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| 1 | Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs显示文摘Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis(OA).In this study,we aim to develop a senescence-relevant OA-like cartilage model for developing disease-modifying OA drugs(DMOADs).Spe-cifically,human bone marrow-derived mesenchymal stromal cells(MSCs)were expanded in vitro up to passage 10(P10-MSCs).Following their senescent phenotype formation,P10-MSCs were subjected to pellet culture in chondrogenic medium.Results from qRT-PCR,histology,and immunostaining indicated that cartilage generated from P10-MSCs displayed both senescent and OA-like phenotypes without using other OA-inducing agents,when compared to that from normal passage 4(P4)-MSCs.Interestingly,the same gene expression differences observed between P4-MSCs and P10-MSC-derived cartilage tissues were also observed between the preserved and damaged OA cartilage regions taken from human samples,as demonstrated by RNA sequencing data and other analysis methods.Lastly,the utility of this senescence-initiated OA-like cartilage model in drug development was assessed by testing several potential DMOADs and senolytics.The results suggest that pre-existing cellular senescence can induce the generation of OA-like changes in cartilage.The P4-and P10-MSCs derived cartilage models also represent a novel platform for predicting the efficacy and toxicity of potential DMOADs on both preserved and damaged cartilage in humans. | Ning Wang Yuchen He Silvia Liu Meagan J.Makarcyzk Guanghua Lei Alexander Chang Peter G Alexander Tingjun Hao Anne-Marie Padget Nuria de Pedro Tsapekos Menelaos Hang Lin | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 2 | International trade and shared environmental responsibility by sector. An application to the Spanish economy显示文摘 | María-ángeles Cadarso Luis-Antonio López Nuria Gómez María-ángeles Tobarra | 2012 | Ecological Economics2012，，： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Development of a group-specific immunoassay for sulfonamides application to bee honey analysis显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，2： | 1 |
| 5 | Volatile composition and descriptive sensory analysis of pomegranate juice and wine显示文摘 | Antonio J.Andreu-Sevillaa Pedro M Nuria M Cristina G V | | 0，，54： | 1 |
| 6 | Sticky information and heterogeneous needs as determining factors of R&D coo- peration with customers显示文摘 | Gloria S Nuria G Mariano N | 2009 | Research Policy2009，38，10： | 1 |
| 7 | Chilling and heat requirements of sweet cherry cultivars and the relationship between altitude and the probability of satisfying the chill require- rnents显示文摘 | NURIA A FEDERICO G M ANTONIO C LORENZO B | 2008 | Environmental and Exoerimental Botany2008，，1： | 1 |
| 8 | Synthesis and biological evaluation of 3,4-diaryloxazolones:a new class of orally active cyclooxygenase-2 inhibitors 显示文摘 | Caries P Nuria G Joan F | 2000 | J Med Chem2000，43，2： | 1 |
| 9 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | NURIA G M MARIA 1 A A OLGA M B | 1999 | Meat Science1999，52，： | 1 |
| 10 | Development of a group- specific immtmoassay for sulfonamides application to bee honey analysis 显示文摘 | NURIA P N ESTER G I ANGEL M | 2007 | Talanta2007，71，： | 1 |
| 11 | Feelings of well being in elderly people : relationship to physical activity and physical function 显示文摘 | Nuria G Olga M Raquel M | 2009 | Arch Gerontol Gefiatr2009，48，3： | 1 |
| 12 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | Nuria G M Maria I A A Olga M B | 1999 | Meat Science1999，，52： | 1 |
| 13 | Specific-based im-munoassays for sulfathiazole显示文摘 | Nuria P N Cristina G B Angel M | | 0，，12： | 1 |
| 14 | Transient hypothyroidism after ^131Ⅰ therapy for Graves' disease 显示文摘 | Nuria G Jos6M Amat O | 1995 | J Nucl Med1995，36，： | 1 |
| 15 | Generation of induced pluripotent stem eells from human cord blood using OCT4 and SOX2显示文摘 | ALESSANDRA G NURIA M TROND A | 2009 | Cell Stem Cell2009，5，： | 1 |
| 16 | Highly permeable polylactide-caprolactone nerve guides enhance peripheral nerve regeneration through long gaps显示文摘 | Nuria G Gabriele P | 1999 | Biomaterials1999，20，： | 1 |
| 17 | In virto fermentation and hydration properties of commercial dietary fiber-rich supplements显示文摘 | Isabel G Nuria MC | 1998 | NutrRes1998，18，6： | 1 |
| 18 | Changes in nosocomial infection control: new challenges and responsibilities for the infection control nurse 显示文摘 | NURIA F MONTSERRAT S LOLA G | 2009 | Enferm Infecc Microbiol Clin2009，27，5： | 1 |
| 19 | First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial显示文摘 | Gareth J Morgan Faith E Davies Walter M Gregory Kim Cocks Sue E Bell Alex J Szubert Nuria Navarro-Coy Mark T Drayson Roger G Owen Sylvia Feyler A John Ashcroft Fiona Ross Jennifer Byrne Huw Roddie Claudius Rudin Gordon Cook Graham H Jackson J Anthony Chil | 2010 | The Lancet . 2010 (9757)2010，，： | 1 |
| 20 | Specific-based Immunoassays for sulfathiazole 显示文摘 | Nuria P N Cristina G B Angel M | 2004 | Analytical Biochemistry2004，，12： | 1 |
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