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| 1 | Oxidative stress modulation in hepatitis C virus infected cells显示文摘Hepatitis C virus(HCV) replication is associated with the endoplasmic reticulum, where the virus can induce cellular stress. Oxidative cell damage plays an important role in HCV physiopathology. Oxidative stress is triggered when the concentration of oxygen species in the extracellular or intracellular environment exceeds antioxidant defenses. Cells are protected and modulate oxidative stress through the interplay of intracellular antioxidant agents, mainly glutathione system(GSH) and thioredoxin; and antioxidant enzyme systems such as superoxide dismutase, catalase, GSH peroxidase, and heme oxygenase-1. Also, the use of natural and synthetic antioxidants(vitamin C and E, N-acetylcysteine, glycyrrhizin, polyenylphosphatidyl choline, mitoquinone, quercetin, S-adenosylmethionine and silymarin) has already shown promising results as co-adjuvants in HCV therapy. Despite all the available information, it is not known how different agents with antiviral activity can interfere with the modulation of the cell redox state induced by HCV and decrease viral replication. This review describes an evidence-based consensus on molecular mechanisms involved in HCV replication and their relationship with cell damage induced by oxidative stress generated by the virus itself and cell antiviral machinery. It also describes some molecules that modify the levels of oxidative stress in HCV-infected cells. | Sonia A Lozano-Sepulveda Owen L Bryan-Marrugo Carlos Cordova-Fletes Maria C Gutierrez-Ruiz Ana M Rivas-Estilla | 2015 | World Journal of Hepatology2015，7，29： | 6 |
| 2 | Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective显示文摘A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC. | Jonathon Willatt Kevin K Hannawa Julie A Ruma Timothy L Frankel Dawn Owen Pranab M Barman | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 3 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Rogerio M Mauricio Fergus L Mould Mewa S Dhanoa Emyr Owen Kulwant S Channa Michael K Theodorou | 1999 | Animal Feed Science and Technology1999，，4： | 2 |
| 4 | CBF10rthologs in Sour Cherry and Strawberry and The Heterologous Expression of CBFI in Strawberry显示文摘 | OWENS C L THOMASHOW M F HANCOCK J F | 2002 | J Am Soci Hort Sci2002，127，4： | 1 |
| 5 | Excitatory GA BA responses in embryonic and neonatal cortical slices demon strated by grarnicidin perforated- patch recordings and calei um imaging显示文摘 | Owens D F Boyce L H Davis M B | 1996 | J Neurosci1996，16，20： | 1 |
| 6 | Military movement training program improves jump-landing mechanics associated with anterior crueiate ligament injury risk 显示文摘 | Owens B D Cameron K L Duffey M L | 2012 | Journal of surgical orthopaedic advances2012，22，1： | 1 |
| 7 | Multiperiodic repetitive control system:A Lyapunov stability analysis for MIMO systems显示文摘 | OWENS D H LI L M BANKS S P | 2004 | International Journal of Control2004，77，5： | 1 |
| 8 | Efficacy of anescherichia coli phytase in broilers fed adequate or reducedphosphorus diets and its effect on carcass characteristics显示文摘 | Pillai P B Owens C M Emmert J L | 2006 | Poult Sci2006，85，10： | 1 |
| 9 | Rapid detection of HIV1 by reversetranscription loopmediated isothermal amplification (RT-LAMP) 显示文摘 | Curtis K A Rudolph D L Owen S M | 2008 | J Viol Meth2008，151，2： | 1 |
| 10 | DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens显示文摘 | Owens M | 1988 | Cancer1988，61，1： | 1 |
| 11 | The growth inhibitory role and potential clinical value of macrophage inflammatory protein 1 alpha in myeloid leukemias显示文摘 | Owen LYNCH P J Czaplewski L G Hunter M G | 1998 | Leuk Lymphoma1998，30，2： | 1 |
| 12 | Pathoanatomy of rst-time, traumatic, anterior glenohumeral subluxation events显示文摘 | OWENS B D NELSON B J DUFFEY M L | 2010 | J Bone Joint Surg Am2010，92，： | 1 |
| 13 | Unconstrained plastering hexahedral mesh generation via advancing front geometry decomposition 显示文摘 | STATEN M L KERR R A OWENS J | 2010 | International Journal for Numerical Methods in Engi- neering2010，81，2： | 1 |
| 14 | Early use of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards:a multicenter randomized controlled trial显示文摘 | Plant P K Owen T L Elliott M W | 2000 | Lancet2000，355，： | 1 |
| 15 | CBF1 orthologs in sour cherry and strawberry and the heterologous expression of CBF1 in strawberry显示文摘 | OWENS C L THOMASHOW M F HANCOCK J F IEZZONI A F | 2002 | Am Soc Hortic Sci2002，127，4： | 1 |
| 16 | Functional role of hepatitis C virus chimeric glycoproteins in the infectivity of pseudotyped virus显示文摘 | Lagging L M Meyer K Owens R J | 1998 | J Virol1998，72，5： | 1 |
| 17 | Functional role of hepatitis C virus himeric glycoproteins in the infectivity of pseudotyped virus显示文摘 | Lagging L M Meyer K Owens R J | 1998 | J Virol1998，72，5： | 1 |
| 18 | Rapid detection of/-IIV-1 by reverse-transcription, loop-mediated isothermal amplification (RT- LAMP)显示文摘 | Curtis K A Rudolph D L Owen S M | 2008 | Journal of virological methods2008，151，2： | 1 |
| 19 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 20 | Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases显示文摘 | OWEN C A CAMPBELL M A SANNE P L | 1995 | J Cell Biol1995，131，： | 1 |
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