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| 1 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 2 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 3 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 4 | Antibacterial activity of chitosans and chitosan oligomers with different molecular weights显示文摘 | No H K Park N Y Lee S H | 2002 | Int J Food Microbiol2002，74，： | 1 |
| 5 | Antibacterial Activity of Chitosans and Chitosan Oligomers with Different Molecular Weights显示文摘 | NO H K PARK N Y LEE S H | 2002 | International Journal of Food Microbiology2002，74，12： | 1 |
| 6 | Antibacterial activity of chitosans and chitosan oligomers with different molecular weights显示文摘 | No H K Young Park N Ho Lee S Meyers S P | 2002 | International Journal of Food Microbiology2002，74，12： | 1 |
| 7 | The prevalence of the duodenal ulcer promoting gene(dupA) in Helicobacter pylori islates varies by ethnic group and is not univenally associated with disease development a case-control study显示文摘 | Schmidt HM Andres S Kaakoush NO | | 0，，01： | 1 |
| 8 | Dynamics and control of a tethered flight vehi cle显示文摘 | No T S Jr C J E | 1995 | Journal of Guidance Control and Dynamics1995，18，1： | 1 |
| 9 | Direct metabolomics for plant cells by live single-cell mass spectrometry 显示文摘 | Fujii T Matsuda S Tejedor ML Esaki T Sakane I Mizu- no H Tsuyama N Masujima T | 2015 | Nat Protoc2015，10，： | 1 |
| 10 | Prediction of angio-graphic vasospasm after aneurysmal subarachnoid hemor-rhage:value of the Hijdra sum scoring system显示文摘 | Dupont S A Wijdicks E F Man no E M | 2009 | Neurocrit Care2009，11，： | 1 |
| 11 | Hereditary thrombophilia in Korean patients with idiopathic pulmonary embolism显示文摘 | LEE M NO H J JANG S Y | 2012 | Yonsei Med J2012，53，： | 1 |
| 12 | Trace representation of legendre sequences mersenne prime period显示文摘 | No J S Lee H K | 1996 | IEEE Trans Inform Theory1996，42，11： | 1 |
| 13 | Vehicle longitudinal brake control using variable parameter sliding control显示文摘 | Liang H Chong K T No T S | 2003 | Control Engineering Practice2003，11，： | 1 |
| 14 | Rhizotomy for children with severe spastic cerebral palsy显示文摘 | Ilium NO Torp-Pedersen L Midholm S | 2006 | Ugeskr Laeger2006，168，： | 1 |
| 15 | Lay Theory of Race Affects and Moderates Asian Ameri- cans' Responses Toward American Culture 显示文摘 | No S Hong Y Y Liao H Y Lee K Wood D Chao M M | 2008 | Journal of Personality and Social Psychology2008，，95： | 1 |
| 16 | Chitosan coating improves shelf of eggs显示文摘 | BHALE S NO H K PRINYAWIWATKUL W | 2003 | Joural of Food Science2003，68，7： | 1 |
| 17 | Antibacterial activity of chitosans and chitosan oligorners with different molecular weights显示文摘 | NO H K PARK N Y LEE S H | 2002 | International Journal of Food Microbiology2002，74，12： | 1 |
| 18 | 3 Sheet Mill显示文摘 | RAEN GHOFER TEMUELLER JLKUZDAL Experience with 100% Hydrogen Annealing at LTV's Indiana Harbor No | 1990 | Iron and Steel Engineer1990，67，3： | 1 |
| 19 | A Lyapunov function approach to longitudinal control of vehicles in a platoon显示文摘 | No T S Chong K T Roh D H | 2001 | IEEE Trans on Vehicular Technology2001，50，1： | 1 |
| 20 | 显示文摘 | Balk D S No K S | 1997 | J Mater Proc Technology1997，67，13： | 1 |
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