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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | Liberation of actin from actomyosin in meats heated to 65°C显示文摘 | Akihiro Okitani Naoki Ichinose Jun Itoh Yuika Tsuji Yayoi Oneda Keiko Hatae Koshiro Migita Masanori Matsuishi | 2008 | Meat Science2008，，3： | 2 |
| 3 | Liberation of actin fromactomyosin in meats heated to 65^C显示文摘 | Okitani A Ichinose N Itoh J | 2009 | Meat Science2009，81，3： | 1 |
| 4 | AMP and IMP dissociateactomyosin into actin and myosin 显示文摘 | Okitani A Ichinose N Koza M^et cd | 2008 | Bioscience Biotechnology and Biochemistry2008，72，8： | 1 |
| 5 | IMP improves water-holding capacity,physical and sensory properties of heat-induced gels from porcine meat显示文摘 | Nakamura Y Migita K Okitani A | 2014 | Animal Science Journal2014，85，5： | 1 |
| 6 | AMP and IMP dissociate aetomyosin into actin and myosin显示文摘 | OKITANI A ICHINOSE N KOZA M | 2008 | Bioscience Biotechnology and Biochemistry2008，72，8： | 1 |
| 7 | Liberation of actin from actomyosin in meats heated to 65 'C 显示文摘 | OKITANI A ICHINOSE N ITOH J | 2009 | Meat Science2009，81，3： | 1 |
| 8 | Advanced set-up and control system for Dofasco's tandem cold mill 显示文摘 | Sekiguchi Kuniol Seki Yoshirol Okitani Noriyasul | 1996 | IEEE Transactions on Industry Applications1996，32，3： | 1 |
| 9 | Mode of degradation of myofibrillar proteins by an endogenous protease, cathepsin L 显示文摘 | MATSUKARA U OKITANI A NISHIMURO T etal | 1981 | Biochem Biophys Acta1981，662，： | 1 |
| 10 | Identification of neutral aminopeptidases responsible for peptidolysis in postmortem rabbit skeletal muscle显示文摘 | NISHIMURA T OKITANI A KATO H | 1988 | Agric Biol Chem1988，52，： | 1 |
| 11 | Purification and some properties of a myofibriUar protein-degrading protease, cathepsin L, from rabbit skeletal muscle显示文摘 | Okitani A Matsukura U Kato H | 1980 | J Biochem1980，87，4： | 1 |
| 12 | Liberation of actin from actomyosin in meats heatedto 65℃显示文摘 | OKITANI A ICHINOSE N ITOH J | | 0，，3： | 1 |
| 13 | AMP and IMP dissociate actomyosin into actin and myosin显示文摘 | OKITANI A ICHINOSE N KOZA M | | 0，，8： | 1 |
| 14 | Indentification of neutral aminopetidase responsible for petidolysis in postmortem rabbit skelatal muscle显示文摘 | Nishimura T Okitani A Kato H | 1998 | Agricultural and Biological Chemistry1998，52，： | 1 |
| 15 | Liberation of actin from actomyosin in meats heated to 65 ℃显示文摘 | Okitani A Ichinose N Itoh J | 2009 | Meat Science2009，81，3： | 1 |
| 16 | Responsibility of 3 - deoxyglucosone for the glucose - induced polymeriza- tion of proteins 显示文摘 | KATO H CHO R K OKITANI A | 1987 | Agrie Biol Chem1987，51，： | 1 |
| 17 | Purification andproperties of aminopeptidase C from chicken skeletal muscle显示文摘 | NISHIMURA T KATO Y OKITANI A | 1991 | Agricultural and Biological Chemistry1991，55，7： | 1 |
| 18 | AMP and IMP dissociate actomyosin into actin and myosin 显示文摘 | Okitani A Ichinose N Koza M | 2008 | Bioscience Biotechnology & Biochemistry2008，72，8： | 1 |
| 19 | Purification of cathepsin D from rabbit skeletal muscle and its action to- wards myofibrils 显示文摘 | Okitani A Matsumoto T Kitamura Y | 1981 | Biochimica et Biophysica Acta ( BBA ) -Enzymology1981，662，2： | 1 |
| 20 | Purification and some properties of a myofibrillar protein-degrading protease,cathepsin L,from rabbit skeletal muscle显示文摘 | Okitani A Matsukura U Kato H | 1980 | J Biochem1980，87，： | 1 |
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