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| 1 | PM_(2.5) in an industrial district of Zhengzhou,China:Chemical composition and source apportionment显示文摘郑州是在中国的一个发展中的城市,那被微粒物质的高水平重重地弄脏。在这研究,好微粒物质(PM2.5 ) 在在 2010 的郑州的一个工业区域为他们的化学作文(可溶的离子,元素,元素的碳(EC ) 和器官的碳(OC )) 镇定、分析。分别地, PM2.5 的平均集中与 175 g/m3 的年度一般水准是 181, 122, 186 和 211 g/m3 春天,夏天,秋天和冬季了,远超过美国国家空气质量标准(15 g/m3 ) 的 PM2.5 规定。在郑州的 PM2.5 的主导的部件是第二等的离子(硫酸盐和硝酸盐) 和碳部分。可溶的离子,全部的碳和元素分别地贡献了 41% PM2.5 质量, 13% 和 3% 。土壤灰尘,第二等的喷雾器和煤燃烧,各贡献大约 26% 全部的 PM2.5 质量, 24% 和 23% ,是 PM2.5 的主要来源,根据积极矩阵因式分解分析的结果。生物资源烧的混合来源,油燃烧和焚化贡献了 13% PM2.5。从车辆和工业产生的好微粒物质分别地贡献了大约 10% PM2.5 和 4% 。 | Ningbo Geng Jia Wang Yifei Xu Wending Zhang Chun Chen Ruiqin Zhang | 2013 | Particuology2013，11，1： | 46 |
| 2 | Highly Sensitive MoS_2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site显示文摘Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS_2–ICG hybrid with indocyanine green(ICG) conjugated to the surface of MoS_2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS_2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS_2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS_2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS_2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine. | Chengbo Liu Jingqin Chen Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song | 2018 | Nano-Micro Letters2018，10，3： | 10 |
| 3 | Hexabromocyclododecane and tetrabromobisphenol A in sediments and paddy soils from Liaohe River Basin, China: Levels, distribution and mass inventory显示文摘Hexabromocyclododecane(HBCD) and tetrabromobisphenol A(TBBPA) are two kinds of brominated flame retardants and widely present in the environment and biota. The levels,spatial distributions and mass inventories of HBCD and TBBPA were investigated in sediments and paddy soils from the Liaohe River Basin in northeast China. The concentrations of ΣHBCD and TBBPA were in the range of not detected(nd) to 4.02 ng/g dry weight(dw) and 0.03 to 4.06 ng/g dw, respectively. γ-HBCD was dominated in sediments,while the abundance of α-HBCD was relatively high in paddy soils. The spatial distributions of HBCD and TBBPA in surface sediments and paddy soils indicated that the local point-input was their major source. The significant correlation between total organic carbon(TOC) contents and the HBCD levels suggested that TOC content also exerted an influence on the distribution of HBCD in sediments. Meanwhile, it was found that the irrigation with river water was not the major transportation pathway of HBCD and TBBPA in paddy soils. Based on the study, it was estimated that there were about 1.67 tons HBCD and 2.20 tons TBBPA deposited into sediments of the Liaohe River system every year. The total mass inventories of HBCD and TBBPA in sediments were far higher than that in paddy soils. | Fang Li Jing Jin Dongqin Tan Longxing Wang Ningbo Geng Rong Cao Yuan Gao Jiping Chen | 2016 | Journal of Environmental Sciences2016，28，10： | 7 |
| 4 | Modified Multi-Key Fully Homomorphic Encryption Based on NTRU Cryptosystem without Key-Switching显示文摘The Multi-Key Fully Homomorphic Encryption (MKFHE) based on the NTRU cryptosystem is an important alternative to the post-quantum cryptography due to its simple scheme form,high efficiency,and fewer ciphertexts and keys.In 2012,Lopez-Alt et al.proposed the first NTRU-type MKFHE scheme,the LTV12 scheme,using the key-switching and modulus-reduction techniques,whose security relies on two assumptions:the Ring Learning With Error (RLWE) assumption and the Decisional Small Polynomial Ratio (DSPR) assumption.However,the LTV12and subsequent NTRU-type schemes are restricted to the family of power-of-2 cyclotomic rings,which may affect the security in the case of subfield attacks.Moreover,the key-switching technique of the LTV12 scheme requires a circular application of evaluation keys,which causes rapid growth of the error and thus affects the circuit depth.In this paper,an NTRU-type MKFHE scheme over prime cyclotomic rings without key-switching is proposed,which has the potential to resist the subfield attack and decrease the error exponentially during the homomorphic evaluating process.First,based on the RLWE and DSPR assumptions over the prime cyclotomic rings,a detailed analysis of the factors affecting the error during the homomorphic evaluations in the LTV12 scheme is provided.Next,a Low Bit Discarded&Dimension Expansion of Ciphertexts (LBD&DEC) technique is proposed,and the inherent homomorphic multiplication decryption structure of the NTRU is proposed,which can eliminate the key-switching operation in the LTV12 scheme.Finally,a leveled NTRU-type MKFHE scheme is developed using the LBD&DEC and modulus-reduction techniques.The analysis shows that the proposed scheme compared to the LTV12 scheme can decrease the magnitude of the error exponentially and minimize the dimension of ciphertexts. | Xiaoliang Che Tanping Zhou Ningbo Li Haonan Zhou Zhenhua Chen Xiaoyuan Yang | 2020 | Tsinghua Science and Technology2020，25，5： | 6 |
| 5 | Single small molecule-assembled nanoparticles mediate efficient oral drug delivery显示文摘Oral drug delivery,which requires surviving the harsh environment in the gastrointestinal(Gl)tract and penetrating the intestinal epithelium,has not bee n achieved using simple formulatio n nan oparticles(NPs).Medici nal natural products(MNPs)have bee n widely used in traditi onal medicine for disease management through oral consumption.However,most pharmacologically active compounds within MNPs do not have the properties suitable for oral applicatio ns.We hypothesize that some MNPs contain n atural nano materials that can convert those compounds into oral formulations by forming NPs.After screening 66 MNPs,we identified five classes of small molecules that form NPs,many of which are capable of efficient drug encapsulation and Gl penetration.We show that one of them,dehydrotrametenolic acid(DTA),is capable of mediating oral delivery for effective disease treatment.We determined that DTA NPs assemble through hydrogen bonding and penetra怕the Gl tract via apical sodium-depe ndent bile acid tran sporter.Our study reveals a no vel class of single comp orient,small molecule-assembled NPs for oral drug delivery,and suggests a n ovel approach to modernizi ng MNPs through nano material discovery. | Xin Yang Chao Ma Zeming Chen Jun Liu Fuyao Liu Rongbin Xie Haitian Zhao Gang Deng Ann TChen Ningbo Gong Lei Yao Pengjian Zuo Kangkang Zhi Jiacheng Wang Xiaobin Gao Jing Wang Louzhen Fan Jiangbing Zhou | 2019 | Nano Research2019，12，10： | 4 |
| 6 | Wind power forecasting error-based dispatch method for wind farm cluster显示文摘With the technical development of wind power forecasting,making wind power generation schedule in power systems become an inevitable tendency.This paper proposes a new dispatch method for wind farm(WF)cluster by considering wind power forecasting errors.A probability distribution model of wind power forecasting errors and a mathematic expectation of the power shortage caused by forecasting errors are established.Then,the total mathematic expectation of power shortage from all WFs is minimized.Case study with respect to power dispatch in a WF cluster is conducted using forecasting and actual wind power data within 30 days from sites located at Gansu Province.Compared with the variable proportion method,the power shortage of the WF cluster caused by wind power forecasting errors is reduced.Along with the increment of wind power integrated into power systems,the method positively influences future wind power operation. | Ning CHEN Qi WANG Liangzhong YAO Lingzhi ZHU Yi TANG Fubao WU Mei CHEN Ningbo WANG | 2013 | Journal of Modern Power Systems and Clean Energy2013，1，1： | 3 |
| 7 | Effects of Thermal and Hydric Conditions on Egg Incubation and Hatchling Phenotypes in Two Phrynocephalus Lizards显示文摘Flexible-shelled eggs of the lizards Phrynocephalus przewalskii and P. versicolor were incubated under different thermal and hydric conditions to elicit the effects of incubation environment on hatching success, embryonic development and duration as well as hatchling phenotypes. Embryogenesis of the two species was not sensitive to changes in the hydric environment except P. przewalskii incubated in 30°C group. Temperature significantly altered the duration of embryogenesis, with cooler temperatures leading to a longer incubation period. Hatching success was greater at 26 and 30°C than at 34°C. The hatchlings incubated at 26 and 30°C had longer snout-vent length, larger body mass, and better locomotor performance than those incubated at 34°C. Compared to P. przewalskii, P. versicolor had a shorter incubation period and yielded smaller hatchlings, which then had a higher survival rate in cooler and drier habitats. We conclude that an incubation temperature of 30°C would produce the best balance among developmental rate, hatching success, and post-hatching performance. We speculate that the upper temperature limit for incubation of P. versicolor eggs may be slightly higher than 34°C. | Xiaolong TANG Feng YUE Ming MA Ningbo WANG Jianzheng HE Qiang CHEN | 2012 | Asian Herpetological Research2012，3，3： | 3 |
| 8 | Solution-processable graphene mesh transparent electrodes for organic solar cells显示文摘有好电导率和透明性的 Graphene 网孔电极(GME ) 被标准工业影印石版术和 O2 血浆蚀刻过程用 graphene 答案制作了。器官光电( OPV )用 GME 的房间作为有poly-( 3-hexylthiophene )的混合的透明电极, /phenyl-C61-butyric 酸甲基酉旨( P3HT/PC61BM )作为活跃的层被制作了并且展出2.04%的力量变换效率( PCE ),为透明基于电极的太阳能电池迄今为止报导了的处理答案的 graphene 的最高的 PCE 。 | Qian Zhang Xiangjian Wan Fei Xing Lu Huang Guankui Long Ningbo Yi Wang Ni Zhibo Liu Jianguo Tian Yongsheng Chen | 2013 | Nano Research2013，6，7： | 3 |
| 9 | Metabolic regulation of T cell development by Sinl-mTORC2 is mediated by pyruvate kinase M2显示文摘Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mT0RC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and metabolism has not been fully studied. We show here that genetic ablation of Sinl, an essential component of mTORC2, in T lineage cells results in severely impaired thymocyte development at the CD4^- CD8^- double negative (DN) stages but not at the CD4^+ CD8^+ double positive (DP) or later stages. Notably, Sinl-deficient DN thymocytes show markedly reduced proliferation and glycolysis.Importantly, we discover that the M2 isoform of pyruvate kinase (PKM2) is a novel and crucial Sinl effector in promoting DN thymocyte development and metabolism. At the molecular level, we show that Sinl-mTORC2 controls PKM2 expression through an AKT-dependent PPAR-y nuclear translocation. Together, our study unravels a novel mTORC2-PPAR-γ-PKM2 pathway in immune-metabolic regulation of early thymocyte development. | Xinxing Ouyang Yuheng Han Guojun Qu Man Li Ningbo Wu Hongzhi Liu Omotooke Arojo Hongxiang Sun Xiaobo Liu Dou Liu Lei Chen Qiang Zou Bing Su | 2019 | Journal of Molecular Cell Biology2019，11，2： | 3 |
| 10 | MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis显示文摘T cell-mediated immunity in the intestine is stringently controlled to ensure proper immunity against pathogenic microbes and to prevent autoimmunity,a known cause of inflammatory bowel disease.However,precisely how T cells regulate intestine immunity remains to be fully understood.In this study,we found that mitogen-activated protein kinase kinase kinase 2(MAP3K2)is required for the CD4^(+)T cell-mediated inflammation in the intestine.Using a T cell transfer colitis model,we found that MAP3K2-deficient naïve CD4^(+)T cells had a dramatically reduced ability to induce colitis compared to wild type T cells.In addition,significantly fewer IFN-γ-but more IL-17A-producing CD4^(+)T cells in the intestines of mice receiving MAP3K2-deficient T cells than in those from mice receiving wild type T cells was observed.Interestingly,under well-defined in vitro differentiation conditions,MAP3K2-deficient naïve T cells were not impaired in their ability to differentiate into Th1,Th17 and Treg.Furthermore,the MAP3K2-regulated colitis severity was mediated by Th1 but not Th17 cells in the intestine.At the molecular level,we showed that MAP3K2-mediated Th1 cell differentiation in the intestine was regulated by IL-18 and required specific JNK activation.Together,our study reveals a novel regulatory role of MAP3K2 in intestinal T cell immunity via the IL-18-MAP3K2-JNK axis and may provide a novel target for intervention in T cell-mediated colitis. | Ningbo Wu Dongping Chen Hongxiang Sun Jianmei Tan Yao Zhang Tianyu Zhang Yuheng Han Hongzhi Liu Xinxing Ouyang Xiao-Dong Yang Xiaoyin Niu Jie Zhong Zhengting Wang Bing Su | 2021 | Science China(Life Sciences)2021，64，3： | 3 |
| 11 | Magnetic properties and crystallization behavior of nanocrystalline FeSiBPCuAl alloys显示文摘Magnetic properties and crystallization behavior of nanocrystalline (Fe83.3Si4B8P4Cu0.7)100-xAlx (x=0-1.5 at%) alloys were investigated in this study.Experimental results show that coercive force decreases and saturation magnetization slightly decreases with the increase of Al content,but the glass forming ability has been improved at the same time.Crystallization behavior including the evolution of microstructure has also been studied.The growth of α-Fe precipitated from the matrix is quick when it is annealed by conventional method and the mean size of α-Fe grains increases from below 2-3 nm to 18-29 nm.Nanocrystalline (Fe83.3Si4B8P4Cu0.7)99Al1 alloy with coercive force of 8.9 A/m and saturation magnetization of 187 emu/g is probably a promising candidate in the field of soft magnetic materials. | DONG BangShao1,ZHOU ShaoXiong1,HU MingJun2,KONG FanLi2,CHEN WenZhi1 & SHEN BaoLong2 1 Central Iron & Steel Research Institute,Advanced Technology & Materials Co.,Ltd.,Beijing 100081,China 2 Magnetic Materials and Advanced Devices Departments,Ningbo Institute of Material Technology & Engineering,Chinese Academy of Sciences,Ningbo 315201,China | 2010 | Science China(Technological Sciences)2010，53，6： | 2 |
| 12 | Genomic analyses reveal distinct genetic architectures and selective pressures in Chinese donkeys显示文摘Donkey(Equus asinus)is an important livestock animal in China because of its draft and medicinal value.After a long period of natural and artificial selection,the variety and phenotype of donkeys have become abundant.We clarified the genetic and demographic characteristics of Chinese domestic donkeys and the selection pressures by analyzing 78 whole genomes from 12 breeds.According to population structure,most Chinese domestic donkeys showed a dominant ancestral type.However,the Chinese donkeys still represented a significant geographical distribution trend.In the selective sweep,gene annotation,functional enrichment,and differential expression analyses between large and small donkey groups,we identified selective signals,including NCAPG and LCORL,which are related to rapid growth and large body size.Our findings elucidate the evolutionary history and formation of different donkey breeds and provide theoretical insights into the genetic mechanism underlying breed characteristics and molecular breeding programs of donkey clades. | Jiafei Shen Jie Yu Xuelei Da Mei Li Gang Wang Ningbo Chen Hong Chen Chuzhao Lei Ruihua Dang | 2021 | Journal of Genetics and Genomics2021，48，8： | 2 |
| 13 | Customized anterior segment photoacoustic imaging for ophthalmic burn evaluation in vivo显示文摘Photoacoustic imaging has many advantages in ophthalmic application including high-resolution,requirement of no exogenous contrast agent,and noninvasive acquisition of both morphologic and functional information.However,due to the limited depth of focus of the imaging method and large curvature of the eye,it remains a challenge to obtain high quality vascular image of entire anterior segment.Here,we proposed a new method to achieve high quality imaging of anterior segment.The new method applied a curvature imaging strategy based on only one time scanning,and hence is time efficient and more suitable for ophthalmic imaging compared to previously reported methods using similar strategy.A custom-built photoacoustic imaging system was adapted for ophthalmic application and a customized image processing method was developed to quantitatively analyze both morphologic and functional information in vasculature of the anterior segment.The results showed that the new method improved the image quality of anterior segment significantly compared to that of conventional high resolution photoacoustic imaging.More importantly,we applied the new method to study ophthalmic disease in an in vivo mouse model for the first time.The results verified the suitability and advantages of the new method for imaging the entire anterior segment and the numerous potentials of applying it in ophthalmic imaging in future. | Huangxuan Zhao Ke Li Fan Yang Wenhui Zhou Ningbo Chen Liang Song Chuansheng Zheng Zhicheng Liu Chengbo Liu | 2021 | Opto-Electronic Advances2021，4，6： | 2 |
| 14 | Photoinduced Second Harmonic Generation of Bi_2S_3 Microcrystallite Doped Silica Glass显示文摘Silica glasses doped with Bi2S3 microcystallite was prepared by the sol-gel process. Photoinduced second harmonic generation (SHG) was observed in the glass when it was irradiated with intense 1.06 μm and frequency doubled laser beams from a mode-locked Nd: YAG laser. It was found that the signal intensity increased with the irradiating time and approached a saturation gradually. The effect may be explained reasonably by the DC field model. | Letters Hongbing CHEN and Hai ping XIA Institute of Optoelectric Materials, Ningbo University, Ningbo 315211, China Congshan ZHU and Fuxi GAN Shanghai Institute of Optics & Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, China | 2001 | Journal of Materials Science & Technology2001，17，5： | 2 |
| 15 | Analytical solution and semi-analytical solution for anisotropic functionally graded beam subject to arbitrary loading显示文摘Analytical and semi-analytical solutions are presented for anisotropic functionally graded beams subject to an arbitrary load,which can be expanded in terms of sinusoidal series.For plane stress problems,the stress function is assumed to consist of two parts,one being a product of a trigonometric function of the longitudinal coordinate(x) and an undetermined function of the thickness coordinate(y),and the other a linear polynomial of x with unknown coefficients depending on y.The governing equations satisfied by these y-dependent functions are derived.The expressions for stresses,resultant forces and displacements are then deduced,with integral constants determinable from the boundary conditions.While the analytical solution is derived for the beam with material coefficients varying exponentially or in a power law along the thickness,the semi-analytical solution is sought by making use of the sub-layer approximation for the beam with an arbitrary variation of material parameters along the thickness.The present analysis is applicable to beams with various boundary conditions at the two ends.Three numerical examples are presented for validation of the theory and illustration of the effects of certain parameters. | HUANG DeJin1,2,DING HaoJiang1 & CHEN WeiQiu3 1 Key Laboratory of Soft Soils and Geoenvironmental Engineering,Ministry of Education,Zhejiang University,Hangzhou 310027,China 2 Faculty of Engineering,Ningbo University,Ningbo 315211,China 3 Department of Engineering Mechanics,Zhejiang University,Hangzhou 310027,China | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，8： | 2 |
| 16 | Image Filter for Removal of Impulse Noise Based on Directional Derivatives显示文摘One of the most common image processing tasks involves the removal of noise from images. Noise can be introduced during image capture, during transmission, or during storage. For design purposes, noise sources are frequently approximated by random variables with a known probability distribution. One common noise model corrupts a signal by introducing impulses. And the surface of the image disturbed by impulse noise displays many peaks or vales. According to the characteristic of impulse noise, a novel algorithm is proposed to the detection of impulse noise point from images based on directional derivatives. First, the theory of calculus on directional derivatives is introduced in detail. Then it is applied to the field of image to removing noise with the discrete form derived from its continuous mathematical model. And a number of contrasting simulations illustrate that our algorithm not only can preserve the structure information while removing impulse noise but also can mostly save the gray value of the pixels undisturbed by noise. In addition, the comparisons of the filtering performance for removing impulse noise are analyzed in detail in the case of different noise densities, and also show that the algorithm suggested outperforms the conventional filter algorithms such as mean filter, median filter and so on in speed and impulse noise reduction, especially in random-valued impulse noise reduction. So it is a very good alternative to the existing schemes. | KONG Tao, LI Jun-li, CHEN Gang (College of Information Science and Engineering, Ningbo University, Ningbo 315211, China) | 2008 | Computer Aided Drafting,Design and Manufacturing2008，18，2： | 2 |
| 17 | EGFR tyrosine kinase inhibitor HS-10182 increases radiation sensitivity in non-small cell lung cancers with EGFR T790M mutation显示文摘Objective:To investigate the potential of HS-10182,a second-generation epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI),as a radiosensitizer in non-small cell lung cancer(NSCLC).Methods:Two cell lines of NSCLCs,A549 that possesses wild-type(WT)EGFRs and H1975 that possesses EGFR L858R/T790M double mutations,were treated with HS-10182 at various concentrations,and cell viabilities were determined using the MTS assay.The cells were tested by clonogenic survival assays to identify the radiosensitivity of both groups.Western blot was performed to analyze the expression of phosphorylated EGFR,AKT,DNA-dependent protein kinase,and catalytic subunit(DNA-PKcs)proteins.Immunofluorescence analyses were performed to examine the formation and changes in nuclearγ-H2AX foci.Cell apoptosis was examined by flow cytometry and Western blots for cleaved caspase-3,-8,-9,and cleaved poly ADP-ribose polymerase(PARP).Furthermore,we established xenograft models in mice and the effects of different treatments on tumor growth were then assessed.Results:Clonogenic survival assays revealed that HS-10182 significantly enhanced the radiosensitivity of H1975 cells but not A549cells[dose enhancement ratios(DERs)=2.36(P<0.05)vs.1.43(P>0.05)].Western blot results showed that HS-10182 increased the levels of cleaved caspase-3,-8,-9,and cleaved PARP in H1975 cells but not in A549 cells.In addition,flow cytometry analysis showed that HS-10182 enhanced irradiation-induced apoptosis in H1975.Immunofluorescence results found that HS-10182increased the average number ofγ-H2AX foci after irradiation in H1975 cells,but not in A549 cells.Combined radiation and HS-10182 treatment increased the expression of DNA-PKcs but this increase was more significant in H1975 cells than in A549 cells.Moreover,HS-10182 suppressed the increased expression of Rad50 in H1975 cells in response to irradiation.In vivo experiments found that the combined therapy significantly inhibited tumor growth.Conclusions:HS-10182 enhances the radiosensitivity of H1975 cells which is possibly because that HS-10182 could enhance irradiation-induced apoptosis,increase irradiation-induced DNA damage,and cause a delay in DNA damage repair.Our findings suggest that radiotherapy combined HS-10182 is a novel treatment for lung cancer cells which have acquired the T790M mutation.HS-10182 could be brought to the clinic as a radiosensitizer in NSCLCs with the EGFR T790M mutation. | Yang Chen Youyou Wang Lujun Zhao Ping Wang Jifeng Sun Rudi Bao Chenghai Li Ningbo Liu | 2018 | Cancer Biology & Medicine2018，15，1： | 2 |
| 18 | An atlas of CNV maps in cattle, goat and sheep显示文摘Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown.Here,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse populations.Using 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle development.The number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between species.We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes.This study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species. | Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu Yudong Cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 19 | Detection of a low observable sea-surface target with micromotion via the Radon-linear canonical transform显示文摘 | Chen Xiaolong Guan Jian Liu Ningbo | 2014 | IEEE Geoscience and Remote Sensing Letters2014，11，7： | 1 |
| 20 | A Lifting Method for Fokker-Planck Equations with Drift-Admitting Jumps显示文摘We develop in this paper a lifting method for Fokker-Planck equations with drift-admitting jumps,such that high-order finite difference schemes.can be constructed directly based on grids with pure solution points.To illustrate the idea,we present as an example the construction of a fifth-order finite difference scheme.The validity of the scheme is demonstrated by conducting numerical experiments for the cases with drift admitting one jump and two jumps,respectively.Additionally,by introducing a splitting technique,we show that the lifting method can be extended to high dimensions.In particular,a two-dimensional case is studied in details to show the effectiveness of the extension. | Ningbo Guol Yaming Chen Xiaogang Deng | 2022 | Communications in Mathematical Research2022，38，3： | 1 |
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