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| 1 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 2 | Nitric oxide activation of a potassium channel (BK_(Ca)) in feline lower esophageal sphincter显示文摘AIM:To assess the effect of nitric oxide (NO) on the large conductance potassium channel (BKCa) in isolated circular (CM) and sling (SM) muscle cells and muscle strips from the cat lower esophageal sphincter (LES) to determine its regulation of resting tone and relaxation.METHODS:Freshly enzymatically-digested and isolated circular smooth muscle cells were prepared from each LES region.To study outward K + currents,the perforated patch clamp technique was employed.To assess LES resting tone and relaxation,muscle strips were mounted in perfused organ baths.RESULTS:(1) Electrophysiological recordings from isolated cells:(a) CM was more depolarized than SM (-39.7 ± 0.8mV vs-48.1 ± 1.6 mV,P < 0.001),and maximal outward current was similar (27.1 ± 1.5 pA/pF vs 25.7 ± 2.0 pA/pF,P > 0.05);(b) The NO donor sodium nitroprusside (SNP) increased outward currents only in CM (25.9 ± 1.9 to 46.7 ± 4.2 pA/pF,P < 0.001) but not SM (23.2 ± 3.1 to 27.0 ± 3.4 pA/pF,P > 0.05);(c) SNP added in the presence of the BK Ca antagonist iberiotoxin (IbTX) produced no increase in the outward current in CM (17.0 ± 2.8 vs 13.7 ± 2.2,P > 0.05);and (d) L-NNA caused a small insignificant inhibition of outward K + currents in both muscles;and (2) Muscle strip studies:(a) Blockade of the nerves with tetrodotoxin (TTX),or BK Ca with IbTX had no significant effect on resting tone of either muscle;and (b) SNP reduced tone in both muscles,and was unaffected by the presence of TTX or IbTX.CONCLUSION:Exogenous NO activates BK Ca only in CM of the cat.However,as opposed to other species,exogenous NO-induced relaxation is predominantly by a non-BK Ca mechanism,and endogenous NO has minimal effect on resting tone. | Marie-Claude L'Heureux Ahmad Muinuddin Herbert Y Gaisano Nicholas E Diamant | 2010 | World Journal of Gastroenterology2010，16，46： | 2 |
| 3 | Multichannel Weighted Speech Classification System for Prediction of major depres- sion in adolescents显示文摘 | Kuan E Margaret L Nicholas B | 2013 | IEEE Transactions On Biomedical En- gineering2013，60，2： | 1 |
| 4 | Global association of air pollution and heart failure: a systematic review and meta-analysis显示文摘 | Anoop SV Shah Jeremy P Langrish Harish Nair David A McAllister Amanda L Hunter Ken Donaldson David E Newby Nicholas L Mills | 2013 | The Lancet2013，，： | 1 |
| 5 | Temperature and the expression of myogenic regulatory factors(MRFs) and myosin heavy chain isoforms during embryogenesis in the com- mon carp Cyprinus carpin L显示文摘 | Nicholas J Thomas E H Christopher L | 2004 | J Expel Biol2004，207，24： | 1 |
| 6 | The effects of infrared radiation on cer- tain insect 显示文摘 | FROST S W DILLS L E NICHOLAS J E | 1944 | Journal of Economic Ento- mology1944，，37： | 1 |
| 7 | Assessing the feasibility of hydrate deposition on pipeline walls-Adhesion force measurements of clathrate hydrate particles on carbon steel 显示文摘 | Nicholas J W Dieker L E Sloan E D et ol | 2009 | Journal of Colloid and lnterface Science2009，331，2： | 1 |
| 8 | Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline aeetyltransferase expression in PC12 cells 显示文摘 | BETTINA E NICHOLAS A WANDA L | 2002 | J Neurochem2002，81，3： | 1 |
| 9 | Single-Molecule Surface-Enhanced Raman Spectroscopy of Crystal Violet Isotopologues:Theory and Experiment显示文摘 | Kleinman S L Ringe E Nicholas Valley | | 0，，： | 1 |
| 10 | The forest vegetation simulator: a review of its structure, content, and applications 显示文摘 | Nicholas L Crookston Gary E Dixon | 2005 | Computers and Electronics in Agriculture2005，49，： | 1 |
| 11 | Cytolytic T-lymphocyte responses to respiratory syncytial virus: Effector cell phenotype and target proteins显示文摘 | Nicholas J A Rubino K L Levely M E | 1990 | J Virol1990，64，： | 1 |
| 12 | Global association of air pollution and heart failure: a systematic review and meta-analysis显示文摘 | Anoop SV Shah Jeremy P Langrish Harish Nair David A McAllister Amanda L Hunter Ken Donaldson David E Newby Nicholas L Mills | 2013 | The Lancet2013，，： | 1 |
| 13 | A novel bioassay for human somatogenic activity in samples supports the clinical reliability of immunoassays显示文摘 | Jennifer E Nicholas J Kinchuen L | 2002 | Clin Endocrinol2002，56，3： | 1 |
| 14 | Production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α by inflammatory granuloma fibroblasts显示文摘 | Stephen W C Robert E S | 1994 | Am J Pathol1994，144，： | 1 |
| 15 | A Fast XPS study of the surface chemistry of ethanol over Pt{1 1 1} 显示文摘 | Adam F L David E G Nicholas J H | 2004 | Surf Sci2004，548，： | 1 |
| 16 | Effect of sample thickness on local contact behavior in a flat-on-flat fretting fatigue apparatus 显示文摘 | HUTSON A L NICHOLAS T OLSON S E | 2001 | International Journal of Fa- tigue2001，23，： | 1 |
| 17 | Networks and compatibility:implications for antitrust显示文摘 | NICHOLAS E WHITE L J | 1994 | European Economic Review1994，38，3： | 1 |
| 18 | The forest vegetation simulator :A review of its structure, content, and applications 显示文摘 | CROOKSTON NICHOLAS L DIXON GARY E | 2005 | Computers and Electronics in Agriculture2005，49，： | 1 |
| 19 | Feasibility of friction stir welding steel 显示文摘 | Thomas WM Threadgill P L Nicholas E D | 1999 | Science and Technology of Welding and Joining1999，4，6： | 1 |
| 20 | Assessing the feasibility of hydrate deposition on pipeline walls-Adhesion force measurements of clathrate hydrate particles on carbon steel显示文摘 | NICHOLAS J W DIEKER L E SLOAN E D | 2009 | Journal of Colloid and Interface Science2009，331，2： | 1 |
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