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| 1 | challenges of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an aggressive malignancy,resulting as the third cause of death by cancer each year. The management of patients with HCC is complex,as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging,clinical and biochemical parameters is routinely performed,a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice,several phase Ⅲ clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Locoregional therapies have also been tested as first line treatment,but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally,robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. | Stefano Colagrande Andrea L Inghilesi Sami Aburas Gian G Taliani Cosimo Nardi Fabio Marra | 2016 | World Journal of Gastroenterology2016，22，34： | 19 |
| 2 | How reliable is current imaging in restaging rectal cancer after neoadjuvant therapy?显示文摘In patients with advanced rectal cancer,neoadjuvant chemo radiotherapy provides tumor downstaging and downsizing and complete pathological response in up to 30%of cases.After proctectomy complete pathological response is associated with low rates of local recurrence and excellent long term survival.Several authors claim a less invasive surgery or a non operative policy in patients with partial or clinical complete response respectively,however to identify patients with true complete pathological response before surgical resection remains a challenge.Current imaging techniques have been reported to be highly accurate in the primary staging of rectal cancer,however neoadjuvant therapy course produces deep modifications on cancer tissue and on surrounding structures such as overgrowth fibrosis,deep stroma alteration,wall thickness,muscle disarrangement,tumor necrosis,calcification,and inflammatory infiltration.As a result,the same imaging techniques,when used for restaging,are far less accurate.Local tumor extent may be overestimated or underestimated.The diagnostic accuracy of clinical examination,rectal ultrasound,computed tomography,magnetic resonance imaging,and positron emission tomography using 18F-fluoro-2’-deoxy-Dglucose ranges between 25%and 75%being less than 60%in most studies,both for rectal wall invasion and for lymph nodes involvement.In particular the ability to predict complete pathological response,in order to tailor the surgical approach,remains low.Due to the radio-induced tissue modifications,combined with imaging technical aspects,low rate accuracy is achieved,making modern imaging techniques still unreliable in restaging rectal cancer after chemo-radiotherapy. | Paola De Nardi Michele Carvello | 2013 | World Journal of Gastroenterology2013，19，36： | 13 |
| 3 | 计算机导航下颌无牙颌不翻瓣种植手术和即刻负重显示文摘当今,尽量减少种植手术中的创伤已经成为了一条金标准,于是计算机导航手术技术开始逐渐兴起。尽管不翻瓣的种植手术有很多临床上的优势,但是由于不是在直视下操作,不翻瓣手术仅局限于一些简单的没有皮质骨板穿通危险的病例。本文结合下颌无牙颌病例,阐述了在计算机导航下采用的不翻瓣种植手术的治疗方案。同时介绍了图像引导种植系统(IGI,DenX Advanced Dental System)。IGI系统可以实时地显示钻针的图像,使得整个不翻瓣种植手术的过程都在监控之下。有术中准确的导航系统的保证,可以精确的实施术前制定的治疗计划,这对于牙弓缺乏参照标志的无牙颌来讲尤其具有价值。根据术前数字化治疗计划.种植体植入的位置可以十分精确,因此可以在术前制作固定的临时修复体并进行即刻负重。这种全新的手术方法使得在完全监控下行不翻瓣种植手术成为了可能,同时减小了种植修复的难度。 | Nardy Casap Eyal Tarazi Alon Wexler Uri Sonnenfeld Joshua Lustmann 朱一博(译) 林野(校) | 2005 | 中国口腔医学继续教育杂志2005，8，4： | 12 |
| 4 | Metabolic syndrome in hypertensive patients:An unholy alliance显示文摘For many years, it has been recognized that hypertension tends to cluster with various anthropometric and metabolic abnormalities including abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, glucose intolerance, insulin resistance and hyperuricemia. This constellation of various conditions has been transformed from a pathophysiological concept to a clinical entity, which has been defined metabolic syndrome(MetS). The consequences of the MetS have been difficult to assess without commonly accepted criteria to diagnose it. For this reason, on 2009 the International Diabetes Federation, the American Heart Association and other scientific organizations proposed a unified MetS definition. The incidence of the MetS has been increasing worldwide in parallel with an increase in overweight and obesity. The epidemic proportion reached by the MetS represents a major public health challenge, because several lines of evidence showed that the MetS, even without type 2 diabetes, confers an increased risk of cardiovascular morbidity and mortality in different populations including also hypertensive patients. It is likely that the enhanced cardiovascular risk associated with MetS in patients with high blood pressure may be largely mediated through an increased prevalence of preclinical cardiovascular and renal changes, such as left ventricular hypertrophy, early carotid atherosclerosis, impaired aortic elasticity, hypertensive retinopathy and microalbuminuria. Indeed, many reports support this notion, showing that hypertensive patients with MetS exhibit, more often than those without it, these early signs of end organ damage, most of which are recognized as significant independent predictors of adverse cardiovascular outcomes. | Giuseppe Mulè IIenia Calcaterra Emilio Nardi Giovanni Cerasola Santina Cottone | 2014 | World Journal of Cardiology2014，6，9： | 10 |
| 5 | Advanced hepatocellular carcinoma and sorafenib: Diagnosis, indications, clinical and radiological follow-up显示文摘Advanced stage hepatocellular carcinoma(HCC) is a category of disease defined by radiological, clinical and hepatic function parameters, comprehending a wide range of patients with different general conditions. The main therapeutic option is represented by sorafenibtreatment, a multi-kinase inhibitor with anti-proliferative and anti-angiogenic effect. Trans-arterial Radio Embolization also represents a promising new approach to intermediate/advanced HCC. Post-marketing clinical studies showed that only a portion of patients actually benefits from sorafenib treatment, and an even smaller percentage of patients treated shows partial/complete response on follow-up examinations, up against relevant costs and an incidence of drug related adverse effects. Although the treatment with sorafenib has shown a significant increase in mean overall survival in different studies, only a part of patients actually shows real benefits, while the incidence of drug related significant adverse effects and the economic costs are relatively high. Moreover, only a small percentage of patients also shows a response in terms of lesion dimensions reduction. Being able to properly differentiate patients who are responding to the therapy from non-responders as early as possible is then still difficult and could be a pivotal challenge for the future; in fact it could spare several patients a therapy often difficult to bear, directing them to other second line treatments(many of which are at the moment still under investigation). For this reason, some supplemental criteria to be added to the standard modified Response Evaluation Criteria in Solid Tumors evaluation are being searched for. In particular, finding some parameters(cellular density, perfusion grade and enhancement rate) able to predict the sensitivity of the lesions to anti-angiogenic agents could help in stratifying patients in terms of treatment responsiveness before the beginning of the therapy itself, or in the first weeks of sorafenib treatment. This would bring a strongly desirable help in clinical managements of these patients. | Stefano Colagrande Francesco Regini Gian Giacomo Taliani Cosimo Nardi Andrea Lorenzo Inghilesi | 2015 | World Journal of Hepatology2015，7，8： | 6 |
| 6 | Multidisciplinary treatment of rectal cancer in 2014: Where are we going?显示文摘In the present review we discuss the recent developments and future directions in the multimodal treatment of locally advanced rectal cancer, with respect to staging and re-staging modalities, to the current role of neoadjuvant chemo-radiation and to the conservative and more limited surgical approaches based on tumour response after neoadjuvant combined therapy. When initial tumor staging is considered a high accuracy has been reported for T pre-treatment staging, while preoperative lymph node mapping is still suboptimal. With respect to tumour re-staging, all the current available modalities still present a limited accuracy, in particular in defining a complete response. The role of short vs long-course radiotherapy regimens as well as the optimal time of surgery are still unclear and under investigation by means of ongoing randomized trials. Observational management or local excision following tumour complete response are promising alternatives to total mesorectal excision, but need further evaluation, and their use outside of a clinical trial is not recommended.The preoperative selection of patients who will benefit from neoadjuvant radiotherapy or not, as well as the proper identification of a clinical complete tumour response after combined treatment modalities,will influence the future directions in the treatment of locally advanced rectal cancer. | Andrea Vignali Paola De Nardi | 2014 | World Journal of Gastroenterology2014，20，32： | 5 |
| 7 | Nitrogen Release from Slow-Release Fertilizers in Soils with Different Microbial Activities显示文摘Soil microbial activity is recognized as an important factor affecting nitrogen (N) release from slow-release fertilizers. However,studies on the effect of size and activity of soil microflora on fertilizer degradation have provided contrasting results. To date, no clear relationships exist between soil microbial activity and the release of N from slow-release fertilizers. Hence, the aim of this study was to better understand such relationships by determining the release of N from three slow-release fertilizers in soils with different microbial activities. Soils were amended with urea-formaldehyde (UF), isobutylidene diurea (IBDU), and crotonylidene diurea (CDU). Urea, a soluble fertilizer, was used as the control. Fertilized soil samples were placed in a leaching system, and the release of N was determined by measuring ammonium-N and nitrate-N concentrations in leachates during 90 d of incubation. Non-linear regression was used to fit N leaching rate to a first-order model. In all the treated soils, N was released in the order: urea (89%–100%) > IBDU (59%–94%) >UF (46%–73%) > CDU (44%–56%). At the end of incubation, N released from CDU did not differ (P > 0.05) among soils. On the contrary, UF and IBDU released significantly lower (P < 0.05) amounts of N in the soil with higher microbial activity and lower pH.The rate constant (K_0) for UF was lower (P < 0.05) in the soil with lower pH. Taken together, our results indicated that soil microbial size and microbial activity had a marginal effect on fertilizer mineralization. | Pierfrancesco NARDI Ulderico NERI Giovanni DI MATTEO Alessandra TRINCHERA Rosario NAPOLI Roberta FARINA Guntur V. SUBBARAO Anna BENEDETTI | 2018 | Pedosphere2018，28，2： | 4 |
| 8 | Intrahepatic cholangiocarcinoma and hepatitis C and B virus infection, alcohol intake, and hepatolithiasis: a case–control study in Italy显示文摘 | Francesco Donato Umberto Gelatti Alessandro Tagger Maurizio Favret Maria Lisa Ribero Francesco Callea Claudia Martelli Antonella Savio Paola Trevisi Giuseppe Nardi | 2001 | Cancer Causes and Control2001，，10： | 3 |
| 9 | Integrating VGI and 2D hydraulic models into a data assimilation framework for real time flood forecasting and mapping显示文摘Crowdsourced data can effectively observe environmental and urban ecosystem processes.The use of data produced by untrained people into flood forecasting models may effectively allow Early Warning Systems(EWS)to better perform while support decision-making to reduce the fatalities and economic losses due to inundation hazard.In this work,we develop a Data Assimilation(DA)method integrating Volunteered Geographic Information(VGI)and a 2D hydraulic model and we test its performances.The proposed framework seeks to extend the capabilities and performances of standard DA works,based on the use of traditional in situ sensors,by assimilating VGI while managing and taking into account the uncertainties related to the quality,and the location and timing of the entire set of observational data.The November 2012 flood in the Italian Tiber River basin was selected as the case study.Results show improvements of the model in terms of uncertainty with a significant persistence of the model updating after the integration of the VGI,even in the case of use of few-selected observations gathered from social media.This will encourage further research in the use of VGI for EWS considering the exponential increase of quality and quantity of smartphone and social media user worldwide. | Antonio Annis Fernando Nardi | 2019 | Geo-Spatial Information Science2019，22，4： | 2 |
| 10 | Imaging of the chemotherapy-induced hepatic damage:Yellow liver,blue liver,and pseudocirrhosis显示文摘The liver is the major drug-metabolizing and drug-detoxifying organ.Many drugs can cause liver damage through various mechanisms;however,the liver response to injury includes a relatively narrow spectrum of alterations that,regardless of the cause,are represented by phlogosis,oxidative stress and necrosis.The combination of these alterations mainly results in three radiological findings:vascular alterations,structural changes and metabolic function reduction.Chemotherapy has changed in recent decades in terms of the drugs,protocols and duration,allowing patients a longer life expectancy.As a consequence,we are currently observing an increase in chemotherapy-associated liver injury patterns once considered unusual.Recognizing this form of damage in an early stage is crucial for reconsidering the therapy regimen and thus avoiding severe complications.In this frontier article,we analyze the role of imaging in detecting some of these pathological patterns,such as pseudocirrhosis,“yellow liver”due to chemotherapy-associated steatosis-steatohepatitis,and“blue liver”,including sinusoidal obstruction syndrome,veno-occlusive disease and peliosis. | Linda Calistri Vieri Rastrelli Cosimo Nardi Davide Maraghelli Sofia Vidali Michele Pietragalla Stefano Colagrande | 2021 | World Journal of Gastroenterology2021，27，46： | 2 |
| 11 | Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients显示文摘 | Donato Santovito Claudia Mandolini Pamela Marcantonio Velia De Nardis Marco Bucci Camilla Paganelli Francesco Magnacca Sante Ucchino Daniela Mastroiacovo Giovambattista Desideri Andrea Mezzetti Francesco Cipollone | 2012 | Expert Opinion on Therapeutic Targets2012，，3： | 2 |
| 12 | Serologic response to hepatitis B vaccine with high dose and increasing number of injections in HIV infected adult patients显示文摘 | Mario Cruciani Carlo Mengoli Giovanni Serpelloni Andrea Lanza Maurizio Gomma Stefano Nardi Claudia Rimondo Francesco Bricolo Sandro Consolaro MariaTeresa Trevisan Oliviero Bosco | 2008 | Vaccine2008，，1： | 2 |
| 13 | Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism显示文摘PTPN22 has been previously found associated with coronary artery disease(CAD). In the present note we have studied the effect of p53 codon 72,acid phosphatse locus 1(ACP1) and adenosine deaminase(ADA) genetic polymorphism on the strength of association between PTPN22 and CAD. We have studied 133 non diabetic subjects with CAD,122 non diabetic cardiovascular patients without CAD and 269 healthy blood donors. Informed written consent was obtained from all subjects and the study was approved by the Ethical Committee. A high significant association between PTPN22 and CAD is observed in carriers of *A allele of ACP1 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to controls and to non diabetic subjects with cardiovascular diseasewithout CAD. A similar pattern is observed in carriers of *Pro allele of p53 codon 72 with a higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other groups. A highly significant association between PTPN22 and CAD is observed in carriers of ADA2 *2 allele with higher proportion of *T allele carriers in non diabetic subjects with CAD as compared to other group. There is a high significant correlation between the number of factors that contributes to increase the strength of association between PTPN22 *T and CAD and the proportion of *T carriers in CAD. ACP1,p53 codon 72 and ADA are involved in immune reaction and give an important additive contribution to the strength of association between PTPN22 and CAD. This study stresses the importance of the simultaneous analysis of multiple genes functionally related to a specific disease: the approach may give important hints to understand multifactorial disorders. | Fulvia Gloria-Bottini Patrizia Saccucci Maria Banci Paolo Nardi Mattia Scognamiglio Antonio Pellegrino Egidio Bottini Luigi Chiariello | 2014 | World Journal of Cardiology2014，6，6： | 2 |
| 14 | 2-Week triple therapy for Helicobacter pylori infection is better than 1-week in clinical Practice: a large prospective single-center randomized st udy显示文摘 | Paoluzi P Iacopini F Crispino P Nardi F Bella A Rivera M Rossi P Gurnari M Caracciolo F Zippi M Pica R | 2006 | Helicobacter2006，11，： | 1 |
| 15 | Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons: a possible novel pathogenetic in Parkinson's disease 显示文摘 | Ziv I Melamed E Nardi N | 1994 | Neurosci Lett1994，170，9： | 1 |
| 16 | Reduction in gram- positive pneumonia and antibiotic consumption following the use of a SDD protocol including nasal and oral mupirocin显示文摘 | Nardi G Di - Silvestre AD De - Monte A | 2001 | Eur J Emerg Med2001，8，3： | 1 |
| 17 | Hypertension and diabetes mellitus are associated with cardiovascular events in the elderly without cardiovascular disease. Results of a 15-year follow-up in a Mediterranean population显示文摘 | D. Noto A.B. Cefalù C.M. Barbagallo M. Sapienza G. Cavera I. Nardi M. Pagano N. Vivona A. Notarbartolo M.R. Averna | 2008 | Nutrition Metabolism and Cardiovascular Diseases2008，，5： | 1 |
| 18 | Live microbial feed supplement in aquaculture for improvement of stress tolerance显示文摘 | Rollo A Sulpizio R Nardi M | 2006 | Fish Physiol Biochem2006，32，2： | 1 |
| 19 | Selective serotonin-reuptake inhibitors in the treatment of panic disorder:a systematic review of placebo-controlled studies显示文摘 | Mochcovitch MD Nardi AE | | 0，，08： | 1 |
| 20 | Relation of C - reactive protein to ox- idative stress and to endothelial activation in essentia lhypertension 显示文摘 | Cottone S MuI~ G Nardi E | 2006 | Am J Hypertens2006，19，3： | 1 |
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