|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antibody engineering: facing new challenges in cancer therapy显示文摘Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as “magic bullets”. Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs,radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies. | Laura S■NZ ■ngel M CUESTA Mana COMPTE Luis ■LVAREZ-VALLINA | 2005 | Acta Pharmacologica Sinica2005，26，6： | 5 |
| 2 | 热化学和等离子辅助预处理与硬质PVD涂层技术的结合显示文摘 | Wolf-DieterMünz 林松盛 代明江 | 2004 | 国外金属热处理2004，25，5： | 3 |
| 3 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 4 | The solar wind plasma upstream of Mars observed by Tianwen-1:Comparison with Mars Express and MAVEN显示文摘On the great journey to Mars,China’s first planetary exploration mission,the Tianwen-1 came within 26 million kilometers of Mars from 31 October 2020 to 25 January 2021 and was getting closer to its destination,the red planet,in search of answers to the cataclysmic climate change that occurred in Martian history.Both the escape of the Martian atmosphere and the loss of surface water were firmly influenced by solar activities.Tianwen-1 provided a unique chance to depict the solar wind streams between Earth and Mars during the minimum of Solar Cycle 25.During the three-month cruise phase of Tianwen-1,the solar wind flows were successively observed at Earth,Tianwen-1,and Mars.After the field of view correction and noise reduction,the solar wind velocity and density measured by Tianwen-1 show good agreement with those at Earth and Mars.The results indicate that the performance of the ion analyzer onboard the Tianwen-1 orbiter is reliable and stable.It is worth looking forward to the joint observations of ion escape with other Mars probes in the following Martian years. | Kai FAN Limei YAN Yong WEI Aibing ZHANG Linggao KONG Markus FRÄNZ Fei HE Lihui CHAI Chongjing YUAN Yuqi WANG Jun ZHONG Zhaojin RONG Zhonghua YAO Yongxin PAN Jun CUI Jiansen HE Wenya LI Binbin TANG Chi WANG | 2022 | Science China Earth Sciences2022，65，4： | 2 |
| 5 | Influence of high power densities on the composition of pulsed magnetron plasmas显示文摘 | A.P. Ehiasarian R. New W.-D. Münz L. Hultman U. Helmersson V. Kouznetsov | 2002 | Vacuum2002，，2： | 2 |
| 6 | Immune escape by Epstein–Barr virus associated malignancies显示文摘 | Christian Münz Ann Moormann | 2008 | Seminars in Cancer Biology2008，，6： | 2 |
| 7 | 人工草地奶牛系统优化生产模式的研究Ⅰ原系统监测及分析显示文摘对贵州省清镇、威宁两地四个不同奶牛系统的草地生产、家畜生产、放牧管理等方面的监测资料进行了系统的分析。指出了监测系统在管理和对策上还存在的问题,并提出了具体的改进方法。 | 蒋文兰 宋福元 熊胜利 B. M. Butler B. M. B Computing Ltd NZ | 1996 | 草业学报1996，5，1： | 2 |
| 8 | Soil microbial diversity and community structure under wheat as influence by tillage and crop rotation显示文摘 | Lupwayi NZ Rice WA Clayton GW | 1998 | Soil Biology and Biochemistry1998，30，： | 1 |
| 9 | MRI findings of intramedullary spinal cryptococcoma显示文摘 | G(U)LTASLI NZ ERCAN K ORHUN S | 2007 | Diagn Interv Radiol2007，13，2： | 1 |
| 10 | Toxoplasma gondii rhoptry protein 38 gene: sequence variation among isolates from different hosts and geographical locations显示文摘 | Xu Y Zhang NZ Chen J | 2014 | Genet Mol Res2014，13，： | 1 |
| 11 | Shear bond strengths and microleakage of four types of dentin adhesive materials 显示文摘 | Ateyah NZ Elhejazi AA | 2004 | J Contemp Dent Pract2004，5，1： | 1 |
| 12 | Neprilysin gene expression requires binding of the amyloid precursor protein intra- cellular domain to its promoter: implications for Alzheimer disease 显示文摘 | Belyaev ND Nalivaeva NN Makova NZ | 2009 | EMBO Reports2009，10，： | 1 |
| 13 | Musculoskeletal symptoms among dentists in relation to work posture 显示文摘 | RATZON NZ YAROS T MIZLIK A | 2000 | Work2000，15，3： | 1 |
| 14 | Surgical considerations in the Hartmann's procedure显示文摘 | Chua Cl Aust NZ | 1996 | J Surg1996，66，： | 1 |
| 15 | Application of the Hem-o-lok ligation system in laparoscopic nephrectomy 显示文摘 | Ping H Xing NZ Zhang JH | 2010 | Surg Endosc2010，24，6： | 1 |
| 16 | Comparative preclinicalanti-proliferative activity of lobaplatin vs cisplatin,carboplatin,oxaliplatin and satraplatin in breast and ovariancancers显示文摘 | Alami NZ Li ZH Engel JG | 2007 | Cancer Research2007，67，： | 1 |
| 17 | The efficacy of intraverous amiodarone for the conversion of chronic atrial fibrillation 显示文摘 | Faitel K Naini M | 1996 | Arch Intern Med1996，156，： | 1 |
| 18 | The A Family History Study of Chronic Fatigue Syndrome 显示文摘 | Walsh CM Zainal NZ Middleton SJ | 2001 | Psychiatr Genet2001，11，3： | 1 |
| 19 | Transgenic mice overexpressioning tratrate-resistant acid phosphatase exhibit an increased rate of bone turnover显示文摘 | ANGEL NZ WALSH N FORWOOD MR | 2000 | Bone Miner Res2000，15，： | 1 |
| 20 | Neurogranin and synaptic plasticity balance 显示文摘 | Zhong L Gerges NZ | 2010 | Commun Integr Biol2010，3，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员