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您的检索式：作者名="Noo Li Jeon"
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| 1 | Biological applica- tions of microfluidic gradient devices 显示文摘 | Sudong Kim Hyung Joon Kim Noo Li Jeon | 2010 | Integrative Biology2010，2，1112： | 1 |
| 2 | U-IMPACT:a universal 3D microfluidic cell culture platform显示文摘The development of organs-on-a-chip has resulted in advances in the reconstruction of 3D cellular microenvironments.However,there remain limitations regarding applicability and manufacturability.Here,we present an injection-molded plastic array 3D universal culture platform(U-IMPACT)for various biological applications in a single platform,such as cocultures of various cell types,and spheroids(e.g.,tumor spheroids,neurospheres)and tissues(e.g.,microvessels).The U-IMPACT consists of three channels and a spheroid zone with a 96-well plate form factor.Specifically,organoids or spheroids(~500μm)can be located in designated areas,while cell suspensions or cellladen hydrogels can be selectively placed in three channels.For stable multichannel patterning,we developed a new patterning method based on capillary action,utilizing capillary channels and the native contact angle of the materials without any modification.We derived the optimal material hydrophilicity(contact angle of the body,45–90°;substrate,<30°)for robust patterning through experiments and theoretical calculations.We demonstrated that the U-IMPACT can implement 3D tumor microenvironments for angiogenesis,vascularization,and tumor cell migration.Furthermore,we cultured neurospheres from induced neural stem cells.The U-IMPACT can serve as a multifunctional organ-on-achip platform for high-content and high-throughput screening. | Seung-Ryeol Lee Youngtaek Kim Suryong Kim Jiho Kim Seonghyuk Park Stephen Rhee Dohyun Park Byungjun Lee Kyusuk Baek Ho-Young Kim Noo Li Jeon | 2022 | Microsystems & Nanoengineering2022，8，6： | 0 |
| 3 | Design rules for a tunable merged-tip microneedle显示文摘This publication proposes the use of an elasto-capillarity-driven self-assembly for fabricating a microscale merged-tip structure out of a variety of biocompatible UV-curable polymers for use as a microneedle platform.In addition,the novel merged-tip microstructure constitutes a new class of microneedles,which incorporates the convergence of biocompatible polymer micropillars,leading to the formation of a sharp tip and an open cavity capable of both liquid trapping and volume control.When combined with biocompatible photopolymer micropillar arrays fabricated with photolithography,elasto-capillarity-driven self-assembly provides a means for producing a complex microneedle-like structure without the use of micromolding or micromachining.This publication also explores and defines the design rules by which several fabrication aspects,such as micropillar dimensions,shapes,pattern array configurations,and materials,can be manipulated to produce a customizable microneedle array with controllable cavity volumes,fracture points,and merge profiles.In addition,the incorporation of a modular through-hole micropore membrane base was also investigated as a method for constitutive payload delivery and fluid-sampling functionalities.The flexibility and fabrication simplicity of the merged-tip microneedle platform holds promise in transdermal drug delivery applications. | Jungeun Lim Dongha Tahk James Yu Dal-Hee Min Noo Li Jeon | 2018 | Microsystems & Nanoengineering2018，4，1： | 0 |
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