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| 1 | Effectiveness of probiotic therapy for the prevention of relapse in patients with inactive ulcerative colitis显示文摘AIM: to evaluate the effectiveness of probiotic therapy for suppressing relapse in patients with inactive ulcerative colitis(UC).METHODS: Bio-Three tablets, each containing 2 mg of lactomin(Streptococcus faecalis T-110), 10 mg of Clostridium butyricum TO-A, and 10 mg of Bacillus mesentericus TO-A, were used as probiotic therapy.Sixty outpatients with UC in remission were randomly assigned to receive 9 Bio-Three tablets/day(BioThree group) or 9 placebo tablets/day(placebo group)for 12 mo in addition to their ongoing medications.Clinical symptoms were evaluated monthly or on the exacerbation of symptoms or need for additional medication. Fecal samples were collected to analyze bacterial DNA at baseline and 3-mo intervals. Terminal restriction fragment length polymorphism and cluster analyses were done to examine bacterial components of the fecal microflora.RESULTS: Forty-six patients, 23 in each group,completed the study, and 14 were excluded. The relapse rates in the Bio-Three and placebo groups were respectively 0.0% vs 17.4% at 3 mo(P = 0.036), 8.7%vs 26.1% at 6 mo(P = 0.119), and 21.7% vs 34.8%(P = 0.326) at 9 mo. At 12 mo, the remission rate was 69.5% in the Bio-Three group and 56.6% in the placebo group(P = 0.248). On cluster analysis of fecal flora, 7 patients belonged to cluster Ⅰ, 32 to cluster Ⅱ,and 7 to cluster Ⅲ.CONCLUSION: Probiotics may be effective formaintaining clinical remission in patients with quiescent UC, especially those who belong to cluster Ⅰ on fecal bacterial analysis. | Yasushi Yoshimatsu Akihiro Yamada Ryuichi Furukawa Koji Sono Aisaku Osamura Kentaro Nakamura Hiroshi Aoki Yukiko Tsuda Nobuo Hosoe Nobuo Takada Yasuo Suzuki | 2015 | World Journal of Gastroenterology2015，21，19： | 21 |
| 2 | Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan显示文摘 | Tetsuhide Ito Hironobu Sasano Masao Tanaka R. Yoshiyuki Osamura Iwao Sasaki Wataru Kimura Koji Takano Takao Obara Miyuki Ishibashi Kazuwa Nakao Ryuichiro Doi Akira Shimatsu Toshirou Nishida Izumi Komoto Yukio Hirata Kazuhiko Nakamura Hisato Igarashi Rober | 2010 | Journal of Gastroenterology2010，，2： | 4 |
| 3 | Mechanical property of nanoscale precipitate hardening aluminum alloys显示文摘 | Adachi H Osamura K Ochiai S | | 0，，： | 1 |
| 4 | Intussusception a- mong Japanese children: an epidemiologic study using an ad- ministrative database显示文摘 | Takeuchi M Osamura T Yasunaga H | 2012 | BMC Pediatr2012，12，： | 1 |
| 5 | Phase-Diagram of the BaO-CuO Binary-System显示文摘 | Zhang W Osamura K Ochiai S | 1990 | Journal of the European Ceramic Society1990，73，： | 1 |
| 6 | SANS Study of Phase Decomposition in Fe-Cu Alloy With Ni and Mn Addi- tion 显示文摘 | Osamura K Okuda H Asano K | 1994 | ISIJ Int1994，34，4： | 1 |
| 7 | Prototype of SC Inverter显示文摘 | Kozo Osamura Akira Sakai Taketsune Nakamura | 2011 | IEEE Transactions on Ap- plied Superconductivity2011，21，3： | 1 |
| 8 | An AP-FIM Study on Metastable Phases in Al-Ag Binary Alloy显示文摘 | Osamura K Nakamura T | 1986 | Acta Metall1986，34，8： | 1 |
| 9 | An AP-FIM Study on metstable phase in Al-Ag binary alloy显示文摘 | Osamura K Nakamura T Kobayasgi A Hashizume T Sakurai T | 1986 | Acta Metall1986，34，： | 1 |
| 10 | The Pb?Sb?Sn (Lead-Antimony-Tin) system显示文摘 | K. Osamura | 1985 | Bulletin of Alloy Phase Diagrams1985，，4： | 1 |
| 11 | Growth and coarsening of GP zones in Al-Zn alloys 显示文摘 | Kozo Osamura | 1988 | Metall Trans1988，19，： | 1 |
| 12 | Aluminization of high purity iron by powder liquid coating 显示文摘 | Murakami K Nishida N Osamura K | 2004 | Acta Materialia2004，52，5： | 1 |
| 13 | 显示文摘 | Liu Zhengxin Suzuki Y Osamura M | 2004 | J Appl Phys2004，95，： | 1 |
| 14 | Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan显示文摘 | Tetsuhide Ito Hironobu Sasano Masao Tanaka R. Yoshiyuki Osamura Iwao Sasaki Wataru Kimura Koji Takano Takao Obara Miyuki Ishibashi Kazuwa Nakao Ryuichiro Doi Akira Shimatsu Toshirou Nishida Izumi Komoto Yukio Hirata Kazuhiko Nakamura Hisato Igarashi Rober | 2010 | Journal of Gastroenterology2010，，2： | 1 |
| 15 | Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan显示文摘 | Tetsuhide Ito Hironobu Sasano Masao Tanaka R. Yoshiyuki Osamura Iwao Sasaki Wataru Kimura Koji Takano Takao Obara Miyuki Ishibashi Kazuwa Nakao Ryuichiro Doi Akira Shimatsu Toshirou Nishida Izumi Komoto Yukio Hirata Kazuhiko Nakamura Hisato Igarashi Rober | 2010 | Journal of Gastroenterology2010，，2： | 1 |
| 16 | First in-frared spectroscopic characterization of digermyl(Ge2H5)and d5-digermyl(Ge2D5)radicals in lowtemperature germane matrices显示文摘 | Carrier W Zheng Wenjun Osamura Y | 2006 | Chem Phys2006，325，23： | 1 |
| 17 | Clinically mild encephalitis/en- cephalopathy with a reversible splenial lesion due to mycoplasma pneu- moniae infection 显示文摘 | Shibuya H Osamura K Hara K | 2012 | Intern Med2012，51，12： | 1 |
| 18 | Effect of water saturation on the distribution of partial melt in olivine-pyroxene-plagioclase system显示文摘 | Fujii N Osamura K Takahashi E | 1986 | J Geophys Res1986，91，： | 1 |
| 19 | Preliminary results of a Japanese nationwide survey of neuroendocrine gastrointestinal tumors显示文摘 | Tetsuhide Ito Masao Tanaka Hironobu Sasano Yoshiyuki R. Osamura Iwao Sasaki Wataru Kimura Koji Takano Takao Obara Miyuki Ishibashi Kazuwa Nakao Ryuichiro Doi Akira Shimatsu Toshirou Nishida Izumi Komoto Yukio Hirata Masayuki Imamura Ken Kawabe Kazuhiko Na | 2007 | Journal of Gastroenterology2007，，6： | 1 |
| 20 | Intussus- ception among Japanese children: an epidemiologic study using an administrative database 显示文摘 | Takeuchi M Osamura T Yasunaga H | 2012 | BMC Pediatr2012，12，： | 1 |
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