|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation显示文摘Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. The root of Paeonia lactiflora Pall has been considered useful for the treatment of various disorders in traditional oriental medicine. Paeonol, found in the root of Paeonia lactiflora Pall, has a wide range of pharmacological functions, including anti-oxidative, anti-inflammatory and neuroprotective activities. The objective of this study was to examine the efficacy of paeonol in the repression of inflammation-induced neurotoxicity and microglial cell activation. Organotypic hippocampal slice cultures and primary microglial cells from rat brain were stimulated with bacterial lipopolysaccharide. Paeonol pretreatment was performed for 30 minutes prior to lipopolysaccharide addition. Cell viability and nitrite (the production of nitric oxide), tumor necrosis factor-alpha and interleukin-1beta products were measured after lipopolysaccharide treatment. In organotypic hippocampal slice cultures, paeonol blocked lipopolysaccharide-related hippocampal cell death and inhibited the release of nitrite and interleukin-1beta. Paeonol was effective in inhibiting nitric oxide release from primary microglial cells. It also reduced the lipopolysaccharide-stimulated release of tumor necrosis factor-alpha and interleukin-1β from microglial cells. Paeonol possesses neuroprotective activity in a model of inflammation-induced neurotoxicity and reduces the release of neurotoxic and proinflammatory factors in activated microglial cells. | Kyong Nyon Nam Byung-Cheol Woo Sang-Kwan Moon Seong-Uk Park Joo-young Park Jae-Woong Hwang Hyung-Sup Bae Chang-Nam Ko Eunjoo Hwang Lee | 2013 | Neural Regeneration Research2013，8，18： | 4 |
| 2 | Berberine inhibits inflammatory activation of rat brain microglia显示文摘Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors.Berberine,the effective ingredient of Coptidis Rhizoma and Cortex Phellodendri,has a wide range of pharmacological functions,including anti-inflammatory,anti-atherosclerotic and anti-cancer effects.The neuroprotective potential of berberine has previously been demonstrated.The present study aimed to examine whether berberine could repress microglial activation and can be considered a potential therapeutic candidate to target neurodegenerative diseases.Primary microglial cells and BV2 microglial cells were cultured and stimulated with bacterial lipopolysaccharide (LPS).Berberine chloride was treated prior to LPS or simultaneously with LPS stimulation.Results revealed that berberine was effective at inhibiting nitric oxide release from primary microglial cells when cells were exposed to the compound prior to LPS or simultaneously with LPS.It also reduced the LPS-stimulated production of tumor necrosis factor-α,interleukin-1β,prostaglandin E2,and intracellular reactive oxygen species and nuclear factor-kappa activation.Additionally,berberine reduced nitric oxide release from microglia stimulated with interferon-γ and amyloid β.These results suggest that berberine provides neuroprotection by reducing the production of various neurotoxic molecules from activated microglia. | Kyong Nyon Nam Jae-Hong Kim Hoon-Ji Jung Jung-Mi Park Sang-Kwan Moon Young-Suk Kim Sun Yeou Kim Eunjoo H. Lee | 2010 | Neural Regeneration Research2010，5，18： | 3 |
| 3 | Spatial distribution of particulate matter (PM 10 and PM 2.5 ) in Seoul Metropolitan Subway stations显示文摘 | Ki Youn Kim Yoon Shin Kim Young Man Roh Cheol Min Lee Chi Nyon Kim | 2007 | Journal of Hazardous Materials2007，，1： | 2 |
| 4 | Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells显示文摘 | Kyong Nyon Nam Young-Min Park Hoon-Ji Jung Jung Yeon Lee Byung Duk Min Seong-Uk Park Woo-Sang Jung Ki-Ho Cho Ji-Ho Park Insug Kang Joung-Woo Hong Eunjoo H. Lee | 2010 | European Journal of Pharmacology2010，，1： | 1 |
| 5 | Rheology of Blends of a Thermotropic Liquid Crystalline Polymer with Polyphenylene Sulfide显示文摘 | Minsoo Han Woo Nyon Kim David W Giles | 2004 | Polym Eng Sci2004，41，9： | 1 |
| 6 | Mediated amperometric immunosensing using single walled carbon nanotube forests显示文摘 | Ma'ire O' Connor Sang Nyon Kim Anthony J Killard | 2004 | Analyst2004，129，12： | 1 |
| 7 | Synthesis and characterization of sulfonated polyol-based waterborne polyurethane-polyacrylate hybrid emulsions显示文摘 | Dong Hyup Park Je Kon Oh Sang Bum Kim Woo Nyon Kim | 2013 | Macromolecular Research2013，，11： | 1 |
| 8 | Genipin inhibits the inflammatory response of rat brain microglial cells显示文摘 | Kyong Nyon Nam Yo-Sup Choi Hoon-Ji Jung Gun Hyuk Park Jung-Mi Park Sang-Kwan Moon Ki-Ho Cho Chulhun Kang Insug Kang Myung Sook Oh Eunjoo H. Lee | 2010 | International Immunopharmacology2010，，： | 1 |
| 9 | Therapeutic tar-get-site variability in alpha(1)-antitrypsin characterized at high resolution显示文摘 | Patschull A O Segu L Nyon M P | 2011 | Acta Crystallogr Sect F Struct Biol Cryst Commun2011，67，12： | 1 |
| 10 | Compatibilizing effects for improving mechanical properties of biodegradable poly (lactic acid) and polycarbonate blends显示文摘 | Jae Bok Lee Yun Kyun Lee Gi Dae Choi Sang Wook Na Tae Sung Park Woo Nyon Kim | 2011 | Polymer Degradation and Stability2011，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员