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| 1 | Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathologicalsignificance显示文摘 | Yojiro Hashiguchi Naohiro Nishida Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hideshi Ishii Hidetaka Mochizuki Kazuo Hase Yuichiro Doki Masaki Mori | 2012 | International Journal of Oncology2012，，5： | 2 |
| 2 | Near-Infrared Spectroscopy for Assessment of Tissue Oxygen Saturation of Transplanted Jejunal Autografts in Cervical Esophageal Reconstruction显示文摘 | Yasumitsu Hirano Kenji Omura Hidemaro Yoshiba Naohiro Ohta Chikashi Hiranuma Kanae Nitta Yuji Nishida Go Watanabe | 2005 | Surgery Today2005，，1： | 1 |
| 3 | Biochemistry and physiology of mitochondrial ion channels involved in cardioprotection显示文摘 | Hirofumi Nishida Akio Matsumoto Naohiro Tomono Takahiro Hanakai Shintaro Harada Haruaki Nakaya | 2009 | FEBS Letters2009，，10： | 1 |
| 4 | MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells显示文摘 | Naohiro Nishida Shinya Yamashita Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hirofumi Yamamoto Hideshi Ishii Yuichiro Doki Masaki Mori | 2012 | Annals of Surgical Oncology2012，，9： | 1 |
| 5 | MicroRNA miR-125b is a prognostic marker in human colorectal cancer显示文摘 | Naohiro Nishida Takehiko Yokobori Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hideshi Ishii Yuichiro Doki Hiroyuki Kuwano Masaki Mori | 2011 | International Journal of Oncology2011，，5： | 1 |
| 6 | Abnormal Expression of PFDN4 in Colorectal Cancer: A Novel Marker for Prognosis显示文摘 | Norikatsu Miyoshi Hideshi Ishii Koshi Mimori Naohiro Nishida Masayoshi Tokuoka Hirofumi Akita Mitsugu Sekimoto Yuichiro Doki Masaki Mori | 2010 | Annals of Surgical Oncology2010，，11： | 1 |
| 7 | EGFR gets in the way of microRNA biogenesis显示文摘 | Naohiro Nishida Koshi Mimori Masaki Mori George A Calin | 2013 | Cell Research2013，23，10： | 1 |
| 8 | The combination of the expression of hexokinase 2 and pyruvate kinaseM2 is a prognostic marker in patients with pancreatic cancer显示文摘 | Hisataka Ogawa Hiroaki Nagano Masamitsu Konno Hidetoshi Eguchi Jun Koseki Koichi Kawamoto Naohiro Nishida Hugh Colvin Akira Tomokuni Yoshito Tomimaru Naoki Hama Hiroshi Wada Shigeru Marubashi Shogo Kobayashi Masaki Mori Yuichiro Doki Hideshi Ishii | 2015 | Molecular and Clinical Oncology2015，，3： | 1 |
| 9 | Protracted anaphylaxis developed after peginterferon α-2a administration for chronic hepatitis C显示文摘Peginterferon is a key drug used to treat chronic viral hepatitis that is known for causing various side effects.Side effects occurring immediately after administration include headache, nausea, and influenza-like symptoms, such as fever and joint pain.However, reports of anaphylactic shock are extremely rare.Here we report a patient with protracted anaphylaxis who suffered shock symptoms after peginterferon α-2a administration for chronic hepatitis C.Although the patient improved temporarily with shock treatment, symptoms of anaphylaxis recurred.As peginterferon is often administered on an outpatient basis, it is important to recognize life-threatening side effects that may develop in a protracted manner. | Akihiko Sakatani Yoshinori Doi Takaaki Matsuda Yasutaka Sasai Naohiro Nishida Megumi Sakamoto Naoto Uenoyama Yoshiya Matsumoto Kazuo Kinoshita | 2015 | World Journal of Gastroenterology2015，21，9： | 1 |
| 10 | Gallbladder cancer harboring ERBB2 mutation on the primary and metastatic site: A case report显示文摘BACKGROUND Bile duct cancer constitutes gallbladder cancer(GBC),intrahepatic cholangiocarcinoma(ICA),and extrahepatic cholangiocarcinoma(ECA).These three entities show morphological and immunohistochemical resemblance so that it is difficult to differentiate between primary ICA and liver metastasis of GBC,which sometimes becomes a point of discussion in clinical practice.Although these cancers demonstrate significant differences in their mutational landscape,several reports demonstrated shared genomic alteration in paired primary and metastatic site aids in distinguishing metastatic recurrence from second primary cancers.CASE SUMMARY We present a 73-year-old female patient who underwent curative resection for GBC harboring epidermal growth factor receptor 2(ERBB2)activating mutation on next-generation sequencing(NGS)-based genomic testing.One year later,a hepatic lesion was observed on follow-up imaging and she underwent surgical resection for a pathological diagnosis.The histological findings of the hepatic lesion were similar to those of the primary lesion.Additionally,using NGS panel testing,the hepatic lesion was found to have ERBB2 activating mutation,which is the identical mutation detected in the sequencing result of the primary site.ERBB2 activating mutation occurs more frequently in GBC than ICA and ECA.Therefore,in the present case,we think this molecular finding potentiated the diagnosis of the liver mass toward a metastatic recurrence.Additionally,this patient underwent HER2-targeted treatment with lapatinib in combination with capecitabin and obtained clinical benefit.CONCLUSION This case illustrated NGS panel usefulness in distinguishing GBC recurrence from second primary cancer and HER2-targeted agent efficacy on ERBB2 mutated GBC. | Chiaki Inagaki Daichi Maeda Akie Kimura Toru Otsuru Yoshifumi Iwagami Naohiro Nishida Daisuke Sakai Ryo Shitotsuki Shinichi Yachida Yuichiro Doki Taroh Satoh | 2019 | World Journal of Gastrointestinal Oncology2019，11，9： | 1 |
| 11 | Histone deacetylase 1 expression in gastric cancer显示文摘 | Tomoya Sudo Koshi Mimori Naohiro Nishida Ryunosuke Kogo Takeshi Iwaya Fumiaki Tanaka Kohei Shibata Hiromasa Fujita Kazuo Shirouzu Masaki Mori | 2011 | Oncology Reports2011，，4： | 1 |
| 12 | Pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion from an aortic intramural hematoma显示文摘Pancreaticoduodenal artery aneurysms are a rare type of visceral artery aneurysm, whose rupture is associated with high mortality. These aneurysms are of particular interest because local haemodynamic change caused by coeliac artery obstruction plays an important role in their development. However, the pathophysiological mechanism of coeliac artery obstruction is not completely understood. Pressure from the median arcuate ligament is most frequently reported cause. Although it is well-known that stenosis or occlusion of the visceral vessels may be caused by aortic syndrome, reports of pancreaticoduodenal artery aneurysm associated with coeliac artery occlusion due to aortic syndrome are extremely rare. Our case indicates a new aetiology for a pancreaticoduodenal artery aneurysm and demonstrates the rapid deterioration of the patient affected. | Akihiko Sakatani Yoshinori Doi Toshiaki Kitayama Takaaki Matsuda Yasutaka Sasai Naohiro Nishida Megumi Sakamoto Naoto Uenoyama Kazuo Kinoshita | 2016 | World Journal of Gastroenterology2016，22，16： | 1 |
| 13 | Effectiveness and safety of chemotherapy for patients with malignant gastrointestinal obstruction:A Japanese populationbased cohort study显示文摘BACKGROUND The impacts of chemotherapy on patients with malignant gastrointestinal obstructions remain unclear,and multicenter evidence is lacking.AIM To evaluate the effectiveness and safety of chemotherapy in patients with unresectable malignant gastrointestinal obstructions.METHODS We conducted a multicenter retrospective cohort study that compared the chemotherapy group who received any chemotherapeutics after interventions,including palliative surgery or selfexpandable metal stent placement,for unresectable malignant gastrointestinal obstruction vs the best supportive care(BSC)group between 2014 and 2019 in nine hospitals.The primary outcome was overall survival,and the secondary outcomes were patency duration and adverse events,including gastrointestinal perforation and gastrointestinal bleeding.RESULTS In total,470 patients in the chemotherapy group and 652 patients in the BSC group were analyzed.During the follow-up period of 54.1 mo,the median overall survival durations were 19.3 mo in the chemotherapy group and 5.4 mo in the BSC group(log-rank test,P<0.01).The median patency durations were 9.7 mo[95% confidence interval(CI):7.7-11.5 mo]in the chemotherapy group and 2.5 mo(95%CI:2.0-2.9 mo)in the BSC group(log-rank test,P<0.01).The perforation rate was 1.3%(6/470)in the chemotherapy group and 0.9%(6/652)in the BSC group(P=0.567).The gastrointestinal bleeding rate was 1.5%(7/470)in the chemotherapy group and 0.5%(3/652)in the BSC group(P=0.105).CONCLUSION Chemotherapy after interventions for unresectable malignant gastrointestinal obstruction was associated with increased overall survival and patency duration. | Gota Fujisawa Ryota Niikura Takuya Kawahara Tetsuro Honda Kenkei Hasatani Naohiro Yoshida Tsutomu Nishida Tetsuya Sumiyoshi Shu Kiyotoki Takashi Ikeya Masahiro Arai Yoku Hayakawa Takashi Kawai Mitsuhiro Fujishiro | 2022 | World Journal of Clinical Cases2022，10，16： | 0 |
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