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| 1 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 2 | B?cell translocation gene 1 serves as a novel prognostic indicator ofhepatocellular carcinoma显示文摘 | Mitsuro Kanda Hiroyuki Sugimoto Shuji Nomoto Hisaharu Oya Soki Hibino Dai Shimizu Hideki Takami Ryoji Hashimoto Yukiyasu Okamura Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | International Journal of Oncology2015，，2： | 3 |
| 3 | Function and diagnostic value of Anosmin‐1 in gastric cancer progression显示文摘 | Mitsuro Kanda Dai Shimizu Tsutomu Fujii Satoshi Sueoka Yuri Tanaka Kazuhiro Ezaka Hideki Takami Haruyoshi Tanaka Ryoji Hashimoto Naoki Iwata Daisuke Kobayashi Chie Tanaka Suguru Yamada Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasu | 2016 | Int. J. Cancer2016，，3： | 1 |
| 4 | Postoperative adjuvant chemotherapy with S-1 alters recurrence patterns and prognostic factors among patients with stage II/III gastric cancer: A propensity score matching analysis显示文摘 | Mitsuro Kanda Kenta Murotani Daisuke Kobayashi Chie Tanaka Suguru Yamada Tsutomu Fujii Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | Surgery2015，，6： | 1 |
| 5 | Translational implication of Kallmann syndrome-1 gene expression inhepatocellular carcinoma显示文摘 | Yuri Tanaka Mitsuro Kanda Hiroyuki Sugimoto Dai Shimizu Satoshi Sueoka Hideki Takami Kazuhiro Ezaka Ryoji Hashimoto Yukiyasu Okamura Naoki Iwata Chie Tanaka Suguru Yamada Tsutomu Fujii Goro Nakayama Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro | 2015 | International Journal of Oncology2015，，6： | 1 |
| 6 | Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer显示文摘 | Mitsuro Kanda Dai Shimizu Shuji Nomoto Soki Hibino Hisaharu Oya Hideki Takami Daisuke Kobayashi Suguru Yamada Yoshikuni Inokawa Chie Tanaka Tsutomu Fujii Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2014 | J. Surg. Oncol2014，，2： | 1 |
| 7 | Significance of mucin expression in pancreatobiliary neoplasms显示文摘 | Suguru Yonezawa Michiyo Higashi Norishige Yamada Seiya Yokoyama Masamichi Goto | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，2： | 1 |
| 8 | Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer显示文摘 | Mitsuro Kanda Dai Shimizu Shuji Nomoto Soki Hibino Hisaharu Oya Hideki Takami Daisuke Kobayashi Suguru Yamada Yoshikuni Inokawa Chie Tanaka Tsutomu Fujii Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2014 | Oncol2014，，2： | 1 |
| 9 | A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated With Risk for Hepatocellular Carcinoma显示文摘 | Barham K. Abu Dayyeh May Yang Bryan C. Fuchs Daniel L. Karl Suguru Yamada John J. Sninsky Thomas R. O’Brien Jules L. Dienstag Kenneth K. Tanabe Raymond T. Chung | 2011 | Gastroenterology2011，，1： | 1 |
| 10 | Evaluation of MAGE‐D4 expression in hepatocellular carcinoma in Japanese patients显示文摘 | Hideki Takami Mitsuro Kanda Hisaharu Oya Soki Hibino Hiroyuki Sugimoto Masaya Suenaga Suguru Yamada Yoko Nishikawa Mikako Asai Tsutomu Fujii Shuji Nomoto Yasuhiro Kodera | 2013 | J Surg Oncol2013，，8： | 1 |
| 11 | Middle pancreatectomy: Safety and long-term results显示文摘 | Toshio Shikano Akimasa Nakao Yasuhiro Kodera Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Naohito Kanazumi Shuji Nomoto Shin Takeda | 2010 | Surgery2010，，1： | 1 |
| 12 | Significance of mucin expression in pancreatobiliary neoplasms显示文摘 | Suguru Yonezawa Michiyo Higashi Norishige Yamada Seiya Yokoyama Masamichi Goto | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，2： | 1 |
| 13 | Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy显示文摘AIM:To identify sensitive predictors of clinically relevant postoperative pancreatic fistula(POPF)at the acute phase after pancreatectomy.METHODS:This study included 153 patients diagnosed as having POPFs at postoperative day(POD)3after either open pancreatoduodenectomy or distal pancreatectomy between January 2008 and March 2013.The POPFs were categorized into three grades based on the International Study Group on Pancreatic Fistula Definition,and POPFs of grades B or C were considered to be clinically relevant.The predictive performance for the clinically relevant POPF formation of values at PODs 1,3 and 5 as well as time-dependent changes in levels of inflammatory markers,including white blood cell count,neutrophil count,total lymphocyte count,C-reactive protein(CRP),procalcitonin level,plateletto-lymphocyte ratio and neutrophil-to-lymphocyte ratio,and amylase content in the drain fluid were compared using the receiver operating characteristic(ROC)curve and multivariable analyses.A scoring system for the prediction of clinically relevant POPFs was created using five risk factors identified in this study,and its diagnostic performance was also evaluated.RESULTS:Over time,77(50%)of 153 enrolled patients followed a protracted course and were categorized as having clinically relevant POPFs.ROC curve analyses revealed that changes in CRP levels from POD1 to POD 3 had the greatest area under the curve value(0.767)and that an elevated CRP level of 28.4 mg/L yielded the most optimal predictive value for clinically relevant POPFs.Multivariable analyses for the risk factors of clinically relevant POPFs identified invasive carcinomas of the pancreas and elevation of the CRP level(≥28.4 mg/L,from POD 1 to POD 3)as independent diagnostic factors for clinically relevant POPFs(OR 2.94,95%CI:1.08-8.55,P=0.035 and OR 4.82,95%CI:1.25-20.2,P=0.022,respectively).A gradual increase in the prevalence of clinically relevant POPFs in proportion to the risk classification score was confirmed.A highly elevated CRP level and a risk score≥8 were significantly associated with a prolonged duration of drain placement and postoperative hospitalization.CONCLUSION:A steep rise in the serum CRP level from POD 1 to POD 3 was a highly predictive factor for subsequent clinically relevant POPFs. | Mitsuro Ka Tsutomu Fujii Hideki Takami Masaya Suenaga Yoshikuni Inokawa Suguru Yamada Daisuke Kobayashi Chie Tanaka Hiroyuki Sugimoto Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro Kodera | 2014 | World Journal of Gastroenterology2014，20，26： | 1 |
| 14 | Middle pancreatectomy: Safety and long-term results显示文摘 | Toshio Shikano Akimasa Nakao Yasuhiro Kodera Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Naohito Kanazumi Shuji Nomoto Shin Takeda | 2010 | Surgery2010，，1： | 1 |
| 15 | Classification of the celiac axis stenosis owing to median arcuate ligament compression, based on severity of the stenosis with subsequent proposals for management during pancreatoduodenectomy显示文摘 | Takashi Sugae Tsutomu Fujii Yasuhiro Kodera Akiyuki Kanzaki Kazuo Yamamura Suguru Yamada Hiroyuki Sugimoto Shuji Nomoto Shin Takeda Akimasa Nakao | 2012 | Surgery2012，，4： | 1 |
| 16 | Epithelial to mesenchymal transition correlates with tumor budding and predicts prognosis in esophageal squamous cell carcinoma显示文摘 | Yukiko Niwa Suguru Yamada Masahiko Koike Mitsuro Kanda Tsutomu Fujii Goro Nakayama Hiroyuki Sugimoto Shuji Nomoto Michitaka Fujiwara Yasuhiro Kodera | 2014 | Oncol2014，，6： | 1 |
| 17 | Clinical significance of zinc-finger E-box binding homeobox 1 mRNA levelsin peritoneal washing for gastric cancer显示文摘 | Norimitsu Yabusaki Suguru Yamada Toshifumi Murai Mitsuro Kanda Daisuke Kobayashi Chie Tanaka Tsutomu Fujii Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro Kodera | 2015 | Molecular and Clinical Oncology2015，，2： | 1 |
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