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| 1 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 2 | Comparison of cerebral activation between motor execution and motor imagery of self-feeding activity显示文摘Motor imagery is defined as an act wherein an individual contemplates a mental action of motor execution without apparent action.Mental practice executed by repetitive motor imagery can improve motor performance without simultaneous sensory input or overt output.We aimed to investigate cerebral hemodynamics during motor imagery and motor execution of a self-feeding activity using chopsticks.This study included 21 healthy right-handed volunteers.The self-feeding activity task comprised either motor imagery or motor execution of eating sliced cucumber pickles with chopsticks to examine eight regions of interest:pre-supplementary motor area,supplementary motor area,bilateral prefrontal cortex,premotor area,and sensorimotor cortex.The mean oxyhemoglobin levels were detected using near-infrared spectroscopy to reflect cerebral activation.The mean oxyhemoglobin levels during motor execution were significantly higher in the left sensorimotor cortex than in the supplementary motor area and the left premotor area.Moreover,significantly higher oxyhemoglobin levels were detected in the supplementary motor area and the left premotor area during motor imagery,compared to motor execution.Supplementary motor area and premotor area had important roles in the motor imagery of self-feeding activity.Moreover,the activation levels of the supplementary motor area and the premotor area during motor execution and motor imagery are likely affected by intentional cognitive processes.Levels of cerebral activation differed in some areas during motor execution and motor imagery of a self-feeding activity.This study was approved by the Ethical Review Committee of Nagasaki University(approval No.18110801)on December 10,2018. | Moemi Matsuo Naoki Iso Kengo Fujiwara Takefumi Moriuchi Daiki Matsuda Wataru Mitsunaga Akira Nakashima Toshio Higashi | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 3 | Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii显示文摘AIM: Hepatitis B virus (HBV) genomes in carriers from Hawaii have not been evaluated previously. The aim of thepresent study was to evaluate the distribution of HBV genotypes and their clinical relevance in Hawaii.METHODS: Genotyping of HBV among 61 multi-ethnicc arriers in Hawaii was performed by genetic methods.Three complete genomes and 61 core promoter/precore regions of HBV were sequenced directly.RESULTS: HBV genotype distribution among the 61 carderswas 23.0% for genotype A, 14.7% for genotype B and 62.3% for genotype C. Genotypes A, B and C were obtained from the carriers whose ethnicities were Filipino and Caucasian,Southeast Asian, and various Asian and Micronesian,respectively. All cases of genotype B were composed of recombinant strains with genotype C in the precore plus core region named genotype Ba. HBeAg was detected more frequently in genotype C than in genotype B (68.4% vs 33.3%, P<0.05) and basal core promoter (BCP) mutation (T1762/A1764) was more frequently found in genotype C than in genotype B. Twelve of the 38 genotype C strains possessed C at nucleotide (nt) position 1858 (C-1858).However there was no significant difference in clinical characteristics between C-1858 and T-1858 variants. Based on complete genome sequences, phylogenetic analysis revealed one patient of Micronesian ethnicity as having C1858 clustered with two isolates from Polynesia with T-1858.In addition, two strains from Asian ethnidties were clustered with known isolates in carriers from Southeast Asia.CONCLUSION: Genotypes A, B and C are predominant types among multi-ethnic HBV carriers in Hawaii, and distribution of HBV genotypes is dependent on the ethnic background of the carriers in Hawaii. | Mayumi Sakurai Fuminaka Sugauchi Naoky Tsai Seiji Suzuki Izumi Hasegawa Kei Fujiwara Etsuro Orito Ryuzo Ueda Masashi Mizokami | 2004 | World Journal of Gastroenterology2004，10，15： | 2 |
| 4 | A Multicenter Survey of the Management After Gastric Endoscopic Submucosal Dissection Related to Postoperative Bleeding显示文摘 | Osamu Goto Mitsuhiro Fujishiro Ichiro Oda Naomi Kakushima Yorimasa Yamamoto Yosuke Tsuji Ken Ohata Takashi Fujiwara Junko Fujiwara Naoki Ishii Chizu Yokoi Shinichi Miyamoto Toshiyuki Itoh Shinji Morishita Takuji Gotoda Kazuhiko Koike | 2012 | Digestive Diseases and Sciences2012，，2： | 2 |
| 5 | Function and diagnostic value of Anosmin‐1 in gastric cancer progression显示文摘 | Mitsuro Kanda Dai Shimizu Tsutomu Fujii Satoshi Sueoka Yuri Tanaka Kazuhiro Ezaka Hideki Takami Haruyoshi Tanaka Ryoji Hashimoto Naoki Iwata Daisuke Kobayashi Chie Tanaka Suguru Yamada Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasu | 2016 | Int. J. Cancer2016，，3： | 1 |
| 6 | Translational implication of Kallmann syndrome-1 gene expression inhepatocellular carcinoma显示文摘 | Yuri Tanaka Mitsuro Kanda Hiroyuki Sugimoto Dai Shimizu Satoshi Sueoka Hideki Takami Kazuhiro Ezaka Ryoji Hashimoto Yukiyasu Okamura Naoki Iwata Chie Tanaka Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro | 2015 | International Journal of Oncology2015，，6： | 1 |
| 7 | Amylase Concentration of the Drainage Fluid as a Risk Factor for Intra-abdominal Abscess Following Gastrectomy for Gastric Cancer显示文摘 | Naoki Iwata Yasuhiro Kodera Takehiko Eguchi Norifumi Ohashi Goro Nakayama Masahiko Koike Michitaka Fujiwara Akimasa Nakao | 2010 | World Journal of Surgery2010，，7： | 1 |
| 8 | A method for using video presentation to increase the vividness and activity of cortical regions during motor imagery tasks显示文摘In recent years,mental practice(MP)using laterally inverted video of a subject’s non-paralyzed upper limb to improve the vividness of presented motor imagery(MI)has been shown to be effective for improving the function of a paralyzed upper limb.However,no studies have yet assessed the activity of cortical regions engaged during MI task performance using inverse video presentations and neurophysiological indicators.This study sought to investigate changes in MI vividness and hemodynamic changes in the cerebral cortex during MI performance under the following three conditions in near-infrared spectroscopy:MI-only without inverse video presentation(MI-only),MI with action observation(AO)of an inverse video presentation of another person’s hand(AO+MI(other hand)),and MI with AO of an inverse video presentation of a participant’s own hand(AO+MI(own hand)).Participants included 66 healthy right-handed adults(41 men and 25 women;mean age:26.3±4.3 years).There were 23 patients in the MI-only group(mean age:26.4±4.1 years),20 in the AO+MI(other hand)group(mean age:25.9±5.0 years),and 23 in the AO+MI(own hand)group(mean age:26.9±4.1 years).The MI task involved transferring 1 cm×1 cm blocks from one plate to another,once per second,using chopsticks held in the non-dominant hand.Based on a visual analog scale(VAS),MI vividness was significantly higher in the AO+MI(own hand)group than in the MI-only group and the AO+MI(other hand)group.A main effect of condition was revealed in terms of MI vividness,as well as regions of interest(ROIs)in certain brain areas associated with motor processing.The data suggest that inverse video presentation of a person’s own hand enhances the MI vividness and increases the activity of motor-related cortical areas during MI.This study was approved by the Institutional Ethics Committee of Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121303)on January 18,2019. | Kengo Fujiwara Masatomo Shibata Yoshinaga Awano Koji Shibayama Naoki Iso Moemi Matsuo Akira Nakashima Takefumi Moriuchi Wataru Mitsunaga Toshio Higashi | 2021 | Neural Regeneration Research2021，16，12： | 1 |
| 9 | Kinetic modeling of homogeneous mercury oxidation: the importance of NO and H20 in predicting oxidation in coal-derived systems 显示文摘 | Niksa S Helble J J Naoki Fujiwara | 2001 | Environmental Science & Technology2001，35，18： | 1 |
| 10 | Edge and Depth from Focus显示文摘 | Naoki Asada Hisanaga Fujiwara Takashi Matsuyama | 1998 | International Journal of Computer Vision1998，，2： | 1 |
| 11 | Edge and depth from focus显示文摘 | Naoki Asada Hisanaga Fujiwara Takashi Matsuyama | 1998 | International Journal of Computer Vision1998，26，2： | 1 |
| 12 | Color representation method using RGB color binary-weighted computer-generated holograms显示文摘We propose a method for color electroholography using a simple red–green–blue(RGB) gradation representation method without controlling the respective brightness of the reference RGB-colored lights. The proposed method uses RGB multiple bit planes comprising RGB binary-weighted computer-generated holograms with various light transmittances. The object points of a given three-dimensional(3D) object are assigned to RGB multiple bit planes according to their RGB gradation levels. The RGB multiple bit planes are sequentially displayed in a time-division-multiplexed manner. Consequently, the proposed method yields a color gradation representation of a reconstructed 3D object. | Masato Fujiwara Naoki Takada Hiromitsu Araki Shohei Ikawa Yuki Maeda Hiroaki Niwase Minoru Oikawa Takashi Kakue Tomoyoshi Shimobaba Tomoyoshi Ito | 2018 | Chinese Optics Letters2018，16，8： | 1 |
| 13 | Association of the Japanese Orthopaedic Association Score With the Oswestry Disability Index, Roland-Morris Disability Questionnaire, and Short-Form 36显示文摘 | Atsushi Fujiwara Naoki Kobayashi Kazuhiko Saiki Tomoaki Kitagawa Kazuya Tamai Koichi Saotome | 2003 | Spine2003，，14： | 1 |
| 14 | A Predictive Mechanism for Mercury Oxidation on Selective Catalytic Reduction Catalysts under Coal-Derived Flue Gas显示文摘 | Stephen Niksa Naoki Fujiwara | 2005 | Journal of the Air & Waste Management Association2005，，： | 1 |
| 15 | Evaluation of an existing bus network using a transit network optimization model:A case study of the Hiroshima City Bus network显示文摘 | Shimamoto Hiroshi Murayama Naoki Fujiwara Akimasa l | 2010 | Transportation2010，37，5： | 1 |
| 16 | Laparoscopic splenectomy for patients with liver cirrhosis: Improvement of liver function in patients with Child-Pugh class B显示文摘 | Naoki Yamamoto Keiichi Okano Minoru Oshima Shitaro Akamoto Masao Fujiwara Joji Tani Hisaaki Miyoshi Hirohito Yoneyama Tsutomu Masaki Yasuyuki Suzuki | 2015 | Surgery2015，，6： | 1 |
| 17 | The common ?55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population显示文摘 | Taku Hamada Kazuhiko Kotani Shinji Fujiwara Yoshiko Sano Masayuki Domichi Kokoro Tsuzaki Naoki Sakane | 2008 | Metabolism2008，，3： | 1 |
| 18 | A Multicenter Survey of the Management After Gastric Endoscopic Submucosal Dissection Related to Postoperative Bleeding显示文摘 | Osamu Goto Mitsuhiro Fujishiro Ichiro Oda Naomi Kakushima Yorimasa Yamamoto Yosuke Tsuji Ken Ohata Takashi Fujiwara Junko Fujiwara Naoki Ishii Chizu Yokoi Shinichi Miyamoto Toshiyuki Itoh Shinji Morishita Takuji Gotoda Kazuhiko Koike | 2012 | Digestive Diseases and Sciences2012，，2： | 1 |
| 19 | Estimating Hg emissions from coal-fired power stations in China显示文摘 | STEPHEN Niksa NAOKI Fujiwara | 2009 | Fuel2009，88，1： | 1 |
| 20 | Estimating Hg Emissions from Coal-Fired Power Stations in China显示文摘 | Stephen Niksa Naoki Fujiwara | 2009 | FUEL2009，88，1： | 1 |
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