|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Soy-based renoprotection显示文摘Chronic kidney disease(CKD) is a significant publich ealth problem as risk factors such as advanced age, obesity, hypertension and diabetes rise in the global po-pulation. Currently there are no effective pharmacologic treatments for this disease. The role of diet is important for slowing the progression of CKD and managing symptoms in later stages of renal insufficiency. While low protein diets are generally recommended, maintaining adequate levels of intake is critical for health. There is an increasing appreciation that the source of protein may also be important. Soybean protein has been the most extensively studied plant-based protein in subjects with kidney disease and has demonstrated renal protective properties in a number of clinical studies. Soy protein consumption has been shown to slow the decline in estimated glomerular filtration rate and significantly improve proteinuria in diabetic and non-diabetic patients with nephropathy. Soy's beneficial effects on renal function may also result from its impact on certain phy-siological risk factors for CKD such as dyslipidemia, hypertension and hyperglycemia. Soy intake is also associated with improvements in antioxidant status and systemic inflammation in early and late stage CKD pati-ents. Studies conducted in animal models have helped to identify the underlying molecular mechanisms that may play a role in the positive effects of soy protein on renal parameters in polycystic kidney disease, metabolically-induced kidney dysfunction and age-associated prog-ressive nephropathy. Despite the established relationship between soy and renoprotection, further studies are needed for a clear understanding of the role of the cellular and molecular target(s) of soy protein in main-taining renal function. | Nancy J Mc Graw Elaine S Krul Elizabeth Grunz-Borgmann Alan R Parrish | 2016 | World Journal of Nephrology2016，5，3： | 5 |
| 2 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 3 | 16S rRNA based T-RFLP analysis of methane oxidizing bacteria Assessment, critical evaluation of methodology performance and application for landfill site cover soils显示文摘 | NANCY S LEVENTE B THOMAS G R | 2006 | Applied Soil Ecology2006，31，： | 1 |
| 4 | Synthesis and processing of the trasmembrane envelope protein of equine infectious anemia virus显示文摘 | Nancy R Louise H Raymond C S | 1990 | J Virol1990，64，： | 1 |
| 5 | Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer显示文摘AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic adenocarcinoma.METHODS From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after high-dose [59.4 Gy(RBE)] proton radiotherapy with a high rate of local control,acceptable surgical morbidity,and a median survival of 24 mo. | Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven J Hughes John A Stauffer Scott A Celinski Elizabeth A Johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg | 2017 | World Journal of Gastrointestinal Surgery2017，9，4： | 1 |
| 6 | Genomic features of intertypic recombinant Sabin poliovirus strains excreted by primary vaccinees 显示文摘 | Nancy S C Sophie G Natalia R | 2001 | J Virol2001，75，13： | 1 |
| 7 | Efficacy of reco mbinant methionyl human leptin therapy for the extreme insulin resistance of the rabson-mendenhallsy ndrome显示文摘 | Elaine C Janice R Y Nancy S | 2004 | J Clin Endocrinol Metab2004，89，4： | 1 |
| 8 | Development of a monoclonal antibody based enzyme-linked immunosorbent assay to quantify soluble β-glucans in oats and barley显示文摘 | Christof R Nancy A Joanne S | 2003 | Journal of Agricultural and Chemistry2003，51，： | 1 |
| 9 | American Associa- tion of Neuroscience Nurses Scope and Standards of Prac- tice for Neuroscience Advanced Practice Nurses显示文摘 | Chris S A Nancy V Rossi S R | 2010 | J Neu- rosci Nurs2010，42，3： | 1 |
| 10 | Uhrastructural immtmodetection of osteopontin and osteocalcin as major matrix components of renal calculi 显示文摘 | MCKEE M D NANCI A KHAN S R | 1995 | J Bone Miner Res1995，10，12： | 1 |
| 11 | Surface chemical reactivity in selected zero-valent iron samples used in groundwater remediation 显示文摘 | Nancy R Sudipta S Debra R | 1995 | Journal of Hazardous Materials1995，80，： | 1 |
| 12 | Sonication-dependent electroporation of the erythromycin- producing bacterium Saecharopolyspora erythraea显示文摘 | Fitzgerald Nancy B English R Samuel Lampel Jay S | 1998 | Applied and Environmental Microbiology1998，64，4： | 1 |
| 13 | Effects of green tea polyphenols on lens photooxidative stress 显示文摘 | SEYMOUR Z NANCY S R KEEN A R | 1999 | The Biological Bulletin Woods Hole1999，197，2： | 1 |
| 14 | Triggered releaseform polymer capsules 显示文摘 | Aaron P E Susan A O Nancy R S | 2011 | Macromolecules2011，44，14： | 1 |
| 15 | Modafinil in the treatment of excessive daytime sleepiness显示文摘 | Valentino R M Nancy F S | 2007 | Cleveland Clinic Journal of Medicine2007，74，8： | 1 |
| 16 | Fracture and fatigue behavior of a self-healing polymer composite 显示文摘 | Brown E N M White J S Sottos S R Nancy R | 2003 | Materials Research Society Symposium-Proceedings2003，735，： | 1 |
| 17 | Isogene specific oligo arrays reveal multifaceted changes in gene expression during grape berry (Vitis vinifera L.) development显示文摘 | Nancy Terrier David Glissant Jér?me Grimplet Fran?ois Barrieu Philippe Abbal Carole Couture Agnès Ageorges Rossitza Atanassova Céline Léon Jean-Pierre Renaudin Fabienne Dédaldéchamp Charles Romieu Serge Delrot Sa?d Hamdi | 2005 | Planta2005，，5： | 1 |
| 18 | Development of a monoclonal antibody based enzyme-linked immunosoebent assay to quantity soluble β-glucan in oats and barley显示文摘 | Nancy A Joanne S | 2003 | Journal of agricultural and chemistry2003，51，： | 1 |
| 19 | 16s rRNA based T-RFLP analysis of methane oxidizing bacteria-Assessment, critical evaluation of methodology performance and application for landfill site cover soils显示文摘 | Nancy S P Levente B Thomas G R | 2006 | Applied Soil Ecology2006，31，： | 1 |
| 20 | Triggered release from polymer capsules 显示文摘 | Aaron P E Susan A O Nancy R S | 2011 | Macromolecules2011，44，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员