|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Comparison of Existing Clinical Scoring Systems to Predict Persistent Organ Failure in Patients With Acute Pancreatitis显示文摘 | Rawad Mounzer Christopher J. Langmead Bechien U. Wu Anna C. Evans Faraz Bishehsari Venkata Muddana Vikesh K. Singh Adam Slivka David C. Whitcomb Dhiraj Yadav Peter A. Banks Georgios I. Papachristou | 2012 | Gastroenterology2012，，7： | 2 |
| 3 | Improvement in the dissolution rate and tableting properties of cefuroxime axetil by melt-granulated dispersion and surface adsorption显示文摘A combination of melt-granulated dispersion and surface adsorption techniques was used to enhance the dissolution and tableting properties of cefuroxime axetil(CA).Gelucire 50/13 was used as the melt-dispersion carrier and Sylysia 350 was used to adsorb the melt dispersion.Solubility studies showed an 8-fold increase in solubility at a ratio of 1:1.5 for CA:Gelucire 50/13.The minimum quantity of Sylysia 350 required to achieve the desired flowability and compressibility was 0.5 parts of Sylysia 350 per unit of Gelucire 50/13.Phase solubility studies showed negative ΔG_(tr)^(0) values for Gelucire 50/13 at various concentrations(2-10%,vv/v),indicating the spontaneous nature of solubilization.FT-IR and DSC spectra exhibited drug-excipient compatibility.Molecular modeling by a computational method employing energy minimization revealed entrapment of CA in Gelucire 50/13.The total potential energy of CA(70.562 keal/mol)was reduced to 33.578 keal/mol after solid dispersion with Gelucire 50/13.P-XRD studies indicated that the presence of Sylysia 350 is less likely to promote the reversion of the amorphous CA to a crystalline state.In vitro dissolution studies demonstrated an improved dissolution rate,and drug release at 15 min(Q_(15min))exhibited a 15-fold improvement.The rapidly dissolving CA tablets showed improved dissolution with improved tableting properties. | Jammula Sruti Chinam Niranjan Patra Suryakanta Swain Kanhu Charan Panigrahi Allupati Premananda Patro Sarwar Beg Subas Chandra Dinda Muddana Eswara Bhanoji Rao | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 2 |
| 4 | Comparison of BISAP,Ranson's,APACHE-II,and CTSI scores in predicting organ failure,complications,and mortality in acute pancreatitis显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 5 | Comparison of BISAP, Ransong, APACHE - I1 , and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis 显示文摘 | PAPACHRISTOU GI MUDDANA V YADAV D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 6 | Comparison of BISAP,Ranson's,APACHE-II,and CTSI scores in predicting organ failure,complications,and mortality in acute pancreatitis显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 7 | Comparison of BASIP、Ranson's、APACHE II,and CTSI scores in predicting organ failue,complications,and mortality in acute pancreatitis显示文摘 | Papachristou GI Muddana V Yadav | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 8 | Comparison of BISAP,Ranson's,APACHE-Ⅱ,and CTSI scores in predicting organ failure,complications and mortality in acute pancreatitis显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | American Journal of Gastroenterology2010，105，2： | 1 |
| 9 | Comparison of BISAP, Ranson's,APACHE-II,and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 10 | Elevates serum creatinine as a marker of pancreatic necrosis in acute panecreatitis 显示文摘 | Muddana V Whitcomb DC Khalid A | 2009 | Am J Gastmenterol2009，104，1： | 1 |
| 11 | Comparison of BISAP, Ranson's, APACHE-II , and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis 显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 12 | Portosplenomesenteric Venous Thrombosis in Patients With Acute Pancreatitis Is Associated With Pancreatic Necrosis and Usually Has a Benign Course显示文摘 | Jeffrey Easler Venkata Muddana Alessandro Furlan Anil Dasyam Kishore Vipperla Adam Slivka David C. Whitcomb Georgios I. Papachristou Dhiraj Yadav | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 13 | Comparison of BISAP, Ranson' s, APACHE-II , and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 14 | Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute panereatitis 显示文摘 | Papachristou GI Muddana V Yadav D | 2009 | Am J Gastroenterol2009，105，2： | 1 |
| 15 | TNF-alpha gene ( TNFA ) variants increase risk for multi-organ dysfunction syndrome (MODS) in acute pancreatitis显示文摘 | Faraz Bishehsari Arun Sharma Kimberly Stello Chad Toth Michael Richard O’Connell Anna C. Evans Jessica LaRusch Venkata Muddana Georgios I. Papachristou David C. Whitcomb | 2012 | Pancreatology2012，，2： | 1 |
| 16 | Portosplenomesenteric venous thrombosis in patients with acute pancreatitis isassociated with pancreatic necrosis and usuallyhas a benign course显示文摘 | Easier J Muddana V Furlan A | 2014 | Clin Gastroenterol Hepatol2014，12，5： | 1 |
| 17 | Comparison of BISAP, Ranson's,APACHE-II,and CTSI Scores in Predicting Organ Failure, Complications,and Mortality in Acute Pancreatitis 显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Ameriean Journal of Gastroenterology2010，105，2： | 1 |
| 18 | Current an agement and novel insights in acute pancreatitis显示文摘 | Muddana V Whitcomb DC Papachristou GI | 2009 | Expert Rev Gastroenterol Hepatol2009，3，： | 1 |
| 19 | Comparison of BISAP,Ranson1 s,APACHE-Ⅱ,and CTSI scores in predicting organ failure,complications,and mortality in acute pancreatitis 显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
| 20 | Comparison of BISAP,Ranson' s,APACHE-Ⅱ,and CTSI scores in predicting organ failure,complications,and mortality in acute pancreatitis显示文摘 | Papachristou GI Muddana V Yadav D | 2010 | Am J Gastroenterol2010，105，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员