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| 1 | 感染模型家兔体内莫西沙星的药动学显示文摘目的 :研究莫西沙星在感染家兔模型中的药物动力学。方法 :8只家兔经埴入高尔夫练习球并用肺炎链球菌感染 3d后 ,用多剂量口服莫西沙星治疗 ,第 5天进行药动学试验。用高效液相色谱法测定血药浓度。结果 :莫西沙星在家兔体内属线性药物并符合二房室模型 ;达峰时间为 (1.2± 0 .6)h ,峰浓度为 (13 .2± 4 .0 ) μg·ml-1,曲线下面积为 (86.5± 2 1.1) μg·ml-1·h ,消除半衰期为 (13 .0± 6.2 )h。 4只家兔高尔夫练习球内的莫西沙星血清峰浓度 ,在为 3 .6± 2 .1μg·ml-12 4h内的平均曲线下面积为 (65 .4± 2 1.1) μg·ml-1·h。结论 :获得的莫西沙星在家兔模型中的药动学参数 ,对今后莫西沙星的药效学研究有很大的帮助。 | 钟明康 Xuan D Nicolau DP Nightingale CH2 | 2001 | 中国医院药学杂志2001，21，1： | 10 |
| 2 | Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease显示文摘 | Mark L. Palmeri Michael H. Wang Ned C. Rouze Manal F. Abdelmalek Cynthia D. Guy Barry Moser Anna Mae Diehl Kathryn R. Nightingale | 2011 | Journal of Hepatology2011，，3： | 5 |
| 3 | Acoustic Radiation Force Impulse (ARFI) Imaging: A Review显示文摘 | Kathy Nightingale | 2011 | Current Medical Imaging Reviews2011，，4： | 2 |
| 4 | Review of Direct Anatomical Open Surgical Management of Atherosclerotic Aorto-Iliac Occlusive Disease显示文摘 | K.W.H. Chiu R.S.M. Davies P.G. Nightingale A.W. Bradbury D.J. Adam | 2010 | European Journal of Vascular & Endovascular Surgery2010，，： | 2 |
| 5 | Management of patients with a short bowel显示文摘There are two common types of adult patient with a short bowel, those with jejunum in continuity with a functioning colon and those with a jejunostomy. Both groups have potential problems of undemutrition, but this is a greater problem in those without a colon, as they do not derive energy from anaerobic bacterial fermentation of carbohydrate to short chain fatty acids in the colon. Patients with a jejunostomy have major problems of dehydration,sodium and magnesium depletion all due to a large volume of stomal output. Both types of patient have lost at least 60cm of terminal ileum and so will become deficient of vitamin B12. Both groups have a high prevalence of gallstones (45%) resulting from periods of biliary stasis. Patients with a retained colon have a 25% chance of developing calcium oxalats renal atones and they may have problems with D (-)lactic acidosis. The survival of patients with a short bowel,even if they need long-term parenteral nutrition, is good. | Jeremy M D Nightingale | 2001 | World Journal of Gastroenterology2001，7，6： | 2 |
| 6 | Refeeding hypophosphataemia is more common in enteral than parenteral feeding in adult in patients显示文摘 | Sebastian Zeki Alison Culkin Simon M. Gabe Jeremy M. Nightingale | 2010 | Clinical Nutrition2010，，3： | 2 |
| 7 | Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility显示文摘 | Kathryn Nightingale Mary Scott Soo Roger Nightingale Gregg Trahey | 2002 | Ultrasound in Medicine & Biology2002，，2： | 2 |
| 8 | Oncostain M,a cyto- kine released by activated mononuclear cells, induces epi- thelial cell-myofibroblast transdifferentiation via Jak/Statpathway activation 显示文摘 | Nightingale J Patel S Suzuki N | 2004 | Am Soc Nephrol2004，15，： | 1 |
| 9 | Ctalshock index:a reevaluation in acute circulatory failure显示文摘 | Rady MY Nightingal | 1992 | Resu'' scitation1992，23，： | 1 |
| 10 | Use of Monte Carlo simulation to design an optimized pharmacodynamic dosing strategy for meropenem显示文摘 | Kuti JL Dandekar PK Nightingale CH | 2003 | J Clin Pharmacol2003，43，10： | 1 |
| 11 | Quantifying Hepatic Shear Modulus In Vivo Using Acoustic Radiation Force显示文摘 | M.L. Palmeri M.H. Wang J.J. Dahl K.D. Frinkley K.R. Nightingale | 2008 | Ultrasound in Medicine & Biology2008，，4： | 1 |
| 12 | Acoustic radiation force inpulse imaging of the abdomen demonstration of feasibility and utility显示文摘 | Fahey BJ Nightingale KR Nelson RC | | 0，，09： | 1 |
| 13 | Performance Evaluation of Concurrent Multipath Video Streaming in Multihomed Mobile Networks显示文摘 | James Nightingale Qi Wang Christos Grecos Fabrice Labeau | 2013 | International Journal of Digital Multimedia Broadcasting2013，，： | 1 |
| 14 | Population pharmacokinetics and pharmacodynamics of piperacillin/tazobaetam in patients with complicat- ed intra-abdominal infection显示文摘 | Li C Kuti JL Nightingale CH | 2005 | J Antimicrob Chemother2005，56，2： | 1 |
| 15 | Comparison of the effects of salmeterol and formoterol in patients with severe asthma显示文摘 | Nightingale JA Rogers DF Bames PJ | 2002 | Chest2002，121，5： | 1 |
| 16 | Carriage of methicillin-resistant staphylococcus aureus is associated with an increased risk of infection after liver transplantation 显示文摘 | Desai D Desai N Nightingale P | 2005 | Liver Transpl2005，9，7： | 1 |
| 17 | Inheritance of persistent foramen ovale and atrial septal defects and the relation to familial migraine with aura显示文摘 | Wilmshurst PT Pearson J Nightingale S | 2004 | Heart2004，90，11： | 1 |
| 18 | Carriage of methicillin-resistant Staphylococcus aureus is associated with an increased risk of infection after liver transplantation显示文摘 | Desai D Desai N Nightingale P | 2003 | Liver Transplant2003，9，7： | 1 |
| 19 | , A Cognitive Model of Innovation 显示文摘 | Nightingale P | | Research Policy0，1998，： | 1 |
| 20 | Dynamics of particulate dimethylsulfoniopropionate during a Lagrangian experiment in the northern North Sea显示文摘 | Archer S D Smith G C Nightingale P D | 2002 | Deep-Sea Res II2002，49，： | 1 |
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