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| 1 | 北京市老年人健康预期寿命及其变化显示文摘目的 了解北京地区老年人的健康预期寿命和变化。方法 采用纵向研究方法对北京城区(宣武区)、郊区(大兴区)和山区(怀柔县)一个有代表性老年人群(3257人)进行了12年追踪,调查其健康和存活状况。用WHO的基本生活能力评估量表(ADL),评估老年人躯体功能健康状况及变化,采用IMaCH多状态法分析多次调查结果及不同健康状况的转变,计算老年人的健康预期寿命及不同时段的变化。结果 纵向结果显示一些基本特征在不同时段维持不变:老年人的平均预期寿命(LE)、健康预期寿命(ALE)和健康预期寿命比值(ALE/LE)在城区显著高于农村;女性平均预期寿命高于男性,但ALE/LE低于男性。纵向观察的变化表现为:老年人的平均预期寿命有所提高,增加的幅度在农村大于城区,男性大于女性;城区高龄女性老年人的健康预期寿命近年有明显下降;所有老年人的ALE/LE近年呈下降趋势,尤其是城区老年人和高龄老年人更突出。结论 北京地区老年人的健康预期寿命未与预期寿命同步增长,加强心脑血管疾病等慢性病防治,预防残疾和加强功能康复,是提高老年人健康预期寿命和生活质量的基础。 | 汤哲 项曼君 Zachary Zimmer 方向华 Toshiko Kaneda | 2005 | 中华流行病学杂志2005，26，12： | 40 |
| 2 | Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018显示文摘There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases.This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases.By contrast,Caucasians are less likely to develop keloids and hypertrophic scars,and if they do,the scars tend not to be severe.This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms.The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments,with uneven outcomes.To overcome these issues,the Japan Scar Workshop(JSW)has created a tool that allows clinicians to objectively diagnose and distinguish between keloids,hypertrophic scars,and mature scars.This tool is called the JSW Scar Scale(JSS)and it involves scoring the risk factors of the individual patients and the affected areas.The tool is simple and easy to use.As a result,even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity.The JSW has also established a committee that,in cooperation with outside experts in various fields,has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines.These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy.The Consensus Document is provided in this article.It describes(1)the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors,(2)the general treatment algorithms for keloids and hypertrophic scars at different medical facilities,(3)the rationale behind each treatment for keloids and hypertrophic scars,and(4)the body site-specific treatment protocols for these scars.We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars. | Rei Ogawa Sadanori Akita Satoshi Akaishi Noriko Aramaki-Hattori Teruyuki Dohi Toshihiko Hayashi Kazuo Kishi Taro Kono Hajime Matsumura Gan Muneuchi Naoki Murao Munetomo Nagao Keisuke Okabe Fumiaki Shimizu Mamiko Tosa Yasuyoshi Tosa Satoko Yamawaki Shinichi Ansai Norihisa Inazu Toshiko Kamo Reiko Kazki Shigehiko Kuribayashi | 2019 | Burns & Trauma2019，7，1： | 31 |
| 3 | 北京市不同社会经济状况老年人的预期寿命和健康预期寿命显示文摘目的:了解北京老年群体中社会经济状况对人群预期寿命和健康预期寿命的影响。方法:样本来自北京老龄化纵向研究,对象为北京市城区(宣武)、近郊(大兴)、远郊(怀柔)55岁以上的人群,1992年基线调查3257例,由经过培训的调访员入户作问卷调查。1994,1997年对该样本随访,了解存活和健康状况。根据能否独立完成日常生活活动(ADL)认定功能健康与否。社会经济状况(socioeconomicstatus,SES)的指标选用教育、收入、职业和家庭拥有财物4项,并均按两分法分为高、低两水平,根据基线调查结果区分每人的各指标所在的高、低位置。利用IMaCH软件多状态生命表法计算预期寿命(lifeexpectancy,LE)、健康预期寿命(activelifeexpectancy,ALE)。结果:老年人LE和ALE男性均低与于女性,但男性ALE/LE高于女性。按不同指标计算,SES高水平者较低水平者男性LE增加20%~52%(延长2.1~5.77年)、女性增加4%~25%(延长0.6~4.3年),ALE男性增加30%~77%(延长2.1~4.0年)、女性增加5%~73%(延长0.6~5.6年)。不同指标与寿命相关的程度不同,男性中收入和财物拥有与ALE/LE的关系最大,女性以家庭财物拥有影响明显。高、低组间的差距随增龄加大。结论:北京市老年人中SES高水平的人较低SES水平的人,有更长的预期寿命和健康预期寿命和较高的ALE/LE? | 汤哲 Toshiko Kaneda 项曼君 方向华 Zachary Zimmer | 2004 | 中国临床康复2004，8，30： | 17 |
| 4 | Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model显示文摘AIM: To investigate Kupffer cell dynamics and phagocytic activity,using a rat nonalcoholic steatohepatitis (NASH) model. METHODS: Male F344 rats were fed either a control diet or a choline-deficient L-amino acid-defined (CDAA) diet,followed by contrast enhanced ultrasonography (CEUS) using Levovist. The uptake of latex beads by the Kupffer cells was determined by fluorescent microscopy. The status of the Kupffer cells was compared between the two groups,using the immunohistochemical staining technique. RESULTS: After 4 or more wk of the CDAA diet,CEUS examination revealed a decrease in the signal intensity,20 min after intravenous Levovist. Fluorescent microscopic examination showed that the uptake of latex beads by the Kupffer cells was reduced at week 1 and 2 in the study group,compared with the controls,with no further reduction after 3 wk. Immunohistochemical staining revealed no significant difference in the Kupffer cell counts between the control group and the CDAA group. CONCLUSION: CEUS examination using Levovist demonstrated reduced contrast effect and phagocytic activity in the liver parenchymal phase,although the Kupffer cell numbers were unchanged,indicating reduced phagocytic function of the Kupffer cells in the rat NASH model. We believe that CEUS examination using Levovist is a useful screening modality,which can detect NASH in fatty liver patients. | Tatsuhiro Tsujimoto Hideto Kawaratani Toshiyuki Kitazawa Toshiko Hirai Hajime Ohishi Mitsuteru Kitade Hitoshi Yoshiji Masahito Uemura Hiroshi Fukui | 2008 | World Journal of Gastroenterology2008，14，39： | 12 |
| 5 | Selective decrease in colonic CD56^+ T and CD161^+ T cells in the inflamed mucosa of patients with ulcerative colitis显示文摘AIM: To investigate the role of local colonic mucosal NK receptor-positive T (NKR+ T) cells in the regulation of intestinal inflammation, we analyzed the population and function of these cells in ulcerative colitis (UC). METHODS: Colonic mucosal tissues were obtained from colonoscopic biopsies of the descending colon from 96 patients with UC (51 endoscopically uninfl amed, 45 inflamed) and 18 normal controls. Endoscopic appearance and histologic score at the biopsied site were determined by Matts’ classification. A single cell suspension was prepared from each biopsy by collagenase digestion. Two NKR+ T cell subsets, CD56+ (CD56+CD3+) T cells and CD161+ (CD161+CD3+) T cells, were detected by flow cytometric analysis. Intracellular cytokine analysis for anti-in? ammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate- acetate (PMA) and ionomycin. RESULTS: CD56+ T cells and CD161+ T cells are present in the normal human colon and account for 6.7% and 21.3% of all mononuclear cells, respectively. The populations of both CD56+ T cells and CD161+ T cells were decreased significantly in the inflamed mucosa of UC. In contrast, the frequency of conventional T cells (CD56-CD3+ cells and CD161-CD3+ cells) was similar among the patient and control groups. The populations of NKR+ T cells were correlated inversely with the severity of infl ammation, which was classif ied according to the endoscopic and histologic Matts’ criteria. Interestingly, approximately 4% of mucosal NKR+ T cells expressing IL-10 were detected by in vitro stimulation with PMA and ionomycin.CONCLUSION: Selective reduction in the population of colonic mucosal NKR+T cells may contribute to the development of intestinal inflammation in UC. | Masaru Shimamoto Yoshitaka Ueno Shinji Tanaka Toshiko Onitake Rie Hanaoka Kyoko Yoshioka Tsuyoshi Hatakeyama Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，45： | 6 |
| 6 | 卒中对老年人预期寿命的影响及变化趋势显示文摘目的评价卒中对北京地区老年人预期寿命(LE)、健康预期寿命(ALE)和不健康预期寿命(IALE)的影响,以及上述各项预期寿命指标从1992-1997年到2000-2004年的变化趋势。方法采用纵向研究方法对北京市城区(宣武)、近郊区(大兴)和远郊区(怀柔)有代表性老年人群(3257例)进行12年追踪,调查其健康和存活状况。采用WHO的基本生活能力评估量表(ADL),评估老年人躯体功能健康状况及变化,采用SAS分析比较1992-1997年和2000-2004年2个时间段的LE、ALE和IALE变化。结果各年龄卒中组老年人的LE和ALE均低于非卒中组老年人,IALE则高于非卒中组。基线健康状态是ALE的重要决定因素—基线状态为健康的卒中组老年人,其ALE低于非卒中老年人,但是ALE长于IALE,且卒中组与非卒中组的1ALE无差异;而基线不健康的卒中老年人ALE大幅度减少,IALE超出ALE。城市卒中组老年人的LE和ALE均高于农村,而IALE低于农村。到2000-2004年间,无论城乡,是否患卒中,基线调查时是否处于健康状态,LE均有所增加,其中AEL的增加幅度高于IALE,基线不健康的卒中组老年人的ALE增加幅度最大。结论卒中减低老年人生命数量与质量,对于农村老年卒中患者更为明显。从1992-1997年到2000-2004年期间,北京地区无论是城市还是农村,卒中老年人的LE和ALE都有所延长,提示其生命数量和质量得到改善。 | 方向华 汤哲 Zachary Zimmer 项曼君 Toshiko Kaneda | 2009 | 中华流行病学杂志2009，30，2： | 4 |
| 7 | INHIBITION OF FARNESYL PROTEIN TRANSFERASE AND P21^(RAS) MEMEBRANE ASSOCIATION BY D-LIMONENE IN HUMAN PANCREAS TUMOR CELLS IN VITRO显示文摘INTRODUCTIONOncogenicRasproteinsarecausalyimplicatedincertainhumanmalignancies.About50%ofhumancoloncarcinomasand90%ofpancre... | Chen Xiaoguang 1 (陈晓光),Yoshihisa Yano 2, Tadayoshi Hasuma 2, Toshiko Yoshimata 2, Wang Yinna 2 and Shuzo Otani 2 1Department of Pharmacology, Institute of Materia Medica, CAMS & PUMC, Beijing 100050 2Department of Biochemistry | 1999 | Chinese Medical Sciences Journal1999，14，3： | 3 |
| 8 | Percutaneous Left Atrial Appendage Transcatheter Occlusion to Prevent Stroke in High-Risk Patients With Atrial Fibrillation: Early Clinical Experience显示文摘 | Horst Sievert Michael D. Lesh Thomas Trepels Heyder Omran Antonio Bartorelli Paola Della Bella Toshiko Nakai Mark Reisman Carlo DiMario Peter Block Paul Kramer Dirk Fleschenberg Ulrike Krumsdorf Detlef Scherer | 2002 | Circulation: Journal of the American Heart Association2002，，16： | 2 |
| 9 | Paraquat-induced gene expression in rat kidney显示文摘 | Masafumi Tomita Toshiko Okuyama Hironobu Katsuyama Takaki Ishikawa | 2006 | Archives of Toxicology2006，，10： | 2 |
| 10 | Coping With Teacher Demotivation Toward Directed Motivational Currents显示文摘 | Toshiko Sugino Emika Abe Mami Ueda | 2017 | Journal of Literature and Art Studies2017，7，5： | 2 |
| 11 | SAP155-Mediated Splicing of FUSE-Binding Protein-Interacting Repressor Serves as a Molecular Switch for c-myc Gene Expression显示文摘 | Kazuyuki Matsushita Toshiko Kajiwara Mai Tamura Mamoru Satoh Nobuko Tanaka Takeshi Tomonaga Hisahiro Matsubara Hideaki Shimada Rei Yoshimoto Akihiro Ito Shuji Kubo Tohru Natsume David Levens Minoru Yoshida Fumio Nomura | 2012 | Molecular Cancer Research2012，，6： | 2 |
| 12 | Hyperdry human amniotic membrane application as a wound dressing for a full-thickness skin excision after a third-degree burn injury显示文摘Background:Severe burn injuries create large skin defects that render the host susceptible to bacterial infections.Burn wound infection often causes systemic sepsis and severe septicemia,resulting in an increase in the mortality of patients with severe burn injuries.Therefore,appropriate wound care is important to prevent infection and improve patient outcomes.However,it is difficult to heal a third-degree burn injury.The aim of this studywas to investigate whether hyperdry human amniotic membrane(HD-AM)could promote early granulation tissue formation after full-thickness skin excision in third-degree burn injury sites in mice.Methods:After the development of HD-AM and creation of a third-degree burn injury model,the HD-AM was either placed or not placed on the wound area in the HD-AM group or HD-AM group,respectively.The groups were prepared for evaluation on postoperative days 1,4 and 7.Azan staining was used for granulation tissue evaluation,and estimation of CD163,transforming growth factor beta-1(TGF-β1),vascular endothelial growth factor(VEGF),CD31,alpha-smooth muscle actin(α-SMA)and Iba1 expression was performed by immunohistochemical staining.Quantitative reverse-transcription polymerase chain reaction(PCR)was used to investigate gene expression of growth factors,cell migration chemokines and angiogenic and inflammatory markers.Results:The HD-AM group showed significant early and qualitatively good growth of granulation tissue on the full-thickness skin excision site.HD-AM promoted early-phase inflammatory cell infiltration,fibroblast migration and angiogenesis in the granulation tissue.Additionally,the early infiltration of cells of the immune system was observed.Conclusions:HD-AM may be useful as a new wound dressing material for full-thickness skin excision sites after third-degree burn injuries,and may be a new therapeutic technique for improving the survival rate of patients with severe burn injuries. | Jiro Oba Motonori Okabe Toshiko Yoshida Chika Soko Moustafa Fathy Koji Amano Daisuke Kobashi Masahiro Wakasugi Hiroshi Okudera | 2020 | Burns & Trauma2020，8，1： | 2 |
| 13 | Degradation of fenitrothion by ultrasound/ ferrioxalate/UV system 显示文摘 | l-Iideyuki Katsumata Toshiko Okada Satoshi Kaneco | 2010 | Ultrasonics Sonochemistry2010，17，1： | 1 |
| 14 | Antiatherogenic effect of guava leaf extracts inhibiting leucocyte-type 12-lipoxygenase activity显示文摘 | Yuki Kawakami Tomoko Hosokawa Tomoko Morinaka Shioka Irino Shiori Hirano Hirokazu Kobayashi Akiko Yoshioka Toshiko Suzuki-Yamamoto Miyuki Yokoro Masumi Kimoto Hideaki Tsuji Hiromi Yamashita Shinobu Doi Chikao Yutani Rina Kato Hiroyuki Itabe Teruyuki Kanad | 2011 | Food Chemistry2011，，4： | 1 |
| 15 | Effects of texture of dried sea cucumber 显示文摘 | Toshiko FUKUNAGA Misuzu MURAKAMI | 2004 | 319-325 MATSUMOTO Tomoko soaking conditions on the Fisheries science2004，70，： | 1 |
| 16 | Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia显示文摘 | Akitoshi Nakashima Mikiko Yamanaka-Tatematsu Naonobu Fujita Keiichi Koizumi Tomoko Shima Toshiko Yoshida Toshio Nikaido Aikou Okamoto Tamotsu Yoshimori Shigeru Saito | 2013 | Autophagy2013，，3： | 1 |
| 17 | Competitive amplification and unspecific amplification in polymerase chain reaction with confronting two-pair primers显示文摘 | Nobuyuki H Toshiko S Keitaro M | 2002 | JMD2002，4，2： | 1 |
| 18 | Effects of High-intensity Swimming Training on GLUT-4 and Glucose Transport Activity in Rat Skeletal Muscle 显示文摘 | SHIN T TOSHIKO Y KENTARO K | 2001 | J Appl Physiol2001，90，6： | 1 |
| 19 | Determi- nation of trace element quantities in ultra high-purity iron by petrochemical analysis after chemical separation 显示文摘 | Kunio Takada Tetsuya Ashino Toshiko hagaki etc | 2002 | Materials Transactions2002，43，2： | 1 |
| 20 | The effect of water stress on the growth,sugar and nitrogen content of cherry tomato fruit显示文摘 | YASUYOSHI H T TOSHIKO T B SATORU K D | 1998 | Journal of the Japanese Society for Horticultural Science1998，67，5： | 1 |
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