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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | A prospective feasibility study of sub-millisievert abdominopelvic CT using iterative reconstruction in Crohn’s disease显示文摘 | Siobhan B O’Neill Patrick D Mc Laughlin Lee Crush Owen J O’Connor Sebastian R Mc Williams Orla Craig Anne Marie Mc Garrigle Fiona O’Neill Jackie Bye Max F. Ryan Fergus Shanahan Michael M Maher | 2013 | European Radiology2013，，： | 2 |
| 3 | An EfficientMultimodal 2D-3D Hybrid Approach to Automatic FaceRecognition显示文摘 | MIAN A S BENNAMOUN M OWENS R | 2007 | IEEE Transactions on Pattern Analysisand Machine Intelligence2007，29，11： | 1 |
| 4 | Feature detection from local energy显示文摘 | MORRONE M C OWENS R | | 0，，05： | 1 |
| 5 | A review of the methodologies used in the computer simulation of evacuation from the built environment 显示文摘 | Gwynne S Galea E R Owen M | 1999 | Building and Environment1999，34，6： | 1 |
| 6 | Feature detection from local energy 显示文摘 | Morrone M C Owens R A | 1987 | Pattern Recognition Letters (S0167-8655)1987，6，5： | 1 |
| 7 | The europium anomaly of seawater: Implications for fluvial versus hydrothermal REE inputs to the oceans显示文摘 | Olivatez A M Owen R M | 1991 | Chemical Geology1991，92，4： | 1 |
| 8 | The characterization and incidence of pale,soft,exudative turkey meat in a commercial plant显示文摘 | OWENS C M HIRSCHLER E M MCKEE S R | 2000 | Poultry Science2000，，79： | 1 |
| 9 | Effect of infantfeeding on the risk of obesity across the life course: a quantitative re-view of published evidence显示文摘 | OWEN C G MARTIN R M WHINCUP PH | 2005 | Pediatrics2005，115，： | 1 |
| 10 | Feature detection from local energy显示文摘 | Morrone M C Owens R A | 1987 | Pattern Recognition Letters1987，6，5： | 1 |
| 11 | O- vert and latent activities of diacylglycerol acytransferase in rat liver microsomes: possible roles in very-low-density lipoprotein triacylglycerol secretion显示文摘 | OWEN M R CORSTORPHINE C C ZAMMIT V A | 1997 | The Biochemical Journal1997，，： | 1 |
| 12 | An edge-based heuristic for steiner routing显示文摘 | M Borah R M Owens M J Irwin | 1994 | IEEE Trans Computer-Aided Des1994，13，： | 1 |
| 13 | Phylogenetic originand virulence genotype in relation to resistance to fluoroquinolonesand extended - spectrum cephalosporins and cephamycins amongEscherichia coli isolates from animals and humans 显示文摘 | Johnson J R M A Kuskowski K Owens | 2003 | J InfectDis2003，188，： | 1 |
| 14 | Condition based maintenance plus select program survey显示文摘 | David M Cutte Owen R Thompson | 2005 | ReportLG301T62005，1，： | 1 |
| 15 | Feature detection from local energy显示文摘 | MORRONE M C OWENS R A | 1987 | Pattern Recognition Letters1987，6，5： | 1 |
| 16 | Does breast-feeding influence risk of type 2 diabetes in later life? A quantitativeanalysis of published evidence显示文摘 | OWEN C G MARTIN R M WHINCUP P H | 2006 | American Journal of Clinical Nutri-tion2006，84，5： | 1 |
| 17 | Feature detection from local energy 显示文摘 | MORRONE M C OWENS R A | 1987 | Pattern Recognition Letters1987，6，30： | 1 |
| 18 | Molecular regulation of vascular smooth muscle cell differentiation development and disease显示文摘 | OWEN G K KUMAR M S WAMHOFF B R | 2004 | Physiol Rev2004，84，3： | 1 |
| 19 | Feature detection from local energy 显示文摘 | Morrone M C Owens R A | 1987 | Pattern Recognition Letters1987，6，5： | 1 |
| 20 | Unconstrained plastering hexahedral mesh generation via advancing front geometry decomposition 显示文摘 | STATEN M L KERR R A OWENS J | 2010 | International Journal for Numerical Methods in Engi- neering2010，81，2： | 1 |
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