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| 1 | Surveillance of Mycoplasma pneumoniae infection among children in Beijing from 2007 to 2012显示文摘 | Zhao Hanqing Li Shaoli Cao Ling Yuan Yi Xue Guanhua Feng Yanling Yan Chao Wang Liqiong Fan Zhaoyang Sun Hongmei | 2014 | Chinese Medical Journal2014，，7： | 61 |
| 2 | The adsorption behavior of metals in aqueous solution by microplastics effected by UV radiation显示文摘Microplastics are considered as the carrier to heavy metals in the environment.But the sorption ability of microplastics influenced by photo-aging is remaining unclear.In the present study,the sorption of two kinds of metal ions(Cu^2+ and Zn^2+)in the aqueous solution by both the virgin and aged microplastics was investigated.Polyethylene terephthalate(PET)debris,one of the typical kinds of microplastics was chosen in this study.Photo-aging of microplastics in environment was simulated using UV radiation in the laboratory.Date analysis indicated that the aged microplastics had higher adsorption capacity of heavy metals than original ones.This could be related to the increased surface area and oxygen containing function appeared in the surface of aged microplastics after UV radiation.When prolonging the time of radiation,the enhanced adsorption capacities of microplastics appeared for Cu^2+ and Zn^2+.These results showed a great interaction between the aging degree of plastics and sorption capacity to heavy metals.Meanwhile,external conditions including temperature and pH value were also showed great influence to the adsorption behavior. | Qiongjie Wang Yong Zhang Xiaoxue Wangjin Yulai Wang Guanhua Meng Yihua Chen | 2020 | Journal of Environmental Sciences2020，32，1： | 47 |
| 3 | Blue carbon on the rise:challenges and opportunities显示文摘BLUE CARBON ON THE RISE Climate change is a global concem that requires urgent solutions.As a signatory to the Paris Agreement,China has committed to have its greenhouse gas emission reach a peak by the year 2030,which means that severe countermeasures for reducing emissions have to be put into practice.This is a hard mission given that development is still the top priority in the years to come for China.Under such circumstances,enhancing carbon sequestration becomes an effective approach to achieving the goal.While terrestrial green carbon sink is already in practice,the ocean carbon reservoir,containing 93%of global CO2,as 50 and 20 times the carbon inventories of atmosphere and land,respectively,has great potential to expand.Each year,at least 25% of the anthropogenic CO2 has been captured by marine ecosystems as blue carbon [1]. | Nianzhi Jiao Hong Wang Guanhua Xu Salvatore Aricò | 2018 | National Science Review2018，5，4： | 25 |
| 4 | Inhibition of FOXO3a/BIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemia/reperfusion injury显示文摘Salvianolic acid A(SalA) is an effective compound extracted from traditional Chinese medicine Salvia miltiorrhiza Bunge. The Forkhead box O3a(FOXO3a) signaling pathway plays crucial roles in the modulation of ischemia-induced cell apoptosis. However, no information about the regulatory effect of SalA on FoxO3a is available. To explore the anti-cerebral ischemia effect and clarify the therapeutic mechanism of SalA, SH-SY5Y cells and Sprague–Dawley rats were applied, which were exposed to oxygen glucose deprivation/reoxygenation(OGD/R) and middle cerebral artery occlusion/reperfusion(MCAO/R) injuries, respectively. The involved pathway was identified using the specific inhibitor LY294002. Results showed that SalA concentration-dependently inhibited OGD/R injury triggered cell viability loss. SalA reduced cerebral infarction, lowered brain edema, improved neurological function, and inhibited neuron apoptosis in MCAO/R rats, which were attenuated by the treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase(PI3K) specific inhibitor LY294002. SalA time-and concentration-dependently upregulated the phosphorylation levels of protein kinase B(AKT) and its downstream protein FOXO3a. Moreover, the nuclear translocation of FOXO3a was inhibited by SalA both in vivo and in vitro, which was also reversed by LY294002. The above results indicated that SalA fought against ischemia/reperfusion damage at least partially via the AKT/FOXO3a/BIM pathway. | Junke Song Wen Zhang Jinhua Wang Haiguang Yang Qimeng Zhou Haigang Wang Li Li Guanhua Du | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 20 |
| 5 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 6 | Societal response to challenges of global change and human sustainable development显示文摘It is now widely accepted that carbon emission from human activities is an important driving force in global warming, and global change has a deep impact on sustainable development of human society. To meet the challenges of global change, the international community has reached a consensus that developed countries take strict actions in emission reduction, whereas developing countries take spontaneous efforts in reducing emissions under the guiding principle of common but differentiated responsibilities, with an agreed goal to restrict global surface temperature increase due to human activities to within 2℃ of pre-industrial levels. However, there is no clear pathway to reach this goal. A number of related questions must be addressed on principles to be followed, research emphasis and policy measures. Here we argue that response policies to address global change issues must be based on balanced development at regional and international levels, and on advancements in science and technology. This requires consideration of harmony not only between humans and nature but also within human societies, to properly deal with the relationship between global change and sustainable development. We must make equal efforts toward carbon emission reduction and carbon sequestration, and toward mitigation and adaptation. There should be more research support to reduce uncertainties in our understanding of global change. Addressing the challenges of global change creates great opportunities for the development of human society. This will facilitate transformation of energy use structure, improve and restore ecological functioning of the earth environment, transform production modes and ways of living in human society, and promote harmonic and balanced development at regional and international levels. | XU GuanHua GE QuanSheng GONG Peng FANG XiuQi CHENG BangBo HE Bin LUO Yong XU Bing | 2013 | Chinese Science Bulletin2013，58，25： | 15 |
| 7 | Pollution characteristics of atmospheric dustfall and heavy metals in a typical inland heavy industry city in China显示文摘Through field sampling of atmospheric dustfall in regions of Zhuzhou City, China for a period of one year, the deposition fluxes of atmospheric dustfall and five heavy metals contained inside, including Cr, As, Cd, Hg and Pb, were analyzed. Meanwhile the enrichment factor and index methods were used to analyze the pollution characteristics of heavy metals of atmospheric dustfall in Zhuzhou. The annual deposition flux of atmospheric dustfall in Zhuzhou was 50.79 g/(m^2·year), while the annual deposition fluxes of Cr, As, Cd, Hg and Pb were 9.80, 59.69, 140.09, 0.87 and 1074.91 mg/(m^2·year), respectively.The pollution level of atmospheric dustfall in Zhuzhou was relatively lower compared with most other cities in China, but the deposition fluxes of As, Cd, Hg and Pb in atmospheric dustfall in Zhuzhou were much higher than that in most cities and regions around the world. Cd is the typical heavy metal element in atmospheric dustfall in Zhuzhou, and both the enrichment factor and pollution index of Cd were the highest. Cd, Hg, Pb and As in atmospheric dustfall were mainly from human activities. According to the single-factor index, Nemerow index and pollution load index analyses, the atmospheric dustfall in Zhuzhou could easily cause severe heavy metal pollution to urban soil, and the most polluting element was Cd, followed by Pb, As and Hg. Only the pollution level of Cr lay in the safety region and mainly originated from natural sources. | Jinhe Wang Xi Zhang Qing Yang Kai Zhang Yue Zheng Guanhua Zhou | 2018 | Journal of Environmental Sciences2018，30，9： | 14 |
| 8 | Variable frequency of pulse hydraulic fracturing for improving permeability in coal seam显示文摘Variable frequency,a new pattern of pulse hydraulic fracturing,is presented for improving permeability in coal seam.A variable frequency pulse hydraulic fracturing testing system was built,the mould with triaxial loading was developed.Based on the monitor methods of pressure sensor and acoustic emission,the trials of two patterns of pulse hydraulic fracturing of single frequency and variable frequency were carried out,and at last fracturing mechanism was analyzed.The results show that the effect of variable frequency on fracture extension is better than that of single frequency based on the analysis of macroscopic figures and AE.And the shortage of single frequency is somewhat remedied when the frequency is variable.Under variable frequency,the pressure process can be divided into three stages:low frequency band,pressure stability band and high frequency band,and rupture pressure of the sample is smaller than that of the condition of single frequency.Based on the Miner fatigue theory,the effect of different loading sequences on sample rupture is discussed and the results show that it is better to select the sequence of low frequency at first and then high frequency.Our achievements can give a basis for the improvement and optimization of the pulse hydraulic fracturing technology. | Li Quangui Lin Baiquan Zhai Cheng Ni Guanhua Peng Shen Sun Chen Cheng Yanying | 2013 | International Journal of Mining Science and Technology2013，23，6： | 12 |
| 9 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 10 | Quantitative estimation of climate change effects on potential evapotranspiration in Beijing during 1951-2010显示文摘Climate change is likely to affect hydrological cycle through precipitation,evapotranspiration,soil moisture etc.In the present study,an attempt has been made to study the climate change and the sensitivity of estimated evapotranspiration to each climatic variable for a semi-arid region of Beijing in North China using data set from 1951 to 2010.Penman-Monteith method was used to calculate reference crop evapotranspiration(ETo).Changes of ETo to each climatic variable was estimated using a sensitivity analysis method proposed in this study.Results show that in the past 60 years,mean temperature and vapor pressure deficit(VPD) were significantly increasing,relative humidity and sunshine hours were significantly decreasing,and wind speed greatly oscillated without a significant trend.Total precipitation was significantly decreasing in corn season(from June to September),but it was increasing in wheat season(from October to next May).The change rates of temperature,relative humidity,VPD,wind speed,annual total precipitation,sunshine hours and solar radiation were 0.42℃,1.47%,0.04 kPa,0.05 m·s–1,25.0 mm,74.0 hours and 90.7 MJ·m–2per decade,respectively.In the past 60 years,yearly ETo was increasing with a rate of 19.5 mm per decade,and total ETos in wheat and corn seasons were increasing with rates of 13.1 and 5.3 mm per decade,respectively.Sensitivity analysis showed that mean air temperature was the first key factor for ETo change in the past 60 years,causing an annual total ETo increase of 7.4%,followed by relative humidity(5.5%) and sunshine hours(–3.1%);the less sensitivity factors were wind speed(0.7%),minimum temperature(–0.3%) and maximum temperature(–0.2%).A greater reduction of total ETo(12.3%) in the past 60 years was found in wheat season,mainly because of mean temperature(8.6%) and relative humidity(5.4%),as compared to a reduction of 6.0% in ETo during corn season due to sunshine hours(–6.9%),relative humidity(4.7%) and temperature(4.5%).Increasing precipitation in the wheat season will improve crop growth,while decreasing precipitation and increasing ETo in the corn season induces a great pressure for local government and farmers to use water more efficiently by widely adopting water-saving technologies in the future. | LIU Haijun LI Yan JOSEF Tanny ZHANG Ruihao HUANG Guanhua | 2014 | Journal of Geographical Sciences2014，24，1： | 10 |
| 11 | Influence of vegetation parameters on runoff and sediment characteristics in patterned Artemisia capillaris plots显示文摘Vegetation patterns are important in the regulation of earth surface hydrological processes in arid and semi-arid areas. Laboratory-simulated rainfall experiments were used at the State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau, Yangling, northwestern China, to quantify the effects of Artemisia capillaris patterns on runoff and soil loss. The quantitative relationships between runoff/sediment yield and vegeta- tion parameters were also thoroughly analyzed using the path analysis method for identifying the reduction mechanism of vegetation on soil erosion. A simulated rainfall intensity of 90 mm/h was applied on a control plot without vegetation(C0) and on the other three different vegetation distribution patterns: a checkerboard pattern(CP), a banded pattern perpendicular to the slope direction(BP), and a single long strip parallel to the slope direction(LP). Each patterned plot received two sets of experiments, i.e. intact plants and roots only, respectively. All treatments had three replicates. The results showed that all the three other different patterns(CP, BP and LP) of A. capillaris could effectively reduce the runoff and sediment yield. Compared with C0, the other three intact plant plots had a 12%–25% less runoff and 58%–92% less sediment. Roots contributed more to sediment reduction(46%–70%), whereas shoots contributed more to runoff reduction(57%–81%). BP and CP exhibited preferable controlling effects on soil erosion compared with LP. Path analysis indicated that root length density and plant number were key pa- rameters influencing runoff rate, while root surface area density and root weight density were central indicators affecting sediment rate. The results indicated that an appropriate increase of sowing density has practical signifi- cance in conserving soil and water. | GuanHua ZHANG GuoBin LIU PingCang ZHANG Liang YI | 2014 | Journal of Arid Land2014，6，3： | 10 |
| 12 | Review of small aspheric glass lens molding technologies显示文摘 | Shaohui YIN Hongpeng JIA Guanhua ZHANG Fengjun CHEN Kejun ZHU | 2017 | Frontiers of Mechanical Engineering2017，12，1： | 9 |
| 13 | Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice显示文摘A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase(XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the underlying mechanisms. Mice were orally administered 600 mg/kg xanthine once daily for 7 days and intraperitoneally injected 250 mg/kg oxonic acid on the 7 th day to induce hyperuricemia. Meanwhile, J99745(3, 10, and 30 mg/kg), allopurinol(20 mg/kg) or benzbromarone(20 mg/kg) were orally administered to mice for 7 days. On the 7 th day,uric acid and creatinine in serum and urine, blood urea nitrogen(BUN), malondialdehyde(MDA) content and XOD activities in serum and liver were determined. Morphological changes in kidney were observed using hematoxylin and eosin(H&E) staining. Hepatic XOD, renal urate transporter 1(URAT1), glucose transporter type 9(GLUT9), organic anion transporter 1(OAT1) and ATP-binding cassette transporter G2(ABCG2) were detected by Western blot and real time polymerase chain reaction(PCR). The results showed that J99745 at doses of 10 and 30 mg/kg significantly reduced serum urate, and enhanced fractional excretion of uric acid(FEUA). H&E staining confirmed that J99745 provided greater nephroprotective effects than allopurinol and benzbromarone. Moreover, serum and hepatic XOD activities and renal URAT1 expression declined in J99745-treated hyperuricemia mice. In consistence with the ability to inhibit XOD, J99745 lowered serum MDA content in hyperuricemia mice. Our resultssuggest that J99745 exerts urate-lowering effect by inhibiting XOD activity and URAT1 expression, thus representing a promising candidate as an anti-hyperuricemia agent. | Zhizhen Qin Shoubao Wang Yihuang Lin Ying Zhao Shengqian Yang Junke Song Tao Xie Jinlong Tian Song Wu Guanhua Du | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 9 |
| 14 | The Blue-Light Receptor CRY1 Interacts with BZR1 and BIN2 to Modulate the Phosphorylation and Nuclear Function of BZR1 in Repressing BR Signaling in Arabidopsis显示文摘The blue-light receptor cryptochrome 1(CRY1)primarily mediates blue-light inhibition of hypocotyl elongation in Arabidopsis.However,the underlying mechanisms remain largely elusive.We report here that CRY1 inhibits hypocotyl elongation by repressing brassinosteroid(BR)signaling.A genetic interaction assay reveals the negative regulatory effect of CRY1 on the function of BZR1,a core transcription factor in the BR signaling pathway.We demonstrated that CRY1 interacts with the DNA-binding domain of BZR1 to interfere with the DNA-binding ability of BZR1,and represses its transcriptional activity.Furthermore,we found that CRY1 promotes the phosphorylation of BZR1 and inhibits the nuclear accumulation of BZR1.Interestingly,we discovered that CRY1 interacts with the GSK3-like kinase BIN2 and enhances the interaction of BIN2 and BZR1 in a light-dependent manner.Our findings revealed that CRY1 negatively regulates the function of BZR1 through at least two mechanisms:interfering with the DNA-binding ability of BZR1 and promoting the phosphorylation of BZR1.Therefore,we uncover a novel CRY1-BIN2-BZR1 regulatory module that mediates crosstalk between blue light and BR signaling to coordinate plant growth in Arabidopsis. | Guanhua He Jie Liu Huixue Dong Jiaqiang Sun | 2019 | Molecular Plant2019，12，5： | 8 |
| 15 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 16 | Experimental investigation on static/dynamic characteristics of a fast-response pressure sensitive paint显示文摘An optical-based technique using Pressure-Sensitive Paint(PSP) is a promising method to measure the distribution of surface pressure on an aerodynamic model. The static and dynamic characteristics of a fast-response PSP that is developed in the Chinese Academy of Sciences(CAS)are analyzed and tested to serve as the basis for experiments on unsteady surface measurement using a fast-response PSP. Two calibration systems used for this study are set up to investigate the temperature dependency, response time, and resolution. A data processing method, used for dynamic data, is analyzed and selected carefully to determine the optimum signal. Results show that the fastresponse PSP can be used normally at temperatures from 25 ℃ to 80 ℃. The effect of temperature on the accuracy of the measurement must be considered when temperatures are beyond the temperature range of 30–40 ℃. The dynamic calibration device with a solenoid valve can achieve a pressure jump within a millisecond order. The resolution is determined by the signal-to-noise ratio of the photo-multiplier tube. Results of the measurement show that the response time of the PSP decreases with a large pressure variation, and the response time is below 0.016 s when the pressure variation is under 40 kPa. | Ruiyu LI Limin GAO Tianlong ZHENG Guanhua YANG | 2018 | Chinese Journal of Aeronautics2018，31，6： | 8 |
| 17 | Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice显示文摘The purpose of this study was to investigate the effects of salvianolic acid A(SAA) in systemic lupus erythematosus(SLE) induced by pristane in BALB/c mice.Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after intraperitoneal injection of pristane.Mice were then treated with daily oral doses of SAA for 5 months in parallel with mice treated with prednisone and aspirin as positive controls.The levels of autoantibodies were monitored at monthly intervals and nephritic symptoms observed by hematoxylin and eosin(H&E) and periodic acid-Schiff(PAS) staining.Western blot analysis of renal tissue was also employed.SAA treatment caused a significant reduction in the levels of anti-Sm autoantibodies and reduced renal histopathological changes and pathological effects.SAA treatment also significantly inhibited the phosphorylation of IKK,IκB and NFκB in renal tissues of lupus mice.In conclusion,the results suggest that SAA alleviates renal injury in pristane-induced SLE in BALB/c mice through inhibition of phosphorylation of IKK,IκB and NFκB. | Yihuang Lin Yu Yan Huifang Zhang Yucai Chen Yangyang He Shoubao Wang Lianhua Fang Yang Lv Guanhua Du | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 8 |
| 18 | Effect of Water Level Fluctuations on Wintering Goose Abundance in Poyang Lake Wetlands of China显示文摘The Poyang Lake is a Ramsar site and is the important over-wintering site for migratory waterbirds along the East Asian–Australasian Fly way. Examining the effects of water level fluctuations on waterbird abundance and analyzing the influencing mechanism is critical to waterbird protection in the context of hydrological alteration. In this study, the effect of water level regime on wintering goose abundance was examined and the influencing mechanism was interpreted. Synchronous waterbirds survey data, hydrological data, Moderate Resolution Imaging Spectroradiometer-Normalized Difference Vegetation Index(MODIS-NDVI) data and habitat data derived from Landsat TM/ETM data and HJ/CCD data were combined. The satellite-derived Green Wave Index(GWI) based on MODIS-NDVI dataset was applied to detect changes in goose food resources. It was found that habitat size and vegetation conditions are key factors determining goose abundance. Geese numbers were positively correlated with habitat area, while intermediate range of vegetation productivity might benefit the goose abundance. Water level affects goose abundance by changing available habitat areas and vegetation conditions. We suggested that matching hydrological regime and exposed meadows time to wintering geese dynamics was crucial in the Poyang Lake wetlands. Our study could provide sound scientific information for hydrological management in the context of waterbird conservation. | XIA Shaoxia LIU Yu CHEN Bin JIA Yifei ZHANG Huan LIU Guanhua YU Xiubo | 2017 | Chinese Geographical Science2017，27，2： | 8 |
| 19 | Drug screening for influenza neuraminidase inhibitors显示文摘Neuraminidase (NA) is one of the most important targets to screen the drugs of anti-influenza virus A and B. After virtual screening approaches were applied to a compound database which possesses more than 10000 compound structures, 160 compounds were selected for bioactivity assay, then a High Throughput Screening (HTS) model established for influenza virus NA inhibitors was applied to detect these compounds. Finally, three compounds among them displayed higher inhibitory activities, the range of their IC50 was from 0.1 μmol/L to 3μmol/L. Their structural scaffolds are novel and different from those of NA inhibitors approved for influenza treatment, and will be useful for the design and research of new NA inhibitors. The resuit indicated that the combination of virtual screening with HTS was very significant to drug screening and drug discovery. | LIU Ailin, CAO Hongpeng & DU Guanhua Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China | 2005 | Science China(Life Sciences)2005，48，1： | 7 |
| 20 | Comparative study of mechanical-electrical-thermal responses of pouch, cylindrical, and prismatic lithium-ion cells under mechanical abuse显示文摘In the study, mechanical abuse tests mainly in the form of indentation were performed on the cylindrical cell, pouch cell, and prismatic cell. The mechanical force-displacement response, open circuit voltage(OCV), and temperature distribution were recorded and compared. In spherical head indentation tests of the pouch and prismatic cell and lateral indentation of the cylindrical cell, the peak force is strongly correlated with OCV drop and local temperature increase. However, in flat-end cylinder indentation tests, the internal mechanical damage is progressively developed, and the OCV drop and the temperature increase occur before the peak force. The fracture surfaces of the post-mortem samples were examined to investigate the correlation between fracture patterns and internal short circuit(ISC) behaviors(OCVand temperature distribution). Two distinct fracture patterns were observed that the in-plane fracture induced by biaxial stretching and inter-layers' fracture induced by shearing. A strong correlation is observed between the number of shear fractures and OCV drop. An increase in the number of inter-layers' fractures increases the rate of OCV drop. Additionally, the fracture patterns influence the ISC area and location,thereby affecting the heat generation and conduction as well as the temperature distribution. | LI Wei XIA Yong CHEN GuanHua SAHRAEI Elham | 2018 | Science China(Technological Sciences)2018，61，10： | 7 |
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