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| 1 | Science:'记忆碎片'是真的吗?显示文摘半个多世纪以来,神经学家们一直以为长期记忆是由于多个短期记忆储存起来形成的。而最近一项对记忆形成的神经回路的研究则表明这一说法有可能是错的,因为两种类型的记忆(长期与短期)能够同时产生。这项研究是由来自MIT的研究者们做出。他们参考了此前标记特殊”记忆”细胞的手段,并更进一步地强制性使小鼠对特定的记忆作出反应。并且断开了长期与短期记忆的连接。 | Takashi Kitamura Mark D. Morrissey Lillian M. Smith Roger L. Redondo | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Usefulness of vonoprazan,a potassium ion-competitive acid blocker,for primary eradication of Helicobacter pylori显示文摘AIM To investigate usefulness of triple therapy with vonoprazan,a potassium ion-competitive acid blocker and antibiotics,for Helicobacter pylori(H.pylori) eradication.METHODS The H.pylori eradication rate was examined in 2507 patients(2055 undergoing primary eradication and 452 undergoing secondary eradication,excluding patients with subtotal gastrectomy) at the Japanese Red Cross Kyoto Daiichi Hospital from March 2013 to September 2015.For patients treated from March 2013 to February 2015,a proton pump inhibitor(PPI) was used to reduce acid secretion,while vonoprazan was used after March 2015.The success rates of the 2 regimens(PPI + amoxicillin + clarithromycin/metronidazole,or vonoprazan + amoxicillin + clarithromycin/metronidazole) were compared.RESULTS The success rate of primary H.pylori eradication was significantly higher in the vonoprazan group.When stratified by the underlying disease,a significant increase of the H.pylori eradication rate was observed in patients with chronic gastritis.A significantly lower H.pylori eradication rate was observed in younger patients compared to older patients in the PPI group,but there was no difference according to age in the vonoprazan group.On the otherhand,the success rate of secondary eradication was similar at approximately 90% in both groups.CONCLUSION Vonoprazan is very useful for primary eradication of H.pylori,and may become a first-line acid secretion inhibitor instead of PPIs. | Shinya Yamada Takumi Kawakami Yoshikazu Nakatsugawa Takahiro Suzuki Hideki Fujii Naoya Tomatsuri Hideki Nakamura Hideki Sato Yusuke Okuyama Hiroyuki Kimura Norimasa Yoshida | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 8 |
| 3 | Xyloglucan for Generating Tensile Stress to Bend Tree Stem显示文摘响应环境变化,被子植物树由形成紧张木头把他们的茎弄弯,它由充满纤维素的 G 组成(凝胶状) 在纤维房间的墙中的层并且在第二等的木部产生反常张力的应力。我们生产了转基因的白杨植物 overexpressing 在房间墙中减少每特定的多糖,,的几 endoglycanases 第二等的木部由主要、第二等的墙层组成。当水平地放了时,转基因的白杨 overexpressing xyloglucanase 的茎的基础区域不能独自在木部的紧张方面由于低紧张向上弯曲。在野类型的植物, xyloglucan 在多重 layering 期间在 G 层的内部表面被发现。在 situ xyloglucan endotransglucosylase ( XET ),活动证明整个 xyloglucan 的加入,潜在地因为墙紧缩,在内部表面层 S1 和 S2 开始了并且在整个G层开发被保留,当为墙松开的 xyloglucan heptasaccharide ( XXXG )的加入发生在膨胀地区的主要的墙中时。我们建议 xyloglucan 网络被 XET 增强形成在墙界限之间的一个进一步的连接并且分泌了 xyloglucans 以便承受在纤维素 G 层 microfibrils 以内创造的张力的压力。 | Kei'ichi Baba Yong Woo Park Tomomi Kaku Rumi Kaida Miyuki Takeuchi Masato Yoshida Yoshihiro Hosoo Yasuhisa Ojio Takashi Okuyama Toru Taniguchi Yasunori Ohmiya Teiji Kondo Ziv Shani Oded Shoseyov Tatsuya Awano Satoshi Serada Naoko Norioka Shigemi Norioka Takahisa Hayashi | 2009 | Molecular Plant2009，2，5： | 4 |
| 4 | SPATA17的单核苷酸多态性可能是日本减速分裂阻滞患者的遗传危险因素显示文摘遗传机制已经成为一些男性患者不育的一个病因。近年来,通过人类睾丸组织的基因芯片分析鉴定了10个与人类精子发生相关的新基因。其中一个是精子发生相关17基因(SPATA17)。为了研究是否SPATA17基因缺陷与减数分裂导致的无精症有关,我们进行了突变分析,将18个日本减数分裂导致的无精症患者的SPATA17编码区域进行了测序,以及统计分析,其中包括18个减数分裂阻滞患者,20个唯支持细胞综合征(SCOS)患者和96个健康对照男性。没有SPATA17发生突变。但是,减数分裂阻滞患者组检测到了3个单核苷酸多态性(cSNPs:SNPI—SNP3)。减数分裂阻滞患者与其他患者的SNP1和SNP2基因型与等位基因频率无明显不同。但是,SNP3的等位基因频率在减数分裂阻滞患者组中明显升高(P〈0.05)。这项研究表明,sPATA17在人类精子发生,尤其是减数分裂中可能起关键性作用。 | Toshinobu Miyamoto Akira Tsujimura Yasushi Miyagawa Eitetsu Koh Naoko Sakugawa Hiroe Miyakawa Hisashi Sato Mikio Namiki Akihiko Okuyama Kazuo Sengoku | 2009 | Asian Journal of Andrology2009，11，5： | 2 |
| 5 | A comparison of intraoperative celiac plexus block with pharmacological therapy as a treatment for pain of unresectable pancreatic cancer显示文摘 | Masaki Okuyama Takashi Shibata Tetsushi Morita Masashi Kitada Yasuo Tukahara Yukio Fukushima Kimimasa Ikeda Junya Fuzita Takashi Shimano | 2002 | Journal of Hepato - Biliary - Pancreatic Surgery2002，，3： | 2 |
| 6 | Paraquat-induced gene expression in rat kidney显示文摘 | Masafumi Tomita Toshiko Okuyama Hironobu Katsuyama Takaki Ishikawa | 2006 | Archives of Toxicology2006，，10： | 2 |
| 7 | Influence of Housing and Urban Development on Debris Flow Flooding and Deposition显示文摘Debris flows form deposits when they reach an alluvial fan until they eventually stop.However,houses located in the alluvial fan might affect the debris flow flooding and deposition processes.Few previous studies have considered the effects of houses on debris flow flooding and deposition.This study conducted model experiments and numerical simulations using the Kanako2D debris flow simulator to determine the influence of houses on debris flow flooding and deposition.The model experiments showed that when houses are present,the debris flow spreads widely in the cross direction immediately upstream of the houses,especially when the flow discharge is large or the grain size is small.Houses located in the alluvial fan also influence the deposition area.The presence of houses led to flooding and deposition damage in some places and reduced the damage in others.The simulation also demonstrated the influence of houses.Both the model experiment and the simulation showed that houses change the flooding and deposition areas. | Kana NAKATANI Yuki OKUYAMA Yuji HASEGAWA Yoshifumi SATOFUKA Takahisa MIZUYAMA | 2013 | Journal of Mountain Science2013，10，2： | 2 |
| 8 | Intragastric surgery using laparoscopy and oral endoscopy for gastric submucosal tumors显示文摘We review the techniques and outcomes of the intragastric resection for gastric submucosal tumors(GSTs) using laparoscope and oral endoscope. In the literature, the mean operation time, intraoperative blood loss, pathological size of the tumor and postoperative hospital stay were 134 min, minimal, 31 mm and 6.4 d, respectively. There were no particular perioperative complications during the follow-up period(mean: 121.3 mo). Intragastric surgery using laparoscopy and oral endoscopy can be considerably beneficial for patients with GSTs locating in the upper third of the stomach between 2-5 cm in diameter and < 8 cm2 in crosssectional area and located in the upper third of the stomach. | Nobumi Tagaya Teppei Tatsuoka Yawara Kubota Masayuki Takegami Nana Sugamata Kazuyuki Saito Takashi Okuyama Yoshitake Sugamata Masatoshi Oya | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，1： | 2 |
| 9 | Esophagotracheal fistula caused by gastroesophageal reflux 9 years after esophagectomy显示文摘Fistula between digestive tract and airway is one of the complications after esophagectomy with lymph node dissection. A case of esophagotracheal fistula secondary to esophagitis 9 years after esophagectomy and gastric pull-up for treatment of esophageal carcinoma is described. It was successfully treated with transposition of a pedicled pectoralis major muscle flap. | Kiyotomi Maruyama Satoru Motoyama Manabu Okuyama Yusuke Sato Kaori Hayashi Yoshihiro Minamiya Jun-ichi Ogawa | 2007 | World Journal of Gastroenterology2007，13，5： | 2 |
| 10 | Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion显示文摘Here, we report our experience with a case of severe biliary bleeding due to a hepatic arterial pseudoaneurysm that had developed 1 year after endoscopic biliary plastic stent insertion. The patient, a 78-year-old woman, presented with hematemesis and obstructive jaundice. Ruptured hepatic arterial pseudoaneurysm was diagnosed, which was suspected to have been caused by long-term placement of an endoscopic retrograde biliary drainage(ERBD) stent. This episode of biliary bleeding was successfully treated by transarterial embolization(TAE). Pseudoaneurysm leading to hemobilia is a rare but potentially fatal complication in patients with long-term placement of ERBD. TAE is a minimally invasive procedure that offers effective treatment for biliary bleeding. | Muneji Yasuda Hideki Sato Yuki Koyama Tomoki Sakakida Takumi Kawakami Takeshi Nishimura Hideki Fujii Yoshikazu Nakatsugawa Shinya Yamada Naoya Tomatsuri Yusuke Okuyama Hiroyuki Kimura Takaaki Ito Hiroyuki Morishita Norimasa Yoshida | 2017 | World Journal of Gastroenterology2017，23，4： | 2 |
| 11 | Overexpression of bcl-2 protects human hepatoma cells from Fasantibody-mediated apoptosis显示文摘 | Takahashi M Saito H Okuyama T | 1999 | J Hepatol1999，31，2： | 1 |
| 12 | The common γ chain is an indispensable subunit of IL-2 receptor complex显示文摘 | Asao H Okuyama C Kumaki S | 2001 | J Immunol2001，167，1： | 1 |
| 13 | Paraquat-induced gene expression in rat kidney 显示文摘 | Tomita M Okuyama T Katsuyama H | 2006 | Arch Toxicol2006，，10： | 1 |
| 14 | Chemo-enzymatic synthesis of fluorinated 2-N-acetamidosugar nucleotides using UDP-GIcNAc pyrophosphorylase显示文摘 | Feng F Okuyama K Niikura K | 2004 | Org Biomol Chem2004，2，11： | 1 |
| 15 | Zipf's Law in Income Distribution of Companies 显示文摘 | OKUYAMA K TAKAYASU M TAKAYASU H | 1999 | Physica A1999，，269： | 1 |
| 16 | The effects ofprostaglandin E1or oral clonidine premedication on blood lossduring paranasal sinus surgery显示文摘 | Okuyama K Inomata S Toyooka H | 2005 | Can J Anaesth2005，52，5： | 1 |
| 17 | Stable photoluminescence of zinc oxide quantum dots in silica nanoparticles matrix prepared by the combined sol-gel and spray drying method显示文摘 | Mikrajuddin Iskandar F Okuyama K | 2001 | Applied Physics2001，89，11： | 1 |
| 18 | Effectof slag composition on the kinetics of formation ofAl2 03-Mg0 inclusions in aluminum killed ferriticstainless steel显示文摘 | Okuyama G Yamaguchi K Takeuchi S | 2000 | ISIJ International2000，40，2： | 1 |
| 19 | 查看详情显示文摘 | J Kido C Ohtaki K. Hongawa K. Okuyama and K.Nagai Jpn | | 0，，： | 1 |
| 20 | Acetylenes from Cirsium japon - icum 显示文摘 | Yoshihisa Takashi Takeshi Okuyama Akemi Masuda | 1990 | Phytochemistry1990，29，12： | 1 |
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