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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?显示文摘AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality. | Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey Eli García-Ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria José María Remes-Troche | 2015 | World Journal of Hepatology2015，7，17： | 2 |
| 3 | Development of a group-specific immunoassay for sulfonamides application to bee honey analysis显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，2： | 1 |
| 4 | Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells显示文摘 | NURIA P FELIPE C | 2003 | DNA Repair2003，2，12： | 1 |
| 5 | Synthesis and biological evaluation of 3,4-diaryloxazolones:a new class of orally active cyclooxygenase-2 inhibitors 显示文摘 | Caries P Nuria G Joan F | 2000 | J Med Chem2000，43，2： | 1 |
| 6 | Development of a group- specific immtmoassay for sulfonamides application to bee honey analysis 显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，： | 1 |
| 7 | Diversity of bacteroides fragilis strains in their capacity to recover phages from human and animal wastes and from fecally polluted wastewater显示文摘 | Anna P Nuria Q Juan J | 1999 | Appl Environ Microbiol1999，65，4： | 1 |
| 8 | A signaling model of tgemporary layoffs显示文摘 | NURIA R P | 2009 | Oxford Economic Papers2009，61，3： | 1 |
| 9 | Evacuation simulation models:Challenges in modeling high rise building evacuation with cellular automata approaches显示文摘 | Nuria P Ali M | 2008 | Automaiton in Construction2008，，17： | 1 |
| 10 | Specific-based im-munoassays for sulfathiazole显示文摘 | Nuria P N Cristina G B Angel M | | 0，，12： | 1 |
| 11 | Synthesis of haptens and development of a sensitive immunoassay for tetracycline residues application to honey samples 显示文摘 | Nuria P N Sergi M Maquieira A | 2007 | Analytica Chimica Acta2007，594，： | 1 |
| 12 | Modeling crowd and trained leader behavior during building evacuation显示文摘 | Nuria P Notman B | 2006 | IEEE Computer Graphics and Applications2006，26，6： | 1 |
| 13 | Highly permeable polylactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps显示文摘 | Nuria G Gabriele P | 1999 | Biomaterials1999，20，： | 1 |
| 14 | Determination of Bisphenol Digtycidyl Ether Residues in Canned Foods by Pressurized Liquid Extraction and Liquid Chromatography tandem Mass Spectrometry显示文摘 | OLGA P VICENT Y NURIA L | 2006 | Journal of Chromatography A2006，1107，： | 1 |
| 15 | Specific-based Immunoassays for sulfathiazole 显示文摘 | Nuria P N Cristina G B Angel M | 2004 | Analytical Biochemistry2004，，12： | 1 |
| 16 | Specificpolyclonal-based immunoassays for sulfathiazole显示文摘 | Cristina G B (A)ngel M | 2004 | Anal Bioanal Chem2004，379，： | 1 |
| 17 | Development of a group specific immunoassay for sulfonamides application to bee honey analysis显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，2： | 1 |
| 18 | Effect of marbofloxacin on Haemophilus parasuis nasal carriage显示文摘 | Carles Vilalta Nuria Galofré Virginia Aragon Ana María Pérez de Rozas Lorenzo Fraile | 2012 | Veterinary Microbiology (-)2012，，1： | 1 |
| 19 | Expression and molecular a-nalysis of the Arabidopsis DXR gene encoding 1-deoxy-d-xylulose 5-phosphate reductoisomerase,the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway显示文摘 | Lorenzo C P Iván A Nuria C | 2002 | Plant Physiol2002，129，： | 1 |
| 20 | Specific polyclonal-based immunoassays for sulfathiazole 显示文摘 | Nuria P N Cristina G B Angel M | 2004 | Anal Bioanal Chem2004，379，： | 1 |
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