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| 1 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 2 | 16S rRNA gene sequencing analysis of gut microbiome in a mini-pig diabetes model显示文摘Background:Currently,increasing attention is being paid to the important role of intestinal microbiome in diabetes.However,few studies have evaluated the characteristics of gut microbiome in diabetic miniature pigs,despite it being a good model animal for assessing diabetes.Methods:In this study,a mini-pig diabetes model(DM)was established by 9-month high-fat diet(HFD)combined with lowdose streptozotocin,while the animals fed standard chow diet constituted the control group.16S ribosomal RNA(rRNA)gene sequencing was performed to assess the characteristics of the intestinal microbiome in diabetic mini-pigs.Results:The results showed that microbial structure in diabetic mini-pigs was altered,reflected by increases in levels of Coprococcus_3 and Clostridium_sensu_stricto_1,which were positively correlated with diabetes,and decreases in levels of the bac-teria Rikenellaceae,Clostridiales_vadinBB60_group,and Bacteroidales_RF16_group,which were inversely correlated with blood glucose and insulin resistance.Moreover,PICRUSt-predicted pathways related to the glycolysis and Entner-Doudoroff superpathway,enterobactin biosynthesis,and the L-tryptophan biosynthesis were significantly elevated in the DM group.Conclusion:These results reveal the composition and predictive functions of the intestinal microbiome in the mini-pig diabetes model,further verifying the relationship between HFD,gut microbiome,and diabetes,and providing novel insights into the application of the mini-pig diabetes model in gut microbiome research. | Miaomiao Niu Yuqiong Zhao Lei Xiang Yunxiao Jia Jifang Yuan Xin Dai Hua Chen | 2022 | Animal Models and Experimental Medicine2022，5，1： | 2 |
| 3 | Long-term case study of a Wuzhishan miniature pig with diabetes显示文摘Background:Miniature pigs are attractive animal models for exploring diabetes because they are similar to humans in terms of physiological structure and metabolism.However,little is known about the complications of diabetes in pigs.Methods:In this study,a 28-month observation of a Wuzhishan miniature pig with streptozotocin(STZ)-induced(120 mg/kg)diabetes was conducted,to investigate diabetes-related complications and the possibility of self-recovery in miniature pigs.Blood glucose,serum and urinary biochemistry was measured,and histopathologic examinations of eyes,kidney and pancreas were made.Results:During the observation,diabetic complications of eyes and kidney were observed.The eye complications included bilateral cataracts in the 15th month and degeneration of inner retina and microaneurysm in the 28th month.Kidney complications included glomerular mesangial expansion,focal segmental glomerular sclerosis,and renal tubular epithelial degeneration,but no proteinuria was observed.By 28 months after the application of STZ,with no treatment given,blood glucose had recovered and the number of pancreatic islet beta-cells had increased significantly.Conclusions:We showed that the STZ-induced diabetes model in miniature pigs could accurately mimic the pathological changes of human diabetes,and that pancreatic islet beta-cell regeneration did occur in an adult miniature pig,providing a new means for exploring diabetic complications and pancreatic islet beta-cell regeneration. | Miaomiao Niu Yaqian Liu Lei Xiang Yuqiong Zhao Jifang Yuan Yunxiao Jia Xin Dai Hua Chen | 2020 | Animal Models and Experimental Medicine2020，3，1： | 2 |
| 4 | Differences and determinants in access to essential public health services in China: a case study with hypertension people and under-sixes as target population显示文摘 | Niu Hongli Tian Miaomiao Ma Anning Wang Chunping Zhang Liang | 2014 | Chinese Medical Journal2014，，9： | 1 |
| 5 | Least energy solutions of nonlinear Schr odinger equations involving the fractional Laplacian and potential wells显示文摘We are concerned with the existence of least energy solutions of nonlinear Schr¨odinger equations involving the fractional Laplacian(-?)~s u(x)+λV(x)u(x)=u(x)^(p-1),u(x)>=0,x∈R^N,for sufficiently large λ。 | NIU MiaoMiao TANG ZhongWei | 2017 | Science China Mathematics2017，60，2： | 1 |
| 6 | Experimental study on refuse derived fuel gasification with oxygen-rich air in fluidized bed gasifier显示文摘 | FU Qirang HUANG Yaji NIU Miaomiao | 2014 | Journal of Zhejiang University (Engineering Science)2014，48，7： | 1 |
| 7 | RHOBTB2 gene associated epilepsy and paroxysmal movement disorder:two cases report and literature review显示文摘Background:RHOBTB2 gene is associated with developmental and epileptic encephalopathy-64(DEE-64),which is characterized by epilepsy,developmental delay,microcephaly,unspecific facial dysmorphism,and paroxysmal movement disorders.Most previous studies showed that the phenotypes of RHOBTB2 gene include developmental and epileptic encephalopathy(DEE)and DEE with paroxysmal movement disorders.Only one study showed that patient with RHOBTB2 variant had paroxysmal movement disorders with no epilepsy.Case presentations:Two cases with RHOBTB2 variants are presented here:Case one was diagnosed as DEE,he had recurrent afebrile focal status epilepticus and paroxysmal extrapyramidal symptoms in infancy.Interictal electroencephalogram(EEG)showed focal discharges.Brain magnetic resonance imaging(MRI)showed cortical dysplasia.Epilepsy of case one was refractory.Nevertheless,case two only showed paroxysmal movement disorders alone in adolescence.Video EEG showed focal discharges during an interictal dystonic episode and he brain MRI was normal.Conclusion:The phenotypes of RHOBTB2 gene include DEE,paroxysmal movement disorders,and DEE with paroxysmal movement disorders.RHOBTB2 can be one of the pathogenic genes of paroxysmal movement disorders. | Xueyang Niu Yan Sun Ying Yang Miaomiao Cheng Quanzhen Tan Jie Zhang Yuehua Zhang | 2021 | Acta Epileptologica2021，3，1： | 1 |
| 8 | Heterogeneity of Surface Heat Exchange of Slopes and Potential Drivers of the Initiation of Thaw Slump,Qinghai‑Tibet Plateau显示文摘In the mountainous permafrost area,most thaw slumps are distributed in north or northeast-facing shady slope areas.It is commonly known that there is a heterogeneity in permafrost between diferent slope aspects,but there has been a lack of detailed measured data to quantitatively evaluate their relationships,and in-depth understandings on how the slope aspects are linked to the distribution of thaw slumps.This study examined the heterogenous thermal regime,soil moisture content,and surface radiation at two slope sites with opposing aspects in a warming permafrost region on the Qinghai-Tibet Plateau(QTP).The results indicate that similar air temperatures(T_(a))were monitored on the two slopes,but there were signifcant diferences in ground temperature and moisture content in the active layer from 2016 to 2021.The sunny slope exhibited a higher mean annual ground surface temperature(T_(s)),and over the fve years the mean annual temperature at the top of permafrost was 1.3–1.4℃warmer on the sunny slope than the shady slope.On the contrary,the near-surface soil moisture content was about 10–13%lower on the sunny slope(~22–27%)than the shady slope(~35–38%)during the thawing season(June–September).Radiation data indicate that signifcantly higher shortwave downward radiation(DR)appeared at the sunny slope site.However,due to the greater surface albedo,the net radiation(Rn)was lower on the sunny slope.Slope aspect also afects the ground ice content due to its infuence on ground temperature,freeze-thaw cycles,and soil moisture.Shady slopes have a shallower burial of ice-rich permafrost compared to sunny slopes.The results highlight greatly diferent near-surface ground thermal conditions at the two slope sites with diferent aspects in a mountainous permafrost region.This helps identify the slope-related causes of increasing thaw slumps and provides a basis for predicting their future development. | Xingwen Fan Wenjiao Li Xuyang Wu Miaomiao Yao Fujun Niu Zhanju Lin | 2023 | International Journal of Disaster Risk Science2023，14，4： | 0 |
| 9 | Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation显示文摘A distinct population of skeletal stem/progenitor cells(SSPCs)has been identified that is indispensable for the maintenance and remodeling of the adult skeleton.However,the cell types that are responsible for age-related bone loss and the characteristic changes in these cells during aging remain to be determined.Here,we established models of premature aging by conditional depletion of Zmpste24(Z24)in mice and found that Prx1-dependent Z24 deletion,but not Osx-dependent Z24 deletion,caused significant bone loss.However,Acan-associated Z24 depletion caused only trabecular bone loss.Single-cell RNA sequencing(sc RNA-seq)revealed that two populations of SSPCs,one that differentiates into trabecular bone cells and another that differentiates into cortical bone cells,were significantly decreased in Prx1-Cre;Z24^(f/f)mice.Both premature SSPC populations exhibited apoptotic signaling pathway activation and decreased mechanosensation.Physical exercise reversed the effects of Z24depletion on cellular apoptosis,extracellular matrix expression and bone mass.This study identified two populations of SSPCs that are responsible for premature aging-related bone loss.The impairment of mechanosensation in Z24-deficient SSPCs provides new insight into how physical exercise can be used to prevent bone aging. | Ruici Yang Dandan Cao Jinlong Suo Lingli Zhang Chunyang Mo Miaomiao Wang Ningning Niu Rui Yue Weiguo Zou | 2023 | Bone Research2023，11，3： | 0 |
| 10 | Whole-genome sequencing study to identify candidate markers indicating susceptibility to type 2 diabetes in Bama miniature pigs显示文摘Background:Hundreds of single-nucleotide polymorphism(SNP)sites have been found to be potential genetic markers of type 2 diabetes mellitus(T2DM).However,SNPs related to T2DM in minipigs have been less reported.This study aimed to screen the T2DM-susceptible candidate SNP loci in Bama minipigs so as to improve the success rate of the minipig T2DM model.Methods:The genomic DNAs of three Bama minipigs with T2DM,six sibling lowsusceptibility minipigs with T2DM,and three normal control minipigs were compared by whole-genome sequencing.The T2DM Bama minipig-specific loci were obtained,and their functions were annotated.Meanwhile,the Biomart software was used to perform homology alignment with T2DM-related loci obtained from the human genome-wide association study to screen candidate SNP markers for T2DM in Bama miniature pigs.Results:Whole-genome resequencing detected 6960 specific loci in the minipigs with T2DM,and 13 loci corresponding to 9 diabetes-related genes were selected.Further,a set of 122 specific loci in 69 orthologous genes of human T2DM candidate genes were obtained in the pigs.Collectively,a batch of T2DM-susceptible candidate SNP markers in Bama minipigs,covering 16 genes and 135 loci,was established.Conclusions:Whole-genome sequencing and comparative genomics analysis of the orthologous genes in pigs that corresponded to the human T2DM-related variant loci successfully screened out T2DM-susceptible candidate markers in Bama miniature pigs.Using these loci to predict the susceptibility of the pigs before constructing an animal model of T2DM may help to establish an ideal animal model. | Miaomiao Niu Yuqiong Zhao Yunxiao Jia Lei Xiang Xin Dai Hua Chen | 2023 | Animal Models and Experimental Medicine2023，6，4： | 0 |
| 11 | The status and development proposal of carbon sources and sinks monitoring satellite system显示文摘In order to mitigate global warming,the international communities actively explore low-carbon and green development methods.According to the Paris Agreement that came into effect in 2016,there will be a global stocktaking plan to carry out every 5 years from 2023 onwards.In September 2020,China proposed a'double carbon'target of carbon peaking before 2030 and carbon neutrality before 2060.Achieving carbon peaking and carbon neutrality goals requires accurate carbon emissions and carbon absorptions.China’s existing carbon monitoring methods have insufficient detection accuracy,low spatial resolution,and narrow swath,which are difficult to meet the monitoring requirement of carbon sources and sinks monitoring.In order to meet the needs of carbon stocktaking and support the monitoring and supervision of carbon sources and sinks,it is recommended to make full use of the foundation of the existing satellites,improve the detection technical specifications of carbon sources and sinks monitoring measures,and build a multi-means and comprehensive,LEO-GEO orbit carbon monitoring satellite system to achieve higher precision,higher resolution and multi-dimensional carbon monitoring.On this basis,it is recommended to strengthen international cooperation,improve data sharing policy,actively participate in the development of carbon retrieval algorithm and the setting of international carbon monitoring standards,establish an independent and controllable global carbon monitoring and evaluation system,and contribute China’s strength to the global realization of carbon peaking and carbon neutrality. | Guang Meng Yuan Wen Miaomiao Zhang Yilei Gu Wei Xiong Zijun Wang Shengda Niu | 2022 | Carbon Neutrality2022，1，1： | 0 |
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