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| 1 | 中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果显示文摘目的 评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法 1993~ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果 服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %~ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %~ 6 4% )。结论 妇女在妊娠前后每天服用单纯叶酸 40 0 | 李竹 RobertJ Berry 李松 J David Erickson 王红 Cynthia A Moore 赵平 Joseph Mulinare 洪世欣 Lee-Yang C Wong 呼和牧人 Jacqueline Gindler 郝玲 Adolfo Correa 朱慧萍 Elaine Gunter | 2000 | 中华医学杂志2000，80，7： | 185 |
| 2 | Folic acid and preconceptional care 显示文摘 | Levine NH Lyon Daniel K Mulinare J | 2001 | Prim Care Update Ob Gyns2001，8，2： | 1 |
| 3 | Maternal multivitamin use and orofacial clefts in offspring 显示文摘 | Watkins ML Mulinare J | 2001 | Teratology2001，63，： | 1 |
| 4 | Is mutated MTHFR a risk factor for neural tube defects显示文摘 | Posey DL Khoury M J Mulinare J | 1996 | Lancet1996，347，： | 1 |
| 5 | Autosomal tri- somy and maternal use of multivitamin supplements 显示文摘 | Botto LD Mulinare J Yang Q Liu Y Erickson ID | 2004 | Am J Med Genet2004，125，： | 1 |
| 6 | Epidemiology of early amnion rupture spectrum of defects显示文摘 | Garza A Cordero J F Mulinare J | 1988 | Am J Dis Child1988，142，： | 1 |
| 7 | Periconceptional multivitamin use and the occurrence of conotruncal heart defects : re- suits from a population - based, case - control study 显示文摘 | Botto LD Khoury MJ Mulinare J Erickson JD | 1996 | Pediat- rics1996，98，： | 1 |
| 8 | Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps显示文摘 | Botto LD Mulinare J Ericksou JD | 2003 | Am J Med Genet A2003，121，2： | 1 |
| 9 | Case-control study of congenital defects and parental employment in health care显示文摘 | Matte TD Mulinare J Erickson JD | 1993 | Am J Ind Meal1993，24，1： | 1 |
| 10 | Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps显示文摘 | Botto LD Mulinare J Erickson JD | 2003 | Am J Med Genet A2003，121，2： | 1 |
| 11 | Use of Supplements Containing Folic Acid Among Women of Childbearing Age - United States, 2007显示文摘 | Petrini J R Hamner H C Flores A L Mulinare J Prue C | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，1： | 1 |
| 12 | Periconceptional use of multivitamins and the occurrence of neural tube defects显示文摘 | Mulinare J Cordero JF Erickson JD | | JAMA0，260，21： | 1 |
| 13 | Occurrence of congenital heart defects in relation to maternal mulitivitamin use 显示文摘 | Botto LD Mulinare J Erickson JD | 2000 | Am J Epidemiol2000，151，9： | 1 |
| 14 | Trends in Wheat-Flour Fortification with Folic Acid and Iron - Worldwide, 2004 and 2007显示文摘 | Maberly G Grummer-Strawn L Jefferds M E Pe?a-Rosas J P Serdula M K Tyler V Q Berry R J Mulinare J Parvanta I Aburto N J | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，1： | 1 |
| 15 | Tobacco smoke expo- sure and decreased serum and red blood cell folate levels: data from the third national health and nutrition examination survey 显示文摘 | Mannino DM Mulinare J Ford ES | 2013 | Nicotir~e Tob Res2013，5，3： | 1 |
| 16 | Tobacco smoke exposure and decreased serum and red blood cell folate levels:data from the Third National Health and Nutrition Examination Survey显示文摘 | Mannino D M Mulinare J Ford E S | 2003 | Nicotine Tob Res2003，5，3： | 1 |
| 17 | Health Care Provider Knowledge and Practices Regarding Folic Acid, United States, 2002–2003显示文摘 | Jennifer L. Williams Stephen M. Abelman Elizabeth M. Fassett Cheryl E. Stone Joann R. Petrini Karla Damus Joseph Mulinare | 2006 | Maternal and Child Health Journal2006，，1： | 1 |
| 18 | Maternal multivitamin use and orofacial clefts in offspring显示文摘 | ltikala PR Watkins ML Mulinare J | 2001 | Teratology2001，63，2： | 1 |
| 19 | Is muta- ted MTHFR a risk factor for neural tube defects? 显示文摘 | Posey DL Khoury MJ Mulinare J Adams MJ Jr Ou CY | 1996 | Lancet1996，347，9002： | 1 |
| 20 | Risk factors for conotruncal cardiac defects in Atlanta显示文摘 | Adams MM Mulinare J Dooley K | 1989 | J Am Coil Cardiol1989，4，2： | 1 |
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