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| 1 | Effects of Ficus asperifolia on normal rat estrus cyclicity显示文摘Objective:To evaluate Ficus asperifolia(Moraceae)(F.asperifolia)effecting on regular estrus cycle of Wistar rats.Methods:Air-dried fruits of F.asperifolia were extracted using water.Prior to the test,vaginal smear was monitored daily for a 3-week period to select females with normal(regular)estrous cycle.Those with regular estrus cycle weighing between 150-170 g were randomized into three sets of 15 animals each.Each set was then divided into three groups:Group 1(control)was orally administered with distilled water(10 mL/kg body weight)once a day for 1 week starting from the proestrus stage.Groups 2 and 3 were respectively treated with 100and 500 mg/kg body weight of the plant aqueous extract.The two other sets of 15 animals each were similarly treated as the first set for 3 weeks and 6 weeks respectively.Estrus cycle pattern was monitored before and during plant extract application whereas lipid profile,ovary,uterus and liver growth indices were determined at the end of each treatment.Results:F.asperifolia did not disrupt(0%)the order of appearance of normal estrus cycle stages,namely,proestrus,estrus,metestrus and diestrus.Short-term treatment(1 week duration)exhibited high frequency of appearance of proestrus and estrus stages while mid-(3 weeks)and long-term(6 weeks)treatments revealed constancy in the frequency of all stages irrespective to animal groups.The plasma and organ lipid profile,as well as ovary,uterus and liver growth remained unchanged when compared to distilled water-treated animals.Following long-term administration of plant extract(6 weeks),no adverse effect was noticed.Conclusions:Our data partially support the use of F.asperifolia in common medicine. | Esther Ngadjui Pierre Watcho Telesphore Benoit Nguelefack Albert Kamanyi | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 3 |
| 2 | Analgesic and Anticonvulsant Effects of Extracts from the Leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae)显示文摘 | NGUELEFACK T B NANA P ATSAMO A D | 2006 | Journal of Ethnopharmacology2006，10，6： | 1 |
| 3 | Effects of Dracaena arborea(Dracaenaceae) on sexual dysfunction in 4 weeks hyperglycemic male rats显示文摘Objective:To investigate the effects of Dracaena arborea(D.arborea) on the sexual behavior parameters in experienced type-1 diabetic rats.Methods:Aqueous and ethanol(100 and 500mg/kg respectively)extracts of dried root barks of D.arborea.sildenafil citrate(1.44 mg/kg),trimethylamine-N-oxide(TMAO,20 mg/kg)and distilled water(110 mL/kg.were orally administered to 4 weeks streptozolocin-induced diabetic rats.Mount latency and frequency(ML.MF),intromission latency and frequency(IL,IF) and post-ejaculatory interval(PEI) were measured by ejaculating series during 90 min once a week for 4 weeks.Glycemia was determined at the beginning and at the end of the treatment Results:D.arborea did not show any major antihvperglycemic effects.Compared to the control group,a significant(P<0.05-0.001)increase in MF and IF was noticed in rats treated with sildenafil citrate(89.71% and 90.07% respectively),aqueous(500 mg/kg.88.08%and 88.749;respectively) and ethanol(100 mg/kg;89.53%and 89.17respectively) extracts of D.arborea after two weeks(series 1) of treatment.ML,IL and PEI were significantly(P<0.05-0.001) decreased after 4 weeks of daily treatment[sildenafil citrate(96.31.96.31%and 34.98%),and D.arborea aqueous 500 mg/kg(94.33.94.33% and 66.609;i and ethanol extracts 100 mg/kg(96.98.97.089;and 64.26%)].Conclusions:These aphrodisiac potentials of D.arborea in experienced diabetic rats could be due to the antioxidant and androgenic properties of phenols,flavonoids.saponins and sterols revealed in the plant extracts. | Wankeu-Nya M Watcho P Nguelefack TB Cairo-Juarez M Tapondjou L Kamanyi A | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，8： | 1 |
| 4 | Enhancement of ATP sensitive potassium current in cat ventricular myocytes by β-adrenoceptor stimulation显示文摘 | NGUELEFACK T B FODERN C NGUELEFACK-MBUYO E P | 2015 | J Complement Med2015，474，1： | 1 |
| 5 | Evaluation of In Vitro Uterotonic Activities of Fruit Extracts of Ficus asperifolia in Rats显示文摘 | Pierre Watcho Esther Ngadjui Pepin Alango Nkeng-Efouet Telesphore Beno?t Nguelefack Albert Kamanyi | 2011 | Evidence-Based Complementary and Alternative Medicine2011，，： | 1 |
| 6 | Anti-hypertensive effects of the methanol/ methylene chloride stem bark extract of Mamrnea af- ricana in 1-NAME-induced hypertensive rats 显示文摘 | Nguelefack-Mbuyo P E Nguelefack T B Dongmo A B | 2008 | J Ethnopharmaeol2008，117，3： | 1 |
| 7 | Analgesic and Anticonvulsant Effects of Extracts from the Leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae)显示文摘 | NGUELEFACK T B NANA P ATSAMO A D | 2006 | Journal of Ethnopharmacology2006，10，6： | 1 |
| 8 | In vitro chrono-tropic effects of Erythrina senegalensis DC ( Fabaceae) aqueousextract on mouse heart slice and pluripotent stem cell-derived car-diomyocytes显示文摘 | Nembo EN Atsamo AD Nguelefack TB | 2015 | J Ethnopharmacol2015，，165： | 1 |
| 9 | Hypotensive effects of a methanol extract of Bidens pilosa Linn on hypertensive rats显示文摘 | Dimo T Nguelefack T B Kamtchouing P | 1999 | Comptes Rendus De L ''académie Des Sci1999，322，4： | 1 |
| 10 | Anti-inflammatory and analgesic properties of the stem bark extracts of Erythrophleum suaveolens (Caesalpiniaceae), Guillemin & Perrottet显示文摘 | A.B Dongmo A Kamanyi M.S Anchang B Chungag-Anye Nkeh D Njamen T.B Nguelefack T Nole H Wagner | 2001 | Journal of Ethnopharmacology2001，，2： | 1 |
| 11 | Analgesic and Anti-Inflammatory Properties of Extracts from the Bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae) in Mice and Rats显示文摘 | M. Mbiantcha A. Kamanyi R. B. Teponno A. L. Tapondjou P. Watcho T. B. Nguelefack | 2010 | Evidence-Based Complementary and Alternative Medicine2010，，： | 1 |
| 12 | Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents显示文摘 | Albert D. Atsamo Télesphore B. Nguelefack Jacques Y. Datté Albert Kamanyi | 2011 | Journal of Ethnopharmacology2011，，3： | 1 |
| 13 | Antinociceptive and anti-inflammatory activities of Acacia pennata wild(Mimosaceae) 显示文摘 | DONGMO AB NGUELEFACK T LACILLE-DUBOIS MA | 2005 | J Ethnopharmacol2005，98，12： | 1 |
| 14 | Vasodilator effect of the extracts and some coumarins from the stem bark of Mammea afrieana (Guttiferae) 显示文摘 | Dongmo AB Azebaze AGB Nguelefack TB | 2007 | Journal of Ethnopharmacology2007，111，2： | 1 |
| 15 | Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents显示文摘 | Albert D. Atsamo Télesphore B. Nguelefack Jacques Y. Datté Albert Kamanyi | 2011 | Journal of Ethnopharmacology2011，，3： | 1 |
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