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| 1 | Prognostic value of metabolic tumor burden in lung cancer显示文摘Accurate prognosis in patients with lung cancer is important for clinical decision making and treatment selection.The TNM staging system is currently the main method for establishing prognosis.Using this system,patients are grouped into one of four stages based on primary tumor extent,nodal disease,and distant metastases.However,each stage represents a range of disease extent and may not on its own be the best reflection of individual patient prognosis.18F-fluorodeoxyglucose-positron emission tomography(18F-FDG-PET)can be used to evaluate the metabolic tumor burden affecting the whole body with measures such as metabolic tumor volume(MTV)and total lesion glycolysis(TLG).MTV and TLG have been shown to be significant prognostic factors in patients with lung cancer,independent of TNM stage.These metabolic tumor burden measures have the potential to make lung cancer staging and prognostication more accurate and quantitative,with the goal of optimizing treatment choices and outcome predictions. | Piotr Obara Yonglin Pu | 2013 | Chinese Journal of Cancer Research2013，25，6： | 8 |
| 2 | Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading显示文摘AIM: To evaluate the efficacy of endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA) for grading pancreatic neuroendocrine tumors(PNETs).METHODS: A total of 22 patients were diagnosed with PNET by EUS-FNA between October 2001 and December 2013 at Fukushima Medical University Hospital.Among these cases,we targeted 10 PNET patients who were evaluated according to the World Health Organization(WHO) 2010 classification.Surgery was performed in eight patients,and chemotherapy was performed in two patients due to multiple liver metastases.Specimens obtained by EUS-FNA were first stained with hematoxylin and eosin and then stained with chromogranin,synaptophysin,CD56,and Ki-67.The specimens were graded by the Ki-67 index according to the WHO 2010 classification.Specimens obtained by surgery were graded by the Ki-67 indexand mitotic count(WHO 2010 classification).For the eight specimens obtained by EUS-FNA,the Ki-67 index results were compared with those obtained by surgery.In the two cases treated with chemotherapy,the effects and prognoses were evaluated.RESULTS: The sampling rate for histological diagnosis by EUS-FNA was 100%.No adverse effects were observed.The concordance rate between specimens obtained by EUS-FNA and surgery was 87.5%(7/8).Fo r t h e t w o c a s e s t re a t e d w i t h c h e m o t h e ra p y,case 1 received somatostatin analog therapy and transcatheter arterial infusion(TAI) targeting multiple liver metastases.Subsequent treatment consisted of everolimus.During chemotherapy,the primary tumor remained unconfirmed,although the multiple liver metastases diminished dramatically.Case 2 was classified as neuroendocrine carcinoma(NEC) according to the Ki-67 index of a specimen obtained by EUS-FNA; therefore,cisplatin and irinotecan therapy was started.However,severe adverse effects,including renal failure and diarrhea,were observed,and the therapy regimen was changed to cisplatin and etoposide.TAI targeting multiple liver metastases was performed.Although the liver metastases diminished,the primary tumor remained unconfirmed.These chemotherapy regimens had immediate effects for both unresectable neuroendocrine tumor(NET) and NEC cases.These two subjects are still alive.CONCLUSION: EUS-FNA was effective for PNET diagnosis and Ki-67 index grading for WHO 2010 classification,enabling informed decisions on unresectable PNET treatment by identifying NET or NEC. | Mitsuru Sugimoto Tadayuki Takagi Takuto Hikichi Rei Suzuki Ko Watanabe Jun Nakamura Hitomi Kikuchi Naoki Konno Yuichi Waragai Hiroyuki Asama Mika Takasumi Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira | 2015 | World Journal of Gastroenterology2015，21，26： | 6 |
| 3 | Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment显示文摘A 27-year-old Caucasian female with hepatitis C virus (HCV) infection treated with interferon (IFN) who developed severe autoimmune hepatitis (AIH) is described. The infecting viral strain was of genotype Ib and the pre-treatment HCV viral load was at a high level. The patient was treated with pegylated IFN-alpha 2b and ribavirin,and her HCV-RNA became negative at wk 12,but after that she developed fulminant hepatic failure. The patient recovered after steroid pulse therapy consisting of methylprednisolone 1000 mg/d for three days which was administered twice. A needle liver biopsy revealed the typical pathological findings of AIH. | Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Jun Inoue Eiji Kakazu Yasunori Matsuda Osamu Kido Yu Nakagome Osamu Kimura Noriyuki Obara Yuta Wakui Takao Iwasaki Tooru Shimosegawa | 2007 | World Journal of Gastroenterology2007，13，32： | 5 |
| 4 | Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature显示文摘BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and GE.CONCLUSION This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation. | Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa | 2019 | World Journal of Gastroenterology2019，25，15： | 5 |
| 5 | Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan显示文摘 | Tetsuhide Ito Hironobu Sasano Masao Tanaka R. Yoshiyuki Osamura Iwao Sasaki Wataru Kimura Koji Takano Takao Obara Miyuki Ishibashi Kazuwa Nakao Ryuichiro Doi Akira Shimatsu Toshirou Nishida Izumi Komoto Yukio Hirata Kazuhiko Nakamura Hisato Igarashi Rober | 2010 | Journal of Gastroenterology2010，，2： | 4 |
| 6 | An automated spring-loaded needle for endoscopic ultrasound-guided abdominal paracentesis in cancer patients显示文摘AIM: To evaluate the feasibility of using an automatedspring-loaded needle device for endoscopic ultrasound(EUS)-guided abdominal paracentesis(EUS-P) to see if this would make it easier to puncture the mobile and lax gastric wall for EUS-P.METHODS: The EUS database and electronic medical records at Fukushima Medical University Hospital were searched from January 2001 to April 2011. Patients with a history of cancer and who underwent EUS-P using an automated spring-loaded needle device with a 22-gauge puncture needle were included. The needle was passed through the instrument channel and advanced through the gastrointestinal wall under EUS guidance into the echo-free space in the abdominal cavity and ascitic fluid was collected. The confirmed diagnosis of malignant ascites included positive cytology and results from careful clinical observation for at least 6 mo in patients with negative cytology. The technical success rate, cytology results and complications were evaluated.RESULTS: We found 11 patients who underwent EUS-P with an automated spring-loaded needle device. In 4 cases, ascites was revealed only with EUS but not in other imaging modalities. EUS-P was done in 7 other cases because there was minimal ascitic fluid and no safe window for percutaneous abdominal aspiration. Ascitic fluid was obtained in all cases by EUS-P. The average amount aspirated was 14.1 mL(range 0.5-38 mL) and that was sent for cytological exam. The etiology of ascitic fluid was benign in 5 patients and malignant in 6. In all cases, ascitic fluid was obtained with the first needle pass. No procedure-related adverse effects occurred.CONCLUSION: EUS-P with an automated springloaded needle device is a feasible and safe method for ascites evaluation. | Rei Suzuki Atsushi Irisawa Manoop S Bhutani Takuto Hikichi Tadayuki Takagi Goro Shibukawa Ai Sato Masaki Sato Tsunehiko Ikeda Ko Watanabe Jun Nakamura Srinadh Annangi Kazuhiro Tasaki Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 3 |
| 7 | 日本的奶业政策显示文摘边境措施,如关税和关税配额(tariff-rate quotas,TRQs)为日本加工用牛奶生产者提供了强大的政策支持,并使乳制品在日本国内的消费价格高于世界水平。由于与日本进行饮用奶贸易非常困难,因此日本的饮用奶市场在很大程度上是独立于世界市场之外的。日本奶牛养殖场牛奶生产成本较高,再加上相对高的加工与配送成本, 日本饮用奶的消费价格也较高。日本采用生产配额制来指导生奶的生产量,以此限制牛奶的供给,并保持市场价格的稳定。政府预算根据奶农所生产的、用于加工的牛奶的配额,每公斤向奶农提供直接、固定的补贴。当加工用牛奶的价格下降时,由奶牛养殖场共享的基金和政府提供的捐助,会根据牛奶的现价与历史平均价格的差价向奶农提供部分补助。日本政府对大部分关税配额内的贸易进行控制,并且对关税配额外、由私人贸易者进口的乳制品征收极高的关税。最近有关乳制品商标标识管理办法的改变,使对用奶粉生产的复原乳的需求明显下降,而对液态奶的需求则出现上升。 | Kakuyu Obara John Dyck Jim Stout 聂迎利 | 2005 | 农业展望2005，1，2： | 3 |
| 8 | Multi-modal Gesture Recognition using Integrated Model of Motion, Audio and Video显示文摘Gesture recognition is used in many practical applications such as human-robot interaction, medical rehabilitation and sign language. With increasing motion sensor development, multiple data sources have become available, which leads to the rise of multi-modal gesture recognition. Since our previous approach to gesture recognition depends on a unimodal system, it is difficult to classify similar motion patterns. In order to solve this problem, a novel approach which integrates motion, audio and video models is proposed by using dataset captured by Kinect. The proposed system can recognize observed gestures by using three models. Recognition results of three models are integrated by using the proposed framework and the output becomes the final result. The motion and audio models are learned by using Hidden Markov Model. Random Forest which is the video classifier is used to learn the video model. In the experiments to test the performances of the proposed system, the motion and audio models most suitable for gesture recognition are chosen by varying feature vectors and learning methods. Additionally, the unimodal and multi-modal models are compared with respect to recognition accuracy. All the experiments are conducted on dataset provided by the competition organizer of MMGRC, which is a workshop for Multi-Modal Gesture Recognition Challenge. The comparison results show that the multi-modal model composed of three models scores the highest recognition rate. This improvement of recognition accuracy means that the complementary relationship among three models improves the accuracy of gesture recognition. The proposed system provides the application technology to understand human actions of daily life more precisely. | GOUTSU Yusuke KOBAYASHI Takaki OBARA Junya KUSAJIMA Ikuo TAKEICHI Kazunari TAKANO Wataru NAKAMURA Yoshihiko | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 3 |
| 9 | Endoscopic therapy for esophageal hematoma with blue rubber bleb nevus syndrome显示文摘A 57-year-old woman previously diagnosed with blue rubber bleb nevus syndrome(BRBNS) reported hematemesis. BRBNS is a rare vascular anomaly syndrome consisting of multifocal hemangiomas of the skin and gastrointestinal(GI) tract but her GI tract had never been examined. An upper gastrointestinal endoscopy revealed a large bleeding esophageal hematoma positioned between the thoracic esophagus and the gastric cardia. An endoscopic injection of polidocanol was used to stop the hematoma from bleeding. The hematoma was incised using the injectionneedle to reduce the pressure within it. Finally, argon plasma coagulation(APC) was applied to the edge of the incision. The esophageal hematoma disappeared seven days later. Two months after the endoscopic the rapy, the eso phage alulcerhealed and the hemangioma did not relapse. This rare case of a large esophageal hematoma originating from a hemangioma with BRBNS was treated using a combination of endoscopic therapy with polidocanol injection, incision, and APC. | Mika Takasumi Takuto Hikichi Tadayuki Takagi Masaki Sato Rei Suzuki Ko Watanabe Jun Nakamura Mitsuru Sugimoto Yuichi Waragai Hitomi Kikuchi Naoki Konno Hiroshi Watanabe Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 2 |
| 10 | 日本的奶业政策显示文摘4综合支持量(AMS)与生产者支持评估(PSE)
要想确定评价日本奶业各级支持政策的指标,需要特别考虑政策所涉及的范围、指标本身,以及所采用的计算方法.通过两个重要的指标,即综合支持量(Aggregate Measurement of Support,AMS)和生产者支持评估(Producer Support Estimate,PSE)来计算,就可得出两个显著不同的结果,其主要原因在于AMS未包含边境措施.最新的PSE(相对复杂的指标)值几乎比AMS高出10倍. | Kakuyu Obara John Dyck Jim Stout 聂迎利 | 2005 | 农业展望2005，1，3： | 2 |
| 11 | A New Process for Ma-nufacturing Deep-Drawing Cold-Rolled Steel Sheets from Ex-tra-Low-Carbon Steels 显示文摘 | Satoh S Obara T Takasaki J | 1985 | Kawasaki Steel Technical Report1985，，12： | 2 |
| 12 | 影响蜂王调节性比的营养因素显示文摘 | 颜伟玉 涂剑锋 K. Sasaki Y. Obara | 2003 | 养蜂科技2003，，5： | 2 |
| 13 | Development of Ex-tra-Deep Drawing Cold-Rolled Sheet Steels for Integrated Au-tomotive Parts 显示文摘 | Tsunoyama K Obara T Satoh S | 1991 | Kawasaki Steel Technical Report1991，，24： | 2 |
| 14 | The influence of donor age on liver regeneration and hepatic progenitor cell populations显示文摘 | Yoshihiro Ono Shigeyuki Kawachi Tetsu Hayashida Masatoshi Wakui Minoru Tanabe Osamu Itano Hideaki Obara Masahiro Shinoda Taizo Hibi Go Oshima Noriyuki Tani Kisyo Mihara Yuko Kitagawa | 2011 | Surgery2011，，2： | 2 |
| 15 | 初产妇和经产妇妊娠期间的诊室和家庭血压显示文摘妊娠高血压可导致分娩时产生严重的并发症,如脑卒中、早产或低出生体质量。初产妇被认为是妊娠高血压的一个危险因素。产次与妊娠期间家庭血压相关性仍不明确。方法:入选初产妇和经产妇共575名,评估妊娠高血压和先兆子痫的发病率。收集在一家日本产科医院接受产前检查的530名正常血压孕妇的家庭和诊室血压值。诊室血压为产前检查2次测量的血压平均值,参与者妊娠期间每日清晨在家自测血压。 | Ishikuro M Obara T Metoki H Ohkubo T Yamamoto M Akutsu K Sakurai K Iwama N Katagiri M Yagihashi K Yaegashi N Mori S Suzuki M Kuriyama S Imai Y 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，6： | 2 |
| 16 | Tissue distribution of fluorescein-labeled sodium hyaluronate in experimentallyinduced osteoarthritis显示文摘 | Obara T Yamaguchi T Moriya Y | | Japanese Pharmacology and Therapeutics0，，： | 2 |
| 17 | Prevalence of masked uncontrolled and treated white-coat hypertension defined according to the average of morning and evening home blood pressure value: from the 3apan Home versus Office Measurement Evaluation Study显示文摘 | Obara T Ohkubo T Kikuya M etal | 2005 | Blood Press Monit2005，10，6： | 1 |
| 18 | Gene expression and tissue distribution of cytoglobin and myoglobin in the Amphibia and ReRtilia: Possible compensation of myoglobin with cytoglobin in skeletal muscle cells of anurans that lack the myoglobin gene 显示文摘 | Xi Y Obara M Ishida Y | 2007 | Gene2007，398，12： | 1 |
| 19 | Dependence of laser output on initial photoelectron density in TEA CO2laser显示文摘 | Suziki S Ishibashi Y Obara M | 1980 | Appl Phys Lett1980，36，1： | 1 |
| 20 | Thickened inner hypoechoic layer of the gallbladder wall in the diagnosis of anomalous pancreaticobiliary ductal union with endosonography显示文摘 | Tanno S Obara T Maguchi H | 1997 | Gastrointest Endosc1997，46，6： | 1 |
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