|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 噻唑类化合物应用研究新进展显示文摘噻唑环是一类重要的含氮硫杂原子的五元芳杂环,其特殊的结构使得噻唑类化合物在化学、药学、生物学和材料科学等诸多领域具有广阔的应用前景,显示出巨大的开发价值,受到广泛关注.本文结合作者的研究工作,参考国内外近五年文献,系统地综述了噻唑类化合物在医药、农药、材料、生物染色剂和超分子化学领域应用研究进展. | 崔胜峰 王艳 吕敬松 DAMU Guri L.V. 周成合 | 2012 | 中国科学:化学2012，42，8： | 33 |
| 2 | p27在单侧输尿管结扎大鼠肾间质纤维化模型中的表达显示文摘目的 :观察单侧输尿管梗阻 (unilateralureteralobstruction ,UUO)大鼠模型中p2 7在肾小管中的表达 ,了解p2 7与肾间质纤维化程度的关系。方法 :建立UUO大鼠模型 ,采用免疫组织化学方法检测UUO组及假手术组(Sham operatedrates,SOR)术后第 7d ,14d ,2 1d肾小管中p2 7的表达及其与肾间质纤维化程度的关系。结果 :UUO组术后第 7d与SOR组比较 ,p2 7在肾小管上皮细胞中的表达无明显变化 ;术后第 14dUUO组p2 7的表达下降 ,与SOR组比较差异有显著性 (P <0 .0 5 ) ;术后第 2 1dUUO组p2 7的表达明显下降 ,与SOR比较差异有显著性 (P <0 .0 1)。结论 :p2 7在早期UUO大鼠模型中的表达无明显变化 ,随着间质纤维化程度的增加 ,p2 | 陶立坚 孙剑 金鸥 张军 沈明 Biao Chen Damu Tang 李桂源 | 2004 | 中南大学学报(医学版)2004，29，1： | 10 |
| 3 | A series of naphthalimide azoles: Design, synthesis and bioactive evaluation as potential antimicrobial agents显示文摘A series of naphthalimide azoles as potential antibacterial and antifungal agents were conveniently and efficiently synthesized starting from commercially available 6-bromobenzo[de]isochromene-1,3-dione. All the new compounds were characterized by NMR, IR, MS and HRMS spectra. Their antimicrobial activities were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi using two-fold serial dilution technique. The biological assay indicated that most of the prepared compounds exhibited inhibition to the tested strains. In particular, the triazolium derivatives not only gave higher efficacy than their corresponding precursory azoles, but also demonstrated comparable or even better potency than the reference drugs Chloromycin, Orbifloxacin and Fluconazole. Some factors including structural fragments, pH and ClogP values of the target molecules were also preliminarily discussed. | DAMU Guri L. V. WANG QingPeng ZHANG HuiZhen ZHANG YiYi LV JingSong ZHOU ChengHe | 2013 | Science China Chemistry2013，56，7： | 8 |
| 4 | Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents显示文摘A series of novel thio-triazole derivatives including thiols, thioethers and thiones as well as some corresponding triazolium compounds were conveniently and efficiently synthesized from commercially available halobenzyl halides and thiosemicarbazide. All the new compounds were characterized by 1 H NMR, 13 C NMR, FTIR, MS and HRMS spectra. Their antibacterial and antifungal activities in vitro were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two-fold serial dilution technique. The preliminary bioassay indicated that some prepared triazoles exhibited effective antibacterial and antifungal activities. Especially, 3,4-dichlorobenzyl triazolethione and its triazolium derivatives displayed the most potent activities against all the tested strains. | WANG QingPeng ZHANG JingQing DAMU Guri L.V. WAN Kun ZHANG HuiZhen ZHOU ChengHe | 2012 | Science China Chemistry2012，55，10： | 7 |
| 5 | Coumarin-derived azolyl ethanols:synthesis,antimicrobial evaluation and preliminary action mechanism显示文摘A series of coumarin-derived azolyl ethanols including imidazolyl,triazolyl,tetrazolyl,benzotriazolyl,thiol-imidazolyl and thiol-triazolyl ones were conveniently synthesized and characterized by IR,~1H NMR,^(13)C NMR and high-resolution mass spectra(HRMS) spectra.Some of the prepared compounds showed appropriate logP_(ow) values and effective antibacterial and antifungal activities.Noticeably,compound 14 with bis-triazolyl ethanol group exhibited low minimal inhibitory concentration(MIC)value of 8 μg/mL against MRSA,which was comparable or even superior to reference drugs Norfloxacin(MIC=8μg/mL)and Chloramphenicol(MIC=16μg/mL).It could also effectively inhibit the growth of the tested fungal strains compared to Fluconazole.Further binding studies of coumarin 14 with calf thymus DNA were investigated by UV-Vis absorption and fluorescence spectroscopy.It was found that compound 14 could interact with calf thymus DNA by groove binding to form14-DNA complex via both hydrogen bonds and van der Waals force,which might be the factor to exert the powerful antimicrobial activity. | Xin-Mei Peng Kannekanti Vijaya Kumar Guri L.V. Damu Cheng-He Zhou | 2016 | Science China Chemistry2016，59，7： | 4 |
| 6 | 应用基于2幅2D门静脉造影反向投影的3D路径图改善经颈静脉肝内门体静脉分流术的穿刺显示文摘本研究目的是通过应用3D路径图防止经颈静脉肝内门体静脉分流术(TIPS)穿刺失败。本研究经机构伦理委员会批准.所有病人行TIPs术前均签署知情同意书。4例病人根据00和右前斜300投照分别获得的2幅2DC0:门静脉造影图像,制定3D穿刺路径图。将此路径图叠加在肝脏的透视图像上,引导穿刺。4例病人中有3例首次穿刺即进入靶血管.1例门静脉狭窄者第3次穿刺进入门静脉。此方法能显著提高TIPs手术的安全性,并减少了穿刺时间。 | R. A damus M. Pfister R.W. Loose 李瑞利(译) 季倩(校) 陈光(校) | 2009 | 国际医学放射学杂志2009，32，4： | 3 |
| 7 | p21和p53在肾间质纤维化大鼠中表达的研究显示文摘目的动态观察p21和p53在单侧输尿管梗阻肾间质纤维化大鼠模型中的表达,以及依那普利对其表达的调节。方法将SD大鼠随机分为假手术组(SOR组)、单侧输尿管结扎组(UUO组)和依那普利治疗组(EnT组),每组30只。用Masson染色的方法动态观察梗阻侧肾脏病理变化,用RT—PCR的方法检测梗阻肾皮质p21mRNA和p53mRNA的变化;并观察依那普利对肾皮质p21和p53表达的调节。结果在UUO大鼠模型早期,肾皮质p21mRNA和p53mRNA的表达即有明显增高,随着梗阻时间的延长,p21和p53的表达逐渐增强,二者具备相关性;依那普利能明显抑制p21和p53的表达。结论p21和p53在UUO大鼠肾皮质呈高表达,依那普利可抑制其表达。p21可能通过p53参与介导了。肾小管间质纤维化的发病过程。 | 肖云 陶立坚 Damu Tang 金鸥 周建华 宁旺斌 | 2010 | 中国医师杂志2010，12，2： | 2 |
| 8 | A solvent - free synthesis of coumarins via Pechmann condensation using heterogeneous catalyst显示文摘 | Maheswam Muchchintala Siddalsh Vidavalur Damu Guri Lakishmi Vasantha | 2006 | Journal of Molcoular Catalysis A: Chemical2006，255，12： | 1 |
| 9 | Total synthesis ofphenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluationof their cytotoxic activity 显示文摘 | SU CR DAMU AG CHIANG PC | 2008 | Bioorg Med Chem2008，16，11： | 1 |
| 10 | Abietane diterpene alkaloids from Salvia yunnanensis显示文摘 | LIN FW DAMU AG WU TS | 2006 | J Nat Prod2006，69，1： | 1 |
| 11 | A rapid and simple determination of proboberberine alkaloids in Rhizoma Coptidis by 1H NMR and its application for quality control of commercial prescriptions显示文摘 | Li CY Tsai SI Damu AG | 2009 | J Pharm Biomed Anal2009，49，5： | 1 |
| 12 | Changes in the gestational age dis- tribution among US singleton birth: impact on rates of late preterm birth, 1992 to 2002 显示文摘 | Davidoff MJ Dias T Damus K | 2006 | Semin Perinato12006，30，： | 1 |
| 13 | Drosophila suzukii new to North America显示文摘 | Hauser M Gaimari S Damus M | 2009 | Fly Times2009，43，： | 1 |
| 14 | Neural tube defect -specific infant mortality in the United States 显示文摘 | Davidoff M J Petrini J Damus K | 2002 | Teratology2002，66，1： | 1 |
| 15 | Health Care Provider Knowledge and Practices Regarding Folic Acid, United States, 2002–2003显示文摘 | Jennifer L. Williams Stephen M. Abelman Elizabeth M. Fassett Cheryl E. Stone Joann R. Petrini Karla Damus Joseph Mulinare | 2006 | Maternal and Child Health Journal2006，，1： | 1 |
| 16 | Cytotoxic and antimalarial β-carboline alkaloids from the roots of Eurycoma longifolia显示文摘 | Kuo P C Shi L S Damu A G | 2003 | J Nat Prod2003，66，： | 1 |
| 17 | New effi- cient synthesis and bioactivity of homoisoflavonoid- s显示文摘 | Rao V M Damu G L V Sudhakar D | 2008 | Archive for Organic Chemistry2008，21，11： | 1 |
| 18 | 查看详情显示文摘 | Maheswara M Siddaiah V Damu G.L Venkata Rao C | | 0，，： | 1 |
| 19 | Neural tube defect-specific infant mortality in the United States显示文摘 | Davidoff MJ Petrini J Damus K | 2002 | Teratology2002，66，1： | 1 |
| 20 | Purification of properties of a thrombin-like enzyme from the venom of Crotalusa damanteus 显示文摘 | Markland FS Damus PS | 1971 | J Boil Chem1971，246，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员