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| 1 | Natural history of hepatic metastases from colorectal cancer-pathobiological pathways with clinical significance显示文摘Colorectal cancer hepatic metastases represent the final stage of a multi-step biological process.This process starts with a series of mutations in colonic epithelial cells,continues with their detachment from the large intestine,dissemination through the blood and/or lymphatic circulation,attachment to the hepatic sinusoids and interactions with the sinusoidal cells,such as sinusoidal endothelial cells,Kupffer cells,stellate cells and pit cells.The metastatic sequence terminates with colorectal cancer cell invasion,adaptation and colonisation of the hepatic parenchyma.All these events,termed the colorectal cancer invasion-metastasis cascade,include multiple molecular pathways,intercellular interactions and expression of a plethora of chemokines and growth factors,and adhesion molecules,such as the selectins,the integrins or the cadherins,as well as enzymes including matrix metalloproteinases.This review aims to present recent advances that provide insights into these cell-biological events and emphasizes those that may be amenable to therapeutic targeting. | Konstantinos A Paschos Ali W Majeed Nigel C Bird | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 2 | Preoarati on of biodegradable insulin nanocapsules from biocompatible microemulsions显示文摘 | Suchat W Nigel M D Thomas R | 2000 | Pharm Res2000，17，6： | 1 |
| 3 | Improvingthe Peer-review Process for Grant Applications显示文摘 | Herbert W Marsh Upaii W Jayasinghe Nigel W Bond | 2008 | AmericanPsychologist2008，63，3： | 1 |
| 4 | Changes in demography and demand for services from people with complex needs and profound and multiple learning disabilities 显示文摘 | Richard PR Nigel T John W | 2008 | Tizard Learn Disabil Rev2008，13，3： | 1 |
| 5 | Impro- ving the Peer-review Process for Grant Applications: Reliability, Validity, Bias, and Generalizability 显示文摘 | Marsh Herbert W JayasingheUpali W Bond Nigel W | 2008 | Am Psychol2008，63，3： | 1 |
| 6 | Ductility of squareconfined concrete columns 显示文摘 | Park R Nigel Priestley M J Gill W D | 1982 | Journal of the Structural Division ASCE1982，108，4： | 1 |
| 7 | Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions显示文摘 | Suchat W Nigel M D Thomas R | 2000 | Pharm Res2000，6，： | 1 |
| 8 | Inhibition of ethylene-induced a-farnesene synthase gene PcAFS1expression in ‘d'Anjou' pears with 1-MCP reduces synthesis and oxidation of a-farnesene and delays development of superficial scald显示文摘 | Nigel E G Jinhe B Bruce D W | 2006 | Postharvest Biology and Technology2006，41，： | 1 |
| 9 | Phylogenetic classification of Cordyceps and the clavicipitaceous fungi显示文摘 | Sung G H Nigel L Hywel-Jones N L Sung J M Luangsa-Ard J J Shrestha B Spatafora J W | 2007 | Studies in Mycology2007，57，： | 1 |
| 10 | Low hematocrit and serum albumin concentrations underlie the overestimation of tacrolimus concentrations by microparticle enzyme immunoassay versus liquid chromatography-tandem mass spectrometry显示文摘 | Nigel W Christopher EG Jemimah EA | 2005 | Clin Chem2005，51，3： | 1 |
| 11 | The Effects of the Phytoestrogen Genistein on the Postnatal Development of the Rat显示文摘 | Richard W Le Nigel Br Gillian M M | 2003 | Toxicol Sci2003，71，： | 1 |
| 12 | Protease-activated receptors in inflammation, neuronal signaling and pain显示文摘 | Nathalie Vergnolle John L Wallace Nigel W Bunnett Morley D Hollenberg | 2001 | Trends in Pharmacological Sciences2001，，3： | 1 |
| 13 | Extending the Service Life of 15 kV Polyethylene URD Ca-ble Using Silicone Liquid显示文摘 | Nigel Hampton Rick Har Nannery P R Tarpey J W | 1989 | IEEE Transactions on PowerDelivery1989，4，4： | 1 |
| 14 | Phylogenetic classification of Cordyceps and the clavicipitaceous fungi显示文摘 | Sung Gi-Ho Nigel L Hywel-Jones Sung Jae-Mo Jennifer Luangsa-ard J Bhushan Shrestha Joseph W Spatafora | 2007 | Studies in Mycology2007，57，： | 1 |
| 15 | Salesforce Performance and Behavior-based Management Processes in Business-to-Business Sales Organizations 显示文摘 | PIERCY NIGEL F CRAVENS DAVID W MORGAN NElL A | 1998 | European Journal of Marketing1998，32，12： | 1 |
| 16 | Complementary approaches to estimation of the global burden of diabetes显示文摘 | Nigel U Leonor G David W | | 0，，9825： | 1 |
| 17 | Impact of weather on transit ridership in chicago, illinois 显示文摘 | GUO Zhan NIGEL W H M ADAM R | 2007 | Transportation Research Record2007，2034，1： | 1 |
| 18 | Relationships between Sales Management Control, Territory Design, Salesforce Performance and Sales Organization Effectiveness显示文摘 | PIERCY NIGEL F CRAVENS DAVID W MORGAN NEIL A | 1999 | British Journal of Management1999，，10： | 1 |
| 19 | C-peptide reverses TGF- 13 1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy显示文摘 | CLAIRE E H GARY B W NIGEL J B | 2009 | Am J Physiol Renal Physiol2009，296，3： | 1 |
| 20 | Constant elevation of southern Tibet over the past 15 million years 显示文摘 | Robert A S Nigel W H Mike W | 2003 | Nature2003，421，： | 1 |
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