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| 1 | Combined obeticholic acid and apoptosis inhibitor treatment alleviates liver fibrosis显示文摘Obeticholic acid(OCA), the first FXR-targeting drug, has been claimed effective in the therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be effective against liver fibrosis, possibly due to the lower dosage to reduce the incidence of the side-effect of pruritus. Here we propose a combinatory therapeutic strategy of OCA and apoptosis inhibitor for combating against liver fibrosis. CCl4-injured mice, D-galactosamine/LPS(GalN/LPS)-treated mice and cycloheximide/TNFα(CHX/TNFα)-treated HepG2 cells were employed to assess the effects of OCA, or together with IDN-6556, an apoptosis inhibitor. OCA treatment significantly inhibited hepatic stellate cell(HSC)activation/proliferation and prevented fibrosis. Elevated bile acid(BA) levels and hepatocyte apoptosis triggered the activation and proliferation of HSCs. OCA treatment reduced BA levels but could not inhibit hepatocellular apoptosis. An enhanced anti-fibrotic effect was observed when OCA was co-administrated with IDN-6556. Our study demonstrated that OCA inhibits HSCs activation/proliferation partially by regulating BA homeostasis and thereby inhibiting activation of HSCs. The findings in this study suggest that combined use of apoptosis inhibitor and OCA at lower dosage represents a novel therapeutic strategy for liver fibrosis. | Jiyu Zhou Ningning Huang Yitong Guo Shuang Cui Chaoliang Ge Qingxian He Xiaojie Pan Guangji Wang Hong Wang Haiping Hao | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 13 |
| 2 | Large-area high quality PtSe2 thin film with versatile polarity显示文摘Two-dimensional(2D)materials have attracted increasing attention for their outstanding structural and electrical properties.However,for mass-production of field effect transistors(FETs)and potential applications in integrated circuits,large-area and uniform 2D thin films with high mobility,large on-off ratio,and desired polarity are needed to synthesize firstly.Here,a transfer-free growth method for platinum diselenide(PtSe2)films has been developed.The PtSe2 films have been synthesized with various thicknesses in centimeter-sized scale.Typical FET made from a few layer PtSe2 show p-type unipolar,with a high field-effect hole mobility of 6.2 cm^(2) V^(−1) s^(−1) and an on-off ratio of 5×10^(3).The versatile semimetal-unipolar-ambipolar transition in synthesized PtSe2 films is also firstly observed as the thickness thinning.This work realizes the large-scale preparation of PtSe2 with prominent electrical properties and provides a new strategy for polarity's modulation. | Wei Jiang Xudong Wang Yan Chen Guangjian Wu Kun Ba Ningning Xuan Yangye Sun Peng Gong Jingxian Bao Hong Shen Tie Lin Xiangjian Meng Jianlu Wang Zhengzong Sun | 2019 | InfoMat2019，1，2： | 5 |
| 3 | CMOS-compatible all-optical modulator based on the saturable absorption of graphene显示文摘Graphene resting on a silicon-on-insulator platform offers great potential for optoelectronic devices.In the paper,we demonstrate all-optical modulation on the graphene-silicon hybrid waveguides(GSHWs)with tens of micrometers in length.Owing to strong interaction between graphene and silicon strip waveguides with compact light confinement,the modulation depth reaches 22.7%with a saturation threshold down to 1.38 pJ per pulse and a 30-μm-long graphene pad.A response time of 1.65 ps is verified by a pump-probe measurement with an energy consumption of 2.1 pJ.The complementary metal-oxide semiconductor compatible GSHWs with the strip configuration exhibit great potential for ultrafast and broadband all-optical modulation,indicating that employing two-dimensional materials has become a complementary technology to promote the silicon photonic platform. | HONG WANG NINGNING YANG LIMIN CHANG CHAOBIAO ZHOU SHIYU LI MENG DENG ZHENWEI LI QIANG LIU CHI ZHANG ZHIYONG LI YI WANG | 2020 | Photonics Research2020，8，4： | 4 |
| 4 | In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT显示文摘In this paper,we proposed a contrast-enhanced homemade spectral domain optical coherence tomography(SD-OCT)method for monitoring of brain microcirculation.We used the polyethylene glycol(PEG)-ylated gold nanorods(GNRs)as a contrast-enhanced agent,obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood vessels.Owing to high scattering of the PEG-GNRs,more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20 min,the enhancement then declined gradually for 60 min.Our results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo,especially for studies of the brain microcirculation,which could be serviced for disease mechanism research and therapeutic drug monitoring. | Shaozhuang Yang Liwei Liu Yixin Chang Ningning Zhang Kun Liu Liang Hong Bingling Chen Yue Zhao Rui Hu Junle Qu | 2019 | Journal of Innovative Optical Health Sciences2019，，1： | 2 |
| 5 | Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid显示文摘Liver injury caused by acetaminophen(AP)overdose is a leading public health problem.Although APinduced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone(NAPQI),a toxic metabolite of AP,resulting in cell damage,emerging evidence indicates that AP-induced liver injury is also associated with gut microbiota.However,the gut microbiota-involved mechanism remains largely unknown.In our study,we found that vancomycin(Vac)pretreatment(100 mg/kg,twice a day for 4 days)attenuated AP-induced liver injury,altered the composition of gut microbiota,and changed serum metabolic profile.Moreover,we identified Vac pretreatment elevated cecum and serum 2-hydroxybutyric acid(2-HB),which ameliorated AP-induced cell damage and liver injury in mice by reducing AP bioavailability and elevating GSH levels.Our current results revealed the novel role of 2-HB in protecting AP-induced liver injury and add new evidence for gut microbiota in affecting AP toxicity. | Ningning Zheng Yu Gu Ying Hong Lili Sheng Linlin Chen Feng Zhang Jie Hou Weidong Zhang Zean Zhang Wei Jia Houkai Li | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 1 |
| 6 | Effect of Cellulose Acetate Butyrate Microencapsulated Ammonium Polyphosphate on the Flame Re~cy, Mechanical, Elecmcal, and Thermal Properties of Intumescent Flame-Retardant Ethylene Vinyl Acetate Copolymer/Microencapsulated Ammonium Pol- yphosphate/Polyamide-6 Blends 显示文摘 | Wang Bibo Tang Qinbo Hong Ningning | 2011 | ACS Applied Matereri- al&Interfaces2011，3，9： | 1 |
| 7 | Effect of cellulose acetate butyrate microencapsulated ammonium polyphosphate on the flame retardancy,mechanical,electrical,and thermal properties of intumescent flame-retardant ethylene-vinyl acetate copolymer/microencapsulated ammonium polyphosphate/polyamide-6 blends显示文摘 | Bibo Wang Qinbo Tang Ningning Hong | 2011 | ACS Applied Materials&Interfaces2011，3，9： | 1 |
| 8 | Mass transfer techniques for large-scaleand high-density microLED arrays显示文摘Inorganic-based micro light-emitting diodes (microLEDs) offer more fascinating properties and unique demands in next-generation displays. However, the small size of the microLED chip (1–100 µm) makes it extremely challenging for high efficiency and low cost to accurately, selectively, integrate millions of microLED chips. Recent impressive technological advances have overcome the drawbacks of traditional pick-and-place techniques when they were utilized in the assembly of microLED display, including the most broadly recognized laser lift-off technique, contact micro-transfer printing (µTP) technique, laser non-contact µTP technique, and self-assembly technique. Herein, we firstly review the key developments in mass transfer technique and highlight their potential value, covering both the state-of-the-art devices and requirements for mass transfer in the assembly of the ultra-large-area display and virtual reality glasses. We begin with the significant challenges and the brief history of mass transfer technique, and expand that mass transfer technique is composed of two major techniques, namely, the epitaxial Lift-off technique and the pick-and-place technique. The basic concept and transfer effects for each representative epitaxial Lift-off and pick-and-place technique in mass transfer are then overviewed separately. Finally, the potential challenges and future research directions of mass transfer are discussed. | Furong Chen Jing Bian Jinlong Hu Ningning Sun Biao Yang Hong Ling Haiyang Yu Kaixin Wang Mengxin Gai Yuhang Ma YongAn Huang | 2022 | International Journal of Extreme Manufacturing2022，4，4： | 1 |
| 9 | Flame retardant polystyrene copolymers: preparation, thermal properties, and fire toxicities显示文摘 | Weizhao Hu Jing Zhan Ningning Hong T. Richard Hull Anna A. Stec Lei Song Jian Wang Yuan Hu | 2014 | Polym Adv Technol2014，，6： | 1 |
| 10 | Enhanced mechanical, thermal and flame retardant properties by combining graphene nanosheets and metal hydroxide nanorods for Acrylonitrile–Butadiene–Styrene copolymer composite显示文摘 | Ningning Hong Jing Zhan Xin Wang Anna A. Stec T. Richard Hull Hua Ge Weiyi Xing Lei Song Yuan Hu | 2014 | Composites Part A2014，，： | 1 |
| 11 | A simple assay for direct colorimetrie visualization of trinitrotoluene at picomolar levels using gold nanoparticles显示文摘 | Ying Jiang Hong Zhao Ningning Zhu | 2008 | Angew Chem Inter Ed2008，47，： | 1 |
| 12 | Effect of graphene on the fire and mechanical performances of glass fiber-reinforced polyamide 6 composites containing aluminum hypophosphite显示文摘 | Pan Ying Hong Ningning Zhan Jing | 2014 | Polymer-Plastics Technology and Engineering2014，53，14： | 1 |
| 13 | Facile preparation of graphene supported Co 3 O 4 and NiO for reducing fire hazards of polyamide 6 composites显示文摘 | Ningning Hong Lei Song T. Richard Hull Anna A. Stec Bibo Wang Ying Pan Yuan Hu | 2013 | Materials Chemistry and Physics . 2013 (2-3)2013，，2： | 1 |
| 14 | Cu-Au alloy nanoparticle as oligonucleotides labels for electrochemical stripping detection of DNA hybridization 显示文摘 | Hong Cai Ningning Zhu Ying Jiang | 2003 | Biosensors and Bioelectronics2003，18，： | 1 |
| 15 | Cu@Au alloy nanoparticle as oligonucleotides labels for electrochemical stripping detection of DNA hybridization显示文摘 | Cai Hong Zhu Ningning Jiang Ying | 2003 | Biosensors and Bioelectronics2003，，18： | 1 |
| 16 | Facile preparation of graphene supported Co3O4 and NiO for reducing fire hazards of polyamide 6 composites显示文摘 | Hong Ningning Lei Song Hu Yuan | 2013 | Materials Chemistry & Physics2013，142，23： | 1 |
| 17 | Evidence of aircraft activity impact on local air quality: A study in the context of uncommon airport operation显示文摘Wuhan Tianhe International Airport (WUH) was suspended to contain the spread of COVID-19,while Shanghai Hongqiao International Airport (SHA) saw a tremendousflight reduction.Closure of a major international airport is extremely rare and thus represents a unique opportunity to straightforwardly observe the impact of airport emissions on local air quality.In this study,a series of statistical tools were applied to analyze the variations in air pollutant levels in the vicinity of WUH and SHA.The results of bivariate polar plots show that airport SHA and WUH are a major source of nitrogen oxides.NOx,NO_(2)and NO diminished by 55.8%,44.1%,76.9%,and 40.4%,33.3% and 59.4% during the COVID-19 lockdown compared to those in the same period of 2018 and 2019,under a reduction in aircraft activities by 58.6%and61.4%.The concentration of NO_(2),SO_(2)and PM_(2.5)decreased by 77.3%,8.2%,29.5%,right after the closure of airport WUH on 23 January 2020.The average concentrations of NO,NO_(2)and NOxscatter plots at downwind of SHA after the lockdown were 78.0%,47.9%,57.4%and 62.3%,34.8%,41.8%lower than those during the same period in 2018 and 2019.However,a significant increase in O_(3)levels by 50.0% and 25.9%at WUH and SHA was observed,respectively.These results evidently show decreased nitrogen oxides concentrations in the airport vicinity due to reduced aircraft activities,while amplified O_(3)pollution due to a lower titration by NO under strong reduction in NOxemissions. | Hao Xu Kai Xiao Jun Pan Qingyan Fu Xiaodong Wei Junrui Zhou Yamei Yu Xue Hu Huarui Ren Jinping Cheng Shitao Peng Ningning Hong Yin Ye Ning Su Zehui He Tao Hu | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 18 | Morphology-dependent interfacial interactions of Fe2O3 with Ag nanoparticles for determining the catalytic reduction of p-nitrophenol显示文摘In this work,we fabricated three kinds of Ag/Fe2O3 model catalysts with different morphologies to study the interfacial interactions between Ag and Fe2O3,and how they affected the catalytic activity in hydrogenation of p-nitrophenol was explored.The hydrothermal method was used to synthesize the metal oxide supported silver catalyst,with various morphologies including nanoplates(NPs),nanospheres(NSs),and nanocubes(NCs).The crystal structure,morphology and surface elements of the composite were investigated by various measurements,such as X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM)and X-ray photoelectron spectroscopy(XPS).The catalytic activity was also evaluated by the reduction of p-nitrophenol to p-aminophenol.It was found that the activities of the above catalysts varied with the morphology of the support.Among them,Ag/Fe2O3 NPs promoted the highest performance,Ag/Fe2O3 NSs were slightly inferior,and Ag/Fe2O3 NCs were the worst.At last,we ascribed the remarkable activity of Ag/Fe2O3 NPs to the strong metal-support interactions between Ag and Fe2O3. | Ningning Wang Shuai Zeng Hong Yuan Jin Huang | 2020 | Journal of Environmental Sciences2020，32，6： | 0 |
| 19 | Laser projection proximity transfer for deterministic assembly of microchip arrays at scale显示文摘Deterministic assembly techniques that enable programmatic and massively parallel integration of chips are essential for the development of novel electronic systems such as micro LED displays.However,large-area integration of ultrathin micro-chips with high yield and transfer accuracy remains a great challenge due to the difficulties in selective transfer,adhesion switchability,and transfer deviation.Here,a“laser projection proximity transfer(Laser PPT)”technique is presented for the deterministic assembly of microchip arrays at scale.One of the remarkable features is that the transfer status between the chip and the receiver substrate evolves from the original non-contact mode to contact mode for high-precision transfer,which overcomes the strict requirements of the flatness of stamp and substrate in contact-style transfer,and flight deviation of microchip array in noncontact-style transfer.Another feature is the rapid modulation of interfacial adhesion for reliable transfer via the use of thermally expandable microspheres to form microstructures and combining with a laser-induced blister.The adhesion regulation range is over 20 times without any damage to chip arrays.The results show that the transfer accuracy has been improved substantially with a minimum relative error of~0.5%.Combined with a laser beam projection system,demonstrations of Laser PPT for selective assembly of fragile objects onto challenging non-adhesive/cured surfaces in batch illustrate its potential in the highprecision integration of microscale chips at scale. | HU JinLong CHEN FuRong BIAN Jing SUN NingNing WANG KaiXin LING Hong YU HaiYang GAI MengXin XU LiZhi HUANG YongAn | 2022 | Science China(Technological Sciences)2022，65，9： | 0 |
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