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| 1 | Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B显示文摘AIM: To investigate whether there was a relationship between the liver functions and fibrosis scores of hepatitis B patients and their TNF-α, IFN-γ, IL-4, and TGF-β1 serum levels based on the studies of liver biopsies. METHODS: Thirty patients with chronic hepatitis B (CHB)receiving no treatment and 30 healthy individuals with negative hepatitis serology and normal values of liver biochemistry were studied. After serum samples of the patients were collected, liver needle biopsy was performed on each patient. Cytokine levels were studied by ELISA.The biopsy materials were scored based on Knodell's histological activity index.RESULTS: In comparison of cytokine levels between CHB patients and control group, TNF-α, IL-4, and TGF-β1 levels of the patients were higher in CHB patients than in the controls, while IFN-γ level was lower in the patients than in the controls. There were significant differences between the groups in TNF-α, IL-4, TGF-β1, and IFN-γ (P<0.005,0.03, 0.002, 0.0001, respectively). There was a negativecorrelation between TGF-β1 and IL-4 and IFN-γ (P<0.05),TNF-α and the other cytokines and IFN-γ and IL-4 were not correlated (P>0.05). TGF-β1 was correlated with fibrosis (P<0.05). Liver necroinflammatory activity and fibrosis and TNF-α, IL-4, and IFN-γ were not correlated (P>0.05).CONCLUSION: In the course of HBV infection and its chronic progress, cytokines play an important role. IL-4and IFN-γ are effective in the chronic progression, whileTGF-β1 is effective in the development of fibrosis. Serum cytokine levels may be effective tools in the estimation of chronic progression and fibrosis development. | Nusret Akpolat Seyfettin Yahsi Ahmet Godekmerdan Kutbettin Demirbag Mehmet Yalniz | 2005 | World Journal of Gastroenterology2005，11，21： | 46 |
| 2 | Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats显示文摘AIM: To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bili- ary-obstructed rats. METHODS: Fifty Wistar albino rats were randomly as- signed to 5 groups (10 rats in each). Bile duct was liga- ted in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS: Despite being higher than sham group, he- patic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 μg collagen/mg protein, respectively) compared to BDL (48.3 ± 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supp-lementation prevented the increase in hepatic collagen surface density (7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively) compared to BDL (17.4% ± 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treat- ment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 ± 0.8 vs BDL: 3.1 ± 0.7; P < 0.05). CONCLUSION: Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obs- tructed rats. Oxidative stress may play a role in the patho- genesis of hepatic fibrosis in secondary biliary cirrhosis. | Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner Orhan Tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak | 2006 | World Journal of Gastroenterology2006，12，42： | 4 |
| 3 | A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics显示文摘 | Alexander Hoppe Nusret S. Güldal Aldo R. Boccaccini | 2011 | Biomaterials2011，，11： | 2 |
| 4 | Diagnostic yield of routine duodenal biopsies in iron deficiency anaemia: a study from Western Anatolia显示文摘 | Can Gonen Nusret Yilmaz Muhittin Yalcin Ilkay Simsek Omur Gonen | 2007 | European Journal of Gastroenterology & Hepatology2007，，1： | 1 |
| 5 | Use of Ligasure in Thyroidectomy Procedures: Results of a Prospective Comparative Study显示文摘 | Turkay Kirdak M.D. Nusret Korun M.D. Halil Ozguc M.D | 2005 | World Journal of Surgery2005，，6： | 1 |
| 6 | Does idiosyncratic risk really matter显示文摘 | Turan G Nusret C Yan X M Zhang Z | 2005 | Journal of Finance2005，60，2： | 1 |
| 7 | The Effects of Endothelin Receptor Blockade by Bosentan on the Healing of a Bowel Anastomosis in an Experimental Crohn’s Disease Model显示文摘 | Cuneyt Kirkil Ziya Cetinkaya Bilal Ustundag Nusret Akpolat Refik Ayten Nurullah Bulbuller | 2008 | Journal of Gastrointestinal Surgery2008，，： | 1 |
| 8 | A Refinement Procedure for PID Controllers显示文摘 | Kaya I Nusret T Atherton D | 2006 | Electrical Engineering2006，88，3： | 1 |
| 9 | Value at risk for interest rate- dependent securities 显示文摘 | Nusret C Kevin R F | 2003 | The Journal of Fixed Income2003，，3： | 1 |
| 10 | Effects of ATP-MgC12 on myocardial ischemia-reperfusion injury : an in vivo experimental study 显示文摘 | Zulfikar K S Nusret A Eser O | 2006 | Turk J Vet Anita Sci2006，，30： | 1 |
| 11 | Serum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients With Non-dipper Hypertension显示文摘 | Necip Ermis Julide Yagmur Nusret Acikgoz Mehmet Cansel Bilal Cuglan Hasan Pekdemir Ramazan Ozdemir | 2012 | Clinical and Experimental Hypertension2012，，5： | 1 |
| 12 | A refinement procedure for PID controllers显示文摘 | Ibrahim Kaya Nusret Tan Derek P. Atherton | 2006 | Electrical Engineering2006，，3： | 1 |
| 13 | A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics显示文摘 | Alexander Hoppe Nusret S. Güldal Aldo R. Boccaccini | 2011 | Biomaterials2011，，11： | 1 |
| 14 | Congenital true pancreatic cyst: a rare case显示文摘 | Ahmet Kazez Nusret Akpolat Ercan K | 2006 | Diagn Interv Radiol2006，12，1： | 1 |
| 15 | Premiums on Stock Index Futures-Some Evidence显示文摘 | Bhatt Swati Nusret Cakici | 1990 | The Journal of Futures Markets1990，10，4： | 1 |
| 16 | Do markets overreact?international evidence显示文摘 | Ahmet B Nusret C | 1999 | Journal of Banking and Finance1999，23，： | 1 |
| 17 | Computation of stabilizing PI and PID controllers for processes with timedelay显示文摘 | Nusret Tan | 2005 | ISA Transactions2005，2，： | 1 |
| 18 | Idiosyncratic Volatility and the Cross Section of Expected Returns显示文摘 | BALI TURAN NUSRET CAKICI | 2008 | Journal of Financial and Quantitative Analysis2008，，43： | 1 |
| 19 | Robust Phase Margin, Roubust Gain Margin and Nyquist Envelope of an Interval Plant Family显示文摘 | NUSRET TAN | 2004 | Computers and Eleetrical Engineering2004，30，： | 1 |
| 20 | Do markets overreact? International evidence 显示文摘 | Ahmet B Nusret C | 1999 | Journal of Banking and Finance1999，，23： | 1 |
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