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| 1 | Triple antithrombotic therapy versus double antiplatelet therapy after percutaneous coronary intervention with stent implantation in patients requiring chronic oral anticoagulation: a meta-analysis显示文摘 | Jayswal Saheb K DENG Bing-qing HU Qing-song XIE Shuang-lun GENG Deng-feng NIE Ru-qiong | 2013 | Chinese Medical Journal2013，，13： | 5 |
| 2 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | Newly identified endometrial genes of importance for implantation显示文摘 | Salamonsen L A Nie G Findlay J K | 2002 | J Reprod Immunol2002，53，12： | 1 |
| 5 | ADP-ribosylation factor proteins mediate agonist-induced activation of phospholipase D显示文摘 | Shome K Nie Y Romero G | 1998 | J Biol Chem1998，273，30： | 1 |
| 6 | Karyotyping analysis of mithun (Bos frontalis) and mithun bull×Brahman cow hybrids显示文摘 | Qu K X He Z X Nie W H | 2012 | Genet Mol Res2012，11，1： | 1 |
| 7 | Rho signaling and tight junction functions显示文摘 | Terry S Nie M Matter K | 2010 | Physiology (Bethesda)2010，25，： | 1 |
| 8 | The effect of HLA on immunological response to hepatitis B vaccine in healthy people: a meta-analysis显示文摘 | Li Z K Nie J J Li J | 2013 | Vaccine2013，31，40： | 1 |
| 9 | Journal of Alloys and Compounds显示文摘 | Wang X J Nie K B Hu X S | 2012 | 532: 782012，532，： | 1 |
| 10 | Existence, Uniqueness and Exponential Stability for Stochastic Age-dependent Population 显示文摘 | Zhang Q M Liu W A Nie Z K | 2004 | Applied Mathematics and Computation2004，154，： | 1 |
| 11 | Solute segregation and precipitation in a creep - resistant Mg-Gd-Zn alloy 显示文摘 | Nie J F Oh- ishi K Gao X | 2008 | Acta Mater2008，56，： | 1 |
| 12 | G-Benzoyl-1, 3-benzodioxolane as a photoinitiator for free radical polymerization显示文摘 | Wang K M Nie J | 2009 | J ournal of Photochemistry and Photobiology A: Chemistry2009，204，1： | 1 |
| 13 | Temporal association of elevations in serum cardiac troponin T and myocardial oxidative stress after prolonged exercise in rats显示文摘 | Nie J Close G George K P | 2010 | Eur J Appl Physiol2010，110，6： | 1 |
| 14 | Decrease in breast density in the contralateral normal breast of patients receiving neoadjuvant chemotherapy:MR imaging evaluation显示文摘 | CHEN J H NIE K BAHR I S | | 0，，01： | 1 |
| 15 | Polymorphisms in immtme/inflammatory cytokine genes are related to Parkinson' s disease withcognitive impairment in the Han Chinese population显示文摘 | Nie K Zhang Y Can R | 2013 | Neurosei Lett2013，541，： | 1 |
| 16 | Microstructure and mechanical properties of Si C nanoparticles reinforced magnesium matrix composites fabricated by ultrasonic vibration显示文摘 | Nie K B Wang X J Hu X S Xu L Wu K ZhengM Y | 2011 | Materials Science and Engineering A2011，，15： | 1 |
| 17 | FGF signalling in craniofacial development and developmental disorders 显示文摘 | NIE X LUUKKO K KETYUNEN P | 2006 | Oral Dis2006，12，2： | 1 |
| 18 | Adaptive rood pattern search for fast block-matching motion estimation显示文摘 | Nie Y Ma K | 2002 | IEEE Transactions on Image Process2002，11，12： | 1 |
| 19 | Genotyping of 11 Human papillomaviruses by multiplex PCR with a GeXP analyzer显示文摘 | YANG M J LUO L NIE K | 2012 | J Med Viro12012，84，6： | 1 |
| 20 | Application of a surface acoustic wavesensor system for the determination of non-aqueous solutions and phase transitions in lipid multibilayers显示文摘 | Yao S Chen K Nie L | 1994 | Analytic Chimical Ata1994，289，1： | 1 |
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