|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Metabolomic studies of human gastric cancer:Review显示文摘Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed networks, such as cancerous and noncancerous samples, can provide insight into underlying disease pathology, disease prognosis and diagnosis. Despite the large number of review articles concerning metabolomics and its application in cancer research, biomarker and drug discovery, these reviews do not focus on a specific type of cancer. Metabolomics may provide biomarkers useful for identification of early stage gastric cancer, potentially addressing an important clinical need. Here, we present a short review on metabolomics as a tool for biomarker discovery in human gastric cancer, with a primary focus on its use as a predictor of anticancer drug chemosensitivity, diagnosis, prognosis, and metastasis. | Naresh Doni Jayavelu Nadav S Bar | 2014 | World Journal of Gastroenterology2014，20，25： | 19 |
| 2 | The cartilage matrisome in adolescent idiopathic scoliosis显示文摘The human spinal column is a dynamic,segmented,bony,and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility.Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.The most common developmental disorder of the spine is scoliosis,a lateral deformity in the shape of the spinal column.Scoliosis may be part of the clinical spectrum that is observed in many developmental disorders,but typically presents as an isolated symptom in otherwise healthy adolescent children.Adolescent idiopathic scoliosis(AIS)has defied understanding in part due to its genetic complexity.Breakthroughs have come from recent genome-wide association studies(GWAS)and next generation sequencing(NGS)of human AIS cohorts,as well as investigations of animal models.These studies have identified genetic associations with determinants of cartilage biogenesis and development of the intervertebral disc(IVD).Current evidence suggests that a fraction of AIS cases may arise from variation in factors involved in the structural integrity and homeostasis of the cartilaginous extracellular matrix(ECM).Here,we review the development of the spine and spinal cartilages,the composition of the cartilage ECM,the so-called'matrisome'and its functions,and the players involved in the genetic architecture of AIS.We also propose a molecular model by which the cartilage matrisome of the IVD contributes to AIS susceptibility. | Carol AWise Diane Sepich Aki Ushiki Anas MKhanshour Yared HKidane Nadja Makki Christina AGurnett Ryan SGray Jonathan JRios Nadav Ahituv Lila Solnica-Krezel | 2020 | Bone Research2020，8，1： | 5 |
| 3 | 区域新构造活动的水下事件沉积响应:以死海盆地和柴达木盆地为例显示文摘自20世纪70年代以来,位于构造活跃区的盆地沉积序列的岩性、粒度与沉积速率的正向突变,常被用来指示区域新构造活动。然而,这种常规方法已经受到国内外学者强有力的质疑——用来推断构造活动的沉积学证据也可由气候因素引起。因而,需寻找某种独立于气候因素的沉积学证据来可靠地指示新构造活动。震积岩,由地震震动引起的、保存于湖相或海相地层序列中的事件沉积,能可靠的指示区域新构造活动。新兴的交叉研究方向——湖泊/海洋古地震学,通过研究保存于水下沉积序列中的震积岩,可延长强震记录,加深对断裂带活动性的认识。文章以死海盆地(中东地区)和柴达木盆地(青藏高原东北缘)为例,从水下事件沉积响应的视角,借助超长尺度的震积岩序列,理解千年-构造尺度上的区域新构造活动特性。基于死海湖心457 m长的ICDP 5017-1岩芯保存的震积岩序列,我们建立了一条由151个M_(W)≥7地震事件组成的,全球最长的(220 ka)连续大地震记录,该记录揭示了缓慢滑动的死海断裂带上的大地震具有聚类式的复发特征,以及不同断层分支相互作用、聚类活动的模式;基于青藏高原东北缘柴达木盆地西部的碱山背斜顶部SG-1b岩芯上部260 m沉积序列,我们建立了一条由164个震积岩层位构成的覆盖3.6~1.6 Ma的震积岩序列,该序列在3.6~2.7 Ma时段内相对较为连续,由126个地震事件和5个地震集合组成,揭示了与强烈区域变形有关的晚上新世幕式逆冲过程。 | 卢银 Nadav Wetzler Shmuel Marco 方小敏 | 2022 | 第四纪研究2022，42，3： | 2 |
| 4 | High-fat diet and oral infection induced type 2 diabetes and obesity development under different genetic backgrounds显示文摘Background:Type 2 diabetes(T2D)is an adult-onset and obese form of diabetes caused by an interplay between genetic,epigenetic,and environmental components.Here,we have assessed a cohort of 11 genetically different collaborative cross(CC)mouse lines comprised of both sexes for T2D and obesity developments in response to oral infection and high-fat diet(HFD)challenges.Methods:Mice were fed with either the HFD or the standard chow diet(control group)for 12 weeks starting at the age of 8 weeks.At week 5 of the experiment,half of the mice of each diet group were infected with Porphyromonas gingivalis and Fusobacterium nucleatum bacteria strains.Throughout the 12-week experimental period,body weight(BW)was recorded biweekly,and intraperitoneal glucose tolerance tests were performed at weeks 6 and 12 of the experiment to evaluate the glucose tolerance status of mice.Results:Statistical analysis has shown the significance of phenotypic variations between the CC lines,which have different genetic backgrounds and sex effects in different experimental groups.The heritability of the studied phenotypes was estimated and ranged between 0.45 and 0.85.We applied machine learning methods to make an early call for T2D and its prognosis.The results showed that classification with random forest could reach the highest accuracy classification(ACC=0.91)when all the attributes were used.Conclusion:Using sex,diet,infection status,initial BW,and area under the curve(AUC)at week 6,we could classify the final phenotypes/outcomes at the end stage of the experiment(at 12 weeks). | Iqbal M.Lone Nadav Ben Nun Aya Ghnaim Arne S.Schaefer Yael Houri-Haddad Fuad A.Iraqi | 2023 | Animal Models and Experimental Medicine2023，6，2： | 2 |
| 5 | miR -210 Inhibits Trophoblast Invasion and Is a Serum Biomarker for Preeclampsia 显示文摘 | LAUREN A OLARERIN -GEORGE A O NADAV S | 2013 | American Journal of Pathology2013，183，5： | 1 |
| 6 | Design and performance of a zero-discharge tilapia recirculating system显示文摘 | Nadav Shnel Yoram Barak Tamir Ezer | 2002 | Aquacult Eng2002，26，3： | 1 |
| 7 | Mechanical vapour compression to treat oil field produced water显示文摘 | KOREN A NADAV N | 1994 | Desalination1994，98，123： | 1 |
| 8 | Effect of simvastatin on intestinal recovery following gut ischemia–reperfusion injury in a rat显示文摘 | Nadav Slijper Igor Sukhotnik Elena Chemodanov Yulia Bashenko Ron Shaoul Arnold G. Coran Jorge Mogilner | 2010 | Pediatric Surgery International2010，，1： | 1 |
| 9 | Upgrading conical scan with off-boresight measurements显示文摘 | | 1997 | IEEE transactions aerospace and electronic systems1997，33，4： | 1 |
| 10 | Periodic Ambiguity Function of CW Signals with Perfect Periodic Autocorrelation 显示文摘 | Nadav Levanon Avraham Freedom | 1992 | IEEE TRANSACTION ON AEROSPACE AND ELECTRONIC SYSTEMS1992，28，2： | 1 |
| 11 | Boron removal from the perme- ate of a large SWRO plant in Eilat 显示文摘 | Nadav N Priel M Glueckstern P | 2005 | Desalination2005，185，1： | 1 |
| 12 | Boron removal from seawater reverse osmosis permeate utilizing selective ion exchange resin显示文摘 | Nadav N | 1999 | Desalination1999，124，13： | 1 |
| 13 | Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion显示文摘 | H. M. C. Shantha Kumara Daniel Kirchoff Samer Naffouje Michael Grieco Sonali A. C. Herath Nadav Dujovny Matthew F. Kalady Neil Hyman Linda Njoh Richard L. Whelan | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 14 | Blur Spot Limitations in Distal Endoscope Sensors显示文摘 | Yaron A Mark S Nadav H | 2006 | SPIE2006，，： | 1 |
| 15 | Mitigating Range Ambiguity in High PRF Radar using Inter-Pulse Binary Coding 显示文摘 | Nadav Levanon | 2009 | IEEE Transactions on Aerospace and Electronic Systems2009，45，2： | 1 |
| 16 | Colorectal Resection is Associated With Persistent Proangiogenic Plasma Protein Changes: Postoperative Plasma Stimulates In Vitro Endothelial Cell Growth, Migration, and Invasion显示文摘 | H M.C. Shantha Kumara Daniel Feingold Matthew Kalady Nadav Dujovny Anthony Senagore Neil Hyman Vesna Cekic Richard L. Whelan | 2009 | Annals of Surgery2009，，6： | 1 |
| 17 | Mechanical vapour compression to treat oil field produced water显示文摘 | Koren A Nadav N | 1994 | Desalination1994，98，13： | 1 |
| 18 | Colorectal Resection is Associated With Persistent Proangiogenic Plasma Protein Changes: Postoperative Plasma Stimulates In Vitro Endothelial Cell Growth, Migration, and Invasion显示文摘 | H M.C. Shantha Kumara Daniel Feingold Matthew Kalady Nadav Dujovny Anthony Senagore Neil Hyman Vesna Cekic Richard L. Whelan | 2009 | Annals of Surgery2009，，： | 1 |
| 19 | Human heparanase is localized within lysosomes in a stable form显示文摘 | GOLDSHMIDT O NADAV L AINGOMH | 2002 | Exp Cell Res2002，281，1： | 1 |
| 20 | Activation,processing and trafficking ofextracellular heparanase by primary human fibroblasts显示文摘 | Nadav L Eldor A Yacoby-Zeevi O | 2002 | J Cell Sci2002，115，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员