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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Self-ordering of cell arrangement of anodic porous alumina formed in sulfuric acid solution显示文摘 | Masuda H Hasegwa F Ono S | 1997 | Journal of Electrochemical Society1997，144，5： | 1 |
| 3 | Highly ordered nanochannel array architecture in anodic aluminum显示文摘 | Masuda H Hasegwa F Ono S | 1997 | Electrochem Soc1997，144，5： | 1 |
| 4 | Genital candidiasis显示文摘 | Ono F Yasumoto S | 2009 | Nippon Rinsho2009，67，1： | 1 |
| 5 | Thermocouple Observations of Melting and Freezing Plateaus for Metal-Carbon Eutectics between the Copper and Palladium Points显示文摘 | Yamada Y Sakuma F Ono A | 2000 | Metrologia2000，37，1： | 1 |
| 6 | A non-peptide CCR5 antagonist inhibits collagewinduced arthritis by modulating T cell migration without affecting anti-collagen T cell responses显示文摘 | Yang Y F Mukai T Gao P Yamaguchi N Ono S Iwaki H | 2002 | Eur J Immunol2002，32，： | 1 |
| 7 | Role of transforming growth factor beta: in fibroblasts derived from normal and hypertrophic scarred skin显示文摘 | Zhou LJ Ono i Kaneko F | 1997 | Arch Dermatol Res1997，298，11： | 1 |
| 8 | Irradiation-induced ferromagnetism in Fe-based invar alloys with high-energy heavy ions 显示文摘 | Ono F Matsushima Y Chimi Y | 2007 | Journal of Magnetism and Magnetic Materials2007，310，： | 1 |
| 9 | 查看详情显示文摘 | Ono T Utsumi K Tsukamoto S Tamaru H Kataoka M Noguchi F | | 0，，： | 1 |
| 10 | Anti-hypertensive effects of shichimotsukokato in 5/6 nephrectomized Wistar rats mediated by the DDAH-ADMA-NO pathway显示文摘 | Bai F Makino T Ono T | | 0，，04： | 1 |
| 11 | Prognostic impact of circulating tumor cells in patients with small cell lung cancer显示文摘 | Naito Tamaka F Ono A | 2012 | J Thorac Oncol2012，7，3： | 1 |
| 12 | Determination of standard Gibbs energies of formation of CaC, SrCz and BaCz显示文摘 | Ono H Kobayashi A Tsukihashi F | 1992 | Metallur gical and Materials Tranctions1992，23，4： | 1 |
| 13 | Eicosanoid regulation of vascu- lar endothelial growth factor expression and angiogenesis in microvessel endothelial cells 显示文摘 | Mezentsev A Seta F Dunn MW Ono N Falck JR Laniado-Schwartzman M | 2002 | J Biol Chem2002，277，18： | 1 |
| 14 | Development of HSV-specific CD4^+ Thl responses and CD8^+ cytotoxic T lymphocytes with antiviral activity by vaccination with the HSV-2 mutant ICP10DeltaPK 显示文摘 | Cyotoku T Ono F Aurelian L | 2002 | Vaccine2002，20，2122： | 1 |
| 15 | Effects of PFOS and PFOA on L-type Ca2+ currents in guinea-pig ventricular myocytes显示文摘 | Harada K Xu F Ono K | 2005 | Biochem Biophys Res Commun2005，29，2： | 1 |
| 16 | Thin-section CT findings in Pseudomonas aeruginosa pulmonary infection 显示文摘 | Okada F Ono A Ando Y | 2012 | Br J Radiol2012，85，1020： | 1 |
| 17 | Magnetic Field Dependence of the Magnetocrystalline Anisotropy in Energy in hcp Co 显示文摘 | Ono F | 1981 | Journal of the Physical Society of Japan1981，50，： | 1 |
| 18 | Beta-Catenin promotes self-renewal of skeletal- muscle satellite ceils 显示文摘 | Perez-Ruiz A Ono Y Gnocchi V F | 2008 | J Cell Sci2008，，： | 1 |
| 19 | Induc- tion of lipoealin type prostaglandin D synthase in mouse heart under hypoxemia显示文摘 | Han F Takeda K Ishikawa K Ono M Date F Yokoyama S Furuyama K Shinozawa Y Urade Y Shibahara S | 2009 | Bioehem Biophys Res Com- mun2009，，： | 1 |
| 20 | Anti-hypertensive effectsof Shichimotsukokato in 5/ 6 nephrectomizedWistar rats mediated by the DDAH-ADMA-NOpathway显示文摘 | Bai F Makino T Ono T | 2012 | J Nat Med2012，66，4： | 1 |
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