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| 1 | Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma显示文摘This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin,with a partial response and normalization of α fetoprotein,which allowed curative surgery.The potential synergy between these three drugs needs to be confirmed,and is currently being investigated in a randomized phase Ⅱ trial. | Nicolas Williet Olivier Dubreuil Tarek Boussaha Isabelle Trouilloud Bruno Landi Martin Housset Muriel Botti Philippe Rougier Jacques Belghiti Julien Taieb | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Seasonal Rainfall Forecasts for the Yangtze River Basin of China in Summer 2019 from an Improved Climate Service显示文摘Rainfall forecasts for the summer monsoon season in the Yangtze River basin(YRB) allow decision-makers to plan for possible flooding, which can affect the lives and livelihoods of millions of people. A trial climate service was developed in 2016, producing a prototype seasonal forecast product for use by stakeholders in the region, based on rainfall forecasts directly from a dynamical model. Here, we describe an improved service based on a simple statistical downscaling approach. Through using dynamical forecast of an East Asian summer monsoon(EASM) index, seasonal mean rainfall for the upper and middle/lower reaches of YRB can be forecast separately by use of the statistical downscaling, with significant skills for lead times of up to at least three months. The skill in different sub-basin regions of YRB varies with the target season. The rainfall forecast skill in the middle/lower reaches of YRB is significant in May–June–July(MJJ), and the forecast skill for rainfall in the upper reaches of YRB is significant in June–July–August(JJA). The mean rainfall for the basin as a whole can be skillfully forecast in both MJJ and JJA. The forecasts issued in 2019 gave good guidance for the enhanced rainfall in the MJJ period and the near-average conditions in JJA. Initial feedback from users in the basin suggests that the improved forecasts better meet their needs and will enable more robust decision-making. | Philip E.BETT Nicola MARTIN Adam A.SCAIFE Nick DUNSTONE Gill M.MARTIN Nicola GOLDING Joanne CAMP Peiqun ZHANG Chris D.HEWITT Leon HERMANSON Chaofan LI Hong-Li REN Ying LIU Min LIU | 2020 | Journal of Meteorological Research2020，34，5： | 7 |
| 3 | CT diagnosis of recurrence after pancreatic cancer:Is there a pattern?显示文摘AIM:To investigate predilection sites of recurrence of pancreatic cancer by computed tomography(CT)in follow-up after surgery. METHODS:Seventy seven patients with recurrence after pancreatic cancer surgery were retrospectively identified.The operative technique,R-status,T-stage and development of tumor markers were evaluated. Two radiologists analyzed CT scans with consensus readings.Location of local recurrence,lymph node recurrence and organ metastases were noted.Surgery and progression of findings on follow-up CT were con-sidered as reference standard. RESULTS:The mean follow-up interval was 3.9± 1.8 mo,with a mean relapse-free interval of 12.9± 10.4 mo.The predominant site of recurrence was local (65%),followed by lymph node(17%),liver metastasis (11%)and peritoneal carcinosis(7%).Local recurrence emerged at the superior mesenteric artery(n=28),the hepatic artery(n=8),in an area defined by the surrounding vessels:celiac trunk,portal vein,inferior vena cava(n=22),and in a space limited by the mesenteric artery,portal vein and inferior vena cava(n=17). Lymph node recurrence occurred in the mesenteric root and left lateral to the aorta.Recurrence was confirmed by surgery(n=22)and follow-up CT(n=55).Tumor markers[carbohydrate antigen 19-9(CA19-9),carcinoembryonic antigen(CEA)]increased in accordance with signs of recurrence in most cases(86%CA19-9;79.2% CEA). CONCLUSION:Specific changes of local and lymph node recurrence can be found in the course of the cardinal peripancreatic vessels.The superior mesenteric artery is the leading structure for recurrence. | Tobias Heye Nicola Zausig Miriam Klauss Reinhard Singer Jens Werner Gtz Martin Richter Hans-Ulrich Kauczor Lars Grenacher | 2011 | World Journal of Gastroenterology2011，17，9： | 6 |
| 4 | Genetics of seed flavonoid content and antioxidant activity in cowpea(Vigna unguiculata L. Walp.)显示文摘Information about the type of gene action governing the inheritance of cowpea seed flavonoid content and antioxidant activity is prerequisite for starting an effective breeding program for developing improved varieties. For this purpose, half-diallel crosses among seven diverse parents were made. The homozygous parents and 21 F1 hybrids were evaluated at Maroua in the Sudano-Sahelian zone of Cameroon using a randomized complete block design with three replicates. Flour samples produced from decorticated seeds were used for biochemical analysis. Analysis of variance showed significant differences(P < 0.001) among genotypes for the studied traits with ranges of 363.6–453.9 mg rutin equivalent per 100 g dry weight(DW) for total flavonoids, 13.38–30.73 mg ascorbic acid equivalent per 1 g DW for ferric iron reducing activity, 70.98–266.93 mg trolox equivalent per 100 g DW for 2,2-diphenyl-1-picrylhydrazyl(DPPH) free radical scavenging activity, and 90.93–370.62 mg trolox equivalent per 100 g DW for 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS) free radical scavenging activity. Both additive and non-additive gene effects were significant in the genetic control of these traits, but dominance variance was greater than additive variance. The traits were mainly controlled by overdominance model suggesting a selection in the delayed generations.Broad- and narrow-sense heritability estimates varied from 0.90 to 0.99 and from 0.12 to 0.45,respectively. The variances due to both general and specific combining ability were highly significant for all studied traits. Recessive alleles had positive effects on DPPH and ABTS scavenging activities, whereas dominant alleles had positive effects on flavonoid content and ferric iron reducing activity. These results could help cowpea breeders to improve the antioxidant potential of cowpea seeds by appropriate selection. | Maina Antoine Nassourou Yanou Nicolas Njintang Tchiagam Jean-Baptiste Noubissié Richard Marcel Nguimbou Joseph Martin Bell | 2016 | The Crop Journal2016，4，5： | 5 |
| 5 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 6 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 7 | Predictors of multiple injuries in individual distance runners:A retrospective study of 75,401 entrants in 4 annual races-SAFER XX显示文摘Background There are limited data on factors that predict an increased risk of multiple injuries among distance runners.The objective of this study was to determine risk factors that are predictive of individual runners with a high annual multiple injury risk(MIR).Methods A retrospective,cross-sectional study at 4 annual(2012-2015)Two Oceans 21.1 km and 56.0 km races in South Africa with 75,401 consenting race entrants.Running-related injury data were collected retrospectively through an online pre-race medical screening questionnaire.The average number of injuries for each runner every year was calculated by taking a runner's race entry history and injury history into account and categorizing entrants into 4 MIR categories(high,intermediate,low,and very low(reference)).Multiple logistic regression modeling(odds ratios)was used to determine whether the following factors were predictive of a high MIR(average>1 injury/year):demographics,training and racing,chronic-disease history(composite chronic disease score(CCDS)),and history of allergies.Results Of all entrants,9.2%reported at least 1 injury,and 0.4%of entrants were in the high MIR category;the incidence rate was 2.5 injuries per 10 runner-years(95%confidence interval(95%CI):2.4-2.7).Significant factors predictive of runners in the high MIR category were:running for>20 years:OR=2.0(95%CI:1.3-3.1;p=0.0010);a higher CCDS:OR=2.2(95%CI:2.0-2.4;p<0.0001);and a history of allergies:OR=2.8(95%CI:2.0-3.8;p<0.0001).Conclusion Runners who have been running recreationally for>20 years and those with multiple chronic diseases or a history of allergies were at higher risk of multiple running-related injuries.This high-risk group can be targeted for further study and possible injury-prevention interventions. | Sonja Swanevelder Nicola Sewry Martin Schwellnus Esme Jordaan | 2022 | Journal of Sport and Health Science2022，11，3： | 3 |
| 8 | Diallel analyses of soluble sugar content in cowpea (Vigna unguiculata L.Walp.)显示文摘The content of soluble sugar in cowpea(Vigna unguiculata L. Walp.) seeds is important for their acceptability to consumers. The objective of this study was to evaluate the genetic control of soluble sugar content in cowpea using diallel analysis. For this purpose,half-diallel crosses were made among seven diverse parents. The amount of total soluble sugar was estimated by the phenol sulfuric acid reagent method and reducing sugar were measured by the DNS(3,5-dinitrosalicylic acid) reagent method. The total soluble sugar ranged from 11.12(VYA) to 40.79 mg g^(-1)(IT93 K-693-2) with a mean of 22.31 mg g^(-1).Reducing soluble sugar showed a mean value of 9.11 mg g^(-1) and ranged from 13.61(TVx3236) to 4.98 mg g^(-1)(Lori niebe). Diallel analysis showed that both additive and non-additive gene effects were significant in the genetic control of these traits. However,dominance variance was greater than additive variance for soluble sugar. The traits were controlled mainly by an overdominance model, suggesting the advantage of delaying selection to later generations. Soluble sugar content was found to be highly heritable, with broad-sense heritability ranging from 0.987 to 0.976. Narrow-sense heritability ranged from0.154 to 0.422 and revealed the lower importance of additive variance. Parents and F_1 hybrids differed significantly on the basis of their general and specific combining abilities,respectively. Recessive alleles had positive effects on total soluble sugar and reducing soluble sugar. These results could help cowpea breeders improve the acceptability of cowpea seeds and cowpea-based foods by appropriate selection. | Maina Antoine Nassourou Tchiagam Jean Baptiste Noubissié Yanou Nicolas Njintang Joseph Martin Bell | 2017 | The Crop Journal2017，5，6： | 3 |
| 9 | The role of laparoscopy for gastric surgery in the West显示文摘 | Vivian E. Strong Nicolas Devaud Martin Karpeh | 2009 | Gastric Cancer2009，，3： | 1 |
| 10 | Surgical atrial septal defect closure after interventional occluder placement: Incidence and outcome显示文摘 | Thomas Walther Christian Binner Ardawan Rastan Ingo D?hnert Nicolas Doll Volkmar Falk Friedrich W. Mohr Martin Kostelka | 2007 | The Journal of Thoracic and Cardiovascular Surgery2007，，3： | 1 |
| 11 | Calcium oscillations in higher plants显示文摘 | Nicola H Evans Martin R McAinsh Alistair M Hetherington | 2001 | Current Opinion in Plant Biology2001，，5： | 1 |
| 12 | Biological Signifi- cance of Decreased HSP27 in Human Atherosclerosis 显示文摘 | Martin - Ventura ]L Nicolas V Houard X | 2006 | Arterio- scler Thromb Vasc Biol2006，26，6： | 1 |
| 13 | Reliability of magnetic resonance elastography using multislice two‐dimensional spin‐echo echo‐planar imaging (SE‐EPI) and three‐dimensional inversion reconstruction for assessing renal stiffness显示文摘 | Gavin Low Nicola E. Owen Ilse Joubert Andrew J. Patterson Martin J. Graves Kevin J. Glaser Graeme J.M. Alexander David J. Lomas | 2015 | J. Magn. Reson. Imaging2015，，： | 1 |
| 14 | Combining video instruction followed by voice feedback in a self-learning station for acquisition of Basic Life Support skills: A randomised non-inferiority trial显示文摘 | Nicolas Mpotos Sabine Lemoyne Paul A. Calle Ellen Deschepper Martin Valcke Koenraad G. Monsieurs | 2011 | Resuscitation2011，，7： | 1 |
| 15 | Prognostic Relevance of HPV Infection and p16 Overexpression in Squamous Cell Anal Cancer显示文摘 | Sabine Mai Grit Welzel Martine Ottstadt Frank Lohr Sebastin Severa Elena-Sophie Prigge Nicolas Wentzensen Marcus J. Trunk Frederik Wenz Magnus von Knebel-Doeberitz Miriam Reuschenbach | 2015 | International Journal of Radiation Oncology, Biol2015，，4： | 1 |
| 16 | Daily Variability of Radon Gas in Brazilian Tropics Near Ground Level Surface显示文摘 | Inacio Malmonge Martin Marcelo Pego Gomes Bogos Nubar Sismanoglu Nicolas Cruvinel Lindo | 2015 | Journal of Environmental Science and Engineering(A)2015，4，10： | 1 |
| 17 | On-chip beam rotators,adiabatic mode converters,and waveplates through low-loss waveguides with variable cross-sections显示文摘Photonics integrated circuitry would benefit considerably from the ability to arbitrarily control waveguide cross-sections with high precision and low loss,in order to provide more degrees of freedom in manipulating propagating light.Here,we report a new method for femtosecond laser writing of optical-fiber-compatible glass waveguides,namely spherical phase-induced multicore waveguide(SPIM-WG),which addresses this challenging task with three-dimensional on-chip light control.Fabricating in the heating regime with high scanning speed,precise deformation of cross-sections is still achievable along the waveguide,with shapes and sizes finely controllable of high resolution in both horizontal and vertical transversal directions.We observed that these waveguides have high refractive index contrast of 0.017,low propagation loss of 0.14 dB/cm,and very low coupling loss of 0.19 dB coupled from a single-mode fiber.SPIM-WG devices were easily fabricated that were able to perform on-chip beam rotation through varying angles,or manipulate the polarization state of propagating light for target wavelengths.We also demonstrated SPIM-WG mode converters that provide arbitrary adiabatic mode conversion with high efficiency between symmetric and asymmetric nonuniform modes;examples include circular,elliptical modes,and asymmetric modes from ppKTP(periodically poled potassium titanyl phosphate)waveguides which are generally applied in frequency conversion and quantum light sources.Created inside optical glass,these waveguides and devices have the capability to operate across ultra-broad bands from visible to infrared wavelengths.The compatibility with optical fiber also paves the way toward packaged photonic integrated circuitry,which usually needs input and output fiber connections. | Bangshan Sun Fyodor Morozko Patrick S.Salter Simon Moser Zhikai Pong Raj B.Patel Ian A.Walmsley Mohan Wang Adir Hazan Nicolas Barré Alexander Jesacher Julian Fells Chao He Aviad Katiyi Zhen-Nan Tian Alina Karabchevsky Martin J.Booth | 2022 | Light(Science & Applications)2022，11，8： | 1 |
| 18 | Neuropathy After Herniorrhaphy: Indication for Surgical Treatment and Outcome显示文摘 | Henri Vuilleumier Martin Hübner Nicolas Demartines | 2009 | World Journal of Surgery2009，，4： | 1 |
| 19 | Treatment expectations and satisfaction of treatment‐refractory opioid‐dependent patients in RIOTT, the R andomised I njectable O piate T reatment T rial, the UK ’s first supervised injectable maintenance clinics显示文摘 | Teodora Groshkova Nicola Metrebian Christopher Hallam Vikki Charles Anthea Martin Luciana Forzisi Nicholas Lintzeris John Strang | 2013 | Drug Alcohol Rev2013，，： | 1 |
| 20 | Microstucture modification of amorphous titanium oxide thin films during annealing treatment显示文摘 | Nicolas Martin Christophe Rousselot Daniel Rondor | 1997 | Thin Solid Films1997，，300： | 1 |
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