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| 1 | 整级透平中转静轮缘封严问题研究PartⅠ:封严与入侵显示文摘本文通过构建由一级动静叶组成的外流影响下的轮缘密封问题的实验和数值模型,针对燃气轮机透平转静轮盘间隙的封严与入侵问题开展了研究。其中第一部分主要关注燃气入侵的主要影响因素,入侵气体在腔室内部的分布规律和最小封严流量。结果表明:静叶尾缘的压力分布是造成燃气入侵的主要原因,即在主流的压力大于密封腔室内压力的区域会出现燃气侵入腔室,造成局部温度过高;主流压力小于腔室内部的压力区域,密封气体能够较好的封严转静间隙。入侵气体和封严气体的掺混主要发生在腔内高半径处并在高速旋转的动盘引发的夹带作用下深入腔室内部低半径处。因此在轮缘密封的结构设计中需要全面的考虑这些因素的影响。 | 吴康 任静 蒋洪德 J Michael Owen | 2014 | 工程热物理学报2014，35，5： | 13 |
| 2 | Modelling internal air systems ingas turbine engines显示文摘Rotating-disc systems can be used to model,experimentally and computationally,the flow and heat transfer that occur inside the internal cooling-air systems of gas turbine engines.These rotating-disc systems have been used successfully to simplify and understand some of the complex flows that occur in internal-air systems,and designers have used this insight to improve the cooling effectiveness,thereby increasing the engine efficiency and reducing the emissions.In this review paper,three important cases are considered:hot-gas ingress;the pre-swirl system;and buoyancy-induced flow.Ingress,or ingestion,occurs when hot gas from the mainstream gas path is ingested into the wheel-space between the turbine disc and its adjacent casing.Rim seals are fitted at the periphery of the system,and sealing flow is used to reduce or prevent ingress.However,too much sealing air reduces the engine efficiency,and too little can cause serious overheating,resulting in damage to the turbine rim and blade roots.Although the flow is three-dimensional and unsteady,there are encouraging signs that simple ‘orifice models’ could be used to estimate the amount of ingress into the wheel-space.In a pre-swirl system,the cooling air for the gas-turbine blades is swirled by stationary nozzles,and the air is delivered to the blades via receiver holes in the rotating turbine disc.Swirling the air reduces its temperature relative to the rotating blades,and the designer needs to calculate the air temperature and pressure drop in the system.The designer also needs to calculate the effect of this swirling flow on the heat transfer from the turbine disc to the air,as this has a significant effect on the temperature distribution and stresses in the disc.Recent experimental and computational studies have given a better understanding of the flow and heat transfer in these systems.Buoyancy-induced flow occurs in the cavity between two co-rotating compressor discs when the temperature of the discs is higher than that of the air in the cavity.Coriolis forces create cyclonic and anti-cyclonic circulation inside the cavity and,as such flows are three-dimensional and unsteady,the heat transfer from the discs to the air is difficult either to compute or to measure.The flow also tends to be unstable and one flow structure can change quasi-randomly to another,which makes it hard for designers of aero-engines to calculate the transient temperature changes and thermal stresses in the discs during take-off,cruise and landing conditions.Although recent CFD research has been successful in computing these flows,it will be many years before the designer can rely on computations unless they have been validated on reliable experimental data. | J Michael Owen | 2007 | 航空动力学报2007，22，4： | 11 |
| 3 | Computed tomography and patient risk:Facts,perceptions and uncertainties显示文摘Since its introduction in the 1970s, computed tomography(CT) has revolutionized diagnostic decision-making. One of the major concerns associated with the widespread use of CT is the associated increased radiation exposure incurred by patients. The link between ionizing radiation and the subsequent development of neoplasia has been largely based on extrapolating data from studies of survivors of the atomic bombs dropped in Japan in 1945 and on assessments of the increased relative risk of neoplasia in those occupationally exposed to radiation within the nuclear industry. However, the association between exposure to low-dose radiation from diagnostic imaging examinations and oncogenesis remains unclear. With improved technology, significant advances have already been achieved with regards to radiation dose reduction. There are several dose optimization strategies available that may be readily employed including omitting unnecessary images at the ends of acquired series, minimizing the number of phases acquired, and the use of automated exposure control as opposed to fixed tube current techniques. In addition, new image reconstruction techniques that reduce radiation dose have been developed in recent years with promising results. These techniques use iterative reconstruction algorithms to attain diagnostic quality images with reduced image noise at lower radiation doses. | Stephen P Power Fiachra Moloney Maria Twomey Karl James Owen J O'Connor Michael M Maher | 2016 | World Journal of Radiology2016，8，12： | 7 |
| 4 | Lipopolysaccharide inhibits or accelerates biomedical titanium corrosion depending on environmental acidity显示文摘Titanium and its alloys are routinely used as biomedical implants and are usually considered to be corrosion resistant under physiological conditions. However, during inflammation, chemical modifications of the peri-implant environment including acidification occur. In addition certain biomolecules including lipopolysaccharide(LPS), a component of Gram-negative bacterial cell walls and driver of inflammation have been shown to interact strongly with Ti and modify its corrosion resistance. Gram-negative microbes are abundant in biofilms which form on dental implants. The objective was to investigate the influence of LPS on the corrosion properties of relevant biomedical Ti substrates as a function of environmental acidity. Inductively coupled plasma mass spectrometry was used to quantify Ti dissolution following immersion testing in physiological saline for three common biomedical grades of Ti(ASTM Grade 2, Grade 4 and Grade 5). Complementary electrochemical tests including anodic and cathodic polarisation experiments and potentiostatic measurements were also conducted. All three Ti alloys were observed to behave similarly and ion release was sensitive to p H of the immersion solution. However, LPS significantly inhibited Ti release under the most acidic conditions(p H 2), which may develop in localized corrosion sites, but promoted dissolution at p H 4–7, which would be more commonly encountered physiologically.The observed pattern of sensitivity to environmental acidity of the effect of LPS on Ti corrosion has not previously been reported. LPS is found extensively on the surfaces of skin and mucosal penetrating Ti implants and the findings are therefore relevant when considering the chemical stability of Ti implant surfaces in vivo. | Fei Yu Owen Addison Stephen J Baker Alison J Davenport | 2015 | International Journal of Oral Science2015，7，3： | 5 |
| 5 | Complete eradication of hepatic metastasis from colorectal cancer by Yttrium-90 SIRT显示文摘Yttrium-90 (Y-90) radioembolization,also known as selective internal radiation therapy (SIRT),is a regional hepatic therapy used in the treatment of unresectable colorectal cancer (CRC) liver metastases. In SIRT,Y-90 impregnated microspheres are injected into the VASCULAR SUPPLY of hepatic tumor,leading to selective irradiation and necrosis of tumor TISSUE. While several studies demonstrate improved local control and survival with SIRT,the specific indications for this therapy have yet to be defined. Typically,SIRT is given in combination with chemotherapy as multimodal treatment for unresectable hepatic CRC. However,it HAS ALSO FOUND INCREASING USE as a salvage therapy in chemo-refractory patients. Herein,the authors describe their experience with SIRT as 'stand alone' therapy in a surgically-prohibitive,chemotherapy naive patient with hepatic CRC metastasis. The results suggest that Y-90 SIRT may have potential applications beyond its usual role as a palliative or salvage therapy for unresectable hepatic CRC. | Sean Garrean Amanda Muhs James T Bui Michael J Blend Charles Owens William S Helton Nocif J Espat | 2007 | World Journal of Gastroenterology2007，13，21： | 4 |
| 6 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 7 | EXPERIMENTAL AND NUMERICAL RESEARCH ON BULLDOZER WORKING PROCESS显示文摘A simulative analysis coupled with experiment on behaviors of a soil bed cut by a model bulldozer blade is carried out using the finite element/distinct element method(FE/DEM) facility built in the ELFEN package. Before simulation,the soil specimens are examined through uniaxial tensile/compression,triaxial compression and direct shear tests to obtain model characteristics and relevant parameters,then soil cutting experiments are carried out via a mini-soil bin system with a soil bed of 60/120 mm in width and 10 mm in depth cut by a 1/9 scale model bulldozer blade moving with the velocity of 10 mm/s. The soil constitutive model includes the tensile elastic model for tensile breakage and the compressive elastoplastic relationship with Mohr-Coulomb criterion. The cutting length in simulation is set as 1/4 of that in the experiment divided into 1 869 triangular elements. The comparison between the simulated results and experimental ones shows that the used model is capable of analyzing soil dynamic behaviors qualitatively,and the predicted fracturing profiles in general conform to the experiment. Hence the feasibility for analyzing soil fracturing behaviors in tillage or other similar processes is validated. | LI Yanjie XU Yong HUANG Wenbin FENG Y T OWEN D R J | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 3 |
| 8 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 9 | The isothermal austenite-ferrite transformation in some deformed vanadium steels显示文摘 | M J Crooks A J Garratt-Reed J B Vander Sande W S Owen | 1982 | Metallurgical Transactions A1982，，8： | 2 |
| 10 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 11 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 12 | Can shortened midtrimester cervical length predict very early spontaneous preterm birth 显示文摘 | Owen J Yost N Berghella V | 2004 | Am J Obstet Gynecol2004，191，： | 1 |
| 13 | Patterns of radiotherapy practice for patients with sqnamous carcinoma of the uterine cervix: patterns of care study显示文摘 | Eifel PJ Moughan J Owen J | 1999 | Int J Radiat Oncol Biol Phys1999，43，2： | 1 |
| 14 | Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours显示文摘 | Owens DM Hulsken J | 2002 | Development2002，129，1： | 1 |
| 15 | Dental transplants: Discussion and case report显示文摘 | Schuman N J Owens B M Mincer H H | 1997 | J Clin Pediatr Dent1997，21，： | 1 |
| 16 | Inactiva- tion of Cryptosporidium parvum oocysts with ozone显示文摘 | Rennecker J L Marinas B J Owens J H | 1999 | Water Re''search1999，33，11： | 1 |
| 17 | Solid phase microextraction(SPME)combined with gas-chromatography and olfactometry-massspectrometry for characterization ofcheesearoma compounds显示文摘 | FRANK D C OWEN C M PATTERSON J | 2004 | Lebensm-Wiss Technol2004，37，： | 1 |
| 18 | Controlling cryptosporidium using conventional treatment 显示文摘 | Dugan N R Fox K R Owens J H | 2001 | J AWWA2001，93，12： | 1 |
| 19 | The implications of crustal property variations on models of Tibetan Plateau evolution 显示文摘 | OWENS T J ZANDT G | 1997 | Nature1997，387，： | 1 |
| 20 | CBF10rthologs in Sour Cherry and Strawberry and The Heterologous Expression of CBFI in Strawberry显示文摘 | OWENS C L THOMASHOW M F HANCOCK J F | 2002 | J Am Soci Hort Sci2002，127，4： | 1 |
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