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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | LC,MS^n and LC-MS/MS studies for the characterization of degradation products of amlodipine显示文摘In the present study,comprehensive stress testing of amlodipine(AM) was carried out according to International Conference on Harmonization(ICH) Q1A(R2) guideline.AM was subjected to acidic,neutral and alkaline hydrolysis,oxidation,photolysis and thermal stress conditions.The drug showed instability in acidic and alkaline conditions,while it remained stable to neutral,oxidative,light and thermal stress.A total of nine degradation products(DPs) were formed from AM.which could be separated by the developed gradient LC method on a C_(18) column.The products formed under various stress conditions were investigated by LC-MS/MS analysis.The previously developed LC method was suitably modified for LC-MS/MS studies by replacing phosphate buffer with ammonium acetate buffer of the same concentration(pH 5.0).A complete fragmentation pathway of the drug was first established to characterize all the degradation products using LC-MS/MS and multi-stage mass(MS^n) fragmentation studies.The obtained mass values were used to study elemental compositions,and the total information helped with the identification of DPs.along with its degradation pathway. | Ravi N.Tiwari Nishit Shah Vikas Bhalani Anand Mahajan | 2015 | Journal of Pharmaceutical Analysis2015，5，1： | 2 |
| 3 | Study on the diagnosis of urothelial cancer using multi-colour fluorescence in situ hybridization ( FISH )-comparative analysis between FISH and cytology显示文摘 | NISHIT ICHIKAWAT IGARASHIT | 2008 | Hinyokika Kiyo2008，54，： | 1 |
| 4 | Influence of organic matter on the availability of certain elements to barley seedlings grown by a modified neubauer method显示文摘 | Nishital H Haug R M Alexander G V | 1973 | Plant and Soil1973，39，1： | 1 |
| 5 | Possibleinteractiveeffectsofdemographicfactorsandstresscopingmechanismsondepressionandanxietyin-maintenancehaemodialysispatients显示文摘 | TakakiJ NishiT Shimoyama-H etal | 2005 | JournalofPsychosomaticResearch2005，58，： | 1 |
| 6 | Analysis of Fe(III)heme binding to cysteine-containing heme-regulatory motifs in proteins显示文摘 | K ii hi Toni Wi p brock Amelie Goradia Nishit | 2013 | ACS chemical biology2013，8，8： | 1 |
| 7 | Combination of IL-12 and IL-18 of electrogene therapy synergistically inhibits tumor growth显示文摘 | Tamura T NishiT Goto T | 2003 | Anticancer Res2003，23，： | 1 |
| 8 | Development of a predictive maintenance model using modified FMEA approach 显示文摘 | Srivastava Nishit Kumar Mondal Sandeep | 2014 | IUP Journal of Operations Management2014，13，2： | 1 |
| 9 | Combination of IL-12 and IL-18 of electrogene therapy synergistically inhibits tumor grewth显示文摘 | Tamura T NishiT Goto T | 2003 | An- ticaneer Res2003，23，： | 1 |
| 10 | A Comprehensive Review on Oxygen Reduction Reaction in Microbial Fuel Cells显示文摘The focus of microbial fuel cell research in recent years has been on the development of materials,microbes,and transfer of charges in the system,resulting in a substantial improvement in current density and improved power generation.The cathode is generally recognized as the limiting factor due to its high-distance proton transfer,slow oxygen reduction reaction(ORR),and expensive materials.The heterogeneous reaction determines power gen-eration in MFC.This comprehensive review describes-recent advancements in the development of cathode mate-rials and catalysts associated with ORR.The recent studies indicated the utilization of different metal oxides,the ferrite-based catalyst to overcome this bottleneck.These studies conclude that some cathode materials,in parti-cular,graphene-based conductive polymer composites with non-precious metal catalysts provide substantial ben-efits for sustainable development in the field of MFCs.Furthermore,it also highlights the potentiality to replace the conventional platinum air cathode for the large-scale production of the next generation of MFCs.It was evi-dent from the experiments that cathode catalyst needs to be blended with conductive carbon materials to make cathode conductive and efficient for ORR.This review discusses various antifouling strategies for cathode biofoul-ing and its effect on the MFC performance.Moreover,it also depicts cost estimations of various catalysts essential for further scale-up of MFC technology. | Pooja Dange Nishit Savla Soumya Pandit Rambabu Bobba Sokhee P.Jung Piyush Kumar Gupta Mohit Sahni Ram Prasad | 2022 | Journal of Renewable Materials2022，10，3： | 0 |
| 11 | Blepharis persica increases testosterone biosynthesis by modulating StAR and 3β-HSD expression in rat testicular tissues显示文摘Objective:To evaluate the effect of methanolic extract and ethyl acetate fraction of methanol extract prepared from the seeds of Blepharis(B.)persica on testosterone biosynthesis and also to elucidate the underlying mechanism.Methods:Forty-eight male Wistar rats were divided into eight groups(n=6 per group).GroupⅠreceived 0.3%w/w gum acacia suspension p.o.and served as the normal control group.GroupⅡwas administered testosterone propionate in arachis oil i.m.as the positive control group.GroupⅢtoⅣreceived B.persica methanolic extract p.o.at doses of 50,100 and 200 mg/kg body weight.GroupⅥtoⅦreceived B.persica ethyl acetate fraction p.o.at doses of 50,100 and 200 mg/kg body weight.The testis was used for biochemical estimation and histological studies.The effects of methanolic extract and ethyl acetate fraction of B.persica on testicular testosterone,mRNA expression corresponding to steroidogenic acute regulatory protein(StAR)and 3β-hydroxysteroid dehydrogenase(3β-HSD)along with 3β-HSD enzyme assay were evaluated in testicular tissues and sperm concentration.Ethyl acetate fraction of B.persica was subjected to column chromatography.Invitro studies were performed using TM3 cell line at three dose levels(50,100,200μg/mL),each for methanolic extract,ethyl acetate fraction and 2-benzoxazolinone for evaluation of their comparative effect on testosterone production.Results:Ethyl acetate fraction and methanolic extract of B.persica could elevate the testicular testosterone content compared to the normal control group.The treatment with methanolic extract and ethyl acetate fraction of B.persica increased the expression of mRNA corresponding to StAR by 6.7 fold and 10.6 fold,respectively,whereas the mRNA expression of 3β-HSD increased by 5.7 fold and 7.3 fold,respectively.Moreover,fraction and extract treatment exhibited increased 3β-HSD activity in the testicular tissues and were found to elevate sperm concentration in seminal fluid.The spermatogenic potential was further ensured by histological observations.2-benzoxazolinone was isolated from ethyl acetate fraction and identified using spectral studies.It showed the ability to increase the testosterone content in the TM3 Leydig cells.Conclusions:Methanolic extract and ethyl acetate fraction of B.persica are able to increase the testicular testosterone in rats by elevating mRNA expression of StAR and 3β-HSD in testicular tissues,leading to increase the sperm concentration. | Nilesh Gaikar Nishit Patel Samir Patel Priyal Patel Piyush Chudasama Manan Raval | 2022 | Asian pacific Journal of Reproduction2022，11，1： | 0 |
| 12 | Utilization of Nanomaterials as Anode Modifiers for Improving Microbial Fuel Cells Performance显示文摘Microbial fuel cells(MFCs)are an attractive innovation at the nexus of energy and water security for the future.MFC utilizes electrochemically active microorganisms to oxidize biodegradable substrates and generate bioelectricity in a single step.The material of the anode plays a vital role in increasing the MFC’s power output.The anode in MFC can be upgraded using nanomaterials providing benefits of exceptional physicochemical properties.The nanomaterials in anode gives a high surface area,improved electron transfer promotes electroactive biofilm.Enhanced power output in terms of Direct current(DC)can be obtained as the consequence of improved microbe-electrode interaction.However,several limitations like complex synthesis and degeneration of property do exist in the development of nanomaterial-based anode.The present review discusses different renewable nanomaterial applied in the anode to recover bioelectricity in MFC.Carbon nanomaterials have emerged in the past decade as promising materials for anode construction.Composite materials have also demonstrated the capacity to become potential anode materials of choice.Application of a few transition metal oxides have been explored for efficient extracellular electron transport(EET)from microbes to the anode. | Nishit Savla Raksha Anand Soumya Pandit Ram Prasad | 2020 | Journal of Renewable Materials2020，8，12： | 0 |
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