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| 1 | Muhifunctional nano- beads based on quantum dots and magnetic nanoparticles: synthe- sis and cancer cell targeting and sorting 显示文摘 | Riccardo D C Nadja C B Andrea R | | ACS Nano0，，： | 1 |
| 2 | Comparison of phenotype of polycystic kindey disease types 1 and 2显示文摘 | Nick H Marjan A Nadja B | 1999 | Lancet1999，353，： | 1 |
| 3 | High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkamides and caffeic acid derivatives from Echinacea purpurea extracts 显示文摘 | Nadja B Cech Maqueita S Eleazer Lawresa T Shoffner | 2006 | J Ghrom A2006，1103，： | 1 |
| 4 | Challenges in the crystal growth of Li2 CuO2 and LiMnPO4 显示文摘 | Nadja W Gunter B Loser W | 2011 | J Cryst Growth2011，318，1： | 1 |
| 5 | Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology显示文摘 | Alexander Zimprich Saskia Biskup Petra Leitner Peter Lichtner Matthew Farrer Sarah Lincoln Jennifer Kachergus Mary Hulihan Ryan J. Uitti Donald B. Calne A.Jon Stoessl Ronald F. Pfeiffer Nadja Patenge Iria Carballo Carbajal Peter Vieregge Friedrich Asmus B | 2004 | Neuron2004，，4： | 1 |
| 6 | Spectrum of molecular defects and mutation deteetion rate in patients with mild and moderate hemophilia A显示文摘 | Nadja B Ameni M Reswith E | 2007 | Hum Murat2007，28，1： | 1 |
| 7 | High performance liquid chromatography/electrosprayionization mass spectrometry for simultaneous analysis of alkamides and caffeic acid derivatives from Echinacea purpurea extracts 显示文摘 | Nadja B Cech Maqueita S Eleazer Lawresa T Shoffner | 2006 | J Chrom A2006，1103，： | 1 |
| 8 | Temperature-sensitive anthocyanin production in flowers of Plantago lanceolata显示文摘 | ELIZABETH A S NADJA B C STACY M D | 2007 | Physiologia Plantarum2007，129，4： | 1 |
| 9 | Association between respiratory infections in early life and later asthma is independent of virus type 显示文摘 | Klaus B Nadja HV | 2015 | J Allergy Clin Immunol2015，136，1： | 1 |
| 10 | A novel DNA binding protein with homology to Myb oncoproteins containing only one repeat can function as a transcriptional activator显示文摘 | NADJA B CLAUS F SALOME P | 1994 | The EMBO Journal1994，13，22： | 1 |
| 11 | A novel DNA binding protein with homology to Myb oncoproteins containing only one repeat can function as a transcriptional activator显示文摘 | Nadja B Claus F Salome P | 1994 | The EMBO Journal1994，22，： | 1 |
| 12 | 鉴定植物天然产物生物活性组分的新方法(英文)显示文摘Countless studies have been devoted to the scientific evaluation of the safety and/or efficacy of botanical natural products.Investigators involved in such studies face a unique set of challenges.Natural products differ from their pharmaceutical counterparts in that they are typically complex mixtures,for which the identities and quantities of components present are not known.To further complicate matters,the composition of these mixtures will vary depending on source material and method of preparation.Investigators conducting clinical trials with complex botanical natural products must choose from a myriad of potential preparations,which may vary greatly in composition.In making such decisions,it is extremely useful to know which components of the mixture are most likely to be responsible for its purported biological activity(the'active constituents').The gold standard approach for identifying active constituents of botanical natural products is bioassay-guided fractionation,in which the mixture is subjected to successive rounds of purification and bioassays until an active compound is identified.Bioassay guided fractionation has historically played a critical role in drug discovery,but is,nonetheless,fraught with challenges.The process is biased towards the most abundant and easily isolatable mixture components,which may not be the most biologically active.Furthermore,if multiple compounds contribute either additively,antagonistically,or synergistically to the observed biological activity of the mixture,activity may be lost upon isolation.As a complementary strategy to bioassay-guided fractionation,our research group has developed untargeted metabolomics strategies to aid in the identification of bioactive mixture components.These strategies involve profiling botanical mixtures using ultraperformance chromatography coupled to high resolving power mass spectrometry.The resulting chemical data is then integrated with biological assay data using biochemometric data analysis strategies.Several case studies will be presented illustrating how this approach can be applied,including for the identification of compounds from the botanical green(Camellia sinensis)that inhibit drug metabolizing enzymes.Such studies are being conducted as part of the Center for Excellence in Natural Product Drug Interaction Studies(Na PDI),which is supported by a cooperative agreement with the National Center for Complementary and Integrative Health,a component of the National Institutes of Health. | Nadja B CECH | 2017 | 中国药理学与毒理学杂志2017，31，10： | 0 |
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