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| 1 | Innate and adaptive immune responses toward nanomedicines显示文摘Since the commercialization of the frst liposomes used for drug delivery,Doxil/Caelyx® and Myocet®,tremendous progress has been made in understanding interactions between nanomedicines and biological systems.Fundamental work at the interface of engineering and medicine has allowed nanomedicines to deliver therapeutic small molecules and nucleic acids more effciently.While nanomedicines are used in oncology for immunotherapy or to deliver combinations of cytotoxics,the clinical successes of gene silencing approaches like patisiran lipid complexes(Onpattro®)have paved the way for a variety of therapies beyond cancer.In parallel,the global severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has highlighted the potential of mR NA vaccines to develop immunization strategies at unprecedented speed.To rationally design therapeutic and vaccines,chemists,materials scientists,and drug delivery experts need to better understand how nanotechnologies interact with the immune system.This review presents a comprehensive overview of the innate and adaptative immune systems and emphasizes the intricate mechanisms through which nanomedicines interact with these biological functions. | Iara Maíra de Oliveira Viana Sabrina Roussel Joan Defrêne Eliana Martins Lima Frédéric Barabé Nicolas Bertrand | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 5 |
| 2 | Corrosion rate determination of rare-earth Mg alloys in a Na_(2)SO_(4)solution by electrochemical measurements and inductive coupled plasma-optical emission spectroscopy显示文摘The corrosion resistance of three Mg alloys containing rare-earth elements(WE43,EV31 and ZE41)was studied and compared to that of two Mg-Al alloys(AZ31 and AZ91)and of pure Mg(99.95 wt.%).Current-voltage curves and electrochemical impedance measurements were performed with rotating disk electrodes in an aerated 0.1 M Na_(2)SO_(4)solution.For all the alloys,it was confirmed that the intermetallic particles acted as local cathodes and that more protective films were formed on the alloys surface by comparison with the pure Mg.Corrosion rates were determined from inductive coupled plasma-optical emission spectroscopy measurements and from the electrochemical measurements.Higher corrosion rates were observed for the rare-earth Mg alloys compared to the AZ series alloys.These data allowed the corrosion mechanisms to be discussed. | Samuel Leleu Bertrand Rives Nicolas Causse Nadine Pébère | 2019 | Journal of Magnesium and Alloys2019，7，1： | 3 |
| 3 | Quantitative structure–activity relationship for 4-hydroxy-2-alkenal induced cytotoxicity in L6 muscle cells显示文摘 | Nicolas J. Pillon Laurent Soulère Roxane E. Vella Marine Croze Bertrand R. Caré Hedi A. Soula Alain Doutheau Michel Lagarde Christophe O. Soulage | 2010 | Chemico-Biological Interactions2010，，1： | 1 |
| 4 | Pentoxifylline Does Not Decrease Short-term Mortality but Does Reduce Complications in Patients With Advanced Cirrhosis显示文摘 | Didier Lebrec Dominique Thabut Frederic Oberti Jean–Marc Perarnau Bertrand Condat Helene Barraud Faouzi Saliba Nicolas Carbonell Philippe Renard Marie–Jose Ramond Richard Moreau Thierry Poynard | 2010 | Gastroenterology2010，，5： | 1 |
| 5 | Endoscopic coronary artery bypass grafting with the aid of robotic assisted instruments显示文摘 | Didier Loulmet Alain Carpentier Nicola d’Attellis Alain Berrebi Cyril Cardon Olivier Ponzio Bertrand Aupècle John Y.M. Relland | 1999 | The Journal of Thoracic and Cardiovascular Surgery1999，，： | 1 |
| 6 | Simplified identification of Lynch syndrome: A prospective, multicenter study显示文摘 | Delphine Bonnet Janick Selves Christine Toulas Marie Danjoux Jean Pierre Duffas Guillaume Portier Sylvain Kirzin Laurent Ghouti Nicolas Carrère Bertrand Suc Laurent Alric Karl Barange Louis Buscail Thierry Chaubard Kamran Imani Rosine Guimbaud | 2012 | Digestive and Liver Disease2012，，6： | 1 |
| 7 | Submarine Hull Integrity under Blast Loading显示文摘 | BERTRAND L NICOLAS L AUDE M | 2009 | International Journal of Impact Engineering2009，36，： | 1 |
| 8 | Outcomes After Ablation for Typical Atrial Flutter (from the Loire Valley Atrial Fibrillation Project)显示文摘 | Nicolas Clementy Laurent Desprets Bertrand Pierre Bénédicte Lallemand Edouard Simeon Anne Brunet-Bernard Dominique Babuty Laurent Fauchier | 2014 | The American Journal of Cardiology2014，，9： | 1 |
| 9 | A hierarchical controller for miniature VTOL UAVs: Design and stability analysis using singular perturbation theory显示文摘 | Sylvain Bertrand Nicolas Guénard Tarek Hamel Hélène Piet-Lahanier Laurent Eck | 2011 | Control Engineering Practice2011，，10： | 1 |
| 10 | Solubility and emulsifying properties of caseins and whey proteins modified enzimatically by trypsin 显示文摘 | Chobert J M Bertrand - Hard C Nicolas M G | 1988 | J Agri Food Chem1988，36，5： | 1 |
| 11 | Value of Clinical,Functional,and Oximetric Data for the Prediction of Obstructive Sleep Apnea in Obese显示文摘 | Bertrand H Nicolas R Matthieu C | 1999 | CHEST1999，116，6： | 1 |
| 12 | D Allele of the Angiotensin I-Converting Enzyme Is a Major Risk Factor for Restenosis After Coronary Stenting显示文摘 | Carole Amant Christophe Bauters Jean-Christophe Bodart Jean-Marc Lablanche Gilles Grollier Nicolas Danchin Martial Hamon Florence Richard Nicole Helbecque Eugene P. McFadden Philippe Amouyel Michel E. Bertrand | 1997 | Circulation1997，，： | 1 |
| 13 | Decrease of Prefrontal Metabolism After Subthalamic Stimulation in Obsessive-Compulsive Disorder: A Positron Emission Tomography Study显示文摘 | Florence Le Jeune Marc Vérin Karim N’Diaye Dominique Drapier Emmanuelle Leray Sophie Tezenas Du Montcel Nicolas Baup Antoine Pelissolo Mircea Polosan Luc Mallet Jérome Yelnik Bertrand Devaux Denys Fontaine Isabelle Chereau Aurélie Bourguignon Julie Peron | 2010 | Biological Psychiatry2010，，11： | 1 |
| 14 | Improved access to 2-O-monobenzyl ethers of β-cyclodextrin as precursors of catalysts for organophosphoryl esters hydrolysis显示文摘 | Nicolas M Francois E Bertrand L | 2006 | Carbohydrate Research2006，41，： | 1 |
| 15 | De novo donor‐specific anti‐ HLA antibodies mediated rejection in liver‐transplant patients显示文摘 | Arnaud Del Bello Nicolas Congy‐Jolivet Marie Danjoux Fabrice Muscari Laurence Lavayssière Laure Esposito Isabelle Cardeau‐Desangles Jo?lle Guitard Ga?lle D?rr David Milongo Bertrand Suc Jean Pierre Duffas Laurent Alric Christophe Bureau Céline Guilbeau‐Fr | 2015 | Transpl Int2015，，12： | 1 |
| 16 | The mini-GWAC optical follow-up of gravitational wave alerts – results from the O2 campaign and prospects for the upcoming O3 run显示文摘The second(O2)observational campaign of gravitational waves(GWs)organized by the LIGO/Virgo Collaborations has led to several breakthroughs such as the detection of GW signals from merger systems involving black holes or neutrons stars.During O2,14 GW alerts were sent to the astronomical community with sky regions mostly covering over hundreds of square degrees.Among them,six were finally confirmed as real astrophysical events.Since 2013,a new set of ground-based robotic telescopes called Ground-based Wide Angle Camera system(GWAC)project and its pathfinder mini-GWAC has been developed to contribute to the various challenges of multi-messenger and time domain astronomy.The GWAC system is built up in the framework of the ground-segment system of the SVOM mission that will be devoted to the study of the multi-wavelength transient sky in the next decade.During O2,only the mini-GWAC telescope network was fully operational.Due to the wide field of view and fast automatic follow-up capabilities of the mini-GWAC telescopes,they were adept to efficiently cover the sky localization areas of GW event candidates.In this paper,we present the mini-GWAC pipeline we have set up to respond to GW alerts and we report our optical follow-up observations of eight GW alerts detected during the O2 run.Our observations provided the largest coverage of the GW localization areas with a short latency made by any optical facility.We found tens of optical transient candidates in our images,but none of those could be securely associated with any confirmed black hole-black hole merger event.Based on this first experience and the near future technical improvements of our network system,we will be more competitive in detecting the optical counterparts from some GW events that will be identified during the upcoming O3 run,especially those emerging from binary neutron star mergers. | Damien Turpin Chao Wu Xu-Hui Han Li-Ping Xin Sarah Antier Nicolas Leroy Li Cao Hong-Bo Cai Bertrand Cordier 邓劲松 Wen-Long Dong Qi-Chen Feng Lei Huang Lei Jia Alain Klotz Cyril Lachaud Hua-Li Li 梁恩维 Shun-Fang Liu Xiao-Meng Lu Xian-Min Meng Yu-Lei Qiu Hui-Juan Wang 王竞 Shen Wang 王祥高 Jian-Yan Wei Bo-Bing Wu Yu-Jie Xiao Da-Wei Xu Yang Xu 杨远贵 Pin-Pin Zhang Ruo-Song Zhang Shuang-Nan Zhang Ya-Tong Zheng Si-Cheng Zou | 2020 | Research in Astronomy and Astrophysics2020，20，1： | 1 |
| 17 | Cirrhotic patients in the medical intensive care unit: Early prognosis and long-term survival显示文摘 | Vincent Das Pierre-Yves Boelle Arnaud Galbois Bertrand Guidet Eric Maury Nicolas Carbonell Richard Moreau Georges Offenstadt | 2010 | Critical Care Medicine2010，，11： | 1 |
| 18 | Out-of- plane MEMS-based mechanical airflow sensor co-integrated in SOI CMOS technology 显示文摘 | Andre Nicolas Rue Bertrand Scheen Gilles | 2014 | SENSORS AND ACTUATORS A- PHYSICAL2014，206，： | 1 |
| 19 | Using Microscopy to Help with the Understanding of Degradation Mechanisms Observed in Materials of Pressurized Water Reactors显示文摘 | Laurent Legras Alexandre Volgin Bertrand Radiguet Philippe Pareige Cedric Pokor Brigitte Decamps Thierry Couvant Nicolas Huin Romain Soulas | 2017 | 材料科学与工程(中英文B版)2017，7，5： | 0 |
| 20 | Volume and fat infiltration of spino-pelvic musculature in adults with spinal deformity显示文摘AIM: To investigate fat infiltration and volume of spino-pelvic muscles in adults spinal deformity(ASD) with magnetic resonance imaging(MRI) and 3D reconstructions.METHODS: Nineteen female ASD patients(mean age 60 ± 13) were included prospectively and consecutively and had T1-weighted Turbo Spin Echo sequence MRIs with Dixon method from the proximal tibia up to T12 vertebra. The Dixon method permitted to evaluate the proportion of fat inside each muscle(fat-water ratio). In order to investigate the accuracy of the Dixon method for estimating fat vs water, the same MRI acquisition was performed on phantoms of four vials composed of different proportion of fat vs water. With Muscl'X software, 3D reconstructions of 17 muscles or group of muscles were obtained identifying the muscle's contour on a limited number of axial images [Deformation of parametric specific objects(DPSO) Method]. Musclar volume(Vmuscle), infiltrated fat volume(Vfat) and percentage of fat infiltration [Pfat, calculated as follow: Pfat = 100 ×(Vfat/Vmuscle)] were characterized by extensor or flexor function respectively for the spine, hip and knee and theirs relationship with demographic data were investigated. RESULTS: Phantom acquisition demonstrated a non linear relation between Dixon fat-water ratio and the real fat-water ratio. In order to correct the Dixon fatwater ratio, the non linear relation was approximated with a polynomial function of degree three using the phantom acquisition. On average, Pfat was 13.3% ± 5.3%. Muscles from the spinal extensor group had a Pfat significantly greater than the other muscles groups, and the largest variability(Pfat = 31.9% ± 13.8%, P < 0.001). Muscles from the hip extensor group ranked 2nd in terms of Pfat(14% ± 8%), and were significantly greater than those of the knee extensor(P = 0.030). Muscles from the knee extensor group demonstrated the least Pfat(12% ± 8%). They were also the only group with a significant correlation between Vmuscle and Pfat(r =-0.741, P < 0.001), however this correlation was lacking in the other groups. No correlation was found between the Vmuscle total and age or body mass index. Except for the spine flexors, Pfat was correlated with age. Vmuscle and Vfat distributions demonstrated that muscular degeneration impacted the spinal extensors most.CONCLUSION: Mechanisms of fat infiltration are not similar among the muscle groups. Degeneration impacted the spinal and hip extensors most, key muscles of the sagittal alignment. | Bertrand Moal Nicolas Bronsard José G Raya Jean Marc Vital Frank Schwab Wafa Skalli Virginie Lafage | 2015 | World Journal of Orthopedics2015，6，9： | 0 |
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