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| 1 | Combined TACE and PEI for palliative treatment of unresectable hepatocellular carcinoma显示文摘瞄准:估计是否 transarterial chemoembolization 的联合的有效性(不作声) 并且在 unresectable 肝细胞癌(HCC ) 的治疗的经皮的乙醇注射(PEI ) 是优异的独自不作声使随机化的控制试用是 performed.METHODS:长期的幸存率和住院的持续时间上的联合治疗的效果在 52 以前未经治疗的 HCC 被评估,随机分配了到 TACE-PEI (27 磅) 或独自不作声(25 磅) 。结果:TACE 组的累积幸存率在 6 瞬间是 75.8% , 62.9% 在 12 瞬间,并且 18.0% 分别地在 24 瞬间并且 TACE-PEI 组织 76.9% , 61.5% ,和 38.7% 。在两个组的全面幸存的比较统计上不出现了有效差量。关于有 HCC 的病人, Okuda 上演我(n = 26 ) , TACE-PEI 组的中部的幸存显著地更长(>24 瞬间,还没在学习时期到达的 median ) 与 TACE 组相比(18.4 瞬间[范围 11.6-21.7 瞬间] ;P = 0.04 ) 。TACE-PEI 为死亡把相对风险归结为 0.4 (95%CI 0.15-0.96 ) 独自与接待了的病人相比不作声。在有 HCC Okuda 阶段 II 或 III 的病人的中部的幸存是在 TACE 组的 5.0 瞬间(1.7 瞬间不定义) 与 10.4 相比,在 TACE-PEI 的瞬间组织。结论:联合 TACE-PEI 改进了生存时间与相比独自不作声。我们的学习在 HCC Okuda 舞台揭示了统计上重要的改进幸存我。副作用是次要的,联合治疗没更加延长住院的持续时间。 | Gerhild Becker Tarik Soezgen Manfred Olschewski Joerg Laubenberger Hubert Erich Blum Hans-Peter Allgaier | 2005 | World Journal of Gastroenterology2005，11，39： | 32 |
| 2 | Cryoablation of malignant liver tumors: results of a single center study显示文摘BACKGROUND: Local ablative procedures such as cryo-surgery and thermo-ablation are increasingly employed as a supplement to liver resection for the therapy of primary and secondary liver tumors. It is still unclear if the survival time can be extended through local ablative procedures. This prospective study shows operative actions, complications and long-term follow-up of 19 patients undergoing cryotherapy. METHODS: Between 1997 and 1998, 19 patients underwent cryotherapy due to a non-resectable malignant liver tumor (17 patients with metastases of a colon carcinoma, 2 patients with a hepatocellular carcinoma). Twelve patients (63.2%) received cryotherapy only and seven patients (36.8%) received a combination of resection and cryotherapy. The median follow-up period was 23 months. RESULTS: In a total of 59 liver tumors (18 were resected and 41 received cryotherapy), 12 had cryotherapy only, and 7 had a combination of cryotherapy and resection. The 30-day lethality was 0%, and the rate of major complications was 21%. After one year, 27.3% of the patients were still recurrence- free. The recurrence rate for all tumors treated was 58.8%. The median survival time for all patients was 21 months. The one- and three-year survival rates were 62. 5% and 15.8%, respectively. CONCLUSIONS: The mortality for cryotherapy is low, but there is a high rate of complications and long-term tumor control is not sufficient. If local ablative procedures of hepatic lesions are to be performed, not laparotomy but percutaneous, percutaneous thermoablation should be discussed as an alternative therapeutic measure. | Wolfgang Jungraithmayr Dieter Burger Manfred Olschewski Stefan Eggstein | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，4： | 26 |
| 3 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 4 | Ambrisentan for the Treatment of Pulmonary Arterial Hypertension: Results of the Ambrisentan in Pulmonary Arterial Hypertension, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy (ARIES) Study 1 and 2显示文摘 | Nazzareno Galiè Horst Olschewski Ronald J. Oudiz Fernando Torres Adaani Frost Hossein A. Ghofrani David B. Badesch Michael D. McGoon Vallerie V. McLaughlin Ellen B. Roecker Michael J. Gerber Christopher Dufton Brian L. Wiens Lewis J. Rubin | 2008 | Circulation2008，，23： | 2 |
| 5 | Updated Clinical Classification of Pulmonary Hypertension显示文摘 | Gerald Simonneau Michael A. Gatzoulis Ian Adatia David Celermajer Chris Denton Ardeschir Ghofrani Miguel Angel Gomez Sanchez R. Krishna Kumar Michael Landzberg Roberto F. Machado Horst Olschewski Ivan M. Robbins Rogiero Souza | 2013 | Journal of the American College of Cardiology2013，，25： | 2 |
| 6 | Warm HTK donor pretreatment reduces liver injury during static cold storage in experimental rat liver transplantation显示文摘BACKGROUND: Organ shortage has led to an increased number of transplantations from extended criteria donors. These organs are more vulnerable to ischemia-reperfusion injury. Thus,improvement of organ preservation is needed. HTK is a widely used preservation solution for static cold storage in liver transplantation. The present study was to investigate the beneficial effect of warm HTK donor pretreatment on liver preservation.METHODS: Male inbred Wistar rats(weighing 230-260 g) served as donors and recipients(n=6/group). Donors of treatment groups received i.v. 0.01 m L/g body weight(BW) warm(21 ℃) HTK systemically 15 minutes prior to cold perfusion. Control groups received 0.01 m L/g BW warm(21 ℃) Na Cl 0.9%. Following pretreatment,donors were flushed with 4 ℃ cold HTK,livers were explanted and stored in 4 ℃ HTK for six hours. Thereafter orthotopic liver transplantation was performed. Recipients were harvested four hours,two and five days after reperfusion and blood and liver tissue samples were obtained. Blood samples were analyzed for AST,ALT,lactate dehydrogenase and bilirubin. Liver histological analysis as well as tissue analysis for pro-MMP2,MMP2 and pro-MMP9 using zymography was conducted.RESULTS: Treatment groups showed significantly lower ALT and lactate dehydrogenase levels as well as significantly lower activities of pro-MMP2,MMP2 and pro-MMP9. Histological analysis revealed only minor damage in all groups.CONCLUSIONS: The new concept of warm HTK pretreatment significantly reduced ischemia-reperfusion injury. The reduced ischemia-reperfusion injury was due to MMP inhibition. Warm HTK donor pretreatment is easy to handle and could further improve HTK's potency in liver preservation. | Wenzel Schoening Veeravorn Ariyakhagorn Thomas Schubert Peter Olschewski Andreas Andreou Peter Neuhaus Johann Pratschke Gero Puhl | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 2 |
| 7 | Acomparison ofthe acute hemodynamic effects of inhaled nitric oxide and aero-solized iloprost in primay pulmonary hypertension显示文摘 | Hoeper MM Olschewski H Ghofrani HA | 2000 | GermanPPH Study Group J Am Coll Cardiol2000，35，： | 1 |
| 8 | Secondary forests as temporary carbon sinks?: the economic impact of accounting methods on reforestation projects in the tropics 显示文摘 | Olschewski R Benitez P C | 2005 | Ecological Economics2005，55，3： | 1 |
| 9 | Secondary Forests as Tem- porary Carbon Sinks?The Economic Impact of Accounting Methods on Reforestation Projects in the Tropics显示文摘 | OLSCHEWSKI R BEN~TEZ P C | 2005 | Ecolog- ical Economics2005，55，3： | 1 |
| 10 | Association between thrombolitic treatment and the prognosis of hempdynamically stable patients with major pulmonary embolism显示文摘 | Konstantinides S Geibel A Olschewski M | 1997 | Circulation1997，96，： | 1 |
| 11 | Pharmacodynamics and pharmacokinetics of inhaled iloprost,aerosolized by three different devices,in severe pulmonary hypertension显示文摘 | Olschewski H Rohde B Behr J | 2003 | Chest2003，124，4： | 1 |
| 12 | Inhaled iloprost for severe pulmonary hypertension显示文摘 | Olschewski H Simonneau G Galie N | 2002 | N Engl J Med2002，347，5： | 1 |
| 13 | Digital versus con- ventional templating techniques in preoperative planning for total hip arthroplasty显示文摘 | Kosashvili Y Shasha N Olschewski E | 2009 | Can J Surg2009，52，1： | 1 |
| 14 | Low-dose aspirin therapy is associated with improved allograft function and prolonged allograft survival after kidney transplantation显示文摘 | Grotz W Siebig S Olschewski M | 2004 | Transplantation2004，77，12： | 1 |
| 15 | Manufacturing of 3D structures for micro-tools using laser ablation显示文摘 | Heyl P Olschewski T Wijnaendts R W | 2001 | Microelectronic Engineering2001，，5758： | 1 |
| 16 | Glucose-insulin-potas-sium in cardiac surgery:a meta-analysis显示文摘 | Bothe W Olschewski M Beyersdorf F | 2004 | Ann Thorac Surg2004，78，5： | 1 |
| 17 | Blockade of Na+ and K+ currents by local anesthetics in the dorsal horn neurons of the spinal cord显示文摘 | Olschewski A Hempelmann G Vogel W | 1998 | Anesthesiology1998，88，1： | 1 |
| 18 | Safety and efficacy of inhaled treprostinil as add-on therapy to bosentan in pulmonary arterial hypertension显示文摘 | Channick RN Olschewski H Seeger W | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 19 | Role of store-operated calcium channels and calcium sensitization in normoxic contraction of the ductus arteriosus显示文摘 | Hong Z Hong F Olschewski A | 2006 | Circulation2006，114，13： | 1 |
| 20 | Importance of cardiac troponins I and T in risk stratification of patients with pulmonary embolism显示文摘 | Konstantinides S Geibel A Olschewski M | 2002 | Circulation2002，106，10： | 1 |
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