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| 1 | Controversies regarding and perspectives on clinical utility of biomarkers in hepatocellular carcinoma显示文摘The prevalence of hepatocellular carcinoma(HCC)worldwide parallels that of persistent infection with the hepatitis B virus(HBV)and/or hepatitis C virus(HCV).According to recommendations by the World Health Organization guidelines for HBV/HCV,alpha-fetoprotein(AFP)testing and abdominal ultrasound should be performed in routine surveillance of HCC every 6 mo for high-risk patients.These examinations have also been recommended worldwide by many other HCC guidelines over the past few decades.In recent years,however,the role of AFP in HCC surveillance and diagnosis has diminished due to advances in imaging modalities.AFP was excluded from the surveillance and/or diagnostic criteria in the HCC guidelines published by the American Association for the Study of Liver Diseases in 2010,the European Association for the Study of the Liver in 2012,and the National Comprehensive Cancer Network in 2014.Other biomarkers,including the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),des-γ-carboxyprothrombin,Dickkopf-1,midkine,and micro RNA,are being studied in this regard.Furthermore,increasing attention has focused on the clinical utility of biomarkers as pre-treatment predictors for tumor recurrence and as post-treatment monitors.Serum and tissue-based biomarkers and genomics may aid in the diagnosis of HCC,determination of patient prognosis,and selection of appropriate treatment.However,further studies are needed to better characterize the accuracy and potential role of these approaches in clinical practice. | Pei-Pei Song Ju-Feng Xia Yoshinori Inagaki Kiyoshi Hasegawa Yoshihiro Sakamoto Norihiro Kokudo Wei Tang | 2016 | World Journal of Gastroenterology2016，22，1： | 15 |
| 2 | KL-6 mucin expression in carcinoma of the ampulla of Vater: Association with cancer progression显示文摘AIM: To assess histochemical expression of KL-6 and its clinicopathological significance in carcinoma of the ampulla of Vater.METHODS: Ampullary carcinoma tissues were collected from 38 patients who underwent pancreatoduodenectomy or local resection. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.RESULTS: Positive staining of ampullary carcinoma cells was observed in 26 (68.4%) cases. Staining was not found in the surrounding non-cancer regions of the ampullary tissues. Remarkable KL-6 expression was observed in invasive carcinoma cells in pancreatic and duodenal tissues and in metastatic carcinoma cells in lymph nodes. Positive KL-6 expression was related to lymph node metastasis (P = 0.020), pancreatic invasion (P = 0.016), duodenal invasion (P = 0.034), and advanced stage of TNM clinical classification (P = 0.010). Survival analysis showed that positive expression of KL-6 was related to a poorer prognosis (P = 0.029).CONCLUSION: The aberrant expression of KL-6 mucin is significantly related to unfavorable behaviors of carcinoma of the ampulla of Vater. | Wei Tang Yoshinori Inagaki Norihiro Kokudo Qian Guo Yasuji Seyama Munehiro Nakata Hiroshi Imamura Keiji Sano Yasuhiko Sugawara Masatoshi Makuuchi | 2005 | World Journal of Gastroenterology2005，11，35： | 10 |
| 3 | Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer显示文摘Aberrant expression of glycoconjugates occurs during malignant transformation of cancer cells.Overexpression of sialoglycoconjugates in particular may play an important role in the progression,i.e.,invasion or metastasis,of cancer.Various types of sialoglycoconjugates have been investigated to clarify their biological significance and clinical utility in diagnosing and treating colorectal cancer.This review focuses specifically on expression of mucin(MUC)1 and it suggests that MUC1with the specific structure of a sialo-oligosaccharide has biological significance in determining the metastatic potential of colorectal cancer cells and clinicopathological utility in evaluating the effectiveness of treatments and the prognosis for patients with colorectal cancer.Further studies are expected to contribute to the expanded use of cancer-associated sialoglycoconjugates in cancer diagnosis and therapy. | Yoshinori Inagaki Jianjun Gao Peipei Song Norihiro Kokudo Munehiro Nakata Wei Tang | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 4 | Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues显示文摘瞄准:估计在颜色代替 KL-6 粘蛋白和它的 clinicopathological 意义的细胞的本地化表面的癌以及变形淋巴节点和肝纸巾。方法:Colorectal 癌纸巾和肝纸巾从经历了 colorectomy 或肝切除术的 82 个病人被收集。纸巾受到免疫组织化学的分析使用 KL-6 抗体。结果:82 颜色表面的癌病人, 6 没显示出染色, 29 显示出仅仅在顶端的膜的积极染色,并且 47 显示出在环绕的膜或细胞质的积极染色。积极染色没在非癌的颜色被观察包围肿瘤纸巾的表面的上皮细胞。五年的幸存率在显示出比显示出仅仅在顶端的膜(85.7%) 的积极染色的那些和不显示出染色的那些(100%) 的在环绕的膜或细胞质(63.0%) 的积极染色的情况中是显著地更低的。在 KL-6 粘蛋白的细胞的本地化在环绕的膜或细胞质看了那 KL-6 本地化的 clinicopathological 因素和代用品之间的统计分析显著地与静脉的侵略的存在被联系( P = 0.0003 ),淋巴的侵略( P<0.0001 ),淋巴节点转移( P<0.0001 ),肝转移( P = 0.058 ),并且先进组织学的舞台( P<0.0001 )。积极染色在测试的所有变形损害以及在三原色被观察表面的癌纸巾。结论:潜水艇在颜色的 KL-6 的细胞的染色模式表面的腺癌可以是为象淋巴节点和肝转移那样的相反的行为,以及为病人的预后的重要指示物。 | Qian Guo Wei Tang Yoshinori Inagaki Yutaka Midorikawa Norihiro Kokudo Yasuhiko Sugawara MunehiroNakata Toshiro Konishi Hirokazu Nagawa Masatoshi Makuuchi | 2006 | World Journal of Gastroenterology2006，12，1： | 5 |
| 5 | Added value of indocyanine green fluorescence imaging in liver surgery显示文摘Recently,indocyanine green(ICG)fluorescence imaging has been widely used as a substitute for cholangiography in hepatobiliary surgery,to detect hepatic tumors,for accurate anatomical hepatectomy,and to increase the safety and accuracy of minimally invasive(laparoscopic and robotic)hepatectomy.The clinical relevance of this method has been increasing gradually,as new procedures develop in this field.Various important roles and the latest added value of ICG fluorescence imaging in liver surgery are discussed in this report. | Nobuyuki Takemura Kyoji Ito Fuyuki Inagaki Fuminori Mihara Norihiro Kokudo | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，4： | 2 |
| 6 | Expression of KL-6/MUC1 in pancreatic cancer tissues and its potentialinvolvement in tumor metastasis显示文摘 | Huanli Xu Yoshinori Inagaki Yasuji Seyama Guanhua Du Fengshan Wang Norihiro Kokudo Wei Tang | 2011 | Oncology Reports2011，，2： | 2 |
| 7 | Role of polymer chain end groups in plasma modification for surfacemetallization of polymeric- materials显示文摘 | Norihiro Inagaki | 2009 | Polym Int2009，58，6： | 1 |
| 8 | Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma显示文摘 | Jianjun Gao Yoshinori Inagaki Peipei Song Xianjun Qu Norihiro Kokudo Wei Tang | 2011 | Pharmacological Research2011，，1： | 1 |
| 9 | Surface Characterization of Plasma-Modified Poly (ethylene terephthalate) Film Surfaces 显示文摘 | Norihiro Inagaki Kazuo Narushim Norio Tuchida Kohji Miyazaki | 2004 | Journal of Polymer Science: Part B: Polymer Physics2004，42，： | 1 |
| 10 | Flameretardant effect of tris(2,3-dibromopropyl) phosphate on polystyrene 显示文摘 | Norihiro Inagaki Shiro Sakurai Kakuji Katsuura | 1979 | Journal of Applied Polymer Science1979，，23： | 1 |
| 11 | Des-γ-carboxyl prothrombin induces matrix metalloproteinase activity in hepatocellular carcinoma cells by involving the ERK1/2 MAPK signalling pathway显示文摘 | Pan Yue Zu-Hua Gao Xia Xue Shu-Xiang Cui Cui-Rong Zhao Yi Yuan Zhe Yin Yoshinori Inagaki Norihiro Kokudo Wei Tang Xian-Jun Qu | 2011 | European Journal of Cancer2011，，7： | 1 |
| 12 | Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor显示文摘 | Fanghua Qi Anyuan Li Yoshinori Inagaki Norihiro Kokudo Sumihito Tamura Munehiro Nakata Wei Tang | 2010 | International Immunopharmacology2010，，3： | 1 |
| 13 | Positive KL-6 mucin expression combined with decreased membranous β-cateninexpression indicates worse prognosis in colorectal carcinoma显示文摘 | Wei Zhang Wei Tang Yoshinori Inagaki Ming Qiu Huan-Li Xu Xun Li Yasuhiko Sugawara Hirokazu Nagawa Munehiro Nakata Norihiro Kokudo | 2008 | Oncology Reports2008，，5： | 1 |
| 14 | Subcellular localization of KL-6 mucin in colorectal carcinoma celllines: Association with metastatic potential and cell morphology显示文摘 | Qian Guo Wei Tang Yoshinori Inagaki Norihiro Kokudo Yasuhiko Sugawara Hirona Karako Munehiro Nakata Masatoshi Makuuchi | 2007 | Oncology Reports2007，，5： | 1 |
| 15 | Surface Modification of Polymeric Materials by Remote Plasma显示文摘 | Inagaki Norihiro | | 0，，： | 1 |
| 16 | The management of hepatocellular carcinoma around the world: a comparison of guidelines from 2001 to 2011显示文摘 | Peipei Song Ruoyan G. Tobe Yoshinori Inagaki Norihiro Kokudo Kiyoshi Hasegawa Yasuhiko Sugawara Wei Tang | 2012 | Liver Int2012，，7： | 1 |
| 17 | New ‘multi-omics' approach and its contribution to hepatocellular carcinoma in China显示文摘Hepatocellular carcinoma(HCC)is one of the most common liver neoplasms worldwide,and 70-80%cases are accounted in Asian countries(1).Etiological background of HCC patients is different in each country or area.In China, | Yoshinori Inagaki Peipei Song Norihiro Kokudo Wei Tang | 2014 | Chinese Journal of Cancer Research2014，26，6： | 1 |
| 18 | Role of polymer chain end groups in plasma modification for surfacemetallization of polymericmaterials 显示文摘 | Norihiro Inagaki | 2009 | Polym Int2009，58，6： | 1 |
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