1~S?(G_2~V∪ G_3~E) in terms of the corresponding normalized Laplacian spectra of three connected regular graphs G_1, G_2 and G_3. As applications, we construct some non-regular normalized Laplacian cospectral graphs. In addition, we also give the multiplicative degree-Kirchhoff index, the Kemeny's constant and the number of the spanning trees of G_1~S?(G_2~V∪ G_3~E) on three regular graphs. | Muchun LI You ZHANG Fei WEN | 2019 | Journal of Mathematical Research with Applications2019，39，3： | 1 |
| 10 | On the vertex distinguishing equitable edge-coloring of graphs显示文摘 | Zhang Zhongfu Li Muchun Yao Bing et ol | 2008 | ARS Combinatoria2008，86，： | 1 |
| 11 | Unicyclic Graphs with Five Lapalcian Eigenvalues Different from 0 and 1显示文摘Let U be a unicyclic graph of order n,and mU(1)the multiplicity of Laplacian eigenvalue 1 of U.It is well-known that 0 is a simple Lapalcian eigenvalue of connected graph.This means that if U has five Laplacian eigenvalues different from 0 and 1,then mU(1)=n-6.In this paper,we completely characterize all the unicyclic graphs with mU(1)=n-6. | Mengyue YUAN Fei WEN Muchun LI | 2021 | Journal of Mathematical Research with Applications2021，41，6： | 0 |
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