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| 1 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 2 | Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction显示文摘 | Kwiecinski M Noetel A Elfimova N | 2011 | PLoS One2011，6，24： | 1 |
| 3 | Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate cells by miRNA-29 induction显示文摘 | Kwieeinski M Noetel A Elfimova N | 2011 | PloS one2011，6，24： | 1 |
| 4 | Next generation sequencing of the Ago2 interacting transcriptome identified ehemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells 显示文摘 | Noetel A Elfimova N Ahmuller J | 2013 | J Hepatol2013，58，2： | 1 |
| 5 | Hepatocyte growth factor (HGF) inhibits collagen I and IV synthesis in hepatic stellate ceils by miRNA-29 induction 显示文摘 | Kwiecinski M Noetel A Elfimova N | 2011 | PLoS One2011，6，24： | 1 |
| 6 | Expression of platelet-derived growth factor-C and insulin-like growth factorⅠin hepatic stellate cells is inhibited by miR-29显示文摘 | Kwiecinski M Elfimova N Noetel A Tx U Steffen HM Hacker U | 2012 | Lab Invest2012，92，7： | 1 |
| 7 | Expression ofplatelet-derived growth factor-C and insulin-like growth factor I inhepatic stellate cells is inhibited by miR-29显示文摘 | Kwiecinski M Elfimova N Noetel A | 2012 | Lab Invest2012，92，7： | 1 |
| 8 | Hepatocyte growth factor (HGF) inhibits collage I and 1V synthesis in hepatic stellate cells by miRNA-29 induction 显示文摘 | Kwiecinski M Noetel A Elfimova N | 2011 | PLoS One2011，6，24： | 1 |
| 9 | Mir-29,inhibiting synthesis of profibrogenic mediators,is released into the blood stream after chronic hepatitis C infection,indicating progression of fibrosis(2010)显示文摘 | Kwiecinski M Elfimova N Noetel A Schievenbusch S Strack I Toex U | 2010 | Hepatology2010，52，4： | 1 |
| 10 | Hepatocyte growth factor(HGF)inhibits collagenⅠandⅣsynthesis in hepatic stellate cells by miRNA-29induction显示文摘 | Kwiecinski M Noetel A Elfimova N Trebicka J Schievenbusch S Strack I | 2011 | PLo S One2011，6，24： | 1 |
| 11 | Next generation sequencing of the Ago2 interacting transcriptome identified chemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells显示文摘 | Andrea Noetel Natalia Elfimova Janine Altmüller Christian Becker Diana Becker Wolfgang Lahr Peter Nürnberg Hermann Wasmuth Andreas Teufel Reinhard Büttner Hans Peter Dienes Margarete Odenthal | 2012 | Journal of Hepatology2012，，： | 1 |
| 12 | microRNA are central players in antiand profibrotic gene regulation during liver fibrosis显示文摘 | Noetel A Kwiecinski M Elfimova N Huang J Odenthal M | 2012 | Front Physiol2012，3，： | 1 |
| 13 | Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29显示文摘 | Kwiecinski M Elfimova N Noetel A | 2012 | Lab Invest2012，92，： | 1 |
| 14 | Next generation sequencing of the Ago2 interacting transeriptome identified ehemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells 显示文摘 | Noetel A Elfimova N Altmuller J | 2013 | J Hepatol2013，58，2： | 1 |
| 15 | microRNA are Central Players in Anti-and Profibrotic Gene Regula- tion during Liver Fibrosis 显示文摘 | Noetel A Kwiecinski M Elfimova N | 2012 | Front Physiol2012，3，： | 1 |
| 16 | Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29 显示文摘 | Kwiecinski M Elfimova N Noetel A | 2012 | Lab In- vest2012，92，： | 1 |
| 17 | Expression of platelet-derived growth factor-Cand insulin-like growth factor I in hepatic stellate cell is inhibited by miR-29 显示文摘 | Kwiecinski M Elfimova N Noetel A | 2012 | Lab Invest2012，92，7： | 1 |
| 18 | microRNA are central players in anti- and profihrotie gene regulation during liver fibrosis显示文摘 | Noetel A Kwiecinski M Elfimova N | 2012 | Front Physiol2012，3，49： | 1 |
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