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| 1 | The evolution and functional diversification of animal microRNA genes显示文摘microRNAs (miRNAs ) 是 22 核苷酸(nt ) 的一个丰富的班在更高真核细胞的染色体是弥漫的规章的 RNA。以便充分在染色体理解他们的突起,阐明是必要的能多样化 miRNA 活动的分子的机制。在这评论,我们描述一些允许新奇 miRNA 功能出现的许多策略,与 miRNA 基因怎么在动物演变的特别强调。这些机制在他们的顺序包括变化,处理,或表示模式;miRNA 的获得 * 功能或 antisense 处理;并且 de novo 基因出生。miRNAs 的设备和通用性位于下面多半演变并且变化他们怎么成为了更高的染色体的主导的成分。 | Na Liu Katsutomo Okamura David M Tyler Michael D Phillips Wei-Jen Chung Eric C Lai | 2008 | Cell Research2008,18,10: | 17 |
| 2 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021,29,2: | 9 |
| 3 | 骨折相关性感染定义的共识显示文摘骨折相关性感染(fracture related infection,FRI)是创伤骨科一种常见的严重并发症.迄今为止,尚无明确定义,因此很难对该并发症带来的影响进行准确评估和对现有的研究展开比较.为解决这一难题,在AO基金会的支持下,我们成立了一个由科学家和医学专家组成的专家组,旨在对FRI定义达成的共识. | Metsemakers WJ Morgenstern M McNally MA Moriarty TF McFadyen I Scarborough M Athanasou NA Ochsner PE Kuehl R Raschke M Borens O 谢肇 Velkes S Hungerer S Kates SL Zalavras C Giannoudis PV Richard RG Verhofstad MH 喻胜鹏 孙东 汪小华 | 2018 | 中华骨科杂志2018,38,9: | 8 |
| 4 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017,27,4: | 5 |
| 5 | 激活β_3肾上腺素能受体恢复一氧化氮/氧化还原平衡,增强高血糖患者的内皮功能显示文摘一氧化氮与O_2^-之间的平衡紊乱(即一氧化氮/氧化还原失衡)是糖尿病引起的血管功能障碍的中心病理环节。该研究目的为在高血糖动物模型中探索β_3肾上腺素能受体(β_3adrenergic receptor,β3AR)激活能否耦合激活内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)。 | 刘莉 叶鹏 Karimi Galougahi K Liu CC Garcia A Gentile C Fry NA Hamilton EJ Hawkins CL Figtree GA | 2016 | 中华高血压杂志2016,24,3: | 2 |
| 6 | Posttraumatic cerebral arterial spasm:transcranial Doppler ultrasound,cerebral blood flow,angiographic findings显示文摘 | Martin NA Doberstein C Zane C | 1992 | J Neurosurgery1992,77,4: | 1 |
| 7 | Double-blind, placebo- controlled study of the use of amphetamine in the treatment of aphasia显示文摘 | Delaina WB Sandra C Rajeshwari NA | 2001 | Stroke2001,32,9: | 1 |
| 8 | Nitric Oxide Is Required for Root Organogenesis 显示文摘 | Pagnussat G C Simontacchi M Puntarulo S and Lamatti- na L | 2002 | Plant Physiology2002,129,: | 1 |
| 9 | Inorganic Nanoparticles for MRI Contrast Agents显示文摘 | Na H B Song I C Hyeon T | 2009 | Adv Mater2009,21,21: | 1 |
| 10 | Diet, physical exer- cise and Orlistat administration increase serum anti-Miillerian hor- motxe (AMID levels in women with polycystic ovary syndrome (PCOS) 显示文摘 | Vosnakis C Georgopoulos NA Rousso D | 2013 | Gynecol Endocrinol2013,29,3: | 1 |
| 11 | Mechanisms of hemorrhagic cystitis显示文摘 | Haldar S Dru C Bhowmick NA | 2014 | AmJ Clin Exp Urol2014,2,3: | 1 |
| 12 | 3,5-Dimethylphenylcar- barnates of amylose, chitosan and cellulose bonded on silica gel Com- parison of their chiral recognition abilities as high-performance liquid chromatography chiral stationary phases显示文摘 | Franco P Senso A Minguillo'na C | 1998 | J Chromatography A1998,,: | 1 |
| 13 | Endovascular treatment of intracranial dural arteriovenous fistulas with cortical venous drainage:new management using Onyx显示文摘 | Cognard C Januel AC Silva NA Jr | 2008 | AJNR Am J Neuroradiol2008,29,: | 1 |
| 14 | Comparison of secondary implantation of flexible open-loop anterior chamber and seleral-fixated posterior chamber intraocular lenses显示文摘 | Evereklioglu C Er H Bekir NA et ak | 2003 | J Cataract Refract Surg2003,29,: | 1 |
| 15 | Double-Blind, Placebo- Controlled Study of the Use of Amph-etamine in the Treatment of Aphasia显示文摘 | Delaina WB Sandra C Rajeshwari NA | 2001 | Stroke2001,32,: | 1 |
| 16 | Prevalence of delayed gastric emptying of solids in functional dyspepsia and its relationship to symptoms显示文摘 | Sfarti C Trifan A Hu(t)(a)na(s)u C | 2009 | Rev Med Chir Soc Med Nat Iasi2009,113,4: | 1 |
| 17 | Intergenerational transmission and continuity of stress and depression: depressed women and their offspring in 20 years of follow-up 显示文摘 | Hammen C Hazel NA Brennan PA | 2012 | Psychol Med2012,42,5: | 1 |
| 18 | A Catalytic Nanomaterial-based Optical Chemo-sensor Array 显示文摘 | Na N Zhang S C Wang S A Zhang X R | 2006 | Journal of the AmericanChemical Society2006,128,14: | 1 |
| 19 | Preparation and application of an oil soluble Co-Mo bimetallic catalyst for the hydrocrac- king of oil sands bitumen显示文摘 | Jeon S G Na J G Ko C H | 2011 | Energy & Fuels2011,25,10: | 1 |
| 20 | Impact of tonsillectomy and adenoidectomy on child behavior显示文摘 | Goldstein NA Post C Rosenfeld RM | 2000 | Arch Otolaryngol Head Neck Surg2000,126,: | 1 |