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| 1 | 高PM2.5地区呼吸系统疾病发病率流行病学调查显示文摘目的探讨高PM2.5地区居民呼吸系统疾病发病率情况。方法采取随机抽样方法,廊坊市区、呼和浩特市区常住居民共3564例填写呼吸系统流行病学调查表,统计并比较两地市区居民2008年1月1日至2016年12月30日呼吸系统疾病发病率、症状发生率。在廊坊市区被调查者中随机抽取200例填写2012—2016年每年度呼吸系统流行病学调查表,并统计年均PM2.5浓度,探讨呼吸系统疾病和PM2.5浓度的相关性。结果廊坊市年均PM2.5浓度、空气质量指数明显高于呼和浩特市区(P值均〈0.05)。廊坊市区居民鼻炎、鼻敏感、慢性咽炎、上呼吸道感染、鼻窦炎、支气管炎、支气管哮喘、慢性阻塞性肺疾病(COPD)、肺炎、呼吸系统肿瘤、间质性肺病发病率均高于呼和浩特市区居民(P值均〈0.05);廊坊市区居民咳嗽、咳痰、喘息气促、咽部不适、鼻塞、喉咙痛、喘鸣、呼吸困难发生率高于呼和浩特市区居民(P值均〈0.05)。PM2.5浓度与鼻炎、慢性咽炎、上呼吸道感染、支气管炎、支气管哮喘呈正相关(P值均≤0.05)。结论高PM2.5地区鼻炎、鼻敏感、慢性咽炎、上呼吸道感染、鼻窦炎、支气管炎、支气管哮喘、COPD、肺炎、呼吸系统肿瘤、间质性肺病的发病率较高;高PM2.5地区居民更易发生咳嗽、咳痰、喘息气促、咽部不适、鼻塞、喉咙痛、喘鸣、呼吸困难。 | 高菲 边毓尧 郭文有 修明文 刘永纯 陈光远 Nishant Raj Pandey | 2018 | 国际呼吸杂志2018，38，18： | 13 |
| 2 | Significance of blood pressure variability in patients with sepsis显示文摘BACKGROUND: This study was undertaken to observe the characteristics of blood pressure variability(BPV) and sepsis and to investigate changes in blood pressure and its value on the severity of illness in patients with sepsis.METHODS: Blood parameters, APACHE II score, and 24-hour ambulatory BP were analyzed in 89 patients with sepsis.RESULTS: In patients with APACHE II score>19, the values of systolic blood pressure(SBPV), diasystolic blood pressure(DBPV), non-dipper percentage, cortisol(COR), lactate(LAC), platelet count(PLT) and glucose(GLU) were significantly higher than in those with APACHE II score ≤19(P<0.05), whereas the values of procalcitonin(PCT), white blood cell(WBC), creatinine(Cr), PaO2, C-reactive protein(CRP), adrenocorticotropic hormone(ACTH) and tumor necrosis factor α(TNF-α) were not statistically significant(P>0.05). Correlation analysis showed that APACHE II scores correlated significantly with SBPV and DBPV(P<0.01, r=0.732 and P<0.01, r=0.762). SBPV and DBPV were correlated with COR(P=0.018 and r=0.318; P=0.008 and r=0.353 respectively). However, SBPV and DBPV were not correlated with TNF-α, IL-10, and PCT(P>0.05). Logistic regression analysis of SBPV, DBPV, APACHE II score, and LAC was used to predict prognosis in terms of survival and non-survival rates. Receiver operating characteristics curve(ROC) showed that DBPV was a better predictor of survival rate with an AUC value of 0.890. However, AUC of SBPV, APACHE II score, and LAC was 0.746, 0.831 and 0.915, respectively.CONCLUSIONS: The values of SBPV, DBPV and non-dipper percentage are higher in patients with sepsis. DBPV and SBPV can be used to predict the survival rate of patients with sepsis. | Nishant Raj Paney Yu-yao Bian Song-tao Shou | 2014 | World Journal of Emergency Medicine2014，5，1： | 11 |
| 3 | Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy显示文摘Background:Progressive accumulation ofα-synuclein is a key step in the pathological development of Parkinson’s disease.Impaired protein degradation and increased levels ofα-synuclein may trigger a pathological aggregation in vitro and in vivo.The chaperone-mediated autophagy(CMA)pathway is involved in the intracellular degradation processes ofα-synuclein.Dysfunction of the CMA pathway impairsα-synuclein degradation and causes cytotoxicity.Results:In the present study,we investigated the effects on the CMA pathway andα-synuclein aggregation using bioactive ingredients(Dihydromyricetin(DHM)and Salvianolic acid B(Sal B))extracted from natural medicinal plants.In both cell-free and cellular models ofα-synuclein aggregation,after administration of DHM and Sal B,we observed significant inhibition ofα-synuclein accumulation and aggregation.Cells were co-transfected with a Cterminal modifiedα-synuclein(SynT)and synphilin-1,and then treated with DHM(10μM)and Sal B(50μM)16 hours after transfection;levels ofα-synuclein aggregation decreased significantly(68%for DHM and 75%for Sal B).Concomitantly,we detected increased levels of LAMP-1(a marker of lysosomal homeostasis)and LAMP-2A(a key marker of CMA).Immunofluorescence analyses showed increased colocalization between LAMP-1 and LAMP-2A withα-synuclein inclusions after treatment with DHM and Sal B.We also found increased levels of LAMP-1 and LAMP-2A both in vitro and in vivo,along with decreased levels ofα-synuclein.Moreover,DHM and Sal B treatments exhibited anti-inflammatory activities,preventing astroglia-and microglia-mediated neuroinflammation in BAC-α-syn-GFP transgenic mice.Conclusions:Our data indicate that DHM and Sal B are effective in modulatingα-synuclein accumulation and aggregate formation and augmenting activation of CMA,holding potential for the treatment of Parkinson’s disease. | Jia-Zhen Wu Mustafa Ardah Caroline Haikal Alexander Svanbergsson Meike Diepenbroek Nishant N.Vaikath Wen Li Zhan-You Wang Tiago F.Outeiro Omar M.El-Agnaf Jia-Yi Li | 2019 | Translational Neurodegeneration2019，8，1： | 11 |
| 4 | 未来中国医疗模式发展趋势探讨显示文摘传统医学模式在推动人类健康发展的道路上曾经取得了巨大进步,但如今传统医学模式专业化加深,导致人体'碎片化'的弊端日益显著,而国际上新兴的整合医学也存在专业知识粗糙、相关研究局限于学术层面等明显的缺点。就这两种医疗模式的优劣进行讨论并分析目前医疗模式的困境,提出未来中国医疗模式发展趋势是个体医疗和团队化医疗小组结合,认为其是解决现代医学自身缺陷、缓解医疗矛盾的有效手段。 | 边毓尧 Nishant Raj Pandey 刘创建 修明文 张祎 | 2016 | 医学与社会2016，29，1： | 9 |
| 5 | Effects of polydispersity on the micro–macro behavior of granular assemblies under different deformation paths显示文摘The micromechanical and macromechanical behavior of idealized granular assemblies, made by linearly elastic, frictionless, polydisperse spheres, are studied in a periodic, triaxial box geometry, using the discrete element method. Emphasis is put on the effect of polydispersity under purely isotropic loading and unloading, deviatoric(volume conserving), and uniaxial compression paths.We show that scaled pressure, coordination number and fraction of rattlers behave in a very similar fashion as functions of volume fraction, irrespective of the deformation path applied. Interestingly, they show a systematic dependence on the deformation mode and polydispersity via the respective jamming volume fraction. This confirms that the concept of a single jamming point has to be rephrased to a range of variable jamming points, dependent on microstructure and history of the sample, making the jamming volume fraction a state-variable.This behavior is confirmed when a simplified constitutive model involving structural anisotropy is calibrated using the purely isotropic and deviatoric simulations. The basic model parameters are found to depend on the polydispersity of the sample through the different jamming volume fractions. The predictive power of the calibrated model is checked by comparison with an independent test, namely uniaxial compression. The important features of the uniaxial experiment are captured and a qualitative prediction for the evolution of stress and fabric is shown involving a 'softening' regime in both stress and fabric – stronger for the latter – that was not prescribed into the model a priori. | Nishant Kumar Olukayode I.Imole Vanessa Magnanimo Stefan Luding | 2014 | Particuology2014，12，1： | 5 |
| 6 | Selection of appropriate analytical tools to determine the potency and bioactivity of antibiotics and antibiotic resistance显示文摘Antibiotics are the chemotherapeutic agents that kill or inhibit the pathogenic microorganisms.Resistance of microorganism to antibiotics is a growing problem around the world due to indiscriminate and irrational use of antibiotics.In order to overcome the resistance problem and to safely use antibiotics,the correct measurement of potency and bioactivity of antibiotics is essential.Microbiological assay and high performance liquid chromatography(HPLC) method are used to quantify the potency of antibiotics.HPLC method is commonly used for the quantification of potency of antibiotics,but unable to determine the bioactivity;whereas microbiological assay estimates both potency and bioactivity of antibiotics.Additionally,bioassay is used to estimate the effective dose against antibiotic resistant microbes.Simultaneously,microbiological assay addresses the several parameters such as minimal inhibitory concentration(MIC),minimum bactericidal concentration(MBC),mutation prevention concentration(MPC) and critical concentration(Ccr) which are used to describe the potency in a more informative way.Microbiological assay is a simple,sensitive,precise and cost effective method which gives reproducible results similar to HPLC.However,the HPLC cannot be a complete substitute for microbiological assay and both methods have their own significance to obtain more realistic and precise results. | Nishant A.Dafale Uttam P.Semwal Rupak K.Rajput G.N.Singh | 2016 | Journal of Pharmaceutical Analysis2016，6，4： | 5 |
| 7 | A systematic investigation of secondary phase dissolution in Mg-Sn alloys显示文摘As-cast Mg-Sn alloys(3,6,and 9 wt%Sn)were solution treated at 653,703 and 753 K(380,430 and 480℃)for 1,4,8,12 and 24 h to determine the variation of secondary phase with respect to Sn content,temperature and time.Mg-3 wt%Sn exhibits Mg2Sn dissolution at all solution treatment temperatures whereas Mg-6 and 9 wt%Sn alloy displays Mg2Sn reprecipitation and dissolution depending on the heat treatment temperature.In addition,a combined mathematical model that predicts the secondary phase dissolution and solute redistribution as a function of temperature and time is presented in this work.This model is a significant improvement compared to the previous studies where the dissolution and homogenization processes are considered independently.The effect of grain size and solute mobility upon the dissolution and homogenization kinetics is discussed as well. | Arushi Dev Niladri Naskar Nishant Kumar Ashutosh Jena Manas Paliwal | 2019 | Journal of Magnesium and Alloys2019，7，4： | 5 |
| 8 | 医学整合:专科与综合医疗小组结合模式的探索显示文摘生物医学在推动人类健康的道路上出现的专科化弊端日益显著。整合医学以将医学各领域的知识理论和各专科的实践经验加以整合,使医学更加适合人体健康和疾病治疗的优势,受到人们关注。但由于整合医学缺乏具体操作模式等困难,发展缓慢。对比分析以上两种医疗模式后提出专科化医学与综合医疗小组相结合的具体医疗模式,该模式具有减少漏诊、误诊率,减少医患纠纷,保证医学发展,控制医疗费用等优势。由于我国慢性病人群增多,医患矛盾激化,人们对于卫生资源的需求增加,这种新模式是未来医疗模式的发展方向。 | 边毓尧 Nishant Raj Pandey 刘创建 修明文 张祎 | 2016 | 医学与哲学(A)2016，37，3： | 4 |
| 9 | Acute renal dysfunction in patients with alcoholic hepatitis显示文摘Acute renal dysfunction is common in patients with alco-holic hepatitis(AH).Its presence leads to higher mortality in these patients.Despite advances in medical care,the outcome has changed little over the past decades.Studies using Pentoxifylline and molecular adsorbent recirculation system have shown encouraging data in small studies.Further larger well designed studies are needed to assess these modalities of treatment for the treatment of AH. | Robin Arora Shweta Kathuria Nishant Jalandhara | 2011 | World Journal of Hepatology2011，3，5： | 4 |
| 10 | Economical effect of lumen apposing metal stents for treating benign foregut strictures显示文摘AIM To evaluate the clinical and economical efficacy of lumen apposing metal stent(LAMS) in the treatment of benign foregut strictures.METHODS A single center retrospective database of patients who underwent endoscopic treatment of benign foregut strictures between January 2014 and May 2017 was analyzed. A control group of non-stented patients who underwent three endoscopic dilations was compared to patients who underwent LAMS placement. Statistical tests performed included independent t-tests and fiveparameter regression analysis RESULTS Nine hundred and ninety-eight foregut endoscopic dilations were performed between January 2014 and May 2017. 15 patients underwent endoscopic LAMS placement for treatment of benign foregut stricture. Thirty-six patients with recurrent benign foregut strictures underwent three or more endoscopic dilations without stent placement. The cost ratio of endoscopic dilation to LAMS(stent, placement and retrieval) is 5.77. Cost effective analysis demonstrated LAMS to be economical after three endoscopic dilation overall.LAMS was cost effective after two dilations in the Postsurgical stricture subgroup. CONCLUSION Endoscopists should consider LAMS for the treatment of benign foregut strictures if symptoms persist past three endoscopic dilations. Post-surgical strictures may benefit from LAMS if symptoms persist after two dilations in a post-surgical. Early intervention with LAMS appears to be a clinically and economically viable option for durable symptomatic relief in patients with these strictures. | Alexander Hallac Wichit Srikureja Eashen Liu Parag Dhumal Ashish Thatte Nishant Puri | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，10： | 3 |
| 11 | CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers显示文摘Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation carriers.Methods We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the groups.Markers that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal PD.Results Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy controls.Assessing the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was generated.Conclusions The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal stage.Our findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD. | Nour K.Majbour Jan O.Aasly Eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit Mollenhauer Henk W.Berendse Omar M.A.El-Agnaf | 2020 | Translational Neurodegeneration2020，9，2： | 2 |
| 12 | Novel biomarkers and the future of targeted therapies in cholangiocarcinoma:a narrative review显示文摘Background and Objectives:Cholangiocarcinoma is a highly aggressive and heterogenous group of biliary malignancies arising from any site in the biliary tree,comprising 15%of all primary liver cancers.The nature of the disease and nonspecific presentation leads to late diagnosis and ultimately poor outcomes for patients.Combination gemcitabine and cisplatin has been the standard of care for cholangiocarcinoma(CCA)since 2010,with a median overall survival of 11.7 months.The five-year survival for CCA remains 5-10%,revealing a clear need for improved treatment options.Methods:This targeted review highlights the role of next generation sequencing in CCA and the clinically relevant tumor biomarkers that have become the focus of therapeutic development.Key Content and Findings:These tumor biomarkers or actionable mutations hold the potential to enable earlier diagnosis,provide prognostic information,and guide treatment decisions for patients with CCA.Specifically,the FGFR2 fusion and IDH1 mutation have shown considerable promise in development of targeted therapies.Clinical trials with inhibitors targeting FGFR2 fusion and IDH1 mutation have created expectations that these drugs will soon enter clinical practice.Other biomarkers including KRAS and B-raf protooncogenes,Her2/neu genes,and BRCA1 and 2 tumor-suppressor genes have also been touted as potential targets for future therapies,with early data showing promise for new drug development.Conclusions:The discovery of these actionable mutations and identification of targeted therapies have challenged the notion of a“one-size fits all”for treatment of CCA,and generated optimism that these novel treatments will soon be available for patients with CCA. | Nishant Munugala Shishir K.Maithel Rachna T.Shroff | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 2 |
| 13 | Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma显示文摘 | Tongsen Zheng Xuehui Hong Jiabei Wang Tiemin Pei Yingjian Liang Dalong Yin Ruipeng Song Xuan Song Zhaoyang Lu Shuyi Qi Jiaren Liu Boshi Sun Changming Xie Shangha Pan Yuejin Li Xiaohe Luo Shuai Li Xiang Fang Nishant Bhatta Hongchi Jiang Lianxin Liu | 2014 | Hepatology2014，，： | 2 |
| 14 | The Accountable Care Organization results:Population health management and quality improvement programs associated with increased quality of care and decreased utilization and cost of care显示文摘Objective:The Accountable Care Organization(ACO)model of health care delivery is based on new payment models for general practice to reward improved quality and decreased cost of care.Methods:Banner Health Network(BHN)is one of the original CMS Pioneer ACO programs and implemented a comprehensive disease management program based on the collaborative care model.Key performance indicators for CMS reflected quality and cost of care.Results:BHN has demonstrated both improved quality and cost savings in the first two years of the pilot program.The disease management program based on the collaborative care model appears to have improved patient health outcomes based on quality improvement measures.In addition the program has reduced emergency department and hospital utilization,resulting in cost savings.Conclusions:The BHN quality improvement program is the platform for analyzing and improving on the BHN ACO model.This model appears to have excellent application to the China health care system that is also focused on prevention and improvement of chronic disease and cost-effectiveness. | Ronald O’Donnell Nishant Shaun Anand Caroline Ganser Nancy Wexler | 2015 | Family Medicine and Community Health2015，3，1： | 2 |
| 15 | A :mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch re- pair and meiosis in Saccharomyces cerevisiae 显示文摘 | NISHANT K T PLYS A J ALANI E | 2008 | Genetics2008，179，2： | 1 |
| 16 | Microbial decolorization of reactive black-5 in a two-stage anaerobic-aerobic reactor using acclimatized activated textile sludge显示文摘 | Sagarika Mohanty Nishant Dafale Nageswara Neti Rao | 2006 | Biodegradation2006，17，5： | 1 |
| 17 | Biodegradability enhancement of purified terephthalie acid wastewater by eoagulation-floeculation process as pretreatment 显示文摘 | Manikavasagam Karthik Nishant Dafale Pradyumna Pathe | 2008 | Journal of Hazardous Materials2008，154，： | 1 |
| 18 | Mathematical modeling of electric discharge machining of cast A1-4Cu-6Si alloy-10 wt% SiCP composites显示文摘 | Sushant D Rajesh P Nishant S | 2007 | Journal of Materials Processing Technology2007，194，： | 1 |
| 19 | Material cyborgs; asserted boundaries显示文摘 | Nishant Shah | | 0，，02： | 1 |
| 20 | A novel approach for management of ear keloids: Results of excision combined with 5-fluorouracil injeetion显示文摘 | Nishant K Surendra B | 2012 | Reconstructive & Aesthetic Surgery2012，65，： | 1 |
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